| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9UPR0 | 1127 | PLCL2_HUMAN Inactive phospholipase C-like pro... | 57 | 0.00000000003 | 70.1 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 32 | Q8K394 | 1128 | PLCL2_MOUSE Inactive phospholipase C-like pro... | 57 | 0.00000000002 | 70.1 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 33 | O89040 | 1183 | PLCB2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 50 | 0.00000000003 | 69.7 | 54 | 68 | GO:0005829; C:cytosol; IDA:RGD.::GO:0031680; C:G-protein beta/gamma-subunit complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IDA:UniProtKB. | | | | | | | | | | GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; NAS:UniProtKB. | 34 | P10687 | 1216 | PLCB1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 253 | 0.000000000008 | 71.6 | 28 | 44 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016607; C:nuclear speck; ISS:BHF-UCL. | | | | | | | | | | GO:0005509; F:calcium ion binding; IDA:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; ISS:BHF-UCL.::GO:0021987; P:cerebral cortex development; ISS:BHF-UCL.::GO:0051318; P:G1 phase; ISS:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; ISS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007612; P:learning; IEP:RGD.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007613; P:memory; IEP:RGD.::GO:2000438; P:negative regulation of monocyte extravasation; ISS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; IEP:RGD.::GO:2000560; P:positive regulation of CD24 biosynthetic process; ISS:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; ISS:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; ISS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL.::GO:0034284; P:response to monosaccharide stimulus; IDA:BHF-UCL.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IDA:BHF-UCL. | 35 | Q9NQ66 | 1216 | PLCB1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 253 | 0.000000000002 | 73.9 | 28 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0000790; C:nuclear chromatin; ISS:BHF-UCL.::GO:0016607; C:nuclear speck; IDA:BHF-UCL. | | | | | | | | | | GO:0005516; F:calmodulin binding; IPI:BHF-UCL.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0005096; F:GTPase activator activity; IDA:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; ISS:BHF-UCL.::GO:0021987; P:cerebral cortex development; ISS:BHF-UCL.::GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:BHF-UCL.::GO:0051318; P:G1 phase; ISS:BHF-UCL.::GO:0000086; P:G2/M transition of mitotic cell cycle; ISS:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; ISS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0070498; P:interleukin-1-mediated signaling pathway; IDA:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:BHF-UCL.::GO:0035723; P:interleukin-15-mediated signaling pathway; IDA:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007613; P:memory; ISS:BHF-UCL.::GO:2000438; P:negative regulation of monocyte extravasation; ISS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:BHF-UCL.::GO:2000344; P:positive regulation of acrosome reaction; ISS:BHF-UCL.::GO:2000560; P:positive regulation of CD24 biosynthetic process; ISS:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; ISS:BHF-UCL.::GO:0040019; P:positive regulation of embryonic development; ISS:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; IDA:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; ISS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0080154; P:regulation of fertilization; ISS:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 36 | Q9Z1B3 | 1216 | PLCB1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 253 | 0.000000000008 | 71.6 | 28 | 44 | GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.::GO:0016607; C:nuclear speck; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; ISS:BHF-UCL.::GO:0019899; F:enzyme binding; ISS:BHF-UCL.::GO:0005521; F:lamin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; IDA:BHF-UCL.::GO:0007155; P:cell adhesion; IC:BHF-UCL.::GO:0021987; P:cerebral cortex development; IMP:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; TAS:BHF-UCL.::GO:0045444; P:fat cell differentiation; IDA:BHF-UCL.::GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IMP:BHF-UCL.::GO:0051318; P:G1 phase; IDA:BHF-UCL.::GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; IMP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0030225; P:macrophage differentiation; NAS:BHF-UCL.::GO:0007613; P:memory; IMP:BHF-UCL.::GO:0006397; P:mRNA processing; TAS:BHF-UCL.::GO:2000438; P:negative regulation of monocyte extravasation; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0001556; P:oocyte maturation; NAS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:BHF-UCL.::GO:2000344; P:positive regulation of acrosome reaction; IMP:BHF-UCL.::GO:2000560; P:positive regulation of CD24 biosynthetic process; IDA:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; IMP:BHF-UCL.::GO:0040019; P:positive regulation of embryonic development; IMP:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; IMP:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; IDA:BHF-UCL.::GO:0032417; P:positive regulation of sodium:hydrogen antiporter activity; NAS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0080154; P:regulation of fertilization; IMP:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IMP:BHF-UCL. | 37 | P10894 | 1216 | PLCB1_BOVIN 1-phosphatidylinositol 4,5-bispho... | 253 | 0.0000000000009 | 74.7 | 28 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 38 | A3KGF7 | 1181 | PLCB2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 50 | 0.00000000006 | 68.9 | 54 | 68 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 39 | Q8K2J0 | 785 | PLCD3_MOUSE 1-phosphatidylinositol 4,5-bispho... | 57 | 0.000000000004 | 72.4 | 51 | 68 | GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001525; P:angiogenesis; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0060716; P:labyrinthine layer blood vessel development; IGI:MGI.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; IGI:MGI. | 40 | Q62688 | 1096 | PLCL1_RAT Inactive phospholipase C-like prote... | 77 | 0.0000000007 | 65.5 | 43 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 41 | Q5FX52 | 645 | PLCZ1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 57 | 0.0000000007 | 65.1 | 46 | 68 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 42 | Q3USB7 | 1096 | PLCL1_MOUSE Inactive phospholipase C-like pro... | 77 | 0.0000000007 | 65.5 | 43 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050811; F:GABA receptor binding; TAS:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007610; P:behavior; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 43 | Q8K4D7 | 647 | PLCZ1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 57 | 0.0000000005 | 65.5 | 47 | 67 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006816; P:calcium ion transport; IDA:MGI.::GO:0007343; P:egg activation; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 44 | A5D6R3 | 784 | PLD3A_DANRE 1-phosphatidylinositol 4,5-bispho... | 275 | 0.000000000004 | 72.4 | 28 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 45 | Q01970 | 1234 | PLCB3_HUMAN 1-phosphatidylinositol 4,5-bispho... | 148 | 0.00000000003 | 70.1 | 32 | 49 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 46 | Q99JE6 | 1234 | PLCB3_RAT 1-phosphatidylinositol 4,5-bisphosp... | 148 | 0.00000000004 | 69.7 | 32 | 49 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:UniProtKB.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; NAS:UniProtKB. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IDA:UniProtKB.::GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:RGD. | 47 | P51432 | 1234 | PLCB3_MOUSE 1-phosphatidylinositol 4,5-bispho... | 148 | 0.00000000003 | 69.7 | 32 | 49 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 48 | Q95JS1 | 641 | PLCZ1_MACFA 1-phosphatidylinositol 4,5-bispho... | 57 | 0.0000000005 | 65.9 | 47 | 67 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007338; P:single fertilization; IEA:UniProtKB-KW. | 49 | Q8K4S1 | 2282 | PLCE1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 163 | 0.0000000003 | 67 | 33 | 47 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 50 | Q4KWH5 | 1682 | PLCH1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 169 | 0.0000000009 | 65.5 | 30 | 46 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 51 | Q9P212 | 2302 | PLCE1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 163 | 0.0000000002 | 67.8 | 33 | 47 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; TAS:UniProtKB.::GO:0005057; F:receptor signaling protein activity; TAS:UniProtKB. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; IDA:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; IDA:UniProtKB.::GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; NAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:UniProtKB.::GO:0007204; P:elevation of cytosolic calcium ion concentration; TAS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; NAS:UniProtKB.::GO:0032835; P:glomerulus development; IMP:HGNC.::GO:0007507; P:heart development; TAS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; IC:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0001558; P:regulation of cell growth; TAS:UniProtKB.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0006940; P:regulation of smooth muscle contraction; TAS:UniProtKB. | 52 | Q4KWH8 | 1693 | PLCH1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 169 | 0.0000000003 | 66.6 | 31 | 46 | GO:0031965; C:nuclear membrane; IDA:HPA. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050429; F:calcium-dependent phospholipase C activity; IDA:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:MGI. | 53 | Q99P84 | 2281 | PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 163 | 0.0000000001 | 68.2 | 34 | 49 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IDA:RGD.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB. | 54 | P13217 | 1095 | PIPA_DROME 1-phosphatidylinositol 4,5-bisphos... | 253 | 0.000000001 | 64.7 | 27 | 42 | GO:0016027; C:inaD signaling complex; IPI:FlyBase.::GO:0005624; C:membrane fraction; IDA:FlyBase. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; NAS:FlyBase.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:FlyBase.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008344; P:adult locomotory behavior; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IDA:FlyBase.::GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IMP:FlyBase.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:FlyBase.::GO:0051482; P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger; TAS:FlyBase.::GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.::GO:0008377; P:light-induced release of internally sequestered calcium ion; TAS:FlyBase.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0002385; P:mucosal immune response; IMP:FlyBase.::GO:0046673; P:negative regulation of compound eye retinal cell programmed cell death; IMP:FlyBase.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:FlyBase.::GO:0008654; P:phospholipid biosynthetic process; TAS:FlyBase.::GO:0045494; P:photoreceptor cell maintenance; IMP:FlyBase.::GO:0043052; P:thermotaxis; IMP:FlyBase. | 55 | Q15111 | 1095 | PLCL1_HUMAN Inactive phospholipase C-like pro... | 57 | 0.00000005 | 59.7 | 42 | 65 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; TAS:ProtInc.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 56 | Q1RML2 | 634 | PLCZ1_BOVIN 1-phosphatidylinositol 4,5-bispho... | 57 | 0.0000000009 | 64.7 | 47 | 67 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 57 | Q9QW07 | 1175 | PLCB4_RAT 1-phosphatidylinositol 4,5-bisphosp... | 46 | 0.0000000001 | 67.8 | 59 | 72 | GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005626; C:insoluble fraction; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0043267; P:negative regulation of potassium ion transport; IMP:RGD.::GO:0007602; P:phototransduction; NAS:RGD. | 58 | Q07722 | 1023 | PLCB4_BOVIN 1-phosphatidylinositol 4,5-bispho... | 211 | 0.0000000004 | 66.2 | 28 | 45 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 59 | Q15147 | 1175 | PLCB4_HUMAN 1-phosphatidylinositol 4,5-bispho... | 211 | 0.0000000005 | 65.9 | 28 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 60 | Q39032 | 561 | PLCD1_ARATH Phosphoinositide phospholipase C ... | 231 | 0.0002 | 47.8 | 26 | 41 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0009414; P:response to water deprivation; IEP:TAIR. | 61 | Q86YW0 | 608 | PLCZ1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 57 | 0.0000000006 | 65.5 | 47 | 67 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. |
