| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | O77741 | 538 | NRAM1_PIG Natural resistance-associated macro... | 441 | 1e-46 | 176 | 32 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.::GO:0000165; P:MAPK cascade; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI. | 62 | P49279 | 550 | NRAM1_HUMAN Natural resistance-associated mac... | 453 | 2e-46 | 176 | 31 | 49 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0031902; C:late endosome membrane; TAS:Reactome.::GO:0005764; C:lysosome; ISS:BHF-UCL.::GO:0030670; C:phagocytic vesicle membrane; IDA:BHF-UCL.::GO:0070821; C:tertiary granule membrane; IDA:BHF-UCL. | | | | | | | | | | GO:0005384; F:manganese ion transmembrane transporter activity; ISS:BHF-UCL.::GO:0051139; F:metal ion:hydrogen antiporter activity; IGI:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB. | | | | | | | | | | GO:0032147; P:activation of protein kinase activity; ISS:BHF-UCL.::GO:0048002; P:antigen processing and presentation of peptide antigen; ISS:BHF-UCL.::GO:0070574; P:cadmium ion transmembrane transport; IGI:BHF-UCL.::GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.::GO:0006879; P:cellular iron ion homeostasis; IMP:BHF-UCL.::GO:0050829; P:defense response to Gram-negative bacterium; ISS:BHF-UCL.::GO:0042832; P:defense response to protozoan; ISS:BHF-UCL.::GO:0070839; P:divalent metal ion export; ISS:BHF-UCL.::GO:0006954; P:inflammatory response; ISS:BHF-UCL.::GO:0032623; P:interleukin-2 production; ISS:BHF-UCL.::GO:0032632; P:interleukin-3 production; ISS:BHF-UCL.::GO:0006826; P:iron ion transport; IMP:BHF-UCL.::GO:0043091; P:L-arginine import; ISS:BHF-UCL.::GO:0042116; P:macrophage activation; ISS:BHF-UCL.::GO:0045342; P:MHC class II biosynthetic process; ISS:BHF-UCL.::GO:0048255; P:mRNA stabilization; ISS:BHF-UCL.::GO:0060586; P:multicellular organismal iron ion homeostasis; ISS:BHF-UCL.::GO:0001818; P:negative regulation of cytokine production; ISS:BHF-UCL.::GO:0015707; P:nitrite transport; ISS:BHF-UCL.::GO:0006909; P:phagocytosis; ISS:BHF-UCL.::GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; ISS:BHF-UCL.::GO:0032729; P:positive regulation of interferon-gamma production; ISS:BHF-UCL.::GO:0050766; P:positive regulation of phagocytosis; ISS:BHF-UCL.::GO:0002827; P:positive regulation of T-helper 1 type immune response; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0045730; P:respiratory burst; ISS:BHF-UCL.::GO:0034341; P:response to interferon-gamma; ISS:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0002369; P:T cell cytokine production; ISS:BHF-UCL.::GO:0002309; P:T cell proliferation involved in immune response; ISS:BHF-UCL.::GO:0007035; P:vacuolar acidification; ISS:BHF-UCL.::GO:0042060; P:wound healing; ISS:BHF-UCL. | 63 | P96593 | 425 | MNTH_BACSU Manganese transport protein MntH O... | 511 | 4e-46 | 172 | 29 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 64 | O05916 | 428 | MNTH_MYCTU Probable manganese transport prote... | 485 | 5e-46 | 172 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0034755; P:iron ion transmembrane transport; IMP:MTBBASE.::GO:0071421; P:manganese ion transmembrane transport; IMP:MTBBASE.::GO:0071578; P:zinc ion import; IMP:MTBBASE. | 65 | Q8R7S2 | 421 | MNTH_THETN Probable manganese transport prote... | 452 | 8e-46 | 171 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 66 | A5G348 | 433 | MNTH_ACICJ Probable manganese transport prote... | 429 | 9e-46 | 172 | 30 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 67 | O69443 | 684 | MNTH_MYCBO Probable manganese transport prote... | 485 | 9e-46 | 175 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 68 | Q97TN5 | 431 | MNTH_CLOAB Probable manganese transport prote... | 444 | 2e-45 | 171 | 31 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 69 | Q10Q65 | 524 | NRAM2_ORYSJ Metal transporter Nramp2 OS=Oryza... | 497 | 7e-45 | 171 | 29 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW. | 70 | P51027 | 555 | NRAM1_CHICK Natural resistance-associated mac... | 451 | 3e-44 | 169 | 30 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IMP:BHF-UCL. | | | | | | | | | | GO:0051139; F:metal ion:hydrogen antiporter activity; IGI:BHF-UCL.::GO:0046915; F:transition metal ion transmembrane transporter activity; IGI:BHF-UCL. | | | | | | | | | | GO:0070574; P:cadmium ion transmembrane transport; IGI:BHF-UCL.::GO:0006876; P:cellular cadmium ion homeostasis; IGI:BHF-UCL.::GO:0070839; P:divalent metal ion export; ISS:BHF-UCL.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 71 | Q9FN18 | 512 | NRAM4_ARATH Metal transporter Nramp4 OS=Arabi... | 440 | 9e-44 | 167 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005774; C:vacuolar membrane; IDA:TAIR. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006879; P:cellular iron ion homeostasis; IGI:TAIR.::GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0006828; P:manganese ion transport; IMP:TAIR.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IGI:TAIR.::GO:0010039; P:response to iron ion; IEP:TAIR.::GO:0009624; P:response to nematode; IEP:TAIR. | 72 | Q27946 | 548 | NRAM1_BUBBU Natural resistance-associated mac... | 440 | 1e-43 | 168 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 73 | Q1QZ83 | 431 | MNTH_CHRSD Probable manganese transport prote... | 457 | 1e-43 | 166 | 31 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 74 | P49282 | 568 | NRAM2_MOUSE Natural resistance-associated mac... | 444 | 2e-43 | 167 | 30 | 48 | GO:0005903; C:brush border; IDA:MGI.::GO:0009986; C:cell surface; IDA:MGI.::GO:0005769; C:early endosome; IDA:MGI.::GO:0012505; C:endomembrane system; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005887; C:integral to plasma membrane; IDA:MGI.::GO:0055037; C:recycling endosome; IDA:MGI. | | | | | | | | | | GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:MGI.::GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:MGI.::GO:0015078; F:hydrogen ion transmembrane transporter activity; IDA:MGI. | | | | | | | | | | GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0048821; P:erythrocyte development; IMP:MGI.::GO:0070627; P:ferrous iron import; IDA:MGI.::GO:0006783; P:heme biosynthetic process; IMP:MGI.::GO:0007611; P:learning or memory; IMP:MGI.::GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI. | 75 | P56436 | 548 | NRAM1_CEREL Natural resistance-associated mac... | 441 | 2e-43 | 167 | 31 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 76 | Q2QN30 | 541 | NRAM6_ORYSJ Metal transporter Nramp6 OS=Oryza... | 438 | 3e-43 | 166 | 30 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW. | 77 | Q9C6B2 | 530 | NRAM2_ARATH Metal transporter Nramp2 OS=Arabi... | 442 | 3e-43 | 166 | 29 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 78 | Q95102 | 548 | NRAM1_BISBI Natural resistance-associated mac... | 440 | 3e-43 | 166 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 79 | O54902 | 568 | NRAM2_RAT Natural resistance-associated macro... | 443 | 4e-43 | 166 | 30 | 49 | GO:0031902; C:late endosome membrane; IDA:RGD.::GO:0005765; C:lysosomal membrane; IDA:RGD. | | | | | | | | | | GO:0046870; F:cadmium ion binding; IDA:RGD.::GO:0015086; F:cadmium ion transmembrane transporter activity; IDA:RGD.::GO:0050897; F:cobalt ion binding; IDA:RGD.::GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:RGD.::GO:0005507; F:copper ion binding; IDA:RGD.::GO:0005375; F:copper ion transmembrane transporter activity; IDA:RGD.::GO:0015093; F:ferrous iron transmembrane transporter activity; IMP:RGD.::GO:0005506; F:iron ion binding; IDA:RGD.::GO:0015094; F:lead ion transmembrane transporter activity; IDA:RGD.::GO:0030145; F:manganese ion binding; IDA:RGD.::GO:0005384; F:manganese ion transmembrane transporter activity; IDA:RGD.::GO:0016151; F:nickel cation binding; IDA:RGD.::GO:0015099; F:nickel cation transmembrane transporter activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IDA:RGD. | | | | | | | | | | GO:0071456; P:cellular response to hypoxia; IEP:RGD.::GO:0071281; P:cellular response to iron ion; IEP:RGD.::GO:0071356; P:cellular response to tumor necrosis factor; IEP:RGD.::GO:0046686; P:response to cadmium ion; IEP:RGD.::GO:0010288; P:response to lead ion; IEP:RGD.::GO:0010042; P:response to manganese ion; IMP:RGD. | 80 | Q9SNV9 | 509 | NRAM3_ARATH Metal transporter Nramp3 OS=Arabi... | 440 | 6e-43 | 165 | 29 | 45 | GO:0005794; C:Golgi apparatus; IDA:TAIR.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0009506; C:plasmodesma; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0042742; P:defense response to bacterium; IMP:TAIR.::GO:0055072; P:iron ion homeostasis; IMP:TAIR.::GO:0006828; P:manganese ion transport; IMP:TAIR.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IGI:TAIR.::GO:0010043; P:response to zinc ion; IEP:TAIR. | 81 | P41251 | 548 | NRAM1_MOUSE Natural resistance-associated mac... | 441 | 9e-43 | 165 | 30 | 49 | GO:0009279; C:cell outer membrane; IDA:MGI.::GO:0010008; C:endosome membrane; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005770; C:late endosome; IDA:MGI.::GO:0005764; C:lysosome; IDA:MGI.::GO:0030670; C:phagocytic vesicle membrane; IDA:MGI.::GO:0005773; C:vacuole; IMP:GOC. | | | | | | | | | | GO:0005384; F:manganese ion transmembrane transporter activity; IMP:MGI. | | | | | | | | | | GO:0032147; P:activation of protein kinase activity; IMP:MGI.::GO:0048002; P:antigen processing and presentation of peptide antigen; IMP:MGI.::GO:0006879; P:cellular iron ion homeostasis; IMP:MGI.::GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI.::GO:0042832; P:defense response to protozoan; IMP:MGI.::GO:0070839; P:divalent metal ion export; IDA:BHF-UCL.::GO:0006954; P:inflammatory response; IMP:MGI.::GO:0032623; P:interleukin-2 production; IMP:MGI.::GO:0032632; P:interleukin-3 production; IMP:MGI.::GO:0006826; P:iron ion transport; IMP:MGI.::GO:0043091; P:L-arginine import; IDA:MGI.::GO:0042116; P:macrophage activation; IDA:MGI.::GO:0045342; P:MHC class II biosynthetic process; IMP:MGI.::GO:0048255; P:mRNA stabilization; IMP:MGI.::GO:0060586; P:multicellular organismal iron ion homeostasis; IMP:MGI.::GO:0001818; P:negative regulation of cytokine production; IMP:MGI.::GO:0015707; P:nitrite transport; IDA:MGI.::GO:0006909; P:phagocytosis; IMP:MGI.::GO:0002606; P:positive regulation of dendritic cell antigen processing and presentation; IMP:MGI.::GO:0010628; P:positive regulation of gene expression; IMP:MGI.::GO:0032729; P:positive regulation of interferon-gamma production; IMP:MGI.::GO:0050766; P:positive regulation of phagocytosis; IMP:MGI.::GO:0002827; P:positive regulation of T-helper 1 type immune response; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0000060; P:protein import into nucleus, translocation; IMP:MGI.::GO:0045730; P:respiratory burst; IDA:MGI.::GO:0034341; P:response to interferon-gamma; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0002369; P:T cell cytokine production; IMP:MGI.::GO:0002309; P:T cell proliferation involved in immune response; IMP:MGI.::GO:0007035; P:vacuolar acidification; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI. | 82 | P49280 | 548 | NRAM1_SHEEP Natural resistance-associated mac... | 441 | 1e-42 | 164 | 31 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 83 | Q5QN13 | 550 | NRAM4_ORYSJ Metal transporter Nramp4 OS=Oryza... | 455 | 1e-42 | 164 | 29 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 84 | Q27981 | 548 | NRAM1_BOVIN Natural resistance-associated mac... | 448 | 1e-42 | 164 | 30 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005215; F:transporter activity; IEA:InterPro. | | | | | | | | | | GO:0006811; P:ion transport; IEA:UniProtKB-KW.::GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW. | 85 | Q0T2A8 | 412 | MNTH_SHIF8 Manganese transport protein MntH O... | 437 | 6e-42 | 160 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 86 | Q21434 | 562 | NRAML_CAEEL NRAMP-like transporter smf-1 OS=C... | 445 | 1e-41 | 162 | 28 | 47 | GO:0016324; C:apical plasma membrane; IDA:WormBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046915; F:transition metal ion transmembrane transporter activity; ISS:WormBase. | | | | | | | | | | GO:0055072; P:iron ion homeostasis; IMP:WormBase.::GO:0055071; P:manganese ion homeostasis; IMP:WormBase.::GO:0010042; P:response to manganese ion; IMP:WormBase. | 87 | Q9XT74 | 547 | NRAM1_CANFA Natural resistance-associated mac... | 467 | 1e-41 | 162 | 29 | 48 | GO:0016021; C:integral to membrane; NAS:UniProtKB. | | | | | | | | | | GO:0005384; F:manganese ion transmembrane transporter activity; NAS:UniProtKB. | | | | | | | | | | | 88 | A7MP48 | 412 | MNTH_CROS8 Probable manganese transport prote... | 433 | 4e-40 | 155 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 89 | A8A2P6 | 412 | MNTH_ECOHS Manganese transport protein MntH O... | 437 | 5e-40 | 155 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 90 | Q3YZE0 | 412 | MNTH_SHISS Manganese transport protein MntH O... | 437 | 8e-40 | 154 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | | 91 | Q31Y80 | 412 | MNTH_SHIBS Manganese transport protein MntH O... | 437 | 8e-40 | 154 | 30 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015293; F:symporter activity; IEA:UniProtKB-KW. | | | | | | | | | | |
