| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | O35598 | 749 | ADA10_MOUSE Disintegrin and metalloproteinase... | 380 | 2e-22 | 106 | 27 | 40 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0005798; C:Golgi-associated vesicle; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome.::GO:0014069; C:postsynaptic density; IDA:MGI. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; NAS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001701; P:in utero embryonic development; IMP:UniProtKB.::GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.::GO:0007220; P:Notch receptor processing; NAS:UniProtKB.::GO:0007219; P:Notch signaling pathway; IMP:UniProtKB.::GO:0006913; P:nucleocytoplasmic transport; NAS:UniProtKB.::GO:0006468; P:protein phosphorylation; IDA:UniProtKB. | 62 | Q811Q4 | 763 | ADA29_MOUSE Disintegrin and metalloproteinase... | 212 | 3e-22 | 105 | 34 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 63 | Q9H2U9 | 754 | ADAM7_HUMAN Disintegrin and metalloproteinase... | 383 | 3e-22 | 105 | 26 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 64 | Q3HTN1 | 600 | VM3SA_VIRST Zinc metalloproteinase-disintegri... | 369 | 3e-22 | 105 | 31 | 45 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 65 | P0C6E8 | 435 | VM3G1_TRIGA Zinc metalloproteinase/disintegri... | 291 | 4e-22 | 103 | 33 | 43 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 66 | Q9BZ11 | 813 | ADA33_HUMAN Disintegrin and metalloproteinase... | 370 | 4e-22 | 105 | 27 | 41 | GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB. | | | | | | | | | | GO:0006508; P:proteolysis; NAS:UniProtKB. | 67 | P83912 | 484 | VM2JT_PROJR Zinc metalloproteinase-disintegri... | 334 | 4e-22 | 103 | 29 | 42 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 68 | Q8AWX7 | 488 | VM2AG_GLOHA Zinc metalloproteinase-disintegri... | 341 | 7e-22 | 103 | 28 | 40 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 69 | O14672 | 748 | ADA10_HUMAN Disintegrin and metalloproteinase... | 374 | 1e-21 | 103 | 28 | 41 | GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005798; C:Golgi-associated vesicle; IDA:UniProtKB.::GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005178; F:integrin binding; NAS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; IMP:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007267; P:cell-cell signaling; NAS:UniProtKB.::GO:0051089; P:constitutive protein ectodomain proteolysis; IDA:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0001701; P:in utero embryonic development; ISS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.::GO:0042117; P:monocyte activation; IMP:BHF-UCL.::GO:0007162; P:negative regulation of cell adhesion; IDA:UniProtKB.::GO:0007220; P:Notch receptor processing; TAS:Reactome.::GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.::GO:0051088; P:PMA-inducible membrane protein ectodomain proteolysis; IMP:BHF-UCL.::GO:0030307; P:positive regulation of cell growth; IMP:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0010820; P:positive regulation of T cell chemotaxis; IMP:BHF-UCL.::GO:0006468; P:protein phosphorylation; ISS:UniProtKB.::GO:0034612; P:response to tumor necrosis factor; IDA:BHF-UCL. | 70 | Q10741 | 748 | ADA10_BOVIN Disintegrin and metalloproteinase... | 374 | 3e-21 | 102 | 27 | 40 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005798; C:Golgi-associated vesicle; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001701; P:in utero embryonic development; ISS:UniProtKB.::GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.::GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.::GO:0006468; P:protein phosphorylation; ISS:UniProtKB. | 71 | Q10743 | 544 | ADA10_RAT Disintegrin and metalloproteinase d... | 380 | 4e-21 | 101 | 27 | 40 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0005798; C:Golgi-associated vesicle; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:RGD. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004222; F:metalloendopeptidase activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001701; P:in utero embryonic development; ISS:UniProtKB.::GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.::GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.::GO:0043526; P:neuroprotection; IEP:RGD.::GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.::GO:0006468; P:protein phosphorylation; ISS:UniProtKB.::GO:0045670; P:regulation of osteoclast differentiation; NAS:RGD. | 72 | Q28483 | 756 | ADAM5_MACFA Disintegrin and metalloproteinase... | 190 | 7e-21 | 101 | 32 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 73 | Q61824 | 903 | ADA12_MOUSE Disintegrin and metalloproteinase... | 373 | 8e-21 | 101 | 28 | 43 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 74 | Q28475 | 776 | ADAM7_MACFA Disintegrin and metalloproteinase... | 366 | 1e-20 | 100 | 26 | 39 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 75 | Q63202 | 737 | ADAM2_RAT Disintegrin and metalloproteinase d... | 172 | 1e-20 | 100 | 35 | 52 | GO:0001669; C:acrosomal vesicle; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0009566; P:fertilization; NAS:RGD.::GO:0006508; P:proteolysis; IEA:InterPro.::GO:0007283; P:spermatogenesis; IEP:RGD. | 76 | Q5BK84 | 709 | ADAM5_RAT Disintegrin and metalloproteinase d... | 187 | 2e-20 | 100 | 33 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 77 | Q1PBD1 | 477 | VM2DI_GLOHA Zinc metalloproteinase/disintegri... | 334 | 2e-20 | 98.6 | 28 | 41 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 78 | Q9JI76 | 729 | ADA21_MOUSE Disintegrin and metalloproteinase... | 372 | 3e-20 | 99.4 | 26 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 79 | O43506 | 726 | ADA20_HUMAN Disintegrin and metalloproteinase... | 367 | 3e-20 | 99.4 | 23 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0007338; P:single fertilization; TAS:ProtInc. | 80 | Q90WC0 | 317 | VM2HS_GLOBR Zinc metalloproteinase/disintegri... | 334 | 3e-20 | 96.3 | 28 | 40 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 81 | Q3TTE0 | 751 | ADAM5_MOUSE Disintegrin and metalloproteinase... | 293 | 4e-20 | 99 | 26 | 43 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:InterPro. | 82 | P86092 | 324 | VM3LB_BOTLC Zinc metalloproteinase leucurolys... | 268 | 4e-20 | 95.9 | 31 | 44 | GO:0005576; C:extracellular region; IDA:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007596; P:blood coagulation; IDA:UniProtKB.::GO:0009405; P:pathogenesis; IDA:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 83 | Q0NZY0 | 166 | VM3B1_BOTJA Zinc metalloproteinase-disintegri... | 127 | 5e-20 | 92.8 | 47 | 58 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro. | | | | | | | | | | GO:0007596; P:blood coagulation; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 84 | C9E1R7 | 486 | VM2V2_CROAT Zinc metalloproteinase/disintegri... | 333 | 7e-20 | 97.1 | 27 | 40 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 85 | P70505 | 789 | ADAM1_RAT Disintegrin and metalloproteinase d... | 304 | 8e-20 | 98.2 | 29 | 42 | GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0009566; P:fertilization; NAS:RGD.::GO:0006508; P:proteolysis; NAS:UniProtKB. | 86 | Q13444 | 863 | ADA15_HUMAN Disintegrin and metalloproteinase... | 212 | 9e-20 | 98.2 | 33 | 45 | GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.::GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0019861; C:flagellum; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0007160; P:cell-matrix adhesion; TAS:ProtInc.::GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 87 | Q99965 | 735 | ADAM2_HUMAN Disintegrin and metalloproteinase... | 375 | 9e-20 | 97.8 | 26 | 41 | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. | | | | | | | | | | GO:0005178; F:integrin binding; TAS:ProtInc.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0007342; P:fusion of sperm to egg plasma membrane; TAS:ProtInc.::GO:0006508; P:proteolysis; IEA:InterPro. | 88 | Q28478 | 735 | ADAM2_MACFA Disintegrin and metalloproteinase... | 172 | 1e-19 | 97.8 | 36 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IEA:InterPro. | 89 | Q8JIY1 | 749 | ADA10_XENLA Disintegrin and metalloproteinase... | 374 | 1e-19 | 97.8 | 28 | 40 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0005798; C:Golgi-associated vesicle; ISS:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006509; P:membrane protein ectodomain proteolysis; ISS:UniProtKB.::GO:0007162; P:negative regulation of cell adhesion; ISS:UniProtKB.::GO:0007219; P:Notch signaling pathway; ISS:UniProtKB.::GO:0006468; P:protein phosphorylation; ISS:UniProtKB. | 90 | Q9UKF2 | 790 | ADA30_HUMAN Disintegrin and metalloproteinase... | 250 | 1e-19 | 97.4 | 32 | 44 | GO:0016021; C:integral to membrane; TAS:ProtInc. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; TAS:ProtInc. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 91 | Q9P0K1 | 906 | ADA22_HUMAN Disintegrin and metalloproteinase... | 164 | 2e-19 | 97.1 | 37 | 52 | GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0005178; F:integrin binding; NAS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0007162; P:negative regulation of cell adhesion; NAS:UniProtKB.::GO:0006508; P:proteolysis; IEA:InterPro. |
