| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P53687 | 447 | HST3_YEAST NAD-dependent histone deacetylase ... | 44 | 0.000007 | 53.5 | 50 | 75 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IC:SGD. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006348; P:chromatin silencing at telomere; IGI:SGD.::GO:0016575; P:histone deacetylation; IMP:SGD.::GO:0046459; P:short-chain fatty acid metabolic process; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 2 | Q5A1W9 | 487 | HST3_CANAL NAD-dependent histone deacetylase ... | 47 | 0.000001 | 55.8 | 51 | 81 | | | | | | | | | | | GO:0004407; F:histone deacetylase activity; IMP:CGD.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0071572; P:histone H3-K56 deacetylation; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0045595; P:regulation of cell differentiation; IMP:CGD. | 3 | Q5BE04 | 595 | HST4_EMENI NAD-dependent protein deacetylase ... | 66 | 0.0000006 | 57.4 | 39 | 64 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 4 | Q9UR39 | 415 | HST4_SCHPO NAD-dependent protein deacetylase ... | 51 | 0.0000003 | 57.8 | 49 | 80 | GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.::GO:0005730; C:nucleolus; IDA:PomBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; TAS:PomBase.::GO:0003714; F:transcription corepressor activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0071572; P:histone H3-K56 deacetylation; IMP:PomBase.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:2000283; P:negative regulation of cellular amino acid biosynthetic process; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0006282; P:regulation of DNA repair; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006974; P:response to DNA damage stimulus; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 5 | P53688 | 370 | HST4_YEAST NAD-dependent histone deacetylase ... | 41 | 0.002 | 45.8 | 46 | 73 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006348; P:chromatin silencing at telomere; IGI:SGD.::GO:0016575; P:histone deacetylation; IMP:SGD.::GO:0046459; P:short-chain fatty acid metabolic process; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 6 | Q9VK34 | 823 | SIR2_DROME NAD-dependent histone deacetylase ... | 36 | 0.00008 | 50.4 | 53 | 81 | GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005654; C:nucleoplasm; IDA:FlyBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:FlyBase.::GO:0008134; F:transcription factor binding; IPI:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048149; P:behavioral response to ethanol; IMP:FlyBase.::GO:0006342; P:chromatin silencing; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0042981; P:regulation of apoptotic process; IMP:FlyBase.::GO:0035065; P:regulation of histone acetylation; IMP:FlyBase. | 7 | Q25337 | 373 | SIR2_LEIMA NAD-dependent protein deacetylase ... | 30 | 1 | 36.6 | 50 | 77 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 8 | Q9NTG7 | 399 | SIR3_HUMAN NAD-dependent protein deacetylase ... | 71 | 0.001 | 46.6 | 49 | 63 | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; TAS:ProtInc.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0009060; P:aerobic respiration; IMP:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IMP:UniProtKB.::GO:0006471; P:protein ADP-ribosylation; TAS:ProtInc. | 9 | P06700 | 562 | SIR2_YEAST NAD-dependent histone deacetylase ... | 32 | 0.0001 | 49.7 | 66 | 84 | GO:0000783; C:nuclear telomere cap complex; IDA:SGD.::GO:0005724; C:nuclear telomeric heterochromatin; IDA:SGD.::GO:0030869; C:RENT complex; IDA:SGD. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IDA:SGD.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:SGD.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006333; P:chromatin assembly or disassembly; IDA:SGD.::GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IDA:SGD.::GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; TAS:SGD.::GO:0045910; P:negative regulation of DNA recombination; IGI:SGD.::GO:0008156; P:negative regulation of DNA replication; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 10 | Q57V41 | 351 | SIR2_TRYB2 NAD-dependent protein deacetylase ... | 41 | 1.3 | 36.6 | 51 | 63 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 11 | C8V3W5 | 489 | HST1_EMENI NAD-dependent protein deacetylase ... | 36 | 0.004 | 44.7 | 56 | 86 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 12 | Q8R104 | 257 | SIR3_MOUSE NAD-dependent protein deacetylase ... | 31 | 0.46 | 37.4 | 68 | 81 | GO:0016020; C:membrane; IDA:MGI.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0009060; P:aerobic respiration; ISS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; ISS:UniProtKB. | 13 | Q9USN7 | 332 | HST2_SCHPO NAD-dependent protein deacetylase ... | 50 | 0.007 | 43.5 | 46 | 70 | GO:0005721; C:centromeric heterochromatin; IDA:PomBase.::GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IDA:PomBase.::GO:0033553; C:rDNA heterochromatin; IDA:PomBase.::GO:0031933; C:telomeric heterochromatin; IDA:PomBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; TAS:PomBase.::GO:0003714; F:transcription corepressor activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0000183; P:chromatin silencing at rDNA; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 14 | Q6FWI7 | 509 | SIR2_CANGA NAD-dependent histone deacetylase ... | 33 | 0.0001 | 49.7 | 64 | 82 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 15 | Q9I7I7 | 355 | SIRT2_DROME NAD-dependent protein deacetylase... | 29 | 0.017 | 42.4 | 69 | 86 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase. | 16 | Q54GV7 | 542 | SIR2D_DICDI NAD-dependent deacetylase sir2D O... | 36 | 0.0006 | 47.4 | 47 | 81 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 17 | Q54QE6 | 512 | SIR2A_DICDI NAD-dependent deacetylase sir2A O... | 30 | 0.037 | 41.6 | 60 | 80 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 18 | O59923 | 519 | SIR2_CANAL NAD-dependent histone deacetylase ... | 50 | 0.000006 | 53.9 | 52 | 80 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0000183; P:chromatin silencing at rDNA; IMP:CGD.::GO:0001319; P:inheritance of oxidatively modified proteins involved in replicative cell aging; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0045595; P:regulation of cell differentiation; IMP:CGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 19 | Q5AW69 | 361 | HST21_EMENI NAD-dependent protein deacetylase... | 30 | 0.014 | 42.7 | 63 | 83 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 20 | Q81BT4 | 245 | NPD_BACCR NAD-dependent protein deacetylase O... | 41 | 0.000005 | 52.8 | 56 | 73 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 21 | Q735N7 | 242 | NPD_BACC1 NAD-dependent protein deacetylase O... | 41 | 0.000005 | 52.8 | 56 | 73 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 22 | P53685 | 503 | HST1_YEAST NAD-dependent protein deacetylase ... | 32 | 0.0003 | 48.1 | 63 | 84 | GO:0034967; C:Set3 complex; IDA:SGD. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0045129; F:NAD-independent histone deacetylase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 23 | Q21921 | 607 | SIR2_CAEEL NAD-dependent protein deacetylase ... | 49 | 0.00008 | 50.4 | 47 | 78 | GO:0000784; C:nuclear chromosome, telomeric region; IDA:WormBase. | | | | | | | | | | GO:0019213; F:deacetylase activity; IDA:WormBase.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0040024; P:dauer larval development; IGI:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0070932; P:histone H3 deacetylation; IDA:WormBase. | 24 | Q81NT6 | 242 | NPD_BACAN NAD-dependent protein deacetylase O... | 41 | 0.000006 | 52.4 | 56 | 73 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 25 | Q6HH09 | 245 | NPD_BACHK NAD-dependent protein deacetylase O... | 32 | 0.000007 | 52.4 | 72 | 84 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 26 | Q639M6 | 245 | NPD_BACCZ NAD-dependent protein deacetylase O... | 32 | 0.000007 | 52.4 | 72 | 84 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 27 | Q5RJQ4 | 350 | SIR2_RAT NAD-dependent protein deacetylase si... | 31 | 0.012 | 42.7 | 58 | 81 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 28 | Q5AQ47 | 657 | HST1_CANAL NAD-dependent protein deacetylase ... | 255 | 0.001 | 46.6 | 21 | 36 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0006342; P:chromatin silencing; IEA:InterPro. | 29 | Q60L58 | 602 | SIR2_CAEBR NAD-dependent protein deacetylase ... | 45 | 0.0004 | 48.1 | 47 | 82 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 30 | Q5KZE8 | 247 | NPD2_GEOKA NAD-dependent protein deacetylase ... | 40 | 2.8 | 35 | 43 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 31 | Q8Y3U2 | 229 | NPD_LISMO NAD-dependent protein deacetylase O... | 34 | 0.00003 | 50.4 | 62 | 85 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. |
