| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
961 | Q4R633 | 431 | SGK1_MACFA Serine/threonine-protein kinase Sg... | 234 | 0.000000001 | 65.1 | 26 | 44 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 962 | Q66HE7 | 352 | CDKL1_RAT Cyclin-dependent kinase-like 1 OS=R... | 334 | 0.000000001 | 64.7 | 26 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | GO:0007507; P:heart development; IEP:RGD. | 963 | Q5SUV5 | 386 | MYLK4_MOUSE Myosin light chain kinase family ... | 187 | 0.000000001 | 64.7 | 28 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 964 | Q9UPZ9 | 632 | ICK_HUMAN Serine/threonine-protein kinase ICK... | 240 | 0.000000001 | 65.5 | 25 | 45 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 965 | Q8CEQ0 | 352 | CDKL1_MOUSE Cyclin-dependent kinase-like 1 OS... | 331 | 0.000000001 | 64.3 | 25 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 966 | Q8BLF2 | 595 | CDKL3_MOUSE Cyclin-dependent kinase-like 3 OS... | 237 | 0.000000001 | 65.5 | 24 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 967 | B3NKK1 | 745 | DCLK_DROER Serine/threonine-protein kinase GG... | 288 | 0.000000001 | 65.5 | 28 | 42 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 968 | Q8BRK8 | 552 | AAPK2_MOUSE 5'-AMP-activated protein kinase c... | 323 | 0.000000001 | 65.1 | 23 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004679; F:AMP-activated protein kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0035174; F:histone serine kinase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006914; P:autophagy; IEA:UniProtKB-KW.::GO:0042149; P:cellular response to glucose starvation; IDA:UniProtKB.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0010508; P:positive regulation of autophagy; IMP:UniProtKB.::GO:0045821; P:positive regulation of glycolysis; ISS:UniProtKB.::GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.::GO:2000505; P:regulation of energy homeostasis; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 969 | Q9WVS4 | 420 | MOK_MOUSE MAPK/MAK/MRK overlapping kinase OS=... | 224 | 0.000000001 | 64.7 | 22 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 970 | P49840 | 483 | GSK3A_HUMAN Glycogen synthase kinase-3 alpha ... | 276 | 0.000000001 | 65.1 | 26 | 45 | GO:0030877; C:beta-catenin destruction complex; TAS:UniProtKB.::GO:0005829; C:cytosol; TAS:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0034236; F:protein kinase A catalytic subunit binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL.::GO:0050321; F:tau-protein kinase activity; TAS:UniProtKB. | | | | | | | | | | GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome.::GO:0003214; P:cardiac left ventricle morphogenesis; ISS:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; ISS:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; TAS:UniProtKB.::GO:0061052; P:negative regulation of cell growth involved in cardiac muscle cell development; ISS:BHF-UCL.::GO:0046325; P:negative regulation of glucose import; IMP:BHF-UCL.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; TAS:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; TAS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0032007; P:negative regulation of TOR signaling cascade; ISS:BHF-UCL.::GO:2000077; P:negative regulation of type B pancreatic cell development; TAS:UniProtKB.::GO:0010905; P:negative regulation of UDP-glucose catabolic process; IC:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.::GO:0071879; P:positive regulation of adrenergic receptor signaling pathway; ISS:BHF-UCL.::GO:0030819; P:positive regulation of cAMP biosynthetic process; ISS:BHF-UCL.::GO:2000467; P:positive regulation of glycogen (starch) synthase activity; ISS:BHF-UCL.::GO:0045823; P:positive regulation of heart contraction; ISS:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; NAS:BHF-UCL.::GO:0003073; P:regulation of systemic arterial blood pressure; ISS:BHF-UCL.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 971 | Q8SR90 | 309 | Y8H9_ENCCU Probable cell division protein kin... | 235 | 0.000000001 | 63.9 | 26 | 47 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 972 | P54119 | 324 | CDK1_AJECA Cyclin-dependent kinase 1 OS=capsu... | 251 | 0.000000001 | 64.3 | 24 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 973 | Q5RFL3 | 606 | M3K7_PONAB Mitogen-activated protein kinase k... | 296 | 0.000000001 | 65.5 | 27 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 974 | P27361 | 379 | MK03_HUMAN Mitogen-activated protein kinase 3... | 255 | 0.000000001 | 64.7 | 25 | 43 | GO:0005901; C:caveola; TAS:UniProtKB.::GO:0005856; C:cytoskeleton; TAS:UniProtKB.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004707; F:MAP kinase activity; NAS:UniProtKB.::GO:0019902; F:phosphatase binding; IPI:UniProtKB. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; TAS:Reactome.::GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0072584; P:caveolin-mediated endocytosis; TAS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071260; P:cellular response to mechanical stimulus; IEP:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL.::GO:0033129; P:positive regulation of histone phosphorylation; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051493; P:regulation of cytoskeleton organization; TAS:UniProtKB.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; TAS:Reactome.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0006361; P:transcription initiation from RNA polymerase I promoter; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 975 | Q5EAB2 | 372 | CDK9_BOVIN Cyclin-dependent kinase 9 OS=Bos t... | 243 | 0.000000001 | 64.7 | 26 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 976 | Q86V86 | 326 | PIM3_HUMAN Serine/threonine-protein kinase pi... | 243 | 0.000000001 | 64.3 | 30 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; ISS:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; IMP:UniProtKB. | 977 | Q63454 | 274 | MK04_RAT Mitogen-activated protein kinase 4 O... | 248 | 0.000000002 | 63.5 | 26 | 46 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW. | 978 | Q8VHJ5 | 795 | MARK1_MOUSE Serine/threonine-protein kinase M... | 234 | 0.000000002 | 65.5 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.::GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0050321; F:tau-protein kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0001764; P:neuron migration; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 979 | Q91822 | 323 | PIM3_XENLA Serine/threonine-protein kinase pi... | 260 | 0.000000002 | 63.9 | 30 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. | 980 | O08678 | 793 | MARK1_RAT Serine/threonine-protein kinase MAR... | 234 | 0.000000002 | 65.5 | 25 | 44 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0015630; C:microtubule cytoskeleton; NAS:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0070300; F:phosphatidic acid binding; ISS:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:UniProtKB.::GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0000226; P:microtubule cytoskeleton organization; IDA:RGD.::GO:0001764; P:neuron migration; IDA:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 981 | A2VDU3 | 579 | M3K7_BOVIN Mitogen-activated protein kinase k... | 296 | 0.000000002 | 65.1 | 27 | 42 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 982 | Q01389 | 1478 | BCK1_YEAST Serine/threonine-protein kinase BC... | 246 | 0.000000002 | 65.9 | 24 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043332; C:mating projection tip; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IGI:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:SGD.::GO:0030010; P:establishment of cell polarity; IMP:SGD.::GO:0030242; P:peroxisome degradation; IMP:SGD.::GO:0001101; P:response to acid; IMP:SGD.::GO:0007584; P:response to nutrient; IMP:SGD. | 983 | O43318 | 606 | M3K7_HUMAN Mitogen-activated protein kinase k... | 296 | 0.000000002 | 65.1 | 27 | 42 | GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.::GO:0007252; P:I-kappaB phosphorylation; IDA:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; IDA:UniProtKB.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; NAS:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 984 | Q14680 | 651 | MELK_HUMAN Maternal embryonic leucine zipper ... | 233 | 0.000000002 | 65.5 | 28 | 45 | GO:0005938; C:cell cortex; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IDA:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:UniProtKB.::GO:0030097; P:hemopoiesis; ISS:UniProtKB.::GO:0061351; P:neural precursor cell proliferation; ISS:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. | 985 | Q9NB31 | 497 | CST1_CAEEL Serine/threonine-protein kinase cs... | 295 | 0.000000002 | 65.1 | 24 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.::GO:0048747; P:muscle fiber development; IMP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 986 | Q8TEA7 | 893 | TBCK_HUMAN TBC domain-containing protein kina... | 254 | 0.000000002 | 65.5 | 28 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005097; F:Rab GTPase activator activity; IEA:InterPro. | | | | | | | | | | | 987 | Q62073 | 579 | M3K7_MOUSE Mitogen-activated protein kinase k... | 296 | 0.000000002 | 65.1 | 27 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004708; F:MAP kinase kinase activity; IDA:MGI.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0060546; P:negative regulation of necroptosis; IMP:UniProtKB.::GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:UniProtKB.::GO:0001841; P:neural tube formation; IMP:MGI.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI. | 988 | Q8K0D0 | 523 | CDK17_MOUSE Cyclin-dependent kinase 17 OS=Mus... | 235 | 0.000000002 | 65.1 | 25 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 989 | Q9WV60 | 420 | GSK3B_MOUSE Glycogen synthase kinase-3 beta O... | 238 | 0.000000002 | 64.7 | 26 | 45 | GO:0034747; C:Axin-APC-beta-catenin-GSK3B complex; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0030426; C:growth cone; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0030529; C:ribonucleoprotein complex; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008013; F:beta-catenin binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0050321; F:tau-protein kinase activity; IDA:MGI. | | | | | | | | | | GO:0006916; P:anti-apoptosis; IMP:MGI.::GO:0007409; P:axonogenesis; IGI:MGI.::GO:0044337; P:canonical Wnt receptor signaling pathway involved in positive regulation of apoptotic process; IMP:BHF-UCL.::GO:0016477; P:cell migration; IGI:MGI.::GO:0008283; P:cell proliferation; TAS:MGI.::GO:0007010; P:cytoskeleton organization; TAS:UniProtKB.::GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.::GO:0006983; P:ER overload response; IDA:MGI.::GO:0045444; P:fat cell differentiation; IDA:MGI.::GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.::GO:0044027; P:hypermethylation of CpG island; IMP:BHF-UCL.::GO:0007520; P:myoblast fusion; IDA:MGI.::GO:0051534; P:negative regulation of NFAT protein import into nucleus; ISS:UniProtKB.::GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.::GO:0009887; P:organ morphogenesis; IMP:MGI.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:MGI.::GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:MGI.::GO:0032092; P:positive regulation of protein binding; IDA:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0006611; P:protein export from nucleus; IDA:MGI.::GO:0035372; P:protein localization to microtubule; IGI:MGI.::GO:0000320; P:re-entry into mitotic cell cycle; IDA:MGI.::GO:0006349; P:regulation of gene expression by genetic imprinting; IMP:BHF-UCL.::GO:0032886; P:regulation of microtubule-based process; IDA:UniProtKB. | 990 | Q8BI55 | 632 | DYRK4_MOUSE Dual specificity tyrosine-phospho... | 329 | 0.000000002 | 65.1 | 26 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 991 | Q8T0S6 | 669 | HIPPO_DROME Serine/threonine-protein kinase h... | 338 | 0.000000002 | 65.1 | 25 | 43 | GO:0016020; C:membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004702; F:receptor signaling protein serine/threonine kinase activity; NAS:FlyBase. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IGI:FlyBase.::GO:0035329; P:hippo signaling cascade; TAS:UniProtKB.::GO:0002011; P:morphogenesis of an epithelial sheet; IMP:FlyBase.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:FlyBase.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:FlyBase.::GO:0046621; P:negative regulation of organ growth; TAS:FlyBase.::GO:0045464; P:R8 cell fate specification; IMP:FlyBase.::GO:0010212; P:response to ionizing radiation; IMP:FlyBase.::GO:0072089; P:stem cell proliferation; IDA:FlyBase. |
