| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q6CY10 | 1366 | LTE1_KLULA Guanine nucleotide exchange factor... | 1366 | 0 | 2774 | 100 | 100 | GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 2 | Q75BH9 | 1439 | LTE1_ASHGO Guanine nucleotide exchange factor... | 1484 | 0 | 844 | 38 | 56 | GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 3 | P07866 | 1435 | LTE1_YEAST Guanine nucleotide exchange factor... | 1496 | 0 | 809 | 38 | 56 | GO:0005933; C:cellular bud; IDA:SGD.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0031578; P:mitotic cell cycle spindle orientation checkpoint; TAS:SGD.::GO:0007096; P:regulation of exit from mitosis; TAS:SGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0016192; P:vesicle-mediated transport; IGI:SGD. | 4 | Q6FT12 | 1318 | LTE1_CANGA Guanine nucleotide exchange factor... | 1433 | 0 | 723 | 36 | 54 | GO:0005933; C:cellular bud; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 5 | Q8IS18 | 1037 | GEFE_DICDI Ras guanine nucleotide exchange fa... | 177 | 1e-17 | 92.8 | 32 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 6 | Q8SSQ3 | 929 | GEFM_DICDI Ras guanine nucleotide exchange fa... | 176 | 1e-17 | 92.4 | 30 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 7 | Q9USU1 | 987 | EFC25_SCHPO Ras guanine nucleotide exchange f... | 238 | 4e-17 | 91.3 | 28 | 49 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IMP:PomBase. | | | | | | | | | | GO:0032488; P:Cdc42 protein signal transduction; TAS:PomBase.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 8 | Q552M5 | 1508 | GEFY_DICDI Ras guanine nucleotide exchange fa... | 207 | 4e-17 | 91.3 | 31 | 49 | GO:0005813; C:centrosome; IDA:dictyBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 9 | P04821 | 1589 | CDC25_YEAST Cell division control protein 25 ... | 223 | 0.000000000000003 | 85.5 | 28 | 49 | GO:0005829; C:cytosol; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:SGD. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IMP:SGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0001302; P:replicative cell aging; IMP:SGD.::GO:0007089; P:traversing start control point of mitotic cell cycle; IMP:SGD. | 10 | Q13972 | 1275 | RGRF1_HUMAN Ras-specific guanine nucleotide-r... | 205 | 0.000000000000003 | 85.5 | 25 | 50 | GO:0005829; C:cytosol; ISS:HGNC.::GO:0030426; C:growth cone; ISS:HGNC.::GO:0005886; C:plasma membrane; NAS:UniProtKB.::GO:0019717; C:synaptosome; NAS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:HGNC.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007616; P:long-term memory; NAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0031175; P:neuron projection development; ISS:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0035020; P:regulation of Rac protein signal transduction; ISS:HGNC.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 11 | Q86G47 | 1298 | GEFQ_DICDI Ras guanine nucleotide exchange fa... | 231 | 0.000000000000004 | 85.1 | 27 | 48 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 12 | Q5ZJK0 | 584 | RGPS1_CHICK Ras-specific guanine nucleotide-r... | 116 | 0.000000000000006 | 83.6 | 34 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 13 | Q86X27 | 583 | RGPS2_HUMAN Ras-specific guanine nucleotide-r... | 116 | 0.000000000000006 | 83.6 | 34 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 14 | Q4R7W3 | 557 | RGPS2_MACFA Ras-specific guanine nucleotide-r... | 116 | 0.000000000000006 | 83.2 | 34 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 15 | Q9ERD6 | 590 | RGPS2_MOUSE Ras-specific guanine nucleotide-r... | 116 | 0.000000000000007 | 83.2 | 34 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 16 | P27671 | 1262 | RGRF1_MOUSE Ras-specific guanine nucleotide-r... | 254 | 0.00000000000001 | 83.6 | 24 | 47 | GO:0005829; C:cytosol; IDA:HGNC.::GO:0030426; C:growth cone; IDA:HGNC. | | | | | | | | | | GO:0035254; F:glutamate receptor binding; IPI:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; IDA:HGNC.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0031175; P:neuron projection development; IDA:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:MGI.::GO:0035020; P:regulation of Rac protein signal transduction; IDA:HGNC.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 17 | P28818 | 1244 | RGRF1_RAT Ras-specific guanine nucleotide-rel... | 246 | 0.00000000000004 | 81.6 | 23 | 48 | GO:0005829; C:cytosol; ISS:HGNC.::GO:0030426; C:growth cone; ISS:HGNC. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:HGNC.::GO:0031175; P:neuron projection development; ISS:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0035020; P:regulation of Rac protein signal transduction; ISS:HGNC.::GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 18 | Q54FF3 | 1557 | GEFK_DICDI Ras guanine nucleotide exchange fa... | 214 | 0.0000000000002 | 79.3 | 25 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 19 | Q54PQ4 | 605 | GEFA_DICDI Ras guanine nucleotide exchange fa... | 73 | 0.16 | 40 | 26 | 55 | GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0030250; F:guanylate cyclase activator activity; IMP:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007190; P:activation of adenylate cyclase activity; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 20 | O14827 | 1237 | RGRF2_HUMAN Ras-specific guanine nucleotide-r... | 213 | 0.0000000000003 | 79 | 25 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 21 | B0UXH6 | 581 | RGPS1_DANRE Ras-specific guanine nucleotide-r... | 116 | 0.0000000000003 | 78.2 | 32 | 59 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 22 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 205 | 0.0000000000003 | 78.6 | 25 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 23 | Q8ST25 | 1556 | GEFG_DICDI Ras guanine nucleotide exchange fa... | 180 | 0.0000000000004 | 78.6 | 27 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 24 | Q8SSQ0 | 1721 | GEFR_DICDI Ras guanine nucleotide exchange fa... | 218 | 0.0000000000006 | 77.8 | 27 | 54 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 25 | Q8IS12 | 1138 | GEFN_DICDI Ras guanine nucleotide exchange fa... | 214 | 0.0000000000007 | 77.4 | 26 | 52 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 26 | Q99JE4 | 1190 | RGRF2_RAT Ras-specific guanine nucleotide-rel... | 213 | 0.0000000000007 | 77.4 | 25 | 48 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 27 | P70392 | 1189 | RGRF2_MOUSE Ras-specific guanine nucleotide-r... | 213 | 0.0000000000007 | 77.4 | 25 | 48 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 28 | Q5JS13 | 557 | RGPS1_HUMAN Ras-specific guanine nucleotide-r... | 115 | 0.000000000001 | 76.3 | 34 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 29 | Q02342 | 1095 | CDC25_LACKL Cell division control protein 25 ... | 208 | 0.000000000001 | 77 | 29 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 30 | A7A0P0 | 1252 | SDC25_YEAS7 Guanine nucleotide exchange facto... | 223 | 0.000000000001 | 77 | 30 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 31 | B5VMS9 | 1265 | SDC25_YEAS6 Guanine nucleotide exchange facto... | 223 | 0.000000000001 | 77 | 30 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
