rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q8IZQ1 | 3526 | WDFY3_HUMAN WD repeat and FYVE domain-contain... | 126 | 0.014 | 42.7 | 29 | 40 | GO:0044444; C:cytoplasmic part; IDA:MGI.::GO:0019898; C:extrinsic to membrane; IDA:MGI.::GO:0005635; C:nuclear envelope; IDA:MGI. | | | | | | | | | | GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | | 62 | Q96S99 | 279 | PKHF1_HUMAN Pleckstrin homology domain-contai... | 81 | 0.009 | 42 | 36 | 44 | GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. | 63 | A8QCE4 | 619 | LST2_BRUMA Lateral signaling target protein 2... | 57 | 0.012 | 42.4 | 39 | 51 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 64 | O96838 | 1809 | FYV1_DROME Putative 1-phosphatidylinositol 3-... | 46 | 0.013 | 42.7 | 37 | 61 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0012506; C:vesicle membrane; ISS:UniProtKB. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IMP:FlyBase.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0008333; P:endosome to lysosome transport; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; ISS:UniProtKB. | 65 | Q5JSP0 | 725 | FGD3_HUMAN FYVE, RhoGEF and PH domain-contain... | 27 | 0.013 | 42.4 | 52 | 67 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0031267; F:small GTPase binding; ISS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0046847; P:filopodium assembly; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043088; P:regulation of Cdc42 GTPase activity; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 66 | Q5R5T1 | 737 | FGD3_PONAB FYVE, RhoGEF and PH domain-contain... | 27 | 0.016 | 42 | 52 | 67 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 67 | P53191 | 635 | PIB2_YEAST Phosphatidylinositol 3-phosphate-b... | 37 | 0.03 | 41.2 | 41 | 57 | GO:0005770; C:late endosome; TAS:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 68 | Q06651 | 286 | PIB1_YEAST E3 ubiquitin-protein ligase PIB1 O... | 113 | 0.017 | 41.2 | 29 | 41 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005770; C:late endosome; IDA:SGD. | | | | | | | | | | GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 69 | Q54TC3 | 585 | SLOB1_DICDI Probable inactive serine/threonin... | 91 | 0.018 | 42 | 32 | 41 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004672; F:protein kinase activity; IEA:InterPro. | | | | | | | | | | | 70 | Q05B78 | 254 | ZFY21_BOVIN Zinc finger FYVE domain-containin... | 116 | 1.5 | 35 | 26 | 42 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 71 | Q96T51 | 708 | RUFY1_HUMAN RUN and FYVE domain-containing pr... | 85 | 0.024 | 41.6 | 31 | 47 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 72 | Q960X8 | 760 | HRS_DROME Hepatocyte growth factor-regulated ... | 53 | 3.9 | 34.3 | 32 | 47 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0033565; C:ESCRT-0 complex; IDA:FlyBase.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0008021; C:synaptic vesicle; NAS:FlyBase. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0006897; P:endocytosis; IMP:FlyBase.::GO:0016197; P:endosome transport; TAS:FlyBase.::GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; NAS:FlyBase.::GO:0045752; P:positive regulation of Toll signaling pathway; IMP:FlyBase.::GO:0016082; P:synaptic vesicle priming; NAS:FlyBase.::GO:0008293; P:torso signaling pathway; NAS:FlyBase.::GO:0016050; P:vesicle organization; NAS:FlyBase. | 73 | A8XJZ8 | 651 | LST2_CAEBR Lateral signaling target protein 2... | 37 | 0.026 | 41.6 | 43 | 51 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 74 | Q8VCM3 | 234 | ZFY21_MOUSE Zinc finger FYVE domain-containin... | 48 | 0.028 | 40.4 | 44 | 52 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 75 | Q9TZD0 | 661 | LST2_CAEEL Lateral signaling target protein 2... | 37 | 0.031 | 41.2 | 43 | 51 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:WormBase. | | | | | | | | | | GO:0040027; P:negative regulation of vulval development; IMP:WormBase. | 76 | P34756 | 2278 | FAB1_YEAST 1-phosphatidylinositol 3-phosphate... | 90 | 2.4 | 35.4 | 26 | 40 | GO:0010008; C:endosome membrane; IDA:SGD.::GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0070772; C:PAS complex; IDA:SGD. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IDA:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:SGD. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro. | 77 | D3ZVP7 | 234 | ZFY21_RAT Zinc finger FYVE domain-containing ... | 48 | 0.036 | 40 | 44 | 52 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | | 78 | Q8BIJ7 | 712 | RUFY1_MOUSE RUN and FYVE domain-containing pr... | 85 | 0.049 | 40.4 | 29 | 47 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008565; F:protein transporter activity; IDA:MGI. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0030100; P:regulation of endocytosis; IDA:MGI. | 79 | Q0U4Z8 | 720 | VPS27_PHANO Vacuolar protein sorting-associat... | 37 | 0.068 | 40 | 49 | 59 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro. | 80 | Q54CH1 | 580 | ADCA_DICDI Arrestin domain-containing protein... | 78 | 0.17 | 38.5 | 29 | 47 | GO:0005813; C:centrosome; IDA:dictyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 81 | Q5ABD9 | 841 | VPS27_CANAL Vacuolar protein sorting-associat... | 145 | 0.39 | 37.7 | 25 | 45 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro.::GO:0009405; P:pathogenesis; IMP:CGD. | 82 | Q6CL17 | 603 | VPS27_KLULA Vacuolar protein sorting-associat... | 26 | 1.3 | 35.8 | 50 | 62 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro. | 83 | Q9HCC9 | 887 | LST2_HUMAN Lateral signaling target protein 2... | 66 | 0.17 | 38.9 | 33 | 45 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IDA:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; IMP:UniProtKB. | 84 | Q810J8 | 777 | ZFYV1_MOUSE Zinc finger FYVE domain-containin... | 170 | 0.11 | 39.3 | 24 | 38 | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005795; C:Golgi stack; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005545; F:1-phosphatidylinositol binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB. | 85 | Q6ZPK7 | 905 | LST2_MOUSE Lateral signaling target protein 2... | 66 | 0.13 | 39.3 | 33 | 45 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB. | 86 | Q0P4S0 | 951 | LST2_XENTR Lateral signaling target protein 2... | 74 | 0.27 | 38.1 | 32 | 46 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB. | 87 | Q9NYA4 | 1195 | MTMR4_HUMAN Myotubularin-related protein 4 OS... | 52 | 0.13 | 39.3 | 40 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. | | | | | | | | | | | 88 | A0JMD2 | 969 | LST2_DANRE Lateral signaling target protein 2... | 66 | 0.39 | 37.7 | 32 | 45 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; ISS:UniProtKB. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0032266; F:phosphatidylinositol-3-phosphate binding; ISS:UniProtKB. | | | | | | | | | | GO:0007175; P:negative regulation of epidermal growth factor-activated receptor activity; ISS:UniProtKB. | 89 | Q91XS1 | 1190 | MTMR4_MOUSE Myotubularin-related protein 4 OS... | 52 | 0.15 | 38.9 | 40 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | | 90 | Q7ZXF1 | 1078 | MTMR4_XENLA Myotubularin-related protein 4 OS... | 68 | 9.7 | 33.1 | 28 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | | 91 | Q9Y7M3 | 293 | YNT3_SCHPO FYVE-type zinc finger-containing p... | 102 | 0.2 | 38.1 | 28 | 41 | GO:0000324; C:fungal-type vacuole; IDA:PomBase.::GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | |