| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q6J6I8 | 1863 | BRCA1_GORGO Breast cancer type 1 susceptibili... | 49 | 0.002 | 45.1 | 37 | 59 | GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB. | 62 | Q867B5 | 1043 | RAG1_PIG V(D)J recombination-activating prote... | 95 | 0.002 | 44.7 | 32 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0002331; P:pre-B cell allelic exclusion; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB. | 63 | Q8NHY2 | 731 | RFWD2_HUMAN E3 ubiquitin-protein ligase RFWD2... | 85 | 0.002 | 44.7 | 31 | 45 | GO:0005813; C:centrosome; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:HPA.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; TAS:Reactome. | 64 | Q557K2 | 409 | Y3435_DICDI TNF receptor-associated factor fa... | 224 | 0.002 | 44.3 | 20 | 39 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 65 | Q69ZS0 | 1063 | PZRN3_MOUSE E3 ubiquitin-protein ligase PDZRN... | 198 | 0.003 | 44.3 | 24 | 33 | GO:0031594; C:neuromuscular junction; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007528; P:neuromuscular junction development; IMP:UniProtKB. | 66 | P48754 | 1812 | BRCA1_MOUSE Breast cancer type 1 susceptibili... | 57 | 0.003 | 44.7 | 33 | 53 | GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.::GO:0005813; C:centrosome; TAS:UniProtKB.::GO:0000794; C:condensed nuclear chromosome; IDA:MGI.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0003684; F:damaged DNA binding; IDA:MGI.::GO:0005515; F:protein binding; ISS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051298; P:centrosome duplication; TAS:UniProtKB.::GO:0043009; P:chordate embryonic development; IMP:MGI.::GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IMP:MGI.::GO:0009048; P:dosage compensation by inactivation of X chromosome; IDA:MGI.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0035067; P:negative regulation of histone acetylation; IMP:BHF-UCL.::GO:0051572; P:negative regulation of histone H3-K4 methylation; IMP:BHF-UCL.::GO:0051573; P:negative regulation of histone H3-K9 methylation; IMP:BHF-UCL.::GO:0051571; P:positive regulation of histone H3-K4 methylation; IMP:BHF-UCL.::GO:2000617; P:positive regulation of histone H3-K9 acetylation; IMP:BHF-UCL.::GO:0051574; P:positive regulation of histone H3-K9 methylation; IMP:BHF-UCL.::GO:2000620; P:positive regulation of histone H4-K16 acetylation; IMP:BHF-UCL.::GO:0070512; P:positive regulation of histone H4-K20 methylation; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0044030; P:regulation of DNA methylation; IMP:BHF-UCL.::GO:0006349; P:regulation of gene expression by genetic imprinting; IMP:BHF-UCL. | 67 | Q9R1A8 | 733 | RFWD2_MOUSE E3 ubiquitin-protein ligase RFWD2... | 85 | 0.003 | 43.9 | 31 | 45 | GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 68 | Q75EN0 | 443 | RAD18_ASHGO Postreplication repair E3 ubiquit... | 93 | 0.004 | 43.5 | 30 | 41 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 69 | Q6CSS6 | 229 | CWC24_KLULA Pre-mRNA-splicing factor CWC24 OS... | 37 | 0.004 | 42.7 | 38 | 62 | GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. | 70 | Q6P9F5 | 258 | TRI40_HUMAN Tripartite motif-containing prote... | 51 | 0.004 | 43.1 | 39 | 57 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 71 | Q17RB8 | 773 | LONF1_HUMAN LON peptidase N-terminal domain a... | 70 | 0.004 | 43.9 | 33 | 49 | | | | | | | | | | | GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 72 | Q1XHT8 | 229 | TRI40_PANTR Tripartite motif-containing prote... | 51 | 0.004 | 42.7 | 39 | 57 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 73 | Q6BLM3 | 491 | RAD18_DEBHA Postreplication repair E3 ubiquit... | 55 | 0.005 | 43.5 | 42 | 51 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 74 | Q28GL3 | 416 | RNFT1_XENTR RING finger and transmembrane dom... | 50 | 0.005 | 43.1 | 32 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 75 | O54952 | 1817 | BRCA1_RAT Breast cancer type 1 susceptibility... | 50 | 0.005 | 43.5 | 38 | 56 | GO:0031436; C:BRCA1-BARD1 complex; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; IDA:RGD. | | | | | | | | | | GO:0003684; F:damaged DNA binding; TAS:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007420; P:brain development; IEP:RGD.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0033993; P:response to lipid; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD. | 76 | Q9UPQ7 | 1066 | PZRN3_HUMAN E3 ubiquitin-protein ligase PDZRN... | 198 | 0.006 | 43.1 | 24 | 33 | | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 77 | Q6NZ21 | 419 | RNFT1_DANRE RING finger and transmembrane dom... | 50 | 0.007 | 42.7 | 32 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 78 | Q03605 | 160 | YNN1_CAEEL Uncharacterized RING finger protei... | 44 | 0.008 | 40.8 | 36 | 52 | | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 79 | Q4WZJ6 | 418 | RAD18_ASPFU Postreplication repair E3 ubiquit... | 201 | 0.009 | 42.4 | 24 | 34 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 80 | Q12933 | 501 | TRAF2_HUMAN TNF receptor-associated factor 2 ... | 264 | 0.012 | 42 | 24 | 38 | GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL. | | | | | | | | | | GO:0005174; F:CD40 receptor binding; ISS:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; NAS:ProtInc.::GO:0046625; F:sphingolipid binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.::GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0008633; P:activation of pro-apoptotic gene products; TAS:Reactome.::GO:0043623; P:cellular protein complex assembly; ISS:BHF-UCL.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0070207; P:protein homotrimerization; IPI:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB. | 81 | P24271 | 1041 | RAG1_CHICK V(D)J recombination-activating pro... | 95 | 0.013 | 42.4 | 29 | 43 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0030183; P:B cell differentiation; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB. | 82 | P0CQ64 | 329 | CWC24_CRYNJ Pre-mRNA-splicing factor CWC24 OS... | 37 | 0.013 | 41.6 | 41 | 51 | GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. | 83 | P0CQ65 | 329 | CWC24_CRYNB Pre-mRNA-splicing factor CWC24 OS... | 37 | 0.013 | 41.6 | 41 | 51 | GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. | 84 | Q91829 | 1045 | RAG1_XENLA V(D)J recombination-activating pro... | 90 | 0.014 | 42 | 28 | 44 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0030183; P:B cell differentiation; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB. | 85 | Q810I1 | 483 | TRI50_RAT E3 ubiquitin-protein ligase TRIM50 ... | 80 | 0.015 | 41.6 | 29 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 86 | Q5A4N5 | 378 | RAD18_CANAL Postreplication repair E3 ubiquit... | 37 | 0.015 | 41.6 | 49 | 54 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; IEA:UniProtKB-KW. | 87 | B0BLU1 | 535 | RN168_XENTR E3 ubiquitin-protein ligase RNF16... | 49 | 0.016 | 41.6 | 39 | 57 | GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0043130; F:ubiquitin binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0070535; P:histone H2A K63-linked ubiquitination; ISS:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB. | 88 | Q9VRP9 | 1044 | BRE1_DROME E3 ubiquitin-protein ligase Bre1 O... | 57 | 0.016 | 42 | 35 | 51 | GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0016874; F:ligase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016574; P:histone ubiquitination; IMP:UniProtKB.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0006513; P:protein monoubiquitination; IMP:UniProtKB. | 89 | B3DK16 | 234 | PCF5A_DANRE Polycomb group RING finger protei... | 51 | 0.018 | 40.8 | 35 | 55 | GO:0031519; C:PcG protein complex; ISS:UniProtKB. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 90 | Q91431 | 610 | NF7O_XENLA Nuclear factor 7, ovary OS=Xenopus... | 99 | 0.02 | 41.6 | 31 | 48 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 91 | Q9D4H7 | 753 | LONF3_MOUSE LON peptidase N-terminal domain a... | 146 | 0.021 | 41.6 | 23 | 39 | | | | | | | | | | | GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. |
