rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | Q5L014 | 242 | NPD1_GEOKA NAD-dependent protein deacetylase ... | 55 | 0.44 | 33.5 | 36 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 122 | Q9FE17 | 473 | SIR1_ARATH NAD-dependent protein deacetylase ... | 54 | 0.46 | 33.9 | 31 | 52 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 123 | Q6N6U0 | 253 | NPD_RHOPA NAD-dependent protein deacetylase O... | 35 | 0.48 | 33.5 | 40 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 124 | B8ARK7 | 484 | SIR1_ORYSI NAD-dependent protein deacetylase ... | 48 | 0.57 | 33.5 | 35 | 58 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 125 | Q8VDQ8 | 389 | SIR2_MOUSE NAD-dependent protein deacetylase ... | 51 | 0.71 | 33.1 | 39 | 53 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; ISS:UniProtKB. | | | | | | | | | | GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB.::GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.::GO:0017136; F:NAD-dependent histone deacetylase activity; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0042903; F:tubulin deacetylase activity; ISS:UniProtKB.::GO:0043130; F:ubiquitin binding; ISS:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045843; P:negative regulation of striated muscle tissue development; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 126 | P53686 | 357 | HST2_YEAST NAD-dependent protein deacetylase ... | 87 | 0.73 | 33.1 | 29 | 44 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 127 | Q8IE47 | 273 | SIR5_PLAF7 NAD-dependent protein deacylase Si... | 71 | 0.78 | 33.1 | 30 | 48 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 128 | O59923 | 519 | SIR2_CANAL NAD-dependent histone deacetylase ... | 54 | 0.78 | 33.1 | 30 | 52 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0000183; P:chromatin silencing at rDNA; IMP:CGD.::GO:0001319; P:inheritance of oxidatively modified proteins involved in replicative cell aging; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0045595; P:regulation of cell differentiation; IMP:CGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 129 | Q54GV7 | 542 | SIR2D_DICDI NAD-dependent deacetylase sir2D O... | 48 | 1.1 | 32.7 | 31 | 56 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 130 | Q8Y3U2 | 229 | NPD_LISMO NAD-dependent protein deacetylase O... | 56 | 1.7 | 32 | 30 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 131 | Q95Q89 | 292 | SIR24_CAEEL NAD-dependent protein deacetylase... | 51 | 1.8 | 32 | 37 | 53 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 132 | Q5KZE8 | 247 | NPD2_GEOKA NAD-dependent protein deacetylase ... | 58 | 2.1 | 31.6 | 28 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 133 | Q9RL35 | 299 | NPD1_STRCO NAD-dependent protein deacetylase ... | 30 | 2.2 | 31.6 | 50 | 63 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 134 | Q81BT4 | 245 | NPD_BACCR NAD-dependent protein deacetylase O... | 67 | 2.2 | 31.6 | 24 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 135 | Q735N7 | 242 | NPD_BACC1 NAD-dependent protein deacetylase O... | 68 | 2.4 | 31.6 | 24 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 136 | Q89LY4 | 254 | NPD1_BRAJA NAD-dependent protein deacetylase ... | 49 | 2.5 | 31.6 | 29 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 137 | P53685 | 503 | HST1_YEAST NAD-dependent protein deacetylase ... | 96 | 2.6 | 31.6 | 28 | 42 | GO:0034967; C:Set3 complex; IDA:SGD. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0045129; F:NAD-independent histone deacetylase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 138 | Q757M7 | 559 | SIR2_ASHGO NAD-dependent histone deacetylase ... | 96 | 2.7 | 31.6 | 28 | 43 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 139 | B5YJW3 | 256 | NPD_THEYD NAD-dependent protein deacetylase O... | 28 | 2.7 | 31.2 | 46 | 61 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 140 | Q5AQ47 | 657 | HST1_CANAL NAD-dependent protein deacetylase ... | 77 | 2.8 | 31.6 | 27 | 45 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0006342; P:chromatin silencing; IEA:InterPro. | 141 | Q6HH09 | 245 | NPD_BACHK NAD-dependent protein deacetylase O... | 58 | 3.2 | 31.2 | 26 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 142 | Q81NT6 | 242 | NPD_BACAN NAD-dependent protein deacetylase O... | 58 | 3.2 | 31.2 | 26 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 143 | Q639M6 | 245 | NPD_BACCZ NAD-dependent protein deacetylase O... | 58 | 3.3 | 31.2 | 26 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 144 | Q923E4 | 737 | SIR1_MOUSE NAD-dependent protein deacetylase ... | 76 | 3.4 | 31.2 | 29 | 47 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005719; C:nuclear euchromatin; ISS:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0019904; F:protein domain specific binding; IPI:BHF-UCL.::GO:0003714; F:transcription corepressor activity; IMP:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0001678; P:cellular glucose homeostasis; IMP:UniProtKB.::GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:UniProtKB.::GO:0009267; P:cellular response to starvation; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; IMP:UniProtKB.::GO:0042632; P:cholesterol homeostasis; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0000731; P:DNA synthesis involved in DNA repair; IMP:UniProtKB.::GO:0055089; P:fatty acid homeostasis; IMP:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; ISS:UniProtKB.::GO:2000773; P:negative regulation of cellular senescence; ISS:UniProtKB.::GO:0045599; P:negative regulation of fat cell differentiation; IMP:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; ISS:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IMP:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.::GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.::GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; IMP:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0031648; P:protein destabilization; IDA:UniProtKB.::GO:0016567; P:protein ubiquitination; ISS:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; ISS:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; IMP:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; IMP:BHF-UCL.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; IDA:UniProtKB.::GO:0032868; P:response to insulin stimulus; IDA:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; IMP:BHF-UCL.::GO:0050872; P:white fat cell differentiation; IMP:BHF-UCL. | 145 | Q96EB6 | 747 | SIR1_HUMAN NAD-dependent protein deacetylase ... | 76 | 4 | 31.2 | 29 | 47 | GO:0005677; C:chromatin silencing complex; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005719; C:nuclear euchromatin; IDA:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:BHF-UCL.::GO:0016605; C:PML body; IDA:BHF-UCL.::GO:0033553; C:rDNA heterochromatin; IDA:UniProtKB. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB.::GO:0042393; F:histone binding; IPI:BHF-UCL.::GO:0043398; F:HLH domain binding; IPI:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:BHF-UCL.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); ISS:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IDA:UniProtKB.::GO:0007569; P:cell aging; TAS:BHF-UCL.::GO:0001678; P:cellular glucose homeostasis; ISS:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:BHF-UCL.::GO:0071456; P:cellular response to hypoxia; IMP:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0009267; P:cellular response to starvation; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; ISS:UniProtKB.::GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.::GO:0000183; P:chromatin silencing at rDNA; IDA:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IMP:UniProtKB.::GO:0006260; P:DNA replication; TAS:BHF-UCL.::GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.::GO:0006343; P:establishment of chromatin silencing; IDA:BHF-UCL.::GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006344; P:maintenance of chromatin silencing; IMP:BHF-UCL.::GO:0006346; P:methylation-dependent chromatin silencing; TAS:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.::GO:2000655; P:negative regulation of cellular response to testosterone stimulus; IMP:BHF-UCL.::GO:2000773; P:negative regulation of cellular senescence; IDA:UniProtKB.::GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL.::GO:0045599; P:negative regulation of fat cell differentiation; ISS:BHF-UCL.::GO:0051097; P:negative regulation of helicase activity; IDA:UniProtKB.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; IDA:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0018394; P:peptidyl-lysine acetylation; IMP:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0002821; P:positive regulation of adaptive immune response; IDA:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; IDA:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.::GO:0031937; P:positive regulation of chromatin silencing; IMP:BHF-UCL.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.::GO:0045348; P:positive regulation of MHC class II biosynthetic process; IDA:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0016567; P:protein ubiquitination; IDA:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; IMP:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; ISS:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; ISS:BHF-UCL.::GO:0033158; P:regulation of protein import into nucleus, translocation; IMP:UniProtKB.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; ISS:UniProtKB.::GO:0032868; P:response to insulin stimulus; ISS:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; ISS:BHF-UCL.::GO:0050872; P:white fat cell differentiation; ISS:BHF-UCL. | 146 | Q5BE04 | 595 | HST4_EMENI NAD-dependent protein deacetylase ... | 53 | 4.5 | 30.8 | 28 | 51 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 147 | Q6FWI7 | 509 | SIR2_CANGA NAD-dependent histone deacetylase ... | 96 | 6.1 | 30.4 | 28 | 42 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 148 | Q8N6T7 | 355 | SIR6_HUMAN NAD-dependent protein deacetylase ... | 35 | 6.3 | 30.4 | 43 | 60 | GO:0005724; C:nuclear telomeric heterochromatin; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:UniProtKB. | | | | | | | | | | GO:0003956; F:NAD(P)+-protein-arginine ADP-ribosyltransferase activity; ISS:UniProtKB.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; TAS:BHF-UCL.::GO:0070403; F:NAD+ binding; ISS:UniProtKB.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0006471; P:protein ADP-ribosylation; ISS:UniProtKB.::GO:0010569; P:regulation of double-strand break repair via homologous recombination; IDA:UniProtKB. | 149 | P49454 | 3210 | CENPF_HUMAN Centromere protein F OS=Homo sapi... | 56 | 8.3 | 30.4 | 39 | 50 | GO:0000940; C:condensed chromosome outer kinetochore; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005635; C:nuclear envelope; IDA:UniProtKB.::GO:0016363; C:nuclear matrix; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IDA:UniProtKB. | | | | | | | | | | GO:0003682; F:chromatin binding; NAS:UniProtKB.::GO:0045502; F:dynein binding; IDA:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000085; P:G2 phase of mitotic cell cycle; IMP:UniProtKB.::GO:0051382; P:kinetochore assembly; NAS:UniProtKB.::GO:0051310; P:metaphase plate congression; IDA:UniProtKB.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; NAS:UniProtKB.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0015031; P:protein transport; IDA:UniProtKB.::GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:UniProtKB.::GO:0016202; P:regulation of striated muscle tissue development; ISS:UniProtKB.::GO:0042493; P:response to drug; NAS:UniProtKB. |