| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q7LDG7 | 609 | GRP2_HUMAN RAS guanyl-releasing protein 2 OS=... | 132 | 0.00000004 | 61.2 | 30 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 62 | Q99P84 | 2281 | PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 183 | 0.00000004 | 62 | 25 | 46 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IDA:RGD.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB. | 63 | O15211 | 777 | RGL2_HUMAN Ral guanine nucleotide dissociatio... | 258 | 0.00000008 | 60.5 | 20 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 64 | P43069 | 1333 | CDC25_CANAL Cell division control protein 25 ... | 183 | 0.0000001 | 60.5 | 25 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:CGD. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IMP:CGD.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0071333; P:cellular response to glucose stimulus; IMP:CGD.::GO:0030447; P:filamentous growth; IMP:CGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IGI:CGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 65 | Q8K4S1 | 2282 | PLCE1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 120 | 0.0000002 | 60.1 | 24 | 48 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 66 | P34578 | 1038 | RPGF1_CAEEL Rap guanine nucleotide exchange f... | 154 | 0.0000002 | 59.3 | 27 | 51 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro. | | | | | | | | | | GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 67 | Q13905 | 1077 | RPGF1_HUMAN Rap guanine nucleotide exchange f... | 177 | 0.0000003 | 59.3 | 27 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 68 | Q3MIN7 | 710 | RGL3_HUMAN Ral guanine nucleotide dissociatio... | 179 | 0.0000003 | 58.5 | 25 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 69 | Q12967 | 914 | GNDS_HUMAN Ral guanine nucleotide dissociatio... | 279 | 0.0000004 | 58.5 | 20 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IDA:UniProtKB. | | | | | | | | | | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 70 | Q68EF8 | 662 | RPGFL_MOUSE Rap guanine nucleotide exchange f... | 205 | 0.0000006 | 57.8 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 71 | Q61193 | 778 | RGL2_MOUSE Ral guanine nucleotide dissociatio... | 252 | 0.0000007 | 57.8 | 19 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 72 | Q9UHV5 | 662 | RPGFL_HUMAN Rap guanine nucleotide exchange f... | 205 | 0.0000007 | 57.4 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0007399; P:nervous system development; TAS:ProtInc.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 73 | Q8IS16 | 604 | GEFH_DICDI Ras guanine nucleotide exchange fa... | 175 | 0.0000009 | 57 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 74 | Q8IS19 | 668 | GEFD_DICDI Ras guanine nucleotide exchange fa... | 212 | 0.000001 | 57 | 25 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 75 | Q6P112 | 804 | RGL1_DANRE Ral guanine nucleotide dissociatio... | 272 | 0.000002 | 56.2 | 23 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 76 | Q5R9B2 | 456 | RPGFL_PONPY Rap guanine nucleotide exchange f... | 201 | 0.000002 | 55.5 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 77 | Q9NZL6 | 768 | RGL1_HUMAN Ral guanine nucleotide dissociatio... | 229 | 0.000004 | 55.1 | 21 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 78 | Q60695 | 768 | RGL1_MOUSE Ral guanine nucleotide dissociatio... | 229 | 0.000007 | 54.3 | 20 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 79 | Q32N25 | 594 | GRP2A_XENLA RAS guanyl-releasing protein 2-A ... | 158 | 0.00001 | 53.1 | 25 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 80 | Q0KK55 | 1742 | VKIND_MOUSE Protein very KIND OS=Mus musculus... | 108 | 0.55 | 38.5 | 23 | 42 | GO:0030425; C:dendrite; IDA:MGI.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:MGI. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0021707; P:cerebellar granule cell differentiation; IMP:MGI.::GO:0001934; P:positive regulation of protein phosphorylation; IDA:MGI.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:MGI.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 81 | Q76NI1 | 1749 | VKIND_HUMAN Protein very KIND OS=Homo sapiens... | 165 | 0.00002 | 53.1 | 24 | 47 | | | | | | | | | | | | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 82 | Q8TEU7 | 1601 | RPGF6_HUMAN Rap guanine nucleotide exchange f... | 224 | 0.056 | 41.6 | 27 | 43 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:UniProtKB. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 83 | Q8IV61 | 690 | GRP3_HUMAN Ras guanyl-releasing protein 3 OS=... | 139 | 0.00002 | 52.4 | 25 | 47 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0000165; P:MAPK cascade; NAS:UniProtKB. | 84 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 115 | 0.01 | 44.3 | 30 | 50 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. | 85 | Q8CHG7 | 1496 | RPGF2_MOUSE Rap guanine nucleotide exchange f... | 115 | 0.01 | 44.3 | 30 | 50 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 86 | F1M386 | 1496 | RPGF2_RAT Rap guanine nucleotide exchange fac... | 115 | 0.01 | 44.3 | 30 | 50 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 87 | Q6DCK3 | 594 | GRP2B_XENLA RAS guanyl-releasing protein 2-B ... | 158 | 0.00005 | 51.2 | 23 | 47 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 88 | Q9Z1C8 | 926 | RPGF3_RAT Rap guanine nucleotide exchange fac... | 210 | 0.00007 | 51.2 | 22 | 45 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 89 | A4IJ06 | 791 | GRP1_XENTR RAS guanyl-releasing protein 1 OS=... | 154 | 0.0001 | 50.4 | 25 | 44 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 90 | Q8MVR1 | 2631 | GBPC_DICDI Cyclic GMP-binding protein C OS=Di... | 240 | 0.0001 | 50.8 | 23 | 41 | GO:0005737; C:cytoplasm; IDA:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030553; F:cGMP binding; IDA:dictyBase.::GO:0005525; F:GTP binding; IDA:dictyBase.::GO:0005543; F:phospholipid binding; IDA:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0019934; P:cGMP-mediated signaling; IDA:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0051272; P:positive regulation of cellular component movement; TAS:dictyBase.::GO:0045860; P:positive regulation of protein kinase activity; IMP:dictyBase.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 91 | Q9D300 | 466 | RGF1C_MOUSE Ras-GEF domain-containing family ... | 145 | 0.0001 | 50.1 | 24 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
