| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | P54748 | 844 | PDE4A_RAT cAMP-specific 3',5'-cyclic phosphod... | 299 | 0.0000000009 | 65.1 | 25 | 41 | GO:0005634; C:nucleus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:RGD. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0042493; P:response to drug; IEP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 62 | Q01061 | 534 | PDE1B_BOVIN Calcium/calmodulin-dependent 3',5... | 239 | 0.000000001 | 63.9 | 28 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 63 | P51160 | 858 | PDE6C_HUMAN Cone cGMP-specific 3',5'-cyclic p... | 327 | 0.000000002 | 63.9 | 24 | 41 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007601; P:visual perception; TAS:ProtInc. | 64 | O89084 | 844 | PDE4A_MOUSE cAMP-specific 3',5'-cyclic phosph... | 295 | 0.000000002 | 63.9 | 25 | 40 | GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 65 | Q61481 | 565 | PDE1A_MOUSE Calcium/calmodulin-dependent 3',5... | 243 | 0.000000002 | 63.5 | 28 | 43 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 66 | P27815 | 886 | PDE4A_HUMAN cAMP-specific 3',5'-cyclic phosph... | 295 | 0.000000003 | 63.2 | 25 | 40 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.::GO:0007165; P:signal transduction; TAS:ProtInc. | 67 | P14646 | 736 | PDE4B_RAT cAMP-specific 3',5'-cyclic phosphod... | 299 | 0.000000004 | 63.2 | 25 | 40 | GO:0005829; C:cytosol; IDA:RGD.::GO:0005626; C:insoluble fraction; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 68 | P54750 | 535 | PDE1A_HUMAN Calcium/calmodulin-dependent 3',5... | 243 | 0.000000005 | 62.4 | 28 | 43 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome. | 69 | Q64338 | 706 | PDE1C_MOUSE Calcium/calmodulin-dependent 3',5... | 235 | 0.000000005 | 62.4 | 27 | 45 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 70 | Q63421 | 768 | PDE1C_RAT Calcium/calmodulin-dependent 3',5'-... | 235 | 0.000000006 | 62.4 | 27 | 45 | GO:0043025; C:neuronal cell body; IDA:RGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.::GO:0051592; P:response to calcium ion; IDA:MGI.::GO:0007608; P:sensory perception of smell; IEP:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 71 | P14100 | 530 | PDE1A_BOVIN Calcium/calmodulin-dependent 3',5... | 243 | 0.000000007 | 61.6 | 28 | 43 | | | | | | | | | | | GO:0048101; F:calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 72 | Q14123 | 709 | PDE1C_HUMAN Calcium/calmodulin-dependent 3',5... | 235 | 0.00000002 | 60.8 | 27 | 44 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0004117; F:calmodulin-dependent cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome. | 73 | Q07343 | 736 | PDE4B_HUMAN cAMP-specific 3',5'-cyclic phosph... | 299 | 0.00000002 | 60.8 | 24 | 39 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005626; C:insoluble fraction; TAS:ProtInc.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 74 | O18696 | 664 | PDE1_CAEEL Probable 3',5'-cyclic phosphodiest... | 240 | 0.00000009 | 58.5 | 25 | 41 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0005516; F:calmodulin binding; IPI:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 75 | Q64395 | 199 | PDE1B_CRIGR Calcium/calmodulin-dependent 3',5... | 186 | 0.0000001 | 55.8 | 28 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 76 | Q86H13 | 1039 | PDE4_DICDI cAMP-specific 3',5'-cAMP phosphodi... | 140 | 0.0000006 | 55.8 | 34 | 49 | GO:0005576; C:extracellular region; TAS:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IMP:dictyBase.::GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 77 | P14099 | 921 | PDE2A_BOVIN cGMP-dependent 3',5'-cyclic phosp... | 290 | 0.000002 | 53.9 | 25 | 42 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0030553; F:cGMP binding; ISS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; ISS:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; ISS:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; ISS:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0046038; P:GMP catabolic process; TAS:AgBase.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 78 | O00408 | 941 | PDE2A_HUMAN cGMP-dependent 3',5'-cyclic phosp... | 290 | 0.000006 | 52.8 | 25 | 41 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005262; F:calcium channel activity; TAS:UniProtKB.::GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0030911; F:TPR domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0035690; P:cellular response to drug; IMP:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; IDA:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030224; P:monocyte differentiation; IEP:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; ISS:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 79 | Q922S4 | 916 | PDE2A_MOUSE cGMP-dependent 3',5'-cyclic phosp... | 290 | 0.000006 | 52.8 | 25 | 41 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005759; C:mitochondrial matrix; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0042734; C:presynaptic membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030552; F:cAMP binding; IMP:UniProtKB.::GO:0030553; F:cGMP binding; IDA:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0036004; F:GAF domain binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IMP:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; IDA:UniProtKB.::GO:0046069; P:cGMP catabolic process; IMP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; ISS:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; ISS:UniProtKB. | 80 | Q01062 | 928 | PDE2A_RAT cGMP-dependent 3',5'-cyclic phospho... | 290 | 0.000006 | 52.8 | 25 | 41 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0042734; C:presynaptic membrane; ISS:UniProtKB. | | | | | | | | | | GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IDA:RGD. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; ISS:UniProtKB.::GO:0035690; P:cellular response to drug; ISS:UniProtKB.::GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0036006; P:cellular response to macrophage colony-stimulating factor stimulus; ISS:UniProtKB.::GO:0071260; P:cellular response to mechanical stimulus; ISS:UniProtKB.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0019934; P:cGMP-mediated signaling; ISS:UniProtKB.::GO:0061028; P:establishment of endothelial barrier; IDA:UniProtKB.::GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:UniProtKB.::GO:0033159; P:negative regulation of protein import into nucleus, translocation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043116; P:negative regulation of vascular permeability; ISS:UniProtKB.::GO:0050729; P:positive regulation of inflammatory response; ISS:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; ISS:UniProtKB.::GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB. | 81 | Q8I0P7 | 625 | PDE3_CAEEL Probable 3',5'-cyclic phosphodiest... | 224 | 0.0001 | 48.1 | 26 | 38 | | | | | | | | | | | GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 82 | Q9Y233 | 779 | PDE10_HUMAN cAMP and cAMP-inhibited cGMP 3',5... | 292 | 0.0003 | 47.4 | 24 | 41 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:UniProtKB.::GO:0030553; F:cGMP binding; NAS:UniProtKB.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007165; P:signal transduction; IEA:InterPro. | 83 | B4HEM4 | 1205 | PDE6_DROSE cGMP-specific 3',5'-cyclic phospho... | 167 | 3.9 | 33.9 | 22 | 42 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 84 | B4G4E5 | 1276 | PDE6_DROPE cGMP-specific 3',5'-cyclic phospho... | 167 | 2.7 | 34.7 | 22 | 42 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 85 | Q298P4 | 1267 | PDE6_DROPS cGMP-specific 3',5'-cyclic phospho... | 167 | 2.7 | 34.7 | 22 | 42 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046068; P:cGMP metabolic process; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 86 | Q9QYJ6 | 794 | PDE10_RAT cAMP and cAMP-inhibited cGMP 3',5'-... | 294 | 0.0008 | 45.8 | 23 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0030553; F:cGMP binding; IDA:RGD.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0046069; P:cGMP catabolic process; IDA:RGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 87 | Q8CA95 | 790 | PDE10_MOUSE cAMP and cAMP-inhibited cGMP 3',5... | 294 | 0.001 | 45.4 | 23 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IEA:EC.::GO:0030552; F:cAMP binding; ISS:UniProtKB.::GO:0030553; F:cGMP binding; IEA:UniProtKB-KW.::GO:0004118; F:cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 88 | Q62865 | 1141 | PDE3A_RAT cGMP-inhibited 3',5'-cyclic phospho... | 192 | 0.001 | 45.8 | 26 | 41 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:RGD.::GO:0030552; F:cAMP binding; IDA:RGD.::GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006198; P:cAMP catabolic process; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0001556; P:oocyte maturation; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD. | 89 | Q9Z0X4 | 1141 | PDE3A_MOUSE cGMP-inhibited 3',5'-cyclic phosp... | 190 | 0.001 | 45.4 | 26 | 40 | GO:0005626; C:insoluble fraction; IDA:MGI.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005625; C:soluble fraction; IDA:MGI. | | | | | | | | | | GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001556; P:oocyte maturation; IDA:MGI.::GO:0060282; P:positive regulation of oocyte development; IGI:MGI.::GO:0040020; P:regulation of meiosis; IDA:MGI.::GO:0042493; P:response to drug; IDA:MGI. | 90 | Q13370 | 1112 | PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosp... | 166 | 0.002 | 45.1 | 28 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005783; C:endoplasmic reticulum; ISS:BHF-UCL.::GO:0005794; C:Golgi apparatus; ISS:BHF-UCL.::GO:0032045; C:guanyl-nucleotide exchange factor complex; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:BHF-UCL. | | | | | | | | | | GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043422; F:protein kinase B binding; ISS:BHF-UCL. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IEP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0043951; P:negative regulation of cAMP-mediated signaling; IC:BHF-UCL.::GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IC:BHF-UCL.::GO:0050995; P:negative regulation of lipid catabolic process; IMP:BHF-UCL. | 91 | Q14432 | 1141 | PDE3A_HUMAN cGMP-inhibited 3',5'-cyclic phosp... | 192 | 0.004 | 43.9 | 26 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004119; F:cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006198; P:cAMP catabolic process; IDA:UniProtKB.::GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0071321; P:cellular response to cGMP; IDA:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:UniProtKB.::GO:0019934; P:cGMP-mediated signaling; IMP:UniProtKB.::GO:0006629; P:lipid metabolic process; TAS:ProtInc.::GO:0043116; P:negative regulation of vascular permeability; IMP:UniProtKB.::GO:0043117; P:positive regulation of vascular permeability; IMP:UniProtKB. |
