| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
961 | P43288 | 405 | KSG1_ARATH Shaggy-related protein kinase alph... | 259 | 7e-24 | 108 | 34 | 49 | GO:0005829; C:cytosol; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009933; P:meristem structural organization; IMP:TAIR. | 962 | P30285 | 303 | CDK4_MOUSE Cyclin-dependent kinase 4 OS=Mus m... | 262 | 7e-24 | 107 | 28 | 50 | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:MGI.::GO:0005667; C:transcription factor complex; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051726; P:regulation of cell cycle; IDA:MGI.::GO:0007165; P:signal transduction; IDA:MGI. | 963 | Q9P7I2 | 335 | KCC1_SCHPO Calcium/calmodulin-dependent prote... | 281 | 7e-24 | 108 | 27 | 49 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004683; F:calmodulin-dependent protein kinase activity; TAS:PomBase. | | | | | | | | | | GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0019722; P:calcium-mediated signaling; IC:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase. | 964 | Q7XQP4 | 359 | SAPK7_ORYSJ Serine/threonine-protein kinase S... | 272 | 7e-24 | 108 | 31 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW. | 965 | Q93VK0 | 278 | PPCK2_ARATH Phosphoenolpyruvate carboxylase k... | 266 | 7e-24 | 107 | 30 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0016036; P:cellular response to phosphate starvation; IEP:TAIR.::GO:0046898; P:response to cycloheximide; IDA:UniProtKB.::GO:0009416; P:response to light stimulus; IDA:UniProtKB. | 966 | Q54P26 | 593 | SAMKB_DICDI Probable serine/threonine-protein... | 275 | 7e-24 | 110 | 28 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 967 | Q5RB23 | 1132 | JAK2_PONAB Tyrosine-protein kinase JAK2 OS=Po... | 215 | 0.00002 | 52 | 24 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 968 | O13310 | 469 | ORB6_SCHPO Serine/threonine-protein kinase or... | 306 | 7e-24 | 109 | 27 | 45 | GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase. | | | | | | | | | | GO:0000078; P:cell shape checkpoint; NAS:PomBase.::GO:0071470; P:cellular response to osmotic stress; IMP:PomBase.::GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; TAS:PomBase.::GO:2000100; P:regulation of establishment or maintenance of bipolar cell polarity regulating cell shape; IMP:PomBase.::GO:0007165; P:signal transduction; NAS:PomBase. | 969 | Q62689 | 1132 | JAK2_RAT Tyrosine-protein kinase JAK2 OS=Ratt... | 218 | 0.000001 | 56.2 | 25 | 42 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; IDA:RGD.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016363; C:nuclear matrix; IDA:RGD. | | | | | | | | | | GO:0033130; F:acetylcholine receptor binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0031702; F:type 1 angiotensin receptor binding; IPI:RGD. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0000186; P:activation of MAPKK activity; IMP:RGD.::GO:0031103; P:axon regeneration; IMP:RGD.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0009755; P:hormone-mediated signaling pathway; IDA:RGD.::GO:0008631; P:induction of apoptosis by oxidative stress; IMP:RGD.::GO:0060333; P:interferon-gamma-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0031959; P:mineralocorticoid receptor signaling pathway; IMP:RGD.::GO:0022408; P:negative regulation of cell-cell adhesion; IMP:RGD.::GO:0045822; P:negative regulation of heart contraction; IMP:RGD.::GO:0043526; P:neuroprotection; IMP:RGD.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0050867; P:positive regulation of cell activation; IMP:RGD.::GO:0045597; P:positive regulation of cell differentiation; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0043388; P:positive regulation of DNA binding; IMP:RGD.::GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.::GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.::GO:0032731; P:positive regulation of interleukin-1 beta production; IMP:RGD.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IMP:RGD.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; IMP:RGD.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:RGD.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033194; P:response to hydroperoxide; IMP:RGD.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; IMP:RGD.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IMP:RGD.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IMP:RGD. | 970 | Q54Y55 | 506 | SHKC_DICDI Dual specificity protein kinase sh... | 268 | 7e-24 | 110 | 28 | 49 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051219; F:phosphoprotein binding; ISS:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 971 | Q54I36 | 1338 | PYK3_DICDI Dual specificity protein kinase py... | 178 | 0.52 | 37.7 | 21 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase. | 972 | O60674 | 1132 | JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Ho... | 215 | 0.00002 | 52 | 24 | 41 | GO:0005901; C:caveola; ISS:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0031904; C:endosome lumen; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); IDA:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0019901; F:protein kinase binding; IDA:BHF-UCL.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0030041; P:actin filament polymerization; NAS:BHF-UCL.::GO:0008636; P:activation of caspase activity by protein phosphorylation; ISS:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006928; P:cellular component movement; TAS:ProtInc.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0061180; P:mammary gland epithelium development; ISS:BHF-UCL.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; ISS:BHF-UCL.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL. | 973 | Q6ZI44 | 365 | SAPK6_ORYSJ Serine/threonine-protein kinase S... | 272 | 7e-24 | 108 | 31 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW. | 974 | O19064 | 1131 | JAK2_PIG Tyrosine-protein kinase JAK2 OS=Sus ... | 218 | 0.000003 | 54.7 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 975 | P31693 | 523 | SRC_RSVPA Tyrosine-protein kinase transformin... | 264 | 8e-24 | 110 | 30 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 976 | P08631 | 526 | HCK_HUMAN Tyrosine-protein kinase HCK OS=Homo... | 262 | 8e-24 | 110 | 29 | 52 | GO:0005901; C:caveola; IDA:UniProtKB.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031234; C:extrinsic to internal side of plasma membrane; IMP:UniProtKB.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0002758; P:innate immune response-activating signal transduction; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; TAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043299; P:leukocyte degranulation; TAS:UniProtKB.::GO:0002522; P:leukocyte migration involved in immune response; TAS:UniProtKB.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; TAS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0071801; P:regulation of podosome assembly; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0045728; P:respiratory burst after phagocytosis; TAS:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome. | 977 | Q9STK6 | 516 | WNK3_ARATH Probable serine/threonine-protein ... | 272 | 8e-24 | 110 | 27 | 53 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 978 | Q39238 | 688 | TSL_ARATH Serine/threonine-protein kinase TOU... | 288 | 9e-24 | 111 | 28 | 44 | GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:TAIR. | | | | | | | | | | | 979 | Q02723 | 502 | RKIN1_SECCE Carbon catabolite-derepressing pr... | 269 | 9e-24 | 109 | 28 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW. | 980 | Q54MV2 | 715 | MRKB_DICDI Probable serine/threonine-protein ... | 270 | 9e-24 | 111 | 30 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:dictyBase. | | | | | | | | | | | 981 | P51139 | 411 | MSK3_MEDSA Glycogen synthase kinase-3 homolog... | 259 | 9e-24 | 108 | 35 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 982 | Q6FKD4 | 302 | PHO85_CANGA Negative regulator of the PHO sys... | 241 | 9e-24 | 107 | 30 | 52 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 983 | Q13163 | 448 | MP2K5_HUMAN Dual specificity mitogen-activate... | 273 | 9e-24 | 108 | 27 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:BHF-UCL.::GO:0071363; P:cellular response to growth factor stimulus; ISS:BHF-UCL.::GO:0071499; P:cellular response to laminar fluid shear stress; TAS:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; ISS:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISS:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051247; P:positive regulation of protein metabolic process; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. | 984 | Q62120 | 1129 | JAK2_MOUSE Tyrosine-protein kinase JAK2 OS=Mu... | 218 | 0.000003 | 55.1 | 25 | 43 | GO:0005901; C:caveola; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:BHF-UCL.::GO:0016363; C:nuclear matrix; ISS:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; IPI:MGI.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0019901; F:protein kinase binding; ISS:BHF-UCL. | | | | | | | | | | GO:0008636; P:activation of caspase activity by protein phosphorylation; IDA:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; IDA:UniProtKB.::GO:0000186; P:activation of MAPKK activity; ISS:BHF-UCL.::GO:0031103; P:axon regeneration; ISS:BHF-UCL.::GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:BHF-UCL.::GO:0009755; P:hormone-mediated signaling pathway; ISS:BHF-UCL.::GO:0008631; P:induction of apoptosis by oxidative stress; ISS:BHF-UCL.::GO:0060333; P:interferon-gamma-mediated signaling pathway; ISS:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IMP:UniProtKB.::GO:0061180; P:mammary gland epithelium development; IMP:MGI.::GO:0031959; P:mineralocorticoid receptor signaling pathway; ISS:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0022408; P:negative regulation of cell-cell adhesion; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; IDA:MGI.::GO:0045822; P:negative regulation of heart contraction; ISS:BHF-UCL.::GO:0043526; P:neuroprotection; ISS:BHF-UCL.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0050867; P:positive regulation of cell activation; ISS:BHF-UCL.::GO:0045597; P:positive regulation of cell differentiation; ISS:BHF-UCL.::GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:BHF-UCL.::GO:0043388; P:positive regulation of DNA binding; ISS:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; IMP:BHF-UCL.::GO:0050729; P:positive regulation of inflammatory response; ISS:BHF-UCL.::GO:0032024; P:positive regulation of insulin secretion; ISS:BHF-UCL.::GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:BHF-UCL.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; ISS:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0097012; P:response to granulocyte macrophage colony-stimulating factor stimulus; NAS:BHF-UCL.::GO:0033194; P:response to hydroperoxide; ISS:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; IDA:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; IDA:MGI.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISS:BHF-UCL.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; ISS:BHF-UCL.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; ISS:BHF-UCL. | 985 | Q6PAD2 | 944 | PLK4_XENLA Serine/threonine-protein kinase PL... | 280 | 1e-23 | 111 | 29 | 51 | GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005730; C:nucleolus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | GO:0007099; P:centriole replication; ISS:UniProtKB.::GO:0046601; P:positive regulation of centriole replication; ISS:UniProtKB. | 986 | Q7TSJ6 | 1042 | LATS2_MOUSE Serine/threonine-protein kinase L... | 321 | 1e-23 | 111 | 26 | 44 | GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0034613; P:cellular protein localization; IDA:MGI.::GO:0000082; P:G1/S transition of mitotic cell cycle; IDA:UniProtKB.::GO:0009755; P:hormone-mediated signaling pathway; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IGI:MGI.::GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity; ISS:UniProtKB.::GO:0046620; P:regulation of organ growth; IMP:MGI. | 987 | Q55FJ6 | 507 | Y8078_DICDI Probable serine/threonine-protein... | 233 | 1e-23 | 109 | 28 | 52 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 988 | Q75R65 | 1129 | JAK2_CHICK Tyrosine-protein kinase JAK2 OS=Ga... | 215 | 0.00002 | 52.8 | 24 | 42 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 989 | Q9JIH7 | 2126 | WNK1_RAT Serine/threonine-protein kinase WNK1... | 300 | 1e-23 | 112 | 28 | 50 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IMP:RGD.::GO:0019902; F:phosphatase binding; ISS:UniProtKB.::GO:0019870; F:potassium channel inhibitor activity; IDA:RGD.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0030291; F:protein serine/threonine kinase inhibitor activity; IDA:RGD. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0006811; P:ion transport; ISS:UniProtKB.::GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:RGD. | 990 | Q60DG4 | 943 | NEK4_ORYSJ Serine/threonine-protein kinase Ne... | 275 | 1e-23 | 111 | 26 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 991 | Q9DGE1 | 348 | MK14B_DANRE Mitogen-activated protein kinase ... | 274 | 1e-23 | 107 | 29 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
