| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O54967 | 1055 | ACK1_MOUSE Activated CDC42 kinase 1 OS=Mus mu... | 236 | 0.000000001 | 66.6 | 23 | 39 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030424; C:axon; IDA:MGI.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:MGI.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0030426; C:growth cone; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0050699; F:WW domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 2 | Q5U2X5 | 1040 | ACK1_RAT Activated CDC42 kinase 1 OS=Rattus n... | 236 | 0.000000001 | 66.6 | 23 | 39 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 3 | Q07912 | 1038 | ACK1_HUMAN Activated CDC42 kinase 1 OS=Homo s... | 236 | 0.000000001 | 66.6 | 23 | 39 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030136; C:clathrin-coated vesicle; IDA:UniProtKB.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005154; F:epidermal growth factor receptor binding; IDA:BHF-UCL.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:ProtInc.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IDA:UniProtKB.::GO:0050699; F:WW domain binding; ISS:BHF-UCL. | | | | | | | | | | GO:0007166; P:cell surface receptor signaling pathway; TAS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:2000369; P:regulation of clathrin-mediated endocytosis; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc. | 4 | Q17R13 | 1039 | ACK1_BOVIN Activated CDC42 kinase 1 OS=Bos ta... | 236 | 0.000000001 | 66.2 | 23 | 39 | GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 5 | Q8IR79 | 1257 | LIMK1_DROME LIM domain kinase 1 OS=Drosophila... | 133 | 0.000000001 | 66.2 | 28 | 49 | GO:0005826; C:actomyosin contractile ring; IDA:UniProtKB.::GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.::GO:0030496; C:midbody; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IDA:UniProtKB.::GO:0048749; P:compound eye development; IGI:FlyBase.::GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.::GO:0050770; P:regulation of axonogenesis; IMP:FlyBase.::GO:0051124; P:synaptic growth at neuromuscular junction; IMP:FlyBase. | 6 | A8WWX1 | 545 | MOM4_CAEBR Mitogen-activated protein kinase k... | 278 | 0.000000005 | 63.9 | 23 | 39 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 7 | P06239 | 509 | LCK_HUMAN Tyrosine-protein kinase Lck OS=Homo... | 244 | 0.000000007 | 63.5 | 25 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0000242; C:pericentriolar material; IDA:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0051117; F:ATPase binding; IPI:UniProtKB.::GO:0042609; F:CD4 receptor binding; IPI:UniProtKB.::GO:0042610; F:CD8 receptor binding; IPI:UniProtKB.::GO:0001948; F:glycoprotein binding; IPI:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; IEP:UniProtKB.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050862; P:positive regulation of T cell receptor signaling pathway; NAS:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0042493; P:response to drug; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0030217; P:T cell differentiation; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome. | 8 | Q869X3 | 921 | Y9851_DICDI Probable serine/threonine-protein... | 273 | 0.000000008 | 63.9 | 25 | 41 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 9 | P08631 | 526 | HCK_HUMAN Tyrosine-protein kinase HCK OS=Homo... | 247 | 0.00000001 | 62.8 | 24 | 42 | GO:0005901; C:caveola; IDA:UniProtKB.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031234; C:extrinsic to internal side of plasma membrane; IMP:UniProtKB.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0002758; P:innate immune response-activating signal transduction; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; TAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043299; P:leukocyte degranulation; TAS:UniProtKB.::GO:0002522; P:leukocyte migration involved in immune response; TAS:UniProtKB.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; TAS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0071801; P:regulation of podosome assembly; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0045728; P:respiratory burst after phagocytosis; TAS:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome. | 10 | P07948 | 512 | LYN_HUMAN Tyrosine-protein kinase Lyn OS=Homo... | 245 | 0.00000001 | 62.4 | 24 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; TAS:ProtInc. | | | | | | | | | | GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0050777; P:negative regulation of immune response; TAS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0070668; P:positive regulation of mast cell proliferation; IMP:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; IDA:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090025; P:regulation of monocyte chemotaxis; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB. | 11 | Q95KR7 | 509 | LCK_SAISC Proto-oncogene tyrosine-protein kin... | 244 | 0.00000002 | 62.4 | 26 | 41 | GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB. | 12 | Q5PXS1 | 509 | LCK_AOTNA Tyrosine-protein kinase Lck OS=Aotu... | 244 | 0.00000002 | 62 | 25 | 41 | GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB. | 13 | O14427 | 971 | CLA4_CANAX Serine/threonine-protein kinase CL... | 214 | 0.00000002 | 62.8 | 23 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009405; P:pathogenesis; IEA:UniProtKB-KW. | 14 | P25911 | 512 | LYN_MOUSE Tyrosine-protein kinase Lyn OS=Mus ... | 245 | 0.00000002 | 62 | 24 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005128; F:erythropoietin receptor binding; TAS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0017124; F:SH3 domain binding; IPI:MGI. | | | | | | | | | | GO:0001782; P:B cell homeostasis; IMP:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.::GO:0097028; P:dendritic cell differentiation; IMP:UniProtKB.::GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IMP:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IMP:UniProtKB.::GO:0042541; P:hemoglobin biosynthetic process; TAS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IDA:MGI.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB.::GO:0030889; P:negative regulation of B cell proliferation; IMP:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; IMP:UniProtKB.::GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IMP:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; IMP:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IMP:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IMP:UniProtKB.::GO:0031175; P:neuron projection development; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0002576; P:platelet degranulation; IMP:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; IMP:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0002902; P:regulation of B cell apoptotic process; IMP:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; IMP:UniProtKB.::GO:0050707; P:regulation of cytokine secretion; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; IMP:UniProtKB.::GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; IMP:UniProtKB.::GO:0002513; P:tolerance induction to self antigen; IMP:UniProtKB. | 15 | Q95M30 | 504 | HCK_MACFA Tyrosine-protein kinase HCK OS=Maca... | 247 | 0.00000002 | 62 | 23 | 42 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB. | 16 | Q02977 | 536 | YRK_CHICK Proto-oncogene tyrosine-protein kin... | 242 | 0.00000003 | 61.6 | 25 | 41 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 17 | Q01621 | 509 | LCK_RAT Proto-oncogene tyrosine-protein kinas... | 247 | 0.00000003 | 61.2 | 26 | 41 | GO:0030139; C:endocytic vesicle; IDA:RGD.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0003823; F:antigen binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0032403; F:protein complex binding; IDA:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0006915; P:apoptotic process; IEP:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0070474; P:positive regulation of uterine smooth muscle contraction; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0042542; P:response to hydrogen peroxide; IDA:RGD.::GO:0009612; P:response to mechanical stimulus; IMP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD. | 18 | P06240 | 509 | LCK_MOUSE Proto-oncogene tyrosine-protein kin... | 244 | 0.00000004 | 60.8 | 25 | 41 | GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IMP:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0050856; P:regulation of T cell receptor signaling pathway; IDA:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB. | 19 | Q9LFP7 | 493 | Y5158_ARATH Probable receptor-like protein ki... | 168 | 0.00000004 | 60.8 | 26 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 20 | P27446 | 537 | FYN_XIPHE Tyrosine-protein kinase Fyn OS=Xiph... | 244 | 0.00000005 | 60.8 | 25 | 42 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 21 | Q54RR9 | 1761 | Y9844_DICDI Probable serine/threonine-protein... | 190 | 0.00000005 | 61.2 | 26 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 22 | Q54QQ1 | 1387 | PHG2_DICDI Serine/threonine-protein kinase ph... | 249 | 0.00000006 | 61.2 | 23 | 40 | GO:0030666; C:endocytic vesicle membrane; IDA:dictyBase.::GO:0005886; C:plasma membrane; IDA:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:dictyBase.::GO:0017016; F:Ras GTPase binding; IPI:dictyBase. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:dictyBase.::GO:0000902; P:cell morphogenesis; IMP:dictyBase.::GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0031670; P:cellular response to nutrient; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0051489; P:regulation of filopodium assembly; IMP:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase. | 23 | Q07014 | 512 | LYN_RAT Tyrosine-protein kinase Lyn OS=Rattus... | 245 | 0.00000006 | 60.5 | 24 | 42 | GO:0034666; C:alpha2-beta1 integrin complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0030061; C:mitochondrial crista; IDA:RGD.::GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043208; F:glycosphingolipid binding; IPI:RGD.::GO:0005178; F:integrin binding; IDA:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051219; F:phosphoprotein binding; IPI:RGD.::GO:0005161; F:platelet-derived growth factor receptor binding; IPI:RGD.::GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD. | | | | | | | | | | GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0034605; P:cellular response to heat; IEP:RGD.::GO:0050663; P:cytokine secretion; IMP:RGD.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0002553; P:histamine secretion by mast cell; IMP:RGD.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0014003; P:oligodendrocyte development; IEP:RGD.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0060369; P:positive regulation of Fc receptor mediated stimulatory signaling pathway; IMP:RGD.::GO:0060252; P:positive regulation of glial cell proliferation; IDA:RGD.::GO:0070447; P:positive regulation of oligodendrocyte progenitor proliferation; IMP:RGD.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IMP:RGD.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0048678; P:response to axon injury; IEP:RGD.::GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0006991; P:response to sterol depletion; IEP:RGD.::GO:0009636; P:response to toxin; IEP:RGD.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB. | 24 | P41242 | 505 | MATK_MOUSE Megakaryocyte-associated tyrosine-... | 227 | 0.00000007 | 60.5 | 24 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 25 | P06241 | 537 | FYN_HUMAN Tyrosine-protein kinase Fyn OS=Homo... | 246 | 0.0000001 | 59.7 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; IDA:HGNC.::GO:0005886; C:plasma membrane; IDA:HGNC. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0001948; F:glycoprotein binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; NAS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006816; P:calcium ion transport; NAS:UniProtKB.::GO:0007631; P:feeding behavior; TAS:ProtInc.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; TAS:ProtInc.::GO:0007612; P:learning; TAS:ProtInc.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0050852; P:T cell receptor signaling pathway; IDA:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome. | 26 | P42686 | 505 | SRK1_SPOLA Tyrosine-protein kinase isoform SR... | 227 | 0.0000001 | 59.7 | 23 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 27 | F1QGZ6 | 676 | MELK_DANRE Maternal embryonic leucine zipper ... | 204 | 0.0000001 | 59.7 | 25 | 48 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; ISS:UniProtKB.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0048821; P:erythrocyte development; IMP:ZFIN.::GO:0061351; P:neural precursor cell proliferation; ISS:UniProtKB.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008016; P:regulation of heart contraction; IMP:ZFIN. | 28 | A1Y2K1 | 537 | FYN_PIG Tyrosine-protein kinase Fyn OS=Sus sc... | 246 | 0.0000001 | 59.7 | 25 | 42 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 29 | P41243 | 467 | MATK_RAT Megakaryocyte-associated tyrosine-pr... | 218 | 0.0000001 | 59.3 | 24 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 30 | P39688 | 537 | FYN_MOUSE Tyrosine-protein kinase Fyn OS=Mus ... | 246 | 0.0000001 | 59.3 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0015631; F:tubulin binding; IDA:MGI. | | | | | | | | | | GO:0050798; P:activated T cell proliferation; IMP:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0042552; P:myelination; TAS:MGI.::GO:0010629; P:negative regulation of gene expression; IMP:BHF-UCL.::GO:0042177; P:negative regulation of protein catabolic process; IMP:MGI.::GO:0001764; P:neuron migration; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0008360; P:regulation of cell shape; IDA:MGI.::GO:0045471; P:response to ethanol; IGI:MGI. | 31 | Q62844 | 537 | FYN_RAT Tyrosine-protein kinase Fyn OS=Rattus... | 246 | 0.0000001 | 59.3 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005792; C:microsome; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042609; F:CD4 receptor binding; IPI:RGD.::GO:0042610; F:CD8 receptor binding; IPI:RGD.::GO:0001948; F:glycoprotein binding; IPI:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IDA:RGD.::GO:0042608; F:T cell receptor binding; IDA:RGD. | | | | | | | | | | GO:0071363; P:cellular response to growth factor stimulus; IEP:RGD.::GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.::GO:0035235; P:ionotropic glutamate receptor signaling pathway; TAS:RGD.::GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0042493; P:response to drug; IEP:RGD. |
