| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P06776 | 526 | PDE2_YEAST 3',5'-cyclic-nucleotide phosphodie... | 516 | 4e-90 | 292 | 37 | 55 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IMP:SGD. | 2 | O60658 | 829 | PDE8A_HUMAN High affinity cAMP-specific and I... | 352 | 1e-16 | 87 | 28 | 41 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro. | | | | | | | | | | GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. | 3 | O95263 | 885 | PDE8B_HUMAN High affinity cAMP-specific and I... | 295 | 1e-16 | 86.7 | 27 | 41 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro. | | | | | | | | | | GO:0009187; P:cyclic nucleotide metabolic process; NAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. | 4 | Q9NP56 | 450 | PDE7B_HUMAN cAMP-specific 3',5'-cyclic phosph... | 251 | 2e-16 | 85.1 | 30 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; TAS:ProtInc.::GO:0007268; P:synaptic transmission; TAS:ProtInc. | 5 | E9Q4S1 | 865 | PDE8B_MOUSE High affinity cAMP-specific and I... | 347 | 3e-16 | 85.9 | 27 | 40 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. | 6 | O70628 | 534 | PDE9A_MOUSE High affinity cGMP-specific 3',5'... | 219 | 5e-16 | 84.3 | 31 | 47 | | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 7 | Q23917 | 793 | PDE2_DICDI 3',5'-cyclic-nucleotide phosphodie... | 295 | 0.000000000000003 | 82.4 | 26 | 40 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:dictyBase.::GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:dictyBase.::GO:0031276; P:negative regulation of lateral pseudopodium assembly; IMP:dictyBase.::GO:0051281; P:positive regulation of release of sequestered calcium ion into cytosol; IMP:dictyBase.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.::GO:0006970; P:response to osmotic stress; TAS:dictyBase.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase. | 8 | Q9QXQ1 | 446 | PDE7B_MOUSE cAMP-specific 3',5'-cyclic phosph... | 251 | 0.000000000000005 | 80.9 | 29 | 45 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 9 | O76083 | 593 | PDE9A_HUMAN High affinity cGMP-specific 3',5'... | 221 | 0.000000000000006 | 81.3 | 29 | 45 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; TAS:ProtInc. | 10 | P70453 | 456 | PDE7A_MOUSE High affinity cAMP-specific 3',5'... | 203 | 0.000000000000007 | 80.5 | 33 | 46 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 11 | B0G0Y8 | 466 | PDE3_DICDI cGMP-specific 3',5'-cGMP phosphodi... | 242 | 0.00000000000001 | 80.1 | 33 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; TAS:dictyBase.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046069; P:cGMP catabolic process; TAS:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 12 | Q9N2V9 | 760 | PDE6_CAEEL Probable 3',5'-cyclic phosphodiest... | 286 | 0.00000000000002 | 80.1 | 28 | 44 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0007411; P:axon guidance; IMP:WormBase. | 13 | Q13946 | 482 | PDE7A_HUMAN High affinity cAMP-specific 3',5'... | 203 | 0.00000000000004 | 78.2 | 33 | 46 | GO:0000267; C:cell fraction; NAS:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 14 | P35913 | 854 | PDE6B_HUMAN Rod cGMP-specific 3',5'-cyclic ph... | 345 | 0.00000000000004 | 78.6 | 24 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IMP:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0051480; P:cytosolic calcium ion homeostasis; IMP:BHF-UCL.::GO:0046037; P:GMP metabolic process; IMP:BHF-UCL.::GO:0007603; P:phototransduction, visible light; TAS:ProtInc.::GO:0007601; P:visual perception; TAS:ProtInc. | 15 | P23440 | 856 | PDE6B_MOUSE Rod cGMP-specific 3',5'-cyclic ph... | 345 | 0.00000000000005 | 78.6 | 24 | 43 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009583; P:detection of light stimulus; IMP:MGI.::GO:0060041; P:retina development in camera-type eye; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW. | 16 | P23439 | 853 | PDE6B_BOVIN Rod cGMP-specific 3',5'-cyclic ph... | 345 | 0.00000000000007 | 78.2 | 24 | 43 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW. | 17 | P33726 | 856 | PDE6B_CANFA Rod cGMP-specific 3',5'-cyclic ph... | 345 | 0.0000000000001 | 77.8 | 24 | 43 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW. | 18 | O08593 | 426 | PDE7A_RAT High affinity cAMP-specific 3',5'-c... | 203 | 0.0000000000001 | 76.6 | 32 | 46 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IEP:RGD. | 19 | Q8CG03 | 865 | PDE5A_MOUSE cGMP-specific 3',5'-cyclic phosph... | 324 | 0.0000000000002 | 77 | 25 | 41 | | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046069; P:cGMP catabolic process; IDA:MGI.::GO:0055118; P:negative regulation of cardiac muscle contraction; IMP:BHF-UCL.::GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.::GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IMP:BHF-UCL.::GO:0045745; P:positive regulation of G-protein coupled receptor protein signaling pathway; IC:BHF-UCL.::GO:0043406; P:positive regulation of MAP kinase activity; IMP:BHF-UCL.::GO:0060282; P:positive regulation of oocyte development; IMP:MGI.::GO:0055119; P:relaxation of cardiac muscle; IMP:BHF-UCL.::GO:0007165; P:signal transduction; IEA:InterPro. | 20 | O54735 | 833 | PDE5A_RAT cGMP-specific 3',5'-cyclic phosphod... | 329 | 0.0000000000002 | 76.3 | 24 | 41 | GO:0005829; C:cytosol; IDA:RGD. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:RGD.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007399; P:nervous system development; IEP:RGD.::GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.::GO:0002678; P:positive regulation of chronic inflammatory response; IMP:RGD.::GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.::GO:0002026; P:regulation of the force of heart contraction; IMP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0032496; P:response to lipopolysaccharide; IEP:RGD.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0007614; P:short-term memory; IMP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0042311; P:vasodilation; IEP:RGD. | 21 | O76074 | 875 | PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosph... | 324 | 0.0000000000003 | 75.9 | 25 | 42 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; TAS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; NAS:UniProtKB. | 22 | Q9VJ79 | 1451 | PDE11_DROME Dual 3',5'-cyclic-AMP and -GMP ph... | 287 | 0.0000000000004 | 76.3 | 25 | 46 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:UniProtKB.::GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046058; P:cAMP metabolic process; IDA:UniProtKB.::GO:0046068; P:cGMP metabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 23 | Q28156 | 865 | PDE5A_BOVIN cGMP-specific 3',5'-cyclic phosph... | 324 | 0.0000000000005 | 75.5 | 25 | 42 | | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:AgBase.::GO:0030553; F:cGMP binding; ISS:AgBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046069; P:cGMP catabolic process; ISS:AgBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 24 | O77746 | 865 | PDE5A_CANFA cGMP-specific 3',5'-cyclic phosph... | 324 | 0.0000000000005 | 75.5 | 25 | 42 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 25 | P14644 | 536 | PDE4C_RAT cAMP-specific 3',5'-cyclic phosphod... | 297 | 0.0000000000007 | 74.3 | 26 | 41 | GO:0072372; C:primary cilium; ISS:UniProtKB. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IMP:RGD.::GO:0008144; F:drug binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 26 | O88502 | 823 | PDE8A_MOUSE High affinity cAMP-specific and I... | 301 | 0.000000000001 | 74.3 | 26 | 42 | | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0000156; F:two-component response regulator activity; IEA:InterPro. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. | 27 | Q3UEI1 | 686 | PDE4C_MOUSE cAMP-specific 3',5'-cyclic phosph... | 296 | 0.000000000004 | 72.4 | 26 | 41 | GO:0072372; C:primary cilium; IDA:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 28 | P12252 | 1070 | PDE4B_DROME cAMP-specific 3',5'-cyclic phosph... | 333 | 0.000000000004 | 72.8 | 26 | 40 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048675; P:axon extension; IMP:FlyBase.::GO:0048149; P:behavioral response to ethanol; NAS:FlyBase.::GO:0019933; P:cAMP-mediated signaling; NAS:FlyBase.::GO:0001661; P:conditioned taste aversion; IMP:FlyBase.::GO:0007619; P:courtship behavior; TAS:FlyBase.::GO:0045475; P:locomotor rhythm; NAS:FlyBase.::GO:0046958; P:nonassociative learning; TAS:FlyBase.::GO:0008355; P:olfactory learning; TAS:FlyBase.::GO:0048477; P:oogenesis; TAS:FlyBase.::GO:0007614; P:short-term memory; IMP:FlyBase.::GO:0007268; P:synaptic transmission; IMP:FlyBase. | 29 | Q9W4S9 | 983 | PDE4C_DROME cAMP-specific 3',5'-cyclic phosph... | 333 | 0.000000000005 | 72.4 | 26 | 40 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048675; P:axon extension; IMP:FlyBase.::GO:0048149; P:behavioral response to ethanol; NAS:FlyBase.::GO:0019933; P:cAMP-mediated signaling; NAS:FlyBase.::GO:0001661; P:conditioned taste aversion; IMP:FlyBase.::GO:0007619; P:courtship behavior; TAS:FlyBase.::GO:0045475; P:locomotor rhythm; NAS:FlyBase.::GO:0046958; P:nonassociative learning; TAS:FlyBase.::GO:0008355; P:olfactory learning; TAS:FlyBase.::GO:0048477; P:oogenesis; TAS:FlyBase.::GO:0007614; P:short-term memory; IMP:FlyBase.::GO:0007268; P:synaptic transmission; IMP:FlyBase. | 30 | Q08493 | 712 | PDE4C_HUMAN cAMP-specific 3',5'-cyclic phosph... | 292 | 0.000000000005 | 72 | 26 | 42 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0072372; C:primary cilium; ISS:UniProtKB. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 31 | Q9W4T0 | 903 | PDE4D_DROME cAMP-specific 3',5'-cyclic phosph... | 333 | 0.000000000005 | 72 | 26 | 40 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048675; P:axon extension; IMP:FlyBase.::GO:0048149; P:behavioral response to ethanol; NAS:FlyBase.::GO:0019933; P:cAMP-mediated signaling; NAS:FlyBase.::GO:0001661; P:conditioned taste aversion; IMP:FlyBase.::GO:0007619; P:courtship behavior; TAS:FlyBase.::GO:0045475; P:locomotor rhythm; NAS:FlyBase.::GO:0046958; P:nonassociative learning; TAS:FlyBase.::GO:0008355; P:olfactory learning; TAS:FlyBase.::GO:0048477; P:oogenesis; TAS:FlyBase.::GO:0007614; P:short-term memory; IMP:FlyBase.::GO:0007268; P:synaptic transmission; IMP:FlyBase. |
