| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q8Y3U2 | 229 | NPD_LISMO NAD-dependent protein deacetylase O... | 34 | 0.00003 | 50.4 | 62 | 85 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 32 | P33294 | 670 | SIR2_KLULA NAD-dependent histone deacetylase ... | 241 | 0.0002 | 48.9 | 23 | 38 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 33 | Q757M7 | 559 | SIR2_ASHGO NAD-dependent histone deacetylase ... | 34 | 0.0002 | 48.9 | 65 | 79 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 34 | Q73KE1 | 251 | NPD_TREDE NAD-dependent protein deacetylase O... | 31 | 0.02 | 41.6 | 61 | 77 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 35 | Q96EB6 | 747 | SIR1_HUMAN NAD-dependent protein deacetylase ... | 269 | 0.0001 | 49.7 | 20 | 35 | GO:0005677; C:chromatin silencing complex; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005719; C:nuclear euchromatin; IDA:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:BHF-UCL.::GO:0016605; C:PML body; IDA:BHF-UCL.::GO:0033553; C:rDNA heterochromatin; IDA:UniProtKB. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB.::GO:0042393; F:histone binding; IPI:BHF-UCL.::GO:0043398; F:HLH domain binding; IPI:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:BHF-UCL.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); ISS:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IDA:UniProtKB.::GO:0007569; P:cell aging; TAS:BHF-UCL.::GO:0001678; P:cellular glucose homeostasis; ISS:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:BHF-UCL.::GO:0071456; P:cellular response to hypoxia; IMP:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0009267; P:cellular response to starvation; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; ISS:UniProtKB.::GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.::GO:0000183; P:chromatin silencing at rDNA; IDA:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IMP:UniProtKB.::GO:0006260; P:DNA replication; TAS:BHF-UCL.::GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.::GO:0006343; P:establishment of chromatin silencing; IDA:BHF-UCL.::GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006344; P:maintenance of chromatin silencing; IMP:BHF-UCL.::GO:0006346; P:methylation-dependent chromatin silencing; TAS:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.::GO:2000655; P:negative regulation of cellular response to testosterone stimulus; IMP:BHF-UCL.::GO:2000773; P:negative regulation of cellular senescence; IDA:UniProtKB.::GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL.::GO:0045599; P:negative regulation of fat cell differentiation; ISS:BHF-UCL.::GO:0051097; P:negative regulation of helicase activity; IDA:UniProtKB.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; IDA:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0018394; P:peptidyl-lysine acetylation; IMP:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0002821; P:positive regulation of adaptive immune response; IDA:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; IDA:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.::GO:0031937; P:positive regulation of chromatin silencing; IMP:BHF-UCL.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.::GO:0045348; P:positive regulation of MHC class II biosynthetic process; IDA:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0016567; P:protein ubiquitination; IDA:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; IMP:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; ISS:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; ISS:BHF-UCL.::GO:0033158; P:regulation of protein import into nucleus, translocation; IMP:UniProtKB.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; ISS:UniProtKB.::GO:0032868; P:response to insulin stimulus; ISS:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; ISS:BHF-UCL.::GO:0050872; P:white fat cell differentiation; ISS:BHF-UCL. | 36 | Q923E4 | 737 | SIR1_MOUSE NAD-dependent protein deacetylase ... | 216 | 0.0004 | 48.1 | 22 | 34 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005719; C:nuclear euchromatin; ISS:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0019904; F:protein domain specific binding; IPI:BHF-UCL.::GO:0003714; F:transcription corepressor activity; IMP:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0001678; P:cellular glucose homeostasis; IMP:UniProtKB.::GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:UniProtKB.::GO:0009267; P:cellular response to starvation; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; IMP:UniProtKB.::GO:0042632; P:cholesterol homeostasis; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0000731; P:DNA synthesis involved in DNA repair; IMP:UniProtKB.::GO:0055089; P:fatty acid homeostasis; IMP:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; ISS:UniProtKB.::GO:2000773; P:negative regulation of cellular senescence; ISS:UniProtKB.::GO:0045599; P:negative regulation of fat cell differentiation; IMP:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; ISS:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IMP:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.::GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.::GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; IMP:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0031648; P:protein destabilization; IDA:UniProtKB.::GO:0016567; P:protein ubiquitination; ISS:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; ISS:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; IMP:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; IMP:BHF-UCL.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; IDA:UniProtKB.::GO:0032868; P:response to insulin stimulus; IDA:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; IMP:BHF-UCL.::GO:0050872; P:white fat cell differentiation; IMP:BHF-UCL. | 37 | Q7ZVK3 | 379 | SIR2_DANRE NAD-dependent protein deacetylase ... | 34 | 0.026 | 42 | 53 | 76 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 38 | Q7P1B9 | 244 | NPD_CHRVO NAD-dependent protein deacetylase O... | 192 | 0.36 | 37.7 | 26 | 35 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 39 | Q71W25 | 229 | NPD_LISMF NAD-dependent protein deacetylase O... | 34 | 0.0001 | 48.5 | 62 | 82 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 40 | Q87W79 | 256 | NPD4_PSESM NAD-dependent protein deacylase 4 ... | 203 | 0.0001 | 48.5 | 25 | 36 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 41 | O94640 | 475 | SIR2_SCHPO NAD-dependent histone deacetylase ... | 234 | 0.0008 | 47 | 24 | 36 | GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000775; C:chromosome, centromeric region; IDA:PomBase.::GO:0000781; C:chromosome, telomeric region; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IDA:PomBase.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:PomBase.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0070198; P:protein localization to chromosome, telomeric region; IGI:PomBase.::GO:0051570; P:regulation of histone H3-K9 methylation; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0001302; P:replicative cell aging; ISS:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 42 | Q5RBF1 | 352 | SIR2_PONAB NAD-dependent protein deacetylase ... | 30 | 0.012 | 42.7 | 60 | 80 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 43 | Q4R834 | 389 | SIR2_MACFA NAD-dependent protein deacetylase ... | 30 | 0.013 | 42.7 | 60 | 80 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 44 | Q8IXJ6 | 389 | SIR2_HUMAN NAD-dependent protein deacetylase ... | 30 | 0.014 | 42.7 | 60 | 80 | GO:0005677; C:chromatin silencing complex; NAS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005874; C:microtubule; IDA:UniProtKB. | | | | | | | | | | GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB.::GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0070403; F:NAD+ binding; IDA:UniProtKB.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0043130; F:ubiquitin binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000183; P:chromatin silencing at rDNA; NAS:UniProtKB.::GO:0006348; P:chromatin silencing at telomere; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045843; P:negative regulation of striated muscle tissue development; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0006471; P:protein ADP-ribosylation; NAS:UniProtKB.::GO:0007096; P:regulation of exit from mitosis; NAS:UniProtKB.::GO:0042325; P:regulation of phosphorylation; NAS:UniProtKB.::GO:0051775; P:response to redox state; NAS:UniProtKB. | 45 | Q88ZA0 | 234 | NPD_LACPL NAD-dependent protein deacetylase O... | 32 | 0.0002 | 47.8 | 63 | 88 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 46 | Q8K2C6 | 310 | SIR5_MOUSE NAD-dependent protein deacylase si... | 62 | 0.13 | 39.3 | 32 | 47 | GO:0005758; C:mitochondrial intermembrane space; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0036054; F:protein-malonyllysine demalonylase activity; IMP:UniProtKB.::GO:0036055; F:protein-succinyllysine desuccinylase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; ISS:UniProtKB. | 47 | Q5A985 | 331 | HST2_CANAL NAD-dependent protein deacetylase ... | 46 | 0.005 | 44.3 | 48 | 67 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 48 | Q9I4E1 | 256 | NPD2_PSEAE NAD-dependent protein deacylase 2 ... | 44 | 0.0003 | 47.4 | 45 | 70 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 49 | B5YJW3 | 256 | NPD_THEYD NAD-dependent protein deacetylase O... | 62 | 0.05 | 40.4 | 32 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 50 | Q9KEE5 | 237 | NPD_BACHD NAD-dependent protein deacetylase O... | 31 | 0.0003 | 47 | 61 | 84 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 51 | Q9YB13 | 245 | NPD_AERPE NAD-dependent protein deacylase OS=... | 42 | 0.044 | 40.4 | 50 | 62 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 52 | Q5JG47 | 257 | NPD_PYRKO NAD-dependent protein deacylase OS=... | 40 | 0.011 | 42.7 | 50 | 63 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 53 | Q927A7 | 229 | NPD_LISIN NAD-dependent protein deacetylase O... | 36 | 0.0004 | 46.6 | 53 | 81 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 54 | B8ARK7 | 484 | SIR1_ORYSI NAD-dependent protein deacetylase ... | 54 | 0.0004 | 47.8 | 43 | 72 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 55 | Q9WYW0 | 246 | NPD_THEMA NAD-dependent protein deacetylase O... | 33 | 0.0004 | 47 | 64 | 76 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 56 | O07595 | 247 | NPD_BACSU NAD-dependent protein deacetylase O... | 194 | 3.1 | 34.7 | 25 | 34 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 57 | Q8BKJ9 | 402 | SIR7_MOUSE NAD-dependent protein deacetylase ... | 39 | 0.0006 | 47.4 | 54 | 77 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005731; C:nucleolus organizer region; ISS:UniProtKB. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007072; P:positive regulation of transcription on exit from mitosis; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0009303; P:rRNA transcription; ISS:UniProtKB. | 58 | Q8VDQ8 | 389 | SIR2_MOUSE NAD-dependent protein deacetylase ... | 34 | 0.006 | 43.9 | 56 | 79 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; ISS:UniProtKB. | | | | | | | | | | GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB.::GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.::GO:0017136; F:NAD-dependent histone deacetylase activity; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0042903; F:tubulin deacetylase activity; ISS:UniProtKB.::GO:0043130; F:ubiquitin binding; ISS:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045843; P:negative regulation of striated muscle tissue development; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 59 | Q9RL35 | 299 | NPD1_STRCO NAD-dependent protein deacetylase ... | 56 | 0.0008 | 46.2 | 52 | 64 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 60 | Q88BY5 | 262 | NPD_PSEPK NAD-dependent protein deacylase OS=... | 41 | 0.031 | 41.2 | 51 | 73 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 61 | Q6N6U0 | 253 | NPD_RHOPA NAD-dependent protein deacetylase O... | 47 | 0.0009 | 45.8 | 47 | 62 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. |
