| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
181 | P87378 | 296 | CRK_XENLA Adapter molecule crk OS=Xenopus lae... | 98 | 0.0001 | 47.4 | 30 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB. | 182 | Q7Z6B7 | 1085 | SRGP1_HUMAN SLIT-ROBO Rho GTPase-activating p... | 53 | 0.0001 | 48.1 | 36 | 62 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome. | 183 | Q12965 | 1108 | MYO1E_HUMAN Unconventional myosin-Ie OS=Homo ... | 53 | 0.0001 | 48.1 | 42 | 58 | GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; TAS:UniProtKB. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042623; F:ATPase activity, coupled; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0000146; F:microfilament motor activity; TAS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB. | | | | | | | | | | GO:0030048; P:actin filament-based movement; TAS:UniProtKB.::GO:0006897; P:endocytosis; IMP:UniProtKB.::GO:0032836; P:glomerular basement membrane development; ISS:UniProtKB.::GO:0003094; P:glomerular filtration; ISS:UniProtKB.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB. | 184 | Q9CX99 | 217 | GRAP_MOUSE GRB2-related adapter protein OS=Mu... | 56 | 0.001 | 43.5 | 32 | 54 | | | | | | | | | | | | | | | | | | | | | | 185 | P27870 | 845 | VAV_MOUSE Proto-oncogene vav OS=Mus musculus ... | 74 | 0.0001 | 48.1 | 39 | 46 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI. | | | | | | | | | | GO:0006955; P:immune response; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0006909; P:phagocytosis; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0030217; P:T cell differentiation; TAS:MGI. | 186 | Q9XYM0 | 271 | CRK_DROME Adapter molecule Crk OS=Drosophila ... | 94 | 0.0001 | 47 | 28 | 49 | | | | | | | | | | | GO:0005070; F:SH3/SH2 adaptor activity; IDA:FlyBase. | | | | | | | | | | GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0046529; P:imaginal disc fusion, thorax closure; IMP:FlyBase.::GO:0007520; P:myoblast fusion; TAS:FlyBase.::GO:0046330; P:positive regulation of JNK cascade; IDA:FlyBase.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB. | 187 | Q4P9Q7 | 335 | SHO1_USTMA High osmolarity signaling protein ... | 72 | 0.0001 | 47.4 | 33 | 58 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 188 | P13116 | 532 | SRC2_XENLA Tyrosine-protein kinase Src-2 OS=X... | 88 | 0.0001 | 47.8 | 35 | 52 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 189 | Q6PG29 | 341 | SKAP2_DANRE Src kinase-associated phosphoprot... | 49 | 0.0001 | 47.4 | 45 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0042113; P:B cell activation; IEA:UniProtKB-KW. | 190 | P87379 | 229 | GRB2A_XENLA Growth factor receptor-bound prot... | 54 | 0.0004 | 45.4 | 39 | 59 | GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB. | | | | | | | | | | GO:0007143; P:female meiosis; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 191 | Q925Q9 | 709 | SH3K1_RAT SH3 domain-containing kinase-bindin... | 40 | 0.059 | 39.3 | 35 | 68 | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; TAS:RGD.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB. | 192 | Q1KKZ1 | 329 | SKAP2_TAKRU Src kinase-associated phosphoprot... | 56 | 0.0002 | 47 | 39 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0042113; P:B cell activation; IEA:UniProtKB-KW. | 193 | Q8R550 | 709 | SH3K1_MOUSE SH3 domain-containing kinase-bind... | 40 | 0.06 | 39.3 | 35 | 68 | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB. | 194 | Q68F99 | 337 | STAC3_XENTR SH3 and cysteine-rich domain-cont... | 51 | 0.0002 | 46.6 | 37 | 63 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 195 | Q4P3H6 | 1207 | SLA1_USTMA Actin cytoskeleton-regulatory comp... | 77 | 0.0002 | 47.4 | 35 | 55 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IEA:InterPro.::GO:0030674; F:protein binding, bridging; IEA:InterPro.::GO:0043130; F:ubiquitin binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 196 | Q9Y7Z8 | 1217 | MYO1_SCHPO Myosin-1 OS=Schizosaccharomyces po... | 51 | 0.0002 | 47.4 | 39 | 57 | GO:0030479; C:actin cortical patch; IDA:PomBase.::GO:0005826; C:actomyosin contractile ring; TAS:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0031097; C:medial cortex; IDA:PomBase.::GO:0045121; C:membrane raft; IDA:PomBase.::GO:0045160; C:myosin I complex; TAS:PomBase.::GO:0005628; C:prospore membrane; IDA:PomBase.::GO:0030427; C:site of polarized growth; IDA:PomBase. | | | | | | | | | | GO:0003779; F:actin binding; NAS:PomBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; TAS:PomBase. | | | | | | | | | | GO:0000147; P:actin cortical patch assembly; IGI:PomBase.::GO:0051666; P:actin cortical patch localization; IMP:PomBase.::GO:0045010; P:actin nucleation; IDA:PomBase.::GO:0030476; P:ascospore wall assembly; IMP:PomBase.::GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:PomBase.::GO:0006897; P:endocytosis; ISS:PomBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:PomBase.::GO:0031580; P:membrane raft distribution; IMP:PomBase.::GO:0051127; P:positive regulation of actin nucleation; IMP:PomBase.::GO:0030100; P:regulation of endocytosis; IMP:PomBase. | 197 | P70297 | 548 | STAM1_MOUSE Signal transducing adapter molecu... | 50 | 0.0003 | 46.6 | 38 | 62 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro. | 198 | Q92783 | 540 | STAM1_HUMAN Signal transducing adapter molecu... | 50 | 0.0003 | 46.6 | 38 | 62 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0016044; P:cellular membrane organization; TAS:Reactome.::GO:0016197; P:endosome transport; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome. | 199 | Q91ZR2 | 614 | SNX18_MOUSE Sorting nexin-18 OS=Mus musculus ... | 59 | 0.0003 | 46.6 | 39 | 64 | GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0006897; P:endocytosis; ISS:UniProtKB.::GO:0043547; P:positive regulation of GTPase activity; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 200 | Q6ZMT1 | 411 | STAC2_HUMAN SH3 and cysteine-rich domain-cont... | 54 | 0.0003 | 46.2 | 37 | 59 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 201 | Q8R1B0 | 408 | STAC2_MOUSE SH3 and cysteine-rich domain-cont... | 54 | 0.0004 | 46.2 | 37 | 59 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 202 | Q01406 | 563 | SRC8_CHICK Src substrate protein p85 OS=Gallu... | 54 | 0.0004 | 46.2 | 43 | 57 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | | 203 | Q63767 | 968 | BCAR1_RAT Breast cancer anti-estrogen resista... | 77 | 0.0004 | 46.6 | 34 | 53 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007015; P:actin filament organization; ISS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. | 204 | Q9UNF0 | 486 | PACN2_HUMAN Protein kinase C and casein kinas... | 54 | 0.0004 | 46.2 | 43 | 63 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005215; F:transporter activity; TAS:ProtInc. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 205 | Q63768 | 304 | CRK_RAT Adapter molecule crk OS=Rattus norveg... | 99 | 0.0004 | 45.4 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; TAS:RGD.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0051270; P:regulation of cellular component movement; TAS:RGD.::GO:0035020; P:regulation of Rac protein signal transduction; IMP:RGD.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB. | 206 | Q15080 | 339 | NCF4_HUMAN Neutrophil cytosol factor 4 OS=Hom... | 68 | 0.0004 | 45.8 | 37 | 53 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0043020; C:NADPH oxidase complex; IDA:UniProtKB.::GO:0032010; C:phagolysosome; TAS:Reactome. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0046983; F:protein dimerization activity; TAS:UniProtKB. | | | | | | | | | | GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0007154; P:cell communication; IEA:InterPro.::GO:0006955; P:immune response; TAS:UniProtKB.::GO:0055114; P:oxidation-reduction process; TAS:UniProtKB. | 207 | P46108 | 304 | CRK_HUMAN Adapter molecule crk OS=Homo sapien... | 99 | 0.0004 | 45.4 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome.::GO:0005634; C:nucleus; TAS:ProtInc.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; IDA:UniProtKB.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc. | 208 | Q60598 | 546 | SRC8_MOUSE Src substrate cortactin OS=Mus mus... | 54 | 0.0004 | 46.2 | 43 | 57 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | | 209 | Q1KKW7 | 363 | SKAP1_TAKRU Src kinase-associated phosphoprot... | 56 | 0.0004 | 45.8 | 34 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | | 210 | O43586 | 416 | PPIP1_HUMAN Proline-serine-threonine phosphat... | 67 | 0.0005 | 45.8 | 28 | 52 | GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:InterPro. | | | | | | | | | | GO:0007155; P:cell adhesion; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0035872; P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; TAS:Reactome. | 211 | O94868 | 740 | FCSD2_HUMAN FCH and double SH3 domains protei... | 53 | 0.26 | 37.4 | 28 | 57 | | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | |
