| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q02959 | 697 | HOS3_YEAST Histone deacetylase HOS3 OS=Saccha... | 440 | 2e-95 | 324 | 39 | 57 | GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IPI:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 2 | Q54VQ7 | 1704 | HDA22_DICDI Type-2 histone deacetylase 2 OS=D... | 292 | 3e-19 | 97.8 | 32 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 3 | Q941D6 | 423 | HDA14_ARATH Histone deacetylase 14 OS=Arabido... | 247 | 2e-16 | 87 | 29 | 41 | GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 4 | Q20296 | 955 | HDA6_CAEEL Histone deacetylase 6 OS=Caenorhab... | 93 | 0.00000003 | 61.6 | 35 | 45 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 5 | Q9UBN7 | 1215 | HDAC6_HUMAN Histone deacetylase 6 OS=Homo sap... | 302 | 0.0000000000001 | 79.3 | 28 | 42 | GO:0016235; C:aggresome; IDA:BHF-UCL.::GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0031252; C:cell leading edge; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.::GO:0005875; C:microtubule associated complex; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0043014; F:alpha-tubulin binding; IDA:BHF-UCL.::GO:0008013; F:beta-catenin binding; IPI:BHF-UCL.::GO:0070840; F:dynein complex binding; IDA:BHF-UCL.::GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0051879; F:Hsp90 protein binding; IDA:BHF-UCL.::GO:0008017; F:microtubule binding; ISS:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0031593; F:polyubiquitin binding; IDA:BHF-UCL.::GO:0048156; F:tau protein binding; IDA:BHF-UCL.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0070842; P:aggresome assembly; IMP:BHF-UCL.::GO:0070301; P:cellular response to hydrogen peroxide; IMP:BHF-UCL.::GO:0070846; P:Hsp90 deacetylation; IMP:BHF-UCL.::GO:0032418; P:lysosome localization; IMP:BHF-UCL.::GO:0016236; P:macroautophagy; IMP:BHF-UCL.::GO:0006515; P:misfolded or incompletely synthesized protein catabolic process; IMP:BHF-UCL.::GO:0010727; P:negative regulation of hydrogen peroxide metabolic process; IC:BHF-UCL.::GO:0051354; P:negative regulation of oxidoreductase activity; IC:BHF-UCL.::GO:0045861; P:negative regulation of proteolysis; IMP:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IMP:BHF-UCL.::GO:0070845; P:polyubiquitinated misfolded protein transport; IMP:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL.::GO:0090035; P:positive regulation of chaperone-mediated protein complex assembly; IMP:BHF-UCL.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:BHF-UCL.::GO:0010870; P:positive regulation of receptor biosynthetic process; IMP:BHF-UCL.::GO:0009967; P:positive regulation of signal transduction; IMP:BHF-UCL.::GO:0060765; P:regulation of androgen receptor signaling pathway; TAS:BHF-UCL.::GO:0060632; P:regulation of microtubule-based movement; IC:BHF-UCL.::GO:0010469; P:regulation of receptor activity; IMP:BHF-UCL.::GO:0070848; P:response to growth factor stimulus; IMP:BHF-UCL.::GO:0009636; P:response to toxin; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0090042; P:tubulin deacetylation; ISS:UniProtKB. | 6 | Q969S8 | 669 | HDA10_HUMAN Histone deacetylase 10 OS=Homo sa... | 273 | 0.00000000000003 | 80.9 | 28 | 42 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0004407; F:histone deacetylase activity; IDA:UniProtKB.::GO:0042826; F:histone deacetylase binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 7 | Q9UKV0 | 1011 | HDAC9_HUMAN Histone deacetylase 9 OS=Homo sap... | 404 | 0.00000000000003 | 81.3 | 25 | 41 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB.::GO:0035097; C:histone methyltransferase complex; ISS:UniProtKB.::GO:0005667; C:transcription factor complex; IDA:BHF-UCL. | | | | | | | | | | GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IDA:BHF-UCL.::GO:0003714; F:transcription corepressor activity; ISS:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.::GO:0007507; P:heart development; ISS:BHF-UCL.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0048742; P:regulation of skeletal muscle fiber development; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 8 | Q9Z2V5 | 1149 | HDAC6_MOUSE Histone deacetylase 6 OS=Mus musc... | 347 | 0.0000000000008 | 76.6 | 27 | 41 | GO:0005881; C:cytoplasmic microtubule; IDA:MGI.::GO:0005829; C:cytosol; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0048487; F:beta-tubulin binding; IDA:MGI.::GO:0008017; F:microtubule binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0070842; P:aggresome assembly; IGI:MGI.::GO:0071218; P:cellular response to misfolded protein; IMP:MGI.::GO:0070846; P:Hsp90 deacetylation; IMP:MGI.::GO:0007026; P:negative regulation of microtubule depolymerization; IDA:MGI.::GO:0000209; P:protein polyubiquitination; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0090042; P:tubulin deacetylation; IDA:UniProtKB.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:MGI. | 9 | P56524 | 1084 | HDAC4_HUMAN Histone deacetylase 4 OS=Homo sap... | 269 | 0.00000000000007 | 80.1 | 27 | 42 | GO:0000118; C:histone deacetylase complex; IDA:BHF-UCL.::GO:0017053; C:transcriptional repressor complex; IDA:BHF-UCL. | | | | | | | | | | GO:0033613; F:activating transcription factor binding; IPI:BHF-UCL.::GO:0042826; F:histone deacetylase binding; IPI:BHF-UCL.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0030955; F:potassium ion binding; IDA:BHF-UCL.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IDA:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0014898; P:cardiac muscle hypertrophy in response to stress; TAS:BHF-UCL.::GO:0006338; P:chromatin remodeling; IDA:BHF-UCL.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0070933; P:histone H4 deacetylation; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045820; P:negative regulation of glycolysis; ISS:BHF-UCL.::GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0033235; P:positive regulation of protein sumoylation; IDA:UniProtKB.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043393; P:regulation of protein binding; IMP:BHF-UCL.::GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:BHF-UCL.::GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 10 | Q6P3E7 | 666 | HDA10_MOUSE Histone deacetylase 10 OS=Mus mus... | 331 | 0.0000000000002 | 78.6 | 28 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 11 | Q54X15 | 1489 | HDA21_DICDI Type-2 histone deacetylase 1 OS=D... | 133 | 0.00006 | 51.2 | 29 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 12 | Q99P99 | 1077 | HDAC4_RAT Histone deacetylase 4 OS=Rattus nor... | 276 | 0.0000000000002 | 78.6 | 25 | 42 | GO:0031672; C:A band; IDA:MGI.::GO:0030018; C:Z disc; IDA:MGI. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0042493; P:response to drug; IDA:RGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 13 | Q6NZM9 | 1076 | HDAC4_MOUSE Histone deacetylase 4 OS=Mus musc... | 276 | 0.0000000000003 | 78.2 | 25 | 42 | GO:0042641; C:actomyosin; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI.::GO:0031594; C:neuromuscular junction; IDA:MGI. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IGI:MGI. | | | | | | | | | | GO:0008285; P:negative regulation of cell proliferation; IDA:MGI.::GO:0045820; P:negative regulation of glycolysis; IMP:BHF-UCL.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0002076; P:osteoblast development; IMP:MGI.::GO:0033235; P:positive regulation of protein sumoylation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IMP:MGI.::GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IMP:BHF-UCL.::GO:0001501; P:skeletal system development; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 14 | P83038 | 1080 | HDAC4_CHICK Histone deacetylase 4 OS=Gallus g... | 313 | 0.0000000000004 | 77.8 | 24 | 41 | GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008134; F:transcription factor binding; TAS:UniProtKB. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 15 | Q8C2B3 | 938 | HDAC7_MOUSE Histone deacetylase 7 OS=Mus musc... | 262 | 0.0000000000009 | 76.6 | 24 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.::GO:0003682; F:chromatin binding; IDA:MGI.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0003714; F:transcription corepressor activity; IDA:MGI. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0007043; P:cell-cell junction assembly; IMP:MGI.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0001570; P:vasculogenesis; IMP:MGI. | 16 | Q70I53 | 369 | HDAH_ALCSD Histone deacetylase-like amidohydr... | 260 | 0.000000000001 | 74.7 | 28 | 41 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 17 | Q80ZH1 | 1111 | HDAC5_CRIGR Histone deacetylase 5 OS=Cricetul... | 243 | 0.000000000004 | 74.7 | 26 | 42 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 18 | Q8WUI4 | 952 | HDAC7_HUMAN Histone deacetylase 7 OS=Homo sap... | 261 | 0.000000000007 | 73.6 | 23 | 43 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; IDA:UniProtKB.::GO:0033613; F:activating transcription factor binding; IPI:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0032703; P:negative regulation of interleukin-2 production; IDA:BHF-UCL.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0090050; P:positive regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 19 | Q9UQL6 | 1122 | HDAC5_HUMAN Histone deacetylase 5 OS=Homo sap... | 237 | 0.00000000002 | 72.4 | 24 | 41 | GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0005080; F:protein kinase C binding; IPI:UniProtKB.::GO:0070491; F:repressing transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; NAS:BHF-UCL.::GO:0006338; P:chromatin remodeling; TAS:ProtInc.::GO:0006342; P:chromatin silencing; TAS:ProtInc.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:0010832; P:negative regulation of myotube differentiation; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043393; P:regulation of protein binding; IMP:BHF-UCL.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 20 | Q9Z2V6 | 1113 | HDAC5_MOUSE Histone deacetylase 5 OS=Mus musc... | 237 | 0.00000000002 | 72.4 | 24 | 41 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0000118; C:histone deacetylase complex; TAS:UniProtKB. | | | | | | | | | | GO:0001046; F:core promoter sequence-specific DNA binding; IDA:UniProtKB.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IMP:UniProtKB.::GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL. | | | | | | | | | | GO:0030183; P:B cell differentiation; TAS:UniProtKB.::GO:0071498; P:cellular response to fluid shear stress; IDA:UniProtKB.::GO:0006954; P:inflammatory response; TAS:UniProtKB.::GO:0045843; P:negative regulation of striated muscle tissue development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; TAS:UniProtKB.::GO:0007399; P:nervous system development; TAS:UniProtKB.::GO:2000179; P:positive regulation of neural precursor cell proliferation; IMP:BHF-UCL.::GO:2000648; P:positive regulation of stem cell proliferation; IMP:BHF-UCL.::GO:0010830; P:regulation of myotube differentiation; IDA:UniProtKB.::GO:0061333; P:renal tubule morphogenesis; IMP:UniProtKB. | 21 | Q5R902 | 1122 | HDAC5_PONAB Histone deacetylase 5 OS=Pongo ab... | 237 | 0.00000000004 | 71.2 | 24 | 41 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000118; C:histone deacetylase complex; IEA:InterPro. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 22 | O30107 | 359 | Y130_ARCFU Uncharacterized protein AF_0130 OS... | 266 | 0.00000000004 | 69.7 | 27 | 43 | | | | | | | | | | | GO:0004407; F:histone deacetylase activity; IEA:InterPro. | | | | | | | | | | | 23 | P72702 | 304 | Y245_SYNY3 Uncharacterized protein slr0245 OS... | 271 | 0.00000000004 | 68.9 | 26 | 41 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 24 | Q8RX28 | 660 | HDA5_ARATH Histone deacetylase 5 OS=Arabidops... | 238 | 0.0000000002 | 68.9 | 29 | 42 | GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 25 | Q57955 | 343 | Y535_METJA Uncharacterized protein MJ0535 OS=... | 273 | 0.0000000003 | 67 | 26 | 40 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 26 | Q8LRK8 | 682 | HDA18_ARATH Histone deacetylase 18 OS=Arabido... | 252 | 0.0000000009 | 66.2 | 28 | 44 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0045604; P:regulation of epidermal cell differentiation; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 27 | O27262 | 331 | Y1194_METTH Uncharacterized protein MTH_1194 ... | 96 | 0.000000002 | 63.9 | 32 | 52 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 28 | Q613L4 | 892 | HDA4_CAEBR Histone deacetylase 4 OS=Caenorhab... | 257 | 0.000000002 | 65.1 | 26 | 42 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 29 | Q569C4 | 588 | HDA10_RAT Histone deacetylase 10 OS=Rattus no... | 71 | 0.000000004 | 64.3 | 44 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0014003; P:oligodendrocyte development; IEP:RGD.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 30 | P56523 | 687 | CLR3_SCHPO Histone deacetylase clr3 OS=Schizo... | 289 | 0.00000002 | 62 | 25 | 39 | GO:0005721; C:centromeric heterochromatin; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0030874; C:nucleolar chromatin; IDA:PomBase.::GO:0016581; C:NuRD complex; IDA:PomBase.::GO:0033553; C:rDNA heterochromatin; IDA:PomBase.::GO:0031933; C:telomeric heterochromatin; IDA:PomBase. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC. | | | | | | | | | | GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0000183; P:chromatin silencing at rDNA; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0035391; P:maintenance of chromatin silencing at silent mating-type cassette; NAS:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:PomBase.::GO:0016584; P:nucleosome positioning; IMP:PomBase.::GO:0031060; P:regulation of histone methylation; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 31 | Q8GXJ1 | 552 | HDA15_ARATH Histone deacetylase 15 OS=Arabido... | 258 | 0.0000001 | 59.7 | 27 | 43 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:EC.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IEA:EC.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0009294; P:DNA mediated transformation; IMP:TAIR.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
