| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q9Y7K2 | 2337 | TOR2_SCHPO Phosphatidylinositol 3-kinase tor2... | 2331 | 0 | 2226 | 50 | 67 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0034064; C:Tor2-Mei2-Ste11 complex; IDA:PomBase.::GO:0031931; C:TORC1 complex; IDA:PomBase. | | | | | | | | | | GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0030996; P:cell cycle arrest in response to nitrogen starvation; IMP:PomBase.::GO:0031670; P:cellular response to nutrient; NAS:PomBase.::GO:0010507; P:negative regulation of autophagy; IMP:PomBase.::GO:0010503; P:negative regulation of cell cycle arrest in response to nitrogen starvation; IMP:PomBase.::GO:0010515; P:negative regulation of induction of conjugation with cellular fusion; IMP:PomBase.::GO:0031929; P:TOR signaling cascade; TAS:PomBase. | 2 | Q86C65 | 2380 | TOR_DICDI Target of rapamycin OS=Dictyosteliu... | 2355 | 0 | 2050 | 47 | 63 | GO:0031932; C:TORC2 complex; IPI:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. | 3 | P32600 | 2474 | TOR2_YEAST Serine/threonine-protein kinase TO... | 2364 | 0 | 1990 | 46 | 64 | GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0031931; C:TORC1 complex; IPI:SGD.::GO:0031932; C:TORC2 complex; IPI:SGD. | | | | | | | | | | GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD. | | | | | | | | | | GO:0030037; P:actin filament reorganization involved in cell cycle; TAS:SGD.::GO:0030950; P:establishment or maintenance of actin cytoskeleton polarity; IMP:SGD.::GO:0000080; P:G1 phase of mitotic cell cycle; TAS:SGD.::GO:0010507; P:negative regulation of autophagy; IGI:SGD.::GO:0045807; P:positive regulation of endocytosis; IMP:SGD.::GO:0051726; P:regulation of cell cycle; TAS:SGD.::GO:0001558; P:regulation of cell growth; TAS:SGD.::GO:0007266; P:Rho protein signal transduction; IMP:SGD.::GO:0042254; P:ribosome biogenesis; IMP:SGD.::GO:0031929; P:TOR signaling cascade; IMP:SGD. | 4 | P35169 | 2470 | TOR1_YEAST Serine/threonine-protein kinase TO... | 2388 | 0 | 1988 | 46 | 63 | GO:0010008; C:endosome membrane; IDA:SGD.::GO:0031234; C:extrinsic to internal side of plasma membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0000139; C:Golgi membrane; IDA:SGD.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0031931; C:TORC1 complex; IPI:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0031505; P:fungal-type cell wall organization; IMP:SGD.::GO:0000080; P:G1 phase of mitotic cell cycle; IMP:SGD.::GO:0007126; P:meiosis; IMP:SGD.::GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:SGD.::GO:0010507; P:negative regulation of autophagy; IGI:SGD.::GO:0051726; P:regulation of cell cycle; IMP:SGD.::GO:0001558; P:regulation of cell growth; IMP:SGD.::GO:0006974; P:response to DNA damage stimulus; IMP:SGD.::GO:0042254; P:ribosome biogenesis; IMP:SGD.::GO:0031929; P:TOR signaling cascade; IMP:SGD.::GO:0042790; P:transcription of nuclear large rRNA transcript from RNA polymerase I promoter; IMP:SGD. | 5 | O14356 | 2335 | TOR1_SCHPO Phosphatidylinositol 3-kinase tor1... | 2338 | 0 | 1952 | 45 | 64 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0031932; C:TORC2 complex; IDA:PomBase. | | | | | | | | | | GO:0016303; F:1-phosphatidylinositol-3-kinase activity; TAS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0007569; P:cell aging; TAS:PomBase.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071470; P:cellular response to osmotic stress; IMP:PomBase.::GO:0031142; P:induction of conjugation upon nitrogen starvation; IMP:PomBase.::GO:0043091; P:L-arginine import; IMP:PomBase.::GO:0048015; P:phosphatidylinositol-mediated signaling; NAS:PomBase.::GO:0060357; P:regulation of leucine import; IMP:PomBase.::GO:0009266; P:response to temperature stimulus; IMP:PomBase.::GO:0031929; P:TOR signaling cascade; TAS:PomBase. | 6 | P42345 | 2549 | MTOR_HUMAN Serine/threonine-protein kinase mT... | 254 | 1e-19 | 101 | 30 | 49 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0005942; C:phosphatidylinositol 3-kinase complex; NAS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.::GO:0031931; C:TORC1 complex; IDA:UniProtKB.::GO:0031932; C:TORC2 complex; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051219; F:phosphoprotein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0001030; F:RNA polymerase III type 1 promoter DNA binding; IDA:UniProtKB.::GO:0001031; F:RNA polymerase III type 2 promoter DNA binding; IDA:UniProtKB.::GO:0001032; F:RNA polymerase III type 3 promoter DNA binding; IDA:UniProtKB.::GO:0001156; F:TFIIIC-class transcription factor binding; IDA:UniProtKB. | | | | | | | | | | GO:0016049; P:cell growth; IDA:UniProtKB.::GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.::GO:0031669; P:cellular response to nutrient levels; ISS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.::GO:0046889; P:positive regulation of lipid biosynthetic process; IMP:UniProtKB.::GO:0045945; P:positive regulation of transcription from RNA polymerase III promoter; IMP:UniProtKB.::GO:0045727; P:positive regulation of translation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0030163; P:protein catabolic process; TAS:UniProtKB.::GO:0043200; P:response to amino acid stimulus; IDA:UniProtKB.::GO:0007584; P:response to nutrient; NAS:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0031929; P:TOR signaling cascade; IMP:UniProtKB. | 7 | Q9JLN9 | 2549 | MTOR_MOUSE Serine/threonine-protein kinase mT... | 254 | 5e-20 | 102 | 31 | 49 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0043022; F:ribosome binding; IDA:UniProtKB. | | | | | | | | | | GO:0071456; P:cellular response to hypoxia; IDA:UniProtKB.::GO:0031669; P:cellular response to nutrient levels; IDA:UniProtKB.::GO:0007281; P:germ cell development; IDA:MGI.::GO:0045792; P:negative regulation of cell size; IGI:MGI.::GO:0016242; P:negative regulation of macroautophagy; IMP:MGI.::GO:0051534; P:negative regulation of NFAT protein import into nucleus; IMP:MGI.::GO:0018105; P:peptidyl-serine phosphorylation; IMP:MGI.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MGI.::GO:0030838; P:positive regulation of actin filament polymerization; IDA:MGI.::GO:0010592; P:positive regulation of lamellipodium assembly; IDA:MGI.::GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:UniProtKB.::GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.::GO:0051496; P:positive regulation of stress fiber assembly; IDA:MGI.::GO:0045859; P:regulation of protein kinase activity; IGI:MGI.::GO:0032314; P:regulation of Rac GTPase activity; IMP:MGI.::GO:0043200; P:response to amino acid stimulus; IDA:MGI.::GO:0032868; P:response to insulin stimulus; IDA:MGI.::GO:0031529; P:ruffle organization; IDA:MGI. | 8 | P42346 | 2549 | MTOR_RAT Serine/threonine-protein kinase mTOR... | 254 | 4e-20 | 102 | 31 | 49 | GO:0005829; C:cytosol; IDA:RGD.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0070438; C:mTOR-FKBP12-rapamycin complex; IDA:RGD.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0031931; C:TORC1 complex; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD. | | | | | | | | | | GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.::GO:0031669; P:cellular response to nutrient levels; ISS:UniProtKB.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:RGD.::GO:0045792; P:negative regulation of cell size; IMP:MGI.::GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:RGD.::GO:0046889; P:positive regulation of lipid biosynthetic process; ISS:UniProtKB.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:RGD.::GO:0045727; P:positive regulation of translation; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IMP:RGD.::GO:0043610; P:regulation of carbohydrate utilization; IDA:RGD.::GO:0031998; P:regulation of fatty acid beta-oxidation; IDA:RGD.::GO:0005979; P:regulation of glycogen biosynthetic process; IDA:RGD.::GO:0032095; P:regulation of response to food; IDA:RGD. | 9 | Q9FR53 | 2481 | TOR_ARATH Serine/threonine-protein kinase TOR... | 2443 | 0 | 1672 | 39 | 58 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:UniProtKB.::GO:0043621; F:protein self-association; IPI:TAIR.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0000975; F:regulatory region DNA binding; IDA:UniProtKB. | | | | | | | | | | GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.::GO:0010507; P:negative regulation of autophagy; IMP:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IGI:UniProtKB.::GO:0040019; P:positive regulation of embryonic development; IMP:UniProtKB.::GO:2000234; P:positive regulation of rRNA processing; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IGI:UniProtKB.::GO:0009303; P:rRNA transcription; IMP:TAIR. | 10 | Q0DJS1 | 2465 | TOR_ORYSJ Serine/threonine-protein kinase TOR... | 2415 | 0 | 1635 | 40 | 58 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. | 11 | Q9VK45 | 2470 | TOR_DROME Target of rapamycin OS=Drosophila m... | 269 | 0.00000003 | 63.5 | 23 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004672; F:protein kinase activity; NAS:FlyBase.::GO:0043621; F:protein self-association; IDA:FlyBase. | | | | | | | | | | GO:0006914; P:autophagy; IMP:FlyBase.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0009594; P:detection of nutrient; TAS:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0032456; P:endocytic recycling; IDA:FlyBase.::GO:0008406; P:gonad development; IMP:FlyBase.::GO:0035264; P:multicellular organism growth; IMP:FlyBase.::GO:0030307; P:positive regulation of cell growth; NAS:FlyBase.::GO:0045793; P:positive regulation of cell size; IMP:FlyBase.::GO:0040018; P:positive regulation of multicellular organism growth; TAS:FlyBase.::GO:0046622; P:positive regulation of organ growth; TAS:FlyBase.::GO:0001934; P:positive regulation of protein phosphorylation; IGI:FlyBase.::GO:0090070; P:positive regulation of ribosome biogenesis; IMP:FlyBase.::GO:2000377; P:regulation of reactive oxygen species metabolic process; IGI:FlyBase.::GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase. | 12 | Q95Q95 | 2697 | TOR_CAEEL Target of rapamycin homolog OS=Caen... | 706 | 1e-75 | 285 | 29 | 47 | GO:0005737; C:cytoplasm; IDA:WormBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016301; F:kinase activity; IEA:UniProtKB-KW.::GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro. | | | | | | | | | | GO:0000492; P:box C/D snoRNP assembly; IMP:WormBase.::GO:0043053; P:dauer entry; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0006629; P:lipid metabolic process; IMP:WormBase.::GO:0045727; P:positive regulation of translation; IMP:WormBase.::GO:0009408; P:response to heat; IMP:WormBase.::GO:0031929; P:TOR signaling cascade; IMP:WormBase.::GO:0006412; P:translation; IMP:WormBase. | 13 | Q70PP2 | 3218 | SMG1_DROME Serine/threonine-protein kinase Sm... | 585 | 3e-55 | 218 | 27 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007274; P:neuromuscular synaptic transmission; IDA:FlyBase.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006950; P:response to stress; ISS:UniProtKB.::GO:0050808; P:synapse organization; IDA:FlyBase.::GO:0048489; P:synaptic vesicle transport; IDA:FlyBase. | 14 | Q61CW2 | 2313 | SMG1_CAEBR Serine/threonine-protein kinase sm... | 591 | 3e-50 | 201 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. | 15 | O01510 | 2322 | SMG1_CAEEL Serine/threonine-protein kinase sm... | 599 | 1e-48 | 196 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0030539; P:male genitalia development; IMP:WormBase.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IGI:WormBase. | 16 | Q54ER4 | 3157 | ATR1_DICDI Probable serine/threonine-protein ... | 258 | 0.000005 | 56.2 | 23 | 42 | GO:0005634; C:nucleus; ISS:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000075; P:cell cycle checkpoint; ISS:dictyBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0042770; P:signal transduction in response to DNA damage; ISS:dictyBase. | 17 | Q9DE14 | 2654 | ATR_XENLA Serine/threonine-protein kinase atr... | 268 | 0.00002 | 54.3 | 24 | 44 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB. | 18 | Q8BKX6 | 3658 | SMG1_MOUSE Serine/threonine-protein kinase SM... | 114 | 0.006 | 45.8 | 30 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IEA:UniProtKB-KW. | 19 | Q96Q15 | 3661 | SMG1_HUMAN Serine/threonine-protein kinase SM... | 114 | 0.005 | 46.2 | 30 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0006406; P:mRNA export from nucleus; TAS:UniProtKB.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; IDA:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. | 20 | Q13535 | 2644 | ATR_HUMAN Serine/threonine-protein kinase ATR... | 156 | 0.21 | 40.8 | 23 | 44 | GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0032405; F:MutLalpha complex binding; IDA:MGI.::GO:0032407; F:MutSalpha complex binding; IDA:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0007049; P:cell cycle; TAS:ProtInc.::GO:0071480; P:cellular response to gamma radiation; IDA:BHF-UCL.::GO:0034644; P:cellular response to UV; IMP:BHF-UCL.::GO:0000077; P:DNA damage checkpoint; IDA:UniProtKB.::GO:0006281; P:DNA repair; TAS:Reactome.::GO:0006260; P:DNA replication; TAS:Reactome.::GO:0007275; P:multicellular organismal development; TAS:ProtInc.::GO:0008156; P:negative regulation of DNA replication; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:0090399; P:replicative senescence; IMP:BHF-UCL. | 21 | Q02099 | 2386 | RAD3_SCHPO Protein kinase rad3 OS=Schizosacch... | 283 | 9e-42 | 173 | 36 | 56 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0000228; C:nuclear chromosome; IDA:PomBase.::GO:0043234; C:protein complex; NAS:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:PomBase. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0031573; P:intra-S DNA damage checkpoint; IDA:PomBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; NAS:PomBase. | 22 | Q9JKK8 | 2635 | ATR_MOUSE Serine/threonine-protein kinase ATR... | 156 | 0.72 | 38.9 | 24 | 46 | GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:Reactome. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 23 | Q13315 | 3056 | ATM_HUMAN Serine-protein kinase ATM OS=Homo s... | 298 | 3e-41 | 172 | 34 | 54 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0016303; F:1-phosphatidylinositol-3-kinase activity; IMP:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004677; F:DNA-dependent protein kinase activity; IDA:BHF-UCL.::GO:0032403; F:protein complex binding; IDA:BHF-UCL.::GO:0046983; F:protein dimerization activity; IDA:BHF-UCL.::GO:0047485; F:protein N-terminus binding; IDA:UniProtKB. | | | | | | | | | | GO:0007050; P:cell cycle arrest; IMP:BHF-UCL.::GO:0071480; P:cellular response to gamma radiation; IDA:BHF-UCL.::GO:0006975; P:DNA damage induced protein phosphorylation; IDA:BHF-UCL.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:BHF-UCL.::GO:0071044; P:histone mRNA catabolic process; IDA:UniProtKB.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB.::GO:0030889; P:negative regulation of B cell proliferation; IMP:UniProtKB.::GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; IMP:BHF-UCL.::GO:0002331; P:pre-B cell allelic exclusion; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:0007131; P:reciprocal meiotic recombination; TAS:ProtInc.::GO:0090399; P:replicative senescence; IMP:BHF-UCL. | 24 | Q59LR2 | 2325 | ATR_CANAL Serine/threonine-protein kinase MEC... | 282 | 3e-41 | 172 | 37 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 25 | Q6BV76 | 2948 | ATM_DEBHA Serine/threonine-protein kinase TEL... | 536 | 8e-41 | 170 | 26 | 46 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 26 | Q6PQD5 | 3057 | ATM_PIG Serine-protein kinase ATM OS=Sus scro... | 298 | 2e-40 | 169 | 35 | 55 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005840; C:ribosome; IEA:InterPro. | | | | | | | | | | GO:0016303; F:1-phosphatidylinositol-3-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0047485; F:protein N-terminus binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0003735; F:structural constituent of ribosome; IEA:InterPro. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0071044; P:histone mRNA catabolic process; ISS:UniProtKB.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; ISS:UniProtKB.::GO:0002331; P:pre-B cell allelic exclusion; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.::GO:0006412; P:translation; IEA:InterPro. | 27 | Q9VXG8 | 2517 | ATR_DROME Serine/threonine-protein kinase ATR... | 268 | 3e-40 | 168 | 34 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0007349; P:cellularization; TAS:FlyBase.::GO:0030261; P:chromosome condensation; IGI:FlyBase.::GO:0000076; P:DNA replication checkpoint; IMP:FlyBase.::GO:0045002; P:double-strand break repair via single-strand annealing; IMP:FlyBase.::GO:0045003; P:double-strand break repair via synthesis-dependent strand annealing; IMP:FlyBase.::GO:0001700; P:embryonic development via the syncytial blastoderm; TAS:FlyBase.::GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.::GO:0007444; P:imaginal disc development; TAS:FlyBase.::GO:0007133; P:meiotic anaphase I; IMP:FlyBase.::GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint; IMP:FlyBase.::GO:0048477; P:oogenesis; TAS:FlyBase.::GO:0007131; P:reciprocal meiotic recombination; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0007088; P:regulation of mitosis; IMP:FlyBase.::GO:0007348; P:regulation of syncytial blastoderm mitotic cell cycle; TAS:FlyBase.::GO:0009314; P:response to radiation; TAS:FlyBase.::GO:0000723; P:telomere maintenance; IGI:FlyBase. | 28 | Q6CT34 | 2287 | ATR_KLULA Serine/threonine-protein kinase MEC... | 293 | 2e-39 | 166 | 35 | 54 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007126; P:meiosis; IEA:UniProtKB-KW. | 29 | Q9FKS4 | 2702 | ATR_ARATH Serine/threonine-protein kinase ATR... | 132 | 0.2 | 40.8 | 27 | 44 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0009506; C:plasmodesma; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006281; P:DNA repair; IGI:TAIR.::GO:0007126; P:meiosis; IGI:TAIR.::GO:0032504; P:multicellular organism reproduction; IGI:TAIR.::GO:0032204; P:regulation of telomere maintenance; IGI:TAIR.::GO:0010044; P:response to aluminum ion; IMP:TAIR.::GO:0010332; P:response to gamma radiation; IMP:TAIR.::GO:0043247; P:telomere maintenance in response to DNA damage; TAS:TAIR.::GO:0007004; P:telomere maintenance via telomerase; IMP:TAIR. | 30 | Q9DEI1 | 4146 | PRKDC_XENLA DNA-dependent protein kinase cata... | 514 | 3e-39 | 166 | 27 | 46 | GO:0070419; C:nonhomologous end joining complex; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004677; F:DNA-dependent protein kinase activity; IEA:InterPro. | | | | | | | | | | GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro. | 31 | Q4IB89 | 2813 | ATM_GIBZE Serine/threonine-protein kinase TEL... | 510 | 4e-39 | 165 | 28 | 44 | GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW. |
