| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q02342 | 1095 | CDC25_LACKL Cell division control protein 25 ... | 155 | 0.000000000000007 | 82.8 | 30 | 55 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 62 | B0M0P8 | 2356 | GEFL_DICDI Ras guanine nucleotide exchange fa... | 201 | 0.000000000000009 | 82.8 | 28 | 52 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 63 | Q07890 | 1332 | SOS2_HUMAN Son of sevenless homolog 2 OS=Homo... | 120 | 0.85 | 37 | 28 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. | 64 | Q8IS18 | 1037 | GEFE_DICDI Ras guanine nucleotide exchange fa... | 182 | 0.00000000000003 | 80.9 | 29 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 65 | F1M386 | 1496 | RPGF2_RAT Rap guanine nucleotide exchange fac... | 197 | 0.00000000000003 | 80.9 | 26 | 50 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 66 | Q68EF8 | 662 | RPGFL_MOUSE Rap guanine nucleotide exchange f... | 172 | 0.00000000000003 | 80.1 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 67 | Q8CHG7 | 1496 | RPGF2_MOUSE Rap guanine nucleotide exchange f... | 197 | 0.00000000000004 | 80.5 | 26 | 50 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 68 | Q62245 | 1319 | SOS1_MOUSE Son of sevenless homolog 1 OS=Mus ... | 460 | 0.00000000000005 | 80.1 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 69 | Q8IS11 | 944 | GEFO_DICDI Ras guanine nucleotide exchange fa... | 214 | 0.00000000000006 | 79.7 | 27 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 70 | Q9UHV5 | 662 | RPGFL_HUMAN Rap guanine nucleotide exchange f... | 172 | 0.00000000000006 | 79.3 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0007399; P:nervous system development; TAS:ProtInc.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 71 | Q02384 | 1333 | SOS2_MOUSE Son of sevenless homolog 2 OS=Mus ... | 120 | 1.1 | 36.6 | 28 | 38 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 72 | B0UXH6 | 581 | RGPS1_DANRE Ras-specific guanine nucleotide-r... | 241 | 0.0000000000002 | 77.8 | 27 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 73 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 197 | 0.0000000000002 | 77.8 | 26 | 49 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. | 74 | Q5R9B2 | 456 | RPGFL_PONPY Rap guanine nucleotide exchange f... | 172 | 0.0000000000003 | 76.6 | 27 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 75 | Q9USU1 | 987 | EFC25_SCHPO Ras guanine nucleotide exchange f... | 237 | 0.0000000000006 | 76.6 | 22 | 47 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IMP:PomBase. | | | | | | | | | | GO:0032488; P:Cdc42 protein signal transduction; TAS:PomBase.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 76 | P34578 | 1038 | RPGF1_CAEEL Rap guanine nucleotide exchange f... | 205 | 0.0000000000009 | 75.9 | 26 | 48 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro. | | | | | | | | | | GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 77 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 214 | 0.000000000001 | 75.9 | 26 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 78 | Q07889 | 1333 | SOS1_HUMAN Son of sevenless homolog 1 OS=Homo... | 122 | 0.23 | 38.9 | 30 | 39 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome. | 79 | Q8TEU7 | 1601 | RPGF6_HUMAN Rap guanine nucleotide exchange f... | 204 | 0.00000000002 | 71.6 | 24 | 48 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:UniProtKB. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 80 | Q55EC7 | 960 | GEFX_DICDI RasGEF domain-containing serine/th... | 79 | 0.029 | 41.6 | 32 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 81 | Q3MIN7 | 710 | RGL3_HUMAN Ral guanine nucleotide dissociatio... | 148 | 0.00000000004 | 70.5 | 28 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 82 | Q60695 | 768 | RGL1_MOUSE Ral guanine nucleotide dissociatio... | 148 | 0.0000000001 | 68.9 | 28 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 83 | Q6CY10 | 1366 | LTE1_KLULA Guanine nucleotide exchange factor... | 252 | 0.0000000001 | 69.3 | 24 | 49 | GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 84 | Q9NZL6 | 768 | RGL1_HUMAN Ral guanine nucleotide dissociatio... | 142 | 0.0000000002 | 68.2 | 29 | 52 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 85 | Q8IS12 | 1138 | GEFN_DICDI Ras guanine nucleotide exchange fa... | 194 | 0.0000000002 | 68.6 | 24 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 86 | Q12967 | 914 | GNDS_HUMAN Ral guanine nucleotide dissociatio... | 222 | 0.0000000005 | 67 | 25 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IDA:UniProtKB. | | | | | | | | | | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 87 | Q28EC1 | 472 | RGF1B_XENTR Ras-GEF domain-containing family ... | 260 | 0.0000000006 | 66.2 | 25 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 88 | Q8MVR1 | 2631 | GBPC_DICDI Cyclic GMP-binding protein C OS=Di... | 218 | 0.000000001 | 66.2 | 27 | 46 | GO:0005737; C:cytoplasm; IDA:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030553; F:cGMP binding; IDA:dictyBase.::GO:0005525; F:GTP binding; IDA:dictyBase.::GO:0005543; F:phospholipid binding; IDA:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0019934; P:cGMP-mediated signaling; IDA:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0051272; P:positive regulation of cellular component movement; TAS:dictyBase.::GO:0045860; P:positive regulation of protein kinase activity; IMP:dictyBase.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 89 | P26675 | 1596 | SOS_DROME Protein son of sevenless OS=Drosoph... | 201 | 0.000000002 | 65.5 | 21 | 52 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0045500; P:sevenless signaling pathway; TAS:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0008293; P:torso signaling pathway; TAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase. | 90 | Q6P112 | 804 | RGL1_DANRE Ral guanine nucleotide dissociatio... | 148 | 0.000000002 | 64.7 | 23 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 91 | Q6DHR3 | 514 | RG1BA_DANRE Ras-GEF domain-containing family ... | 260 | 0.000000003 | 63.9 | 23 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
