| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P34135 | 552 | HMDH1_DICDI 3-hydroxy-3-methylglutaryl-coenzy... | 435 | 2e-148 | 465 | 54 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 32 | P16393 | 932 | HMDH_STRPU 3-hydroxy-3-methylglutaryl-coenzym... | 204 | 0.002 | 45.8 | 23 | 41 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 33 | P43256 | 562 | HMDH2_ARATH 3-hydroxy-3-methylglutaryl-coenzy... | 423 | 2e-147 | 462 | 54 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:TAIR. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR.::GO:0016104; P:triterpenoid biosynthetic process; IMP:TAIR. | 34 | P48021 | 593 | HMDH_CAMAC 3-hydroxy-3-methylglutaryl-coenzym... | 415 | 3e-147 | 463 | 55 | 73 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 35 | P14891 | 592 | HMDH1_ARATH 3-hydroxy-3-methylglutaryl-coenzy... | 418 | 4e-147 | 463 | 56 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IDA:TAIR.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:TAIR. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IDA:TAIR.::GO:0060964; P:regulation of gene silencing by miRNA; IMP:TAIR.::GO:0016126; P:sterol biosynthetic process; IMP:TAIR. | 36 | Q00583 | 586 | HMDH3_HEVBR 3-hydroxy-3-methylglutaryl-coenzy... | 422 | 6e-146 | 459 | 54 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 37 | Q41437 | 595 | HMDH2_SOLTU 3-hydroxy-3-methylglutaryl-coenzy... | 415 | 2e-144 | 456 | 54 | 73 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 38 | Q0DY59 | 532 | HMDH1_ORYSJ 3-hydroxy-3-methylglutaryl-coenzy... | 421 | 2e-143 | 451 | 55 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 39 | A2X8W3 | 539 | HMDH1_ORYSI 3-hydroxy-3-methylglutaryl-coenzy... | 421 | 3e-143 | 451 | 55 | 72 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 40 | P14773 | 920 | HMDH_DROME 3-hydroxy-3-methylglutaryl-coenzym... | 216 | 0.000009 | 53.9 | 24 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0018990; P:ecdysis, chitin-based cuticle; IMP:FlyBase.::GO:0035050; P:embryonic heart tube development; IMP:FlyBase.::GO:0035232; P:germ cell attraction; TAS:FlyBase.::GO:0008406; P:gonad development; TAS:FlyBase.::GO:0008299; P:isoprenoid biosynthetic process; TAS:FlyBase.::GO:0007626; P:locomotory behavior; IMP:FlyBase.::GO:0007280; P:pole cell migration; IMP:UniProtKB. | 41 | O76819 | 833 | HMDH_AGRIP 3-hydroxy-3-methylglutaryl-coenzym... | 437 | 7e-128 | 419 | 51 | 68 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 42 | P16237 | 948 | HMDH_SCHMA 3-hydroxy-3-methylglutaryl-coenzym... | 440 | 1e-107 | 367 | 47 | 63 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 43 | O59469 | 413 | HMDH_PYRHO 3-hydroxy-3-methylglutaryl-coenzym... | 420 | 8e-96 | 318 | 43 | 62 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 44 | Q9V1R3 | 408 | HMDH_PYRAB 3-hydroxy-3-methylglutaryl-coenzym... | 420 | 2e-92 | 308 | 43 | 61 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 45 | O26662 | 397 | HMDH_METTH 3-hydroxy-3-methylglutaryl-coenzym... | 412 | 1e-90 | 303 | 42 | 61 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 46 | O08424 | 409 | HMDH_SULSO 3-hydroxy-3-methylglutaryl-coenzym... | 426 | 3e-81 | 277 | 38 | 60 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 47 | Q59468 | 403 | HMDH_HALVD 3-hydroxy-3-methylglutaryl-coenzym... | 360 | 1e-79 | 272 | 44 | 61 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 48 | Q58116 | 405 | HMDH_METJA 3-hydroxy-3-methylglutaryl-coenzym... | 417 | 2e-79 | 271 | 40 | 58 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 49 | Q9YAS4 | 421 | HMDH_AERPE 3-hydroxy-3-methylglutaryl-coenzym... | 412 | 6e-77 | 265 | 43 | 61 | GO:0016021; C:integral to membrane; IEA:InterPro. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 50 | P29058 | 210 | HMDH2_HEVBR 3-hydroxy-3-methylglutaryl-coenzy... | 202 | 6e-77 | 257 | 62 | 80 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0042170; C:plastid membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 51 | P12683 | 1054 | HMDH1_YEAST 3-hydroxy-3-methylglutaryl-coenzy... | 413 | 1e-28 | 128 | 29 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005635; C:nuclear envelope; IDA:SGD. | | | | | | | | | | GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IDA:SGD.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IC:SGD. | 52 | O51628 | 431 | HMDH_BORBU Probable 3-hydroxy-3-methylglutary... | 200 | 0.00001 | 52.8 | 25 | 44 | | | | | | | | | | | GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:EC. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro. | 53 | O28538 | 436 | HMDH_ARCFU 3-hydroxy-3-methylglutaryl-coenzym... | 369 | 0.00004 | 51.2 | 26 | 39 | | | | | | | | | | | GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW. | 54 | Q5MNU5 | 1279 | SCAP_PIG Sterol regulatory element-binding pr... | 204 | 0.0004 | 48.5 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 55 | P97260 | 1276 | SCAP_CRIGR Sterol regulatory element-binding ... | 204 | 0.0005 | 48.1 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008022; F:protein C-terminus binding; IPI:UniProtKB. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; ISS:UniProtKB.::GO:0006993; P:sterol regulatory element binding protein import into nucleus involved in sterol depletion response; IMP:UniProtKB. | 56 | Q12770 | 1279 | SCAP_HUMAN Sterol regulatory element-binding ... | 204 | 0.0006 | 48.1 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0051082; F:unfolded protein binding; NAS:UniProtKB. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0045541; P:negative regulation of cholesterol biosynthetic process; NAS:UniProtKB.::GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; NAS:UniProtKB.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; IMP:UniProtKB. | 57 | A0JPH4 | 1311 | SCAP_XENLA Sterol regulatory element-binding ... | 204 | 0.0007 | 47.8 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 58 | A2RRU4 | 1276 | SCAP_RAT Sterol regulatory element-binding pr... | 204 | 0.0009 | 47.4 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD. | | | | | | | | | | | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 59 | A6QM06 | 1278 | SCAP_BOVIN Sterol regulatory element-binding ... | 204 | 0.001 | 47.4 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. | 60 | Q6GQT6 | 1276 | SCAP_MOUSE Sterol regulatory element-binding ... | 204 | 0.001 | 47 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0015485; F:cholesterol binding; TAS:MGI.::GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0045540; P:regulation of cholesterol biosynthetic process; IMP:MGI.::GO:0042304; P:regulation of fatty acid biosynthetic process; IMP:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI. | 61 | P13702 | 428 | MVAA_PSEMV 3-hydroxy-3-methylglutaryl-coenzym... | 54 | 0.21 | 39.3 | 39 | 52 | | | | | | | | | | | GO:0050662; F:coenzyme binding; IEA:InterPro.::GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:InterPro.::GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:EC. | | | | | | | | | | GO:0015936; P:coenzyme A metabolic process; IEA:InterPro. |
