| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | E1C656 | 942 | HACE1_CHICK E3 ubiquitin-protein ligase HACE1... | 452 | 2e-96 | 343 | 42 | 59 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB. | 32 | A2A5Z6 | 748 | SMUF2_MOUSE E3 ubiquitin-protein ligase SMURF... | 367 | 4e-96 | 337 | 44 | 65 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 33 | Q9HAU4 | 748 | SMUF2_HUMAN E3 ubiquitin-protein ligase SMURF... | 367 | 1e-95 | 335 | 44 | 65 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046332; F:SMAD binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; TAS:Reactome.::GO:0045892; P:negative regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; NAS:UniProtKB.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.::GO:0030579; P:ubiquitin-dependent SMAD protein catabolic process; IDA:BHF-UCL. | 34 | Q9CUN6 | 731 | SMUF1_MOUSE E3 ubiquitin-protein ligase SMURF... | 367 | 4e-95 | 333 | 43 | 66 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; ISS:UniProtKB.::GO:0030279; P:negative regulation of ossification; IMP:MGI.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 35 | P46934 | 1319 | NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4... | 388 | 6e-95 | 345 | 44 | 64 | GO:0016327; C:apicolateral plasma membrane; TAS:BHF-UCL.::GO:0005938; C:cell cortex; IDA:BHF-UCL.::GO:0000785; C:chromatin; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0000151; C:ubiquitin ligase complex; ISS:BHF-UCL. | | | | | | | | | | GO:0031698; F:beta-2 adrenergic receptor binding; IDA:UniProtKB.::GO:0050815; F:phosphoserine binding; ISS:BHF-UCL.::GO:0050816; F:phosphothreonine binding; ISS:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0070063; F:RNA polymerase binding; IPI:BHF-UCL.::GO:0019871; F:sodium channel inhibitor activity; IDA:BHF-UCL.::GO:0043130; F:ubiquitin binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0044111; P:development involved in symbiotic interaction; IMP:UniProtKB.::GO:0042921; P:glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010766; P:negative regulation of sodium ion transport; IDA:UniProtKB.::GO:0010768; P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IMP:BHF-UCL.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031175; P:neuron projection development; IEP:BHF-UCL.::GO:0046824; P:positive regulation of nucleocytoplasmic transport; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0032801; P:receptor catabolic process; IDA:UniProtKB.::GO:0031623; P:receptor internalization; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0051592; P:response to calcium ion; TAS:BHF-UCL.::GO:0019089; P:transmission of virus; IMP:BHF-UCL.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:BHF-UCL. | 36 | F1N6G5 | 909 | HACE1_BOVIN E3 ubiquitin-protein ligase HACE1... | 452 | 8e-95 | 337 | 41 | 58 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 37 | D3ZBM7 | 909 | HACE1_RAT E3 ubiquitin-protein ligase HACE1 O... | 451 | 8e-95 | 337 | 41 | 59 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 38 | Q3U0D9 | 909 | HACE1_MOUSE E3 ubiquitin-protein ligase HACE1... | 452 | 9e-95 | 337 | 41 | 59 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; ISS:UniProtKB.::GO:0007030; P:Golgi organization; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0030334; P:regulation of cell migration; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 39 | Q8IYU2 | 909 | HACE1_HUMAN E3 ubiquitin-protein ligase HACE1... | 452 | 1e-94 | 337 | 41 | 58 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.::GO:0048365; F:Rac GTPase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006944; P:cellular membrane fusion; IMP:UniProtKB.::GO:0007030; P:Golgi organization; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0016601; P:Rac protein signal transduction; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 40 | Q9HCE7 | 757 | SMUF1_HUMAN E3 ubiquitin-protein ligase SMURF... | 367 | 4e-94 | 331 | 43 | 65 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:BHF-UCL. | | | | | | | | | | GO:0048185; F:activin binding; IPI:BHF-UCL.::GO:0070411; F:I-SMAD binding; IPI:BHF-UCL.::GO:0070412; F:R-SMAD binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; IDA:UniProtKB.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0007398; P:ectoderm development; TAS:UniProtKB.::GO:0030514; P:negative regulation of BMP signaling pathway; TAS:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0006611; P:protein export from nucleus; IDA:BHF-UCL.::GO:0034394; P:protein localization at cell surface; IDA:BHF-UCL.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0032801; P:receptor catabolic process; IDA:BHF-UCL.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:Reactome.::GO:0030579; P:ubiquitin-dependent SMAD protein catabolic process; IDA:BHF-UCL. | 41 | Q9PUN2 | 731 | SMUF1_XENLA E3 ubiquitin-protein ligase SMURF... | 367 | 9e-94 | 330 | 43 | 65 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030509; P:BMP signaling pathway; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0007398; P:ectoderm development; TAS:UniProtKB.::GO:0030514; P:negative regulation of BMP signaling pathway; TAS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 42 | P46935 | 887 | NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4... | 388 | 1e-93 | 333 | 43 | 64 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI. | | | | | | | | | | GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. | | | | | | | | | | GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB. | 43 | Q62940 | 887 | NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O... | 389 | 8e-92 | 328 | 42 | 63 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB. | 44 | Q8C863 | 864 | ITCH_MOUSE E3 ubiquitin-protein ligase Itchy ... | 349 | 2e-91 | 326 | 44 | 66 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; IMP:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.::GO:0035519; P:protein K29-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:MGI.::GO:0090085; P:regulation of protein deubiquitination; IMP:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW. | 45 | Q9DBH0 | 870 | WWP2_MOUSE NEDD4-like E3 ubiquitin-protein li... | 349 | 6e-91 | 325 | 44 | 66 | GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:BHF-UCL. | | | | | | | | | | GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 46 | Q96J02 | 903 | ITCH_HUMAN E3 ubiquitin-protein ligase Itchy ... | 349 | 1e-90 | 325 | 44 | 66 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0045236; F:CXCR chemokine receptor binding; IPI:UniProtKB.::GO:0043021; F:ribonucleoprotein complex binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; NAS:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0050687; P:negative regulation of defense response to virus; IMP:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0035519; P:protein K29-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0090085; P:regulation of protein deubiquitination; ISS:BHF-UCL.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 47 | O00308 | 870 | WWP2_HUMAN NEDD4-like E3 ubiquitin-protein li... | 349 | 4e-90 | 322 | 44 | 65 | GO:0005737; C:cytoplasm; ISS:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; TAS:ProtInc. | | | | | | | | | | GO:0001085; F:RNA polymerase II transcription factor binding; IPI:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0051224; P:negative regulation of protein transport; IMP:UniProtKB.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0032410; P:negative regulation of transporter activity; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 48 | Q9V853 | 1061 | SMUF1_DROME E3 ubiquitin-protein ligase Smurf... | 368 | 9e-89 | 322 | 41 | 64 | GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0008101; P:decapentaplegic signaling pathway; IMP:UniProtKB.::GO:0001700; P:embryonic development via the syncytial blastoderm; IMP:UniProtKB.::GO:0048619; P:embryonic hindgut morphogenesis; IMP:UniProtKB.::GO:0010629; P:negative regulation of gene expression; IDA:FlyBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0040008; P:regulation of growth; IMP:FlyBase. | 49 | Q9Y0H4 | 949 | SUDX_DROME E3 ubiquitin-protein ligase Su(dx)... | 349 | 2e-86 | 313 | 43 | 65 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IMP:UniProtKB.::GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IGI:FlyBase.::GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:UniProtKB.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:UniProtKB.::GO:0007219; P:Notch signaling pathway; IGI:FlyBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0035209; P:pupal development; IMP:UniProtKB.::GO:0031623; P:receptor internalization; IMP:UniProtKB.::GO:0032880; P:regulation of protein localization; IMP:FlyBase.::GO:0048190; P:wing disc dorsal/ventral pattern formation; IMP:UniProtKB. | 50 | Q9H0M0 | 922 | WWP1_HUMAN NEDD4-like E3 ubiquitin-protein li... | 349 | 5e-85 | 308 | 42 | 65 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB. | | | | | | | | | | GO:0007417; P:central nervous system development; NAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007165; P:signal transduction; NAS:UniProtKB.::GO:0046718; P:viral entry into host cell; TAS:UniProtKB. | 51 | Q8BZZ3 | 918 | WWP1_MOUSE NEDD4-like E3 ubiquitin-protein li... | 372 | 9e-85 | 307 | 40 | 64 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030324; P:lung development; TAS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0030217; P:T cell differentiation; TAS:UniProtKB. | 52 | Q9UTG2 | 671 | PUB2_SCHPO E3 ubiquitin-protein ligase pub2 O... | 355 | 2e-84 | 300 | 43 | 63 | GO:0051285; C:cell cortex of cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IGI:PomBase. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 53 | Q76N89 | 1606 | HECW1_HUMAN E3 ubiquitin-protein ligase HECW1... | 403 | 5e-81 | 302 | 38 | 60 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 54 | Q8K4P8 | 1604 | HECW1_MOUSE E3 ubiquitin-protein ligase HECW1... | 403 | 8e-81 | 301 | 38 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 55 | Q6I6G8 | 1578 | HECW2_MOUSE E3 ubiquitin-protein ligase HECW2... | 386 | 2e-80 | 300 | 38 | 61 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 56 | Q9P2P5 | 1572 | HECW2_HUMAN E3 ubiquitin-protein ligase HECW2... | 386 | 3e-80 | 300 | 38 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 57 | Q8RWB8 | 1029 | UPL6_ARATH E3 ubiquitin-protein ligase UPL6 O... | 415 | 2e-54 | 213 | 32 | 55 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro. | | | | | | | | | | GO:0006464; P:protein modification process; IEA:InterPro. | 58 | Q05086 | 875 | UBE3A_HUMAN Ubiquitin-protein ligase E3A OS=H... | 396 | 2e-54 | 212 | 35 | 54 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007420; P:brain development; TAS:ProtInc.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 59 | Q1K9C4 | 1029 | YFK7_SCHPO Probable E3 ubiquitin protein liga... | 364 | 7e-54 | 211 | 35 | 55 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005635; C:nuclear envelope; IDA:PomBase. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase. | | | | | | | | | | GO:0033554; P:cellular response to stress; IEP:PomBase.::GO:0030433; P:ER-associated protein catabolic process; ISS:PomBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 60 | Q8CHG5 | 823 | K0317_MOUSE Protein KIAA0317 OS=Mus musculus ... | 399 | 1e-52 | 206 | 34 | 54 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 61 | O15033 | 823 | K0317_HUMAN Protein KIAA0317 OS=Homo sapiens ... | 399 | 1e-52 | 206 | 34 | 54 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. |
