| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | O18993 | 503 | CP3AL_CALJA Cytochrome P450 3A21 OS=Callithri... | 437 | 4e-21 | 100 | 24 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 32 | P47787 | 534 | THAS_PIG Thromboxane-A synthase OS=Sus scrofa... | 443 | 1e-20 | 99 | 25 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IEA:EC. | | | | | | | | | | GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW. | 33 | P11707 | 501 | CP3A6_RABIT Cytochrome P450 3A6 OS=Oryctolagu... | 418 | 4e-20 | 96.7 | 24 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 34 | P20815 | 502 | CP3A5_HUMAN Cytochrome P450 3A5 OS=Homo sapie... | 431 | 7e-20 | 96.3 | 23 | 43 | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005792; C:microsome; TAS:ProtInc. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0019825; F:oxygen binding; TAS:ProtInc. | | | | | | | | | | GO:0009822; P:alkaloid catabolic process; IDA:BHF-UCL.::GO:0042737; P:drug catabolic process; IDA:BHF-UCL.::GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0008202; P:steroid metabolic process; TAS:ProtInc.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 35 | Q64406 | 503 | CP3AF_CAVPO Cytochrome P450 3A15 OS=Cavia por... | 436 | 8e-20 | 96.3 | 24 | 44 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 36 | Q2KIG5 | 533 | THAS_BOVIN Thromboxane-A synthase OS=Bos taur... | 398 | 1e-19 | 95.5 | 26 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IEA:EC. | | | | | | | | | | GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW. | 37 | P08682 | 493 | CP2E1_RABIT Cytochrome P450 2E1 OS=Oryctolagu... | 243 | 4e-19 | 94 | 33 | 50 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 38 | Q64581 | 497 | CP3AI_RAT Cytochrome P450 3A18 OS=Rattus norv... | 491 | 5e-19 | 93.6 | 22 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008390; F:testosterone 16-alpha-hydroxylase activity; IDA:RGD.::GO:0050649; F:testosterone 6-beta-hydroxylase activity; IDA:RGD. | | | | | | | | | | | 39 | Q09128 | 514 | CP24A_RAT 1,25-dihydroxyvitamin D(3) 24-hydro... | 177 | 2e-18 | 91.7 | 32 | 54 | GO:0005739; C:mitochondrion; TAS:RGD. | | | | | | | | | | GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; TAS:BHF-UCL.::GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IDA:RGD.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0042369; P:vitamin D catabolic process; TAS:RGD. | 40 | Q5KQT6 | 512 | CP1A2_FELCA Cytochrome P450 1A2 OS=Felis catu... | 255 | 3e-18 | 91.3 | 26 | 47 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB. | | | | | | | | | | | 41 | P24557 | 533 | THAS_HUMAN Thromboxane-A synthase OS=Homo sap... | 396 | 3e-18 | 91.3 | 24 | 41 | GO:0005788; C:endoplasmic reticulum lumen; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IEA:EC. | | | | | | | | | | GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 42 | P36423 | 533 | THAS_MOUSE Thromboxane-A synthase OS=Mus musc... | 389 | 5e-18 | 90.9 | 24 | 41 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:MGI. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IMP:MGI. | | | | | | | | | | GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW. | 43 | P79152 | 218 | CP3AJ_CAPAE Cytochrome P450 3A19 OS=Capra aeg... | 175 | 5e-18 | 87 | 31 | 53 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 44 | P29980 | 459 | CPXN_NOSS1 Probable cytochrome P450 110 OS=No... | 450 | 7e-18 | 89.7 | 23 | 42 | | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | GO:0009399; P:nitrogen fixation; IEA:UniProtKB-KW. | 45 | P49430 | 533 | THAS_RAT Thromboxane-A synthase OS=Rattus nor... | 412 | 1e-17 | 89.4 | 24 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IEA:EC. | | | | | | | | | | GO:0030644; P:cellular chloride ion homeostasis; IMP:RGD.::GO:0045907; P:positive regulation of vasoconstriction; IMP:RGD.::GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW. | 46 | Q8HYN1 | 508 | CP17A_PANTR Steroid 17-alpha-hydroxylase/17,2... | 448 | 2e-17 | 89 | 23 | 42 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004508; F:steroid 17-alpha-monooxygenase activity; IEA:EC. | | | | | | | | | | GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW. | 47 | Q9MZY0 | 494 | CP2E1_CANFA Cytochrome P450 2E1 OS=Canis fami... | 232 | 2e-17 | 88.6 | 32 | 50 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 48 | P33266 | 449 | CP2E1_MACFA Cytochrome P450 2E1 OS=Macaca fas... | 325 | 2e-17 | 88.6 | 27 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 49 | P08683 | 500 | CP2CB_RAT Cytochrome P450 2C11 OS=Rattus norv... | 347 | 2e-17 | 88.6 | 26 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008390; F:testosterone 16-alpha-hydroxylase activity; IMP:RGD. | | | | | | | | | | GO:0006805; P:xenobiotic metabolic process; TAS:RGD. | 50 | P05093 | 508 | CP17A_HUMAN Steroid 17-alpha-hydroxylase/17,2... | 448 | 3e-17 | 88.2 | 23 | 42 | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0019825; F:oxygen binding; TAS:ProtInc.::GO:0004508; F:steroid 17-alpha-monooxygenase activity; TAS:ProtInc. | | | | | | | | | | GO:0006702; P:androgen biosynthetic process; TAS:Reactome.::GO:0006704; P:glucocorticoid biosynthetic process; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 51 | Q07973 | 514 | CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hyd... | 178 | 3e-17 | 88.2 | 32 | 52 | GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. | | | | | | | | | | GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IDA:UniProtKB.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; TAS:UniProtKB. | | | | | | | | | | GO:0001649; P:osteoblast differentiation; IEP:BHF-UCL.::GO:0042369; P:vitamin D catabolic process; NAS:BHF-UCL.::GO:0070561; P:vitamin D receptor signaling pathway; IEP:BHF-UCL.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 52 | Q64148 | 503 | CP3AA_MESAU Lithocholate 6-beta-hydroxylase O... | 450 | 3e-17 | 87.8 | 22 | 41 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0033777; F:lithocholate 6beta-hydroxylase activity; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 53 | Q54F47 | 495 | C513C_DICDI Probable cytochrome P450 513C1 OS... | 489 | 3e-17 | 87.8 | 22 | 40 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 54 | Q92116 | 521 | CP1A1_STECH Cytochrome P450 1A1 OS=Stenotomus... | 178 | 5e-17 | 87.4 | 28 | 54 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 55 | Q64441 | 514 | CP24A_MOUSE 1,25-dihydroxyvitamin D(3) 24-hyd... | 177 | 5e-17 | 87.4 | 31 | 53 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IMP:MGI.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0042359; P:vitamin D metabolic process; IMP:MGI. | 56 | Q2PG45 | 533 | THAS_MACFA Thromboxane-A synthase OS=Macaca f... | 396 | 7e-17 | 87 | 24 | 40 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0004796; F:thromboxane-A synthase activity; IEA:EC. | | | | | | | | | | GO:0001516; P:prostaglandin biosynthetic process; IEA:UniProtKB-KW. | 57 | P15123 | 487 | CP2CG_RABIT Cytochrome P450 2C16 OS=Oryctolag... | 365 | 7e-17 | 86.7 | 25 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 58 | Q98T91 | 502 | C340_ORYLA Cytochrome P450 3A40 OS=Oryzias la... | 491 | 9e-17 | 86.7 | 23 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 59 | Q6GUQ4 | 493 | CP2E1_MACMU Cytochrome P450 2E1 OS=Macaca mul... | 323 | 1e-16 | 86.3 | 27 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 60 | P56594 | 487 | CP2CL_CANFA Cytochrome P450 2C21 OS=Canis fam... | 361 | 1e-16 | 85.9 | 26 | 44 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 61 | Q8HYN0 | 508 | CP17A_PAPCY Steroid 17-alpha-hydroxylase/17,2... | 369 | 1e-16 | 85.9 | 25 | 43 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004508; F:steroid 17-alpha-monooxygenase activity; IEA:EC. | | | | | | | | | | GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW. |
