| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9EQZ6 | 1011 | RPGF4_MOUSE Rap guanine nucleotide exchange f... | 97 | 0.011 | 44.7 | 21 | 45 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005829; C:cytosol; IDA:MGI. | | | | | | | | | | GO:0030552; F:cAMP binding; IDA:UniProtKB.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0017016; F:Ras GTPase binding; IPI:UniProtKB.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0017156; P:calcium ion-dependent exocytosis; IDA:MGI.::GO:0019933; P:cAMP-mediated signaling; IDA:MGI.::GO:0030073; P:insulin secretion; IDA:MGI.::GO:0017157; P:regulation of exocytosis; IDA:MGI.::GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 32 | P51142 | 736 | DVL2_XENLA Segment polarity protein dishevell... | 64 | 0.015 | 43.9 | 30 | 58 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0035253; C:ciliary rootlet; IDA:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0045545; F:syndecan binding; IPI:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IMP:UniProtKB.::GO:0009948; P:anterior/posterior axis specification; IMP:UniProtKB.::GO:0060070; P:canonical Wnt receptor signaling pathway; IGI:BHF-UCL.::GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0060027; P:convergent extension involved in gastrulation; IMP:UniProtKB.::GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0001736; P:establishment of planar polarity; IMP:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0001843; P:neural tube closure; IMP:UniProtKB.::GO:0022008; P:neurogenesis; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.::GO:0050821; P:protein stabilization; IMP:UniProtKB. | 33 | B1WAP7 | 713 | DVL3_XENTR Segment polarity protein dishevell... | 64 | 0.035 | 42.7 | 30 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 34 | O14641 | 736 | DVL2_HUMAN Segment polarity protein dishevell... | 64 | 0.063 | 42 | 30 | 58 | GO:0045177; C:apical part of cell; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0044340; P:canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; IDA:BHF-UCL.::GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0035329; P:hippo signaling cascade; TAS:Reactome.::GO:0001843; P:neural tube closure; ISS:BHF-UCL.::GO:0003151; P:outflow tract morphogenesis; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0007379; P:segment specification; ISS:BHF-UCL.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. | 35 | Q60838 | 736 | DVL2_MOUSE Segment polarity protein dishevell... | 64 | 0.063 | 42 | 30 | 58 | GO:0045177; C:apical part of cell; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005856; C:cytoskeleton; NAS:BHF-UCL.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IMP:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; NAS:BHF-UCL. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019904; F:protein domain specific binding; IPI:MGI.::GO:0043621; F:protein self-association; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0034613; P:cellular protein localization; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0061098; P:positive regulation of protein tyrosine kinase activity; IGI:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0007379; P:segment specification; IMP:MGI. | 36 | Q9Z1T6 | 2097 | FYV1_MOUSE 1-phosphatidylinositol 3-phosphate... | 48 | 0.088 | 41.6 | 33 | 65 | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB. | 37 | Q9Y2I7 | 2098 | FYV1_HUMAN 1-phosphatidylinositol 3-phosphate... | 48 | 0.095 | 41.6 | 33 | 65 | GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB. | 38 | Q570Y9 | 409 | DPTOR_MOUSE DEP domain-containing mTOR-intera... | 98 | 0.1 | 40.8 | 27 | 45 | | | | | | | | | | | | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 39 | Q8TB45 | 409 | DPTOR_HUMAN DEP domain-containing mTOR-intera... | 110 | 4.4 | 35.8 | 25 | 38 | GO:0005622; C:intracellular; IDA:LIFEdb. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045792; P:negative regulation of cell size; IMP:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB. | 40 | O14640 | 695 | DVL1_HUMAN Segment polarity protein dishevell... | 64 | 0.18 | 40.4 | 28 | 55 | GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; ISS:BHF-UCL.::GO:0019717; C:synaptosome; ISS:BHF-UCL. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.::GO:0006469; P:negative regulation of protein kinase activity; IDA:BHF-UCL.::GO:0021915; P:neural tube development; IEP:BHF-UCL.::GO:0007269; P:neurotransmitter secretion; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0034504; P:protein localization to nucleus; IMP:BHF-UCL.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. | 41 | Q5IS48 | 670 | DVL1_PANTR Segment polarity protein dishevell... | 64 | 0.21 | 40 | 28 | 55 | GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome. | 42 | Q6DKE2 | 717 | DVL3_XENLA Segment polarity protein dishevell... | 50 | 0.23 | 40 | 34 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 43 | Q9WVB9 | 695 | DVL1_RAT Segment polarity protein dishevelled... | 64 | 0.32 | 39.7 | 27 | 55 | GO:0030424; C:axon; IDA:RGD.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0015630; C:microtubule cytoskeleton; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0048365; F:Rac GTPase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome. | 44 | P51141 | 695 | DVL1_MOUSE Segment polarity protein dishevell... | 64 | 0.33 | 39.7 | 27 | 55 | GO:0030424; C:axon; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; NAS:BHF-UCL.::GO:0045202; C:synapse; IDA:MGI.::GO:0019717; C:synaptosome; IDA:MGI. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IDA:MGI.::GO:0007411; P:axon guidance; IDA:MGI.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0048668; P:collateral sprouting; IDA:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IGI:MGI.::GO:0031122; P:cytoplasmic microtubule organization; IDA:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001933; P:negative regulation of protein phosphorylation; IGI:MGI.::GO:0007269; P:neurotransmitter secretion; IGI:MGI.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0060134; P:prepulse inhibition; IMP:MGI.::GO:0035372; P:protein localization to microtubule; IGI:MGI.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IMP:MGI.::GO:0035176; P:social behavior; IMP:MGI. | 45 | Q86G47 | 1298 | GEFQ_DICDI Ras guanine nucleotide exchange fa... | 207 | 0.64 | 38.9 | 21 | 48 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 46 | Q54M77 | 1867 | ROCO8_DICDI Probable serine/threonine-protein... | 63 | 0.65 | 38.9 | 27 | 57 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 47 | P52155 | 419 | RHO_PSEFC Transcription termination factor Rh... | 121 | 0.8 | 38.1 | 26 | 42 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008186; F:RNA-dependent ATPase activity; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006353; P:transcription termination, DNA-dependent; IEA:UniProtKB-KW. | 48 | P54792 | 670 | DVL1L_HUMAN Putative Segment polarity protein... | 80 | 1.2 | 37.7 | 26 | 48 | GO:0005737; C:cytoplasm; NAS:UniProtKB. | | | | | | | | | | GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0007507; P:heart development; NAS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 49 | Q8TCU6 | 1659 | PREX1_HUMAN Phosphatidylinositol 3,4,5-trisph... | 97 | 2 | 37.4 | 24 | 41 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.::GO:0005886; C:plasma membrane; TAS:UniProtKB. | | | | | | | | | | GO:0019899; F:enzyme binding; TAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:UniProtKB.::GO:0005100; F:Rho GTPase activator activity; TAS:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030041; P:actin filament polymerization; TAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0042119; P:neutrophil activation; TAS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0006801; P:superoxide metabolic process; TAS:UniProtKB. | 50 | Q69ZK0 | 1650 | PREX1_MOUSE Phosphatidylinositol 3,4,5-trisph... | 97 | 2.5 | 37 | 24 | 41 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 51 | Q8NF91 | 8797 | SYNE1_HUMAN Nesprin-1 OS=Homo sapiens (Human)... | 151 | 3.9 | 36.2 | 23 | 43 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0045211; C:postsynaptic membrane; IDA:UniProtKB.::GO:0030017; C:sarcomere; IDA:MGI.::GO:0034993; C:SUN-KASH complex; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IDA:UniProtKB.::GO:0005521; F:lamin binding; IPI:UniProtKB. | | | | | | | | | | GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0090286; P:cytoskeletal anchoring at nuclear membrane; IDA:UniProtKB.::GO:0007030; P:Golgi organization; IDA:UniProtKB.::GO:0042692; P:muscle cell differentiation; IDA:UniProtKB.::GO:0090292; P:nuclear matrix anchoring at nuclear membrane; IDA:UniProtKB. | 52 | Q3LAC4 | 1598 | PREX2_MOUSE Phosphatidylinositol 3,4,5-trisph... | 111 | 4.8 | 35.8 | 23 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 53 | Q9HTV1 | 419 | RHO_PSEAE Transcription termination factor Rh... | 121 | 5.2 | 35.4 | 26 | 41 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008186; F:RNA-dependent ATPase activity; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006353; P:transcription termination, DNA-dependent; IEA:UniProtKB-KW. | 54 | Q70Z35 | 1606 | PREX2_HUMAN Phosphatidylinositol 3,4,5-trisph... | 111 | 6.2 | 35.4 | 23 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 55 | Q4PGT8 | 637 | YD156_USTMA WD repeat-containing protein UM00... | 26 | 8.3 | 35 | 58 | 69 | | | | | | | | | | | | | | | | | | | | | | 56 | B4PRE2 | 1917 | DGKH_DROYA Diacylglycerol kinase eta OS=Droso... | 50 | 8.5 | 35 | 38 | 54 | GO:0005768; C:endosome; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004143; F:diacylglycerol kinase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051259; P:protein oligomerization; ISS:UniProtKB. |
