| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
511 | Q5RDW4 | 466 | EM55_PONAB 55 kDa erythrocyte membrane protei... | 57 | 0.81 | 36.6 | 28 | 54 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0032420; C:stereocilium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016740; F:transferase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0090022; P:regulation of neutrophil chemotaxis; ISS:UniProtKB. | 512 | Q13387 | 824 | JIP2_HUMAN C-Jun-amino-terminal kinase-intera... | 62 | 0.82 | 37 | 34 | 45 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL. | | | | | | | | | | GO:0001540; F:beta-amyloid binding; NAS:UniProtKB.::GO:0019894; F:kinesin binding; ISS:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; NAS:UniProtKB.::GO:0030295; F:protein kinase activator activity; IDA:MGI.::GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; ISS:BHF-UCL.::GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.::GO:0000165; P:MAPK cascade; IDA:MGI.::GO:0046958; P:nonassociative learning; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; NAS:UniProtKB.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0060079; P:regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:0046328; P:regulation of JNK cascade; IDA:UniProtKB.::GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; ISS:BHF-UCL.::GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:BHF-UCL.::GO:0007172; P:signal complex assembly; TAS:ProtInc.::GO:0035176; P:social behavior; ISS:BHF-UCL. | 513 | D9IVE5 | 432 | ANM2_XENLA Protein arginine N-methyltransfera... | 84 | 0.83 | 36.6 | 24 | 49 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0030331; F:estrogen receptor binding; ISS:UniProtKB.::GO:0008469; F:histone-arginine N-methyltransferase activity; IDA:UniProtKB. | | | | | | | | | | GO:0048588; P:developmental cell growth; IMP:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0060765; P:regulation of androgen receptor signaling pathway; ISS:UniProtKB. | 514 | Q9JIR0 | 1847 | RIMB1_RAT Peripheral-type benzodiazepine rece... | 65 | 0.86 | 37 | 34 | 52 | GO:0005739; C:mitochondrion; IDA:RGD. | | | | | | | | | | | | | | | | | | | | | 515 | Q6GMN2 | 535 | BAIP2_RAT Brain-specific angiogenesis inhibit... | 71 | 0.86 | 36.6 | 32 | 45 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 516 | O08839 | 588 | BIN1_RAT Myc box-dependent-interacting protei... | 115 | 0.86 | 36.6 | 26 | 44 | GO:0043679; C:axon terminus; IDA:RGD.::GO:0044300; C:cerebellar mossy fiber; IDA:RGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0008021; C:synaptic vesicle; IDA:RGD.::GO:0043196; C:varicosity; IDA:RGD. | | | | | | | | | | GO:0051020; F:GTPase binding; IPI:RGD.::GO:0046982; F:protein heterodimerization activity; IPI:RGD. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0045807; P:positive regulation of endocytosis; IMP:RGD.::GO:0043547; P:positive regulation of GTPase activity; IDA:RGD. | 517 | Q8BKX1 | 535 | BAIP2_MOUSE Brain-specific angiogenesis inhib... | 71 | 0.89 | 36.6 | 32 | 45 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0051017; P:actin filament bundle assembly; IGI:MGI.::GO:0016358; P:dendrite development; IMP:MGI.::GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; IMP:MGI.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007266; P:Rho protein signal transduction; TAS:MGI. | 518 | Q9P0V3 | 963 | SH3B4_HUMAN SH3 domain-binding protein 4 OS=H... | 82 | 0.9 | 36.6 | 28 | 49 | GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 519 | C5MB30 | 340 | SHO1_CANTT High osmolarity signaling protein ... | 74 | 0.93 | 36.2 | 31 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 520 | P08103 | 524 | HCK_MOUSE Tyrosine-protein kinase HCK OS=Mus ... | 62 | 0.95 | 36.6 | 35 | 50 | GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0050830; P:defense response to Gram-positive bacterium; IGI:MGI.::GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IMP:MGI.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB. | 521 | E7A253 | 343 | SHO1_SPORE High osmolarity signaling protein ... | 57 | 0.97 | 36.2 | 35 | 61 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 522 | Q9NZQ3 | 722 | SPN90_HUMAN NCK-interacting protein with SH3 ... | 63 | 1 | 36.6 | 35 | 46 | GO:0005882; C:intermediate filament; NAS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; NAS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0006607; P:NLS-bearing substrate import into nucleus; TAS:ProtInc.::GO:0007165; P:signal transduction; TAS:ProtInc. | 523 | Q86WV1 | 359 | SKAP1_HUMAN Src kinase-associated phosphoprot... | 54 | 1 | 36.2 | 35 | 50 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0003823; F:antigen binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0042169; F:SH2 domain binding; IDA:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; IC:UniProtKB. | | | | | | | | | | GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB. | 524 | Q60437 | 521 | BAIP2_CRIGR Brain-specific angiogenesis inhib... | 71 | 1.1 | 36.2 | 32 | 45 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro. | | | | | | | | | | GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 525 | Q9ESJ4 | 714 | SPN90_MOUSE NCK-interacting protein with SH3 ... | 63 | 1.1 | 36.2 | 33 | 46 | | | | | | | | | | | GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | | 526 | Q6NU51 | 957 | SH34B_XENLA SH3 domain-binding protein 4-B OS... | 56 | 1.1 | 36.2 | 34 | 54 | GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 527 | Q8CIH5 | 1265 | PLCG2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 69 | 1.2 | 36.2 | 30 | 55 | GO:0005829; C:cytosol; IMP:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0032237; P:activation of store-operated calcium channel activity; IMP:MGI.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0002316; P:follicular B cell differentiation; IMP:MGI.::GO:0032959; P:inositol trisphosphate biosynthetic process; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043069; P:negative regulation of programmed cell death; IMP:MGI.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI. | 528 | Q7Z8J6 | 1282 | MYO1_USTMA Myosin-1 OS=Ustilago maydis (strai... | 62 | 1.2 | 36.2 | 34 | 47 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro. | | | | | | | | | | | 529 | Q751J2 | 330 | SHO1_ASHGO High osmolarity signaling protein ... | 44 | 1.2 | 35.8 | 39 | 64 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 530 | Q9ERE9 | 830 | JIP2_MOUSE C-Jun-amino-terminal kinase-intera... | 62 | 1.2 | 36.2 | 34 | 45 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0043025; C:neuronal cell body; IDA:MGI.::GO:0014069; C:postsynaptic density; IDA:BHF-UCL. | | | | | | | | | | GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; ISS:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; IMP:BHF-UCL.::GO:0048813; P:dendrite morphogenesis; IMP:BHF-UCL.::GO:0007254; P:JNK cascade; IDA:MGI.::GO:0007617; P:mating behavior; IMP:BHF-UCL.::GO:0046958; P:nonassociative learning; IMP:BHF-UCL.::GO:2000311; P:regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IMP:BHF-UCL.::GO:0046328; P:regulation of JNK cascade; ISS:UniProtKB.::GO:2000310; P:regulation of N-methyl-D-aspartate selective glutamate receptor activity; IMP:BHF-UCL.::GO:0051966; P:regulation of synaptic transmission, glutamatergic; IMP:BHF-UCL.::GO:0035176; P:social behavior; IMP:BHF-UCL. | 531 | Q5TCZ1 | 1133 | SPD2A_HUMAN SH3 and PX domain-containing prot... | 78 | 1.3 | 36.2 | 26 | 45 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0002102; C:podosome; IDA:UniProtKB. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0006801; P:superoxide metabolic process; IDA:UniProtKB. | 532 | P24135 | 1265 | PLCG2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 69 | 1.3 | 36.2 | 30 | 55 | GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0033198; P:response to ATP; IDA:RGD.::GO:0032026; P:response to magnesium ion; IDA:RGD. | 533 | Q6NU22 | 957 | SH34A_XENLA SH3 domain-binding protein 4-A OS... | 56 | 1.4 | 36.2 | 34 | 54 | GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 534 | P08631 | 526 | HCK_HUMAN Tyrosine-protein kinase HCK OS=Homo... | 55 | 1.4 | 35.8 | 38 | 53 | GO:0005901; C:caveola; IDA:UniProtKB.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031234; C:extrinsic to internal side of plasma membrane; IMP:UniProtKB.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0002758; P:innate immune response-activating signal transduction; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; TAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043299; P:leukocyte degranulation; TAS:UniProtKB.::GO:0002522; P:leukocyte migration involved in immune response; TAS:UniProtKB.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; TAS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0071801; P:regulation of podosome assembly; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0045728; P:respiratory burst after phagocytosis; TAS:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome. | 535 | P49697 | 467 | EM55_TAKRU 55 kDa erythrocyte membrane protei... | 43 | 1.4 | 35.8 | 28 | 58 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 536 | P43069 | 1333 | CDC25_CANAL Cell division control protein 25 ... | 55 | 1.5 | 36.2 | 38 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:CGD. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IMP:CGD.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.::GO:0030447; P:filamentous growth; IMP:CGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IGI:CGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 537 | P07948 | 512 | LYN_HUMAN Tyrosine-protein kinase Lyn OS=Homo... | 42 | 1.5 | 35.8 | 45 | 60 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; TAS:ProtInc. | | | | | | | | | | GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0050777; P:negative regulation of immune response; TAS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0070668; P:positive regulation of mast cell proliferation; IMP:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; IDA:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090025; P:regulation of monocyte chemotaxis; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB. | 538 | O89032 | 1124 | SPD2A_MOUSE SH3 and PX domain-containing prot... | 78 | 1.5 | 36.2 | 26 | 45 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0002102; C:podosome; ISS:UniProtKB. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro. | 539 | Q5JRA6 | 1907 | MIA3_HUMAN Melanoma inhibitory activity prote... | 66 | 1.6 | 36.2 | 33 | 52 | GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0006887; P:exocytosis; IMP:UniProtKB.::GO:0007162; P:negative regulation of cell adhesion; IDA:BHF-UCL.::GO:0030336; P:negative regulation of cell migration; IDA:BHF-UCL.::GO:0002687; P:positive regulation of leukocyte migration; IDA:BHF-UCL.::GO:0015031; P:protein transport; IMP:UniProtKB.::GO:0042060; P:wound healing; IDA:BHF-UCL. | 540 | Q05080 | 669 | CYK2_YEAST Cytokinesis protein 2 OS=Saccharom... | 49 | 1.6 | 35.8 | 31 | 51 | GO:0000142; C:cellular bud neck contractile ring; IDA:SGD.::GO:0000144; C:cellular bud neck septin ring; IDA:SGD. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IPI:SGD. | | | | | | | | | | GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:SGD.::GO:0000281; P:cytokinesis after mitosis; IMP:SGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006974; P:response to DNA damage stimulus; IMP:SGD. | 541 | Q9P864 | 296 | SHO1_CYBJA High osmolarity signaling protein ... | 55 | 1.6 | 35.4 | 33 | 60 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006950; P:response to stress; IEA:UniProtKB-KW. |
