| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
391 | Q7TSC3 | 627 | NEK5_MOUSE Serine/threonine-protein kinase Ne... | 190 | 0.002 | 43.1 | 26 | 42 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 392 | Q23356 | 1096 | MIG15_CAEEL Serine/threonine-protein kinase m... | 182 | 0.002 | 43.5 | 25 | 42 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0010171; P:body morphogenesis; IGI:WormBase.::GO:0033563; P:dorsal/ventral axon guidance; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040039; P:inductive cell migration; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase. | 393 | O14328 | 474 | KSP1_SCHPO Serine/threonine-protein kinase ks... | 128 | 0.002 | 43.1 | 27 | 54 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; ISS:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase. | | | | | | | | | | GO:0007165; P:signal transduction; NAS:PomBase. | 394 | Q9R011 | 647 | PLK3_RAT Serine/threonine-protein kinase PLK3... | 123 | 0.002 | 43.1 | 22 | 50 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0030425; C:dendrite; IDA:RGD.::GO:0005795; C:Golgi stack; ISS:UniProtKB.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005730; C:nucleolus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0002039; F:p53 binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071779; P:G1/S transition checkpoint; ISS:UniProtKB.::GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0090166; P:Golgi disassembly; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; ISS:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; ISS:UniProtKB.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; NAS:RGD.::GO:0006974; P:response to DNA damage stimulus; ISS:UniProtKB.::GO:0006970; P:response to osmotic stress; ISS:UniProtKB.::GO:0009314; P:response to radiation; ISS:UniProtKB.::GO:0000302; P:response to reactive oxygen species; ISS:UniProtKB.::GO:0000084; P:S phase of mitotic cell cycle; ISS:UniProtKB. | 395 | Q12852 | 859 | M3K12_HUMAN Mitogen-activated protein kinase ... | 243 | 0.002 | 43.1 | 21 | 40 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0016572; P:histone phosphorylation; ISS:UniProtKB.::GO:0007254; P:JNK cascade; ISS:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; ISS:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 396 | Q54UL8 | 983 | MPS1_DICDI Probable serine/threonine-protein ... | 244 | 0.002 | 43.1 | 26 | 42 | GO:0005813; C:centrosome; TAS:dictyBase.::GO:0000778; C:condensed nuclear chromosome kinetochore; ISS:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; ISS:dictyBase. | | | | | | | | | | | 397 | P0CD62 | 966 | LIMKB_DICDI Probable LIM domain-containing se... | 124 | 0.002 | 43.1 | 27 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 398 | Q4FZD7 | 595 | PLK5_MOUSE Inactive serine/threonine-protein ... | 104 | 0.002 | 43.1 | 22 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005730; C:nucleolus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0002357; P:defense response to tumor cell; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IDA:UniProtKB.::GO:0006468; P:protein phosphorylation; IEA:InterPro.::GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0006927; P:transformed cell apoptotic process; IMP:UniProtKB. | 399 | P0C264 | 359 | SG110_HUMAN Putative uncharacterized serine/t... | 105 | 0.002 | 42.7 | 27 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 400 | Q968Y9 | 1846 | INSR_CAEEL Insulin-like receptor OS=Caenorhab... | 143 | 0.002 | 43.5 | 27 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:WormBase.::GO:0005009; F:insulin-activated receptor activity; ISS:WormBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017046; F:peptide hormone binding; ISS:WormBase.::GO:0042169; F:SH2 domain binding; ISS:WormBase. | | | | | | | | | | GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.::GO:0043053; P:dauer entry; IMP:WormBase.::GO:0043054; P:dauer exit; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:WormBase.::GO:0046777; P:protein autophosphorylation; ISS:WormBase.::GO:0040034; P:regulation of development, heterochronic; IGI:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0009408; P:response to heat; IMP:WormBase.::GO:0006979; P:response to oxidative stress; IMP:WormBase. | 401 | O54784 | 448 | DAPK3_MOUSE Death-associated protein kinase 3... | 172 | 0.002 | 43.1 | 24 | 45 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 402 | Q8SSH4 | 586 | MPS1_ENCCU Probable serine/threonine-protein ... | 121 | 0.002 | 43.1 | 26 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 403 | Q10GB1 | 599 | NEK1_ORYSJ Serine/threonine-protein kinase Ne... | 141 | 0.002 | 43.1 | 26 | 48 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 404 | P22607 | 806 | FGFR3_HUMAN Fibroblast growth factor receptor... | 254 | 0.002 | 43.1 | 23 | 43 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IMP:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0070977; P:bone maturation; ISS:BHF-UCL.::GO:0002062; P:chondrocyte differentiation; TAS:UniProtKB.::GO:0035988; P:chondrocyte proliferation; TAS:UniProtKB.::GO:0003416; P:endochondral bone growth; TAS:UniProtKB.::GO:0001958; P:endochondral ossification; TAS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0007259; P:JAK-STAT cascade; TAS:ProtInc.::GO:0000165; P:MAPK cascade; TAS:ProtInc.::GO:0048640; P:negative regulation of developmental growth; ISS:BHF-UCL.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IMP:UniProtKB.::GO:0010518; P:positive regulation of phospholipase activity; IMP:UniProtKB.::GO:0042511; P:positive regulation of tyrosine phosphorylation of Stat1 protein; IMP:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB. | 405 | Q8IWU2 | 1503 | LMTK2_HUMAN Serine/threonine-protein kinase L... | 115 | 0.002 | 43.1 | 27 | 49 | GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0055037; C:recycling endosome; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0070853; F:myosin VI binding; IPI:UniProtKB.::GO:0004864; F:protein phosphatase inhibitor activity; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | GO:0045022; P:early endosome to late endosome transport; IMP:UniProtKB.::GO:0032456; P:endocytic recycling; IMP:UniProtKB.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0001881; P:receptor recycling; IMP:UniProtKB.::GO:0033572; P:transferrin transport; IMP:UniProtKB. | 406 | Q60806 | 631 | PLK3_MOUSE Serine/threonine-protein kinase PL... | 123 | 0.002 | 43.1 | 22 | 50 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005795; C:Golgi stack; ISS:UniProtKB.::GO:0005730; C:nucleolus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0002039; F:p53 binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0071779; P:G1/S transition checkpoint; IMP:UniProtKB.::GO:0000082; P:G1/S transition of mitotic cell cycle; ISS:UniProtKB.::GO:0090166; P:Golgi disassembly; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:2000777; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia; ISS:UniProtKB.::GO:0043491; P:protein kinase B signaling cascade; IMP:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0006970; P:response to osmotic stress; ISS:UniProtKB.::GO:0009314; P:response to radiation; ISS:UniProtKB.::GO:0000302; P:response to reactive oxygen species; ISS:UniProtKB.::GO:0000084; P:S phase of mitotic cell cycle; ISS:UniProtKB. | 407 | A6ZQG7 | 855 | HAL5_YEAS7 Serine/threonine-protein kinase HA... | 119 | 0.002 | 43.1 | 26 | 40 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 408 | P16277 | 499 | BLK_MOUSE Tyrosine-protein kinase Blk OS=Mus ... | 133 | 0.002 | 42.7 | 26 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 409 | P21803 | 821 | FGFR2_MOUSE Fibroblast growth factor receptor... | 231 | 0.002 | 43.1 | 23 | 44 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; IMP:UniProtKB.::GO:0005576; C:extracellular region; TAS:MGI.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:MGI.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro.::GO:0008201; F:heparin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001525; P:angiogenesis; IGI:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007409; P:axonogenesis; IMP:MGI.::GO:0030282; P:bone mineralization; IMP:MGI.::GO:0060349; P:bone morphogenesis; IMP:MGI.::GO:0060667; P:branch elongation involved in salivary gland morphogenesis; IMP:MGI.::GO:0060670; P:branching involved in embryonic placenta morphogenesis; IMP:MGI.::GO:0048755; P:branching morphogenesis of a nerve; IMP:MGI.::GO:0060449; P:bud elongation involved in lung branching; IMP:MGI.::GO:0045165; P:cell fate commitment; IDA:MGI.::GO:0048557; P:embryonic digestive tract morphogenesis; IMP:MGI.::GO:0009880; P:embryonic pattern specification; IMP:MGI.::GO:0061031; P:endodermal digestive tract morphogenesis; IMP:MGI.::GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; IMP:MGI.::GO:0035603; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis; IMP:UniProtKB.::GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; IMP:MGI.::GO:0035602; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; IMP:UniProtKB.::GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; IMP:UniProtKB.::GO:0035604; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; IMP:UniProtKB.::GO:0031069; P:hair follicle morphogenesis; IMP:MGI.::GO:0032808; P:lacrimal gland development; IMP:MGI.::GO:0060601; P:lateral sprouting from an epithelium; IMP:MGI.::GO:0070307; P:lens fiber cell development; IGI:MGI.::GO:0060174; P:limb bud formation; IMP:MGI.::GO:0048286; P:lung alveolus development; IMP:MGI.::GO:0060463; P:lung lobe morphogenesis; IMP:MGI.::GO:0060484; P:lung-associated mesenchyme development; IMP:MGI.::GO:0060615; P:mammary gland bud formation; IMP:MGI.::GO:0003149; P:membranous septum morphogenesis; IMP:MGI.::GO:0060915; P:mesenchymal cell differentiation involved in lung development; IGI:MGI.::GO:0060916; P:mesenchymal cell proliferation involved in lung development; IMP:MGI.::GO:0030901; P:midbrain development; IGI:MGI.::GO:0035264; P:multicellular organism growth; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; IGI:MGI.::GO:0045839; P:negative regulation of mitosis; IGI:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0007528; P:neuromuscular junction development; IMP:MGI.::GO:0042476; P:odontogenesis; IMP:MGI.::GO:0035265; P:organ growth; IMP:MGI.::GO:0030916; P:otic vesicle formation; IMP:MGI.::GO:0003148; P:outflow tract septum morphogenesis; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:MGI.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IGI:MGI.::GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.::GO:0051781; P:positive regulation of cell division; IMP:MGI.::GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IMP:MGI.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IGI:MGI.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; IGI:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; IMP:MGI.::GO:0060523; P:prostate epithelial cord elongation; IMP:MGI.::GO:0021860; P:pyramidal neuron development; IMP:UniProtKB.::GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; IMP:MGI.::GO:0010453; P:regulation of cell fate commitment; IMP:MGI.::GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; IMP:MGI.::GO:0040014; P:regulation of multicellular organism growth; IMP:MGI.::GO:0051150; P:regulation of smooth muscle cell differentiation; IMP:MGI.::GO:0008589; P:regulation of smoothened signaling pathway; IMP:MGI.::GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; IMP:MGI.::GO:0048489; P:synaptic vesicle transport; IMP:MGI.::GO:0001657; P:ureteric bud development; IGI:MGI.::GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; TAS:DFLAT.::GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.::GO:0021847; P:ventricular zone neuroblast division; IMP:UniProtKB. | 410 | Q13546 | 671 | RIPK1_HUMAN Receptor-interacting serine/threo... | 151 | 0.002 | 43.1 | 25 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031264; C:death-inducing signaling complex; IDA:BHF-UCL.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:BHF-UCL.::GO:0043235; C:receptor complex; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0070513; F:death domain binding; IPI:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.::GO:0007257; P:activation of JUN kinase activity; TAS:BHF-UCL.::GO:0008633; P:activation of pro-apoptotic gene products; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0060555; P:induction of necroptosis by extracellular signals; IMP:BHF-UCL.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; TAS:BHF-UCL.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IEP:UniProtKB.::GO:0032757; P:positive regulation of interleukin-8 production; IDA:BHF-UCL.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; TAS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.::GO:0032481; P:positive regulation of type I interferon production; TAS:Reactome.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:0070926; P:regulation of ATP:ADP antiporter activity; IMP:BHF-UCL.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IC:BHF-UCL. | 411 | O88764 | 448 | DAPK3_RAT Death-associated protein kinase 3 O... | 172 | 0.002 | 42.7 | 24 | 45 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004683; F:calmodulin-dependent protein kinase activity; TAS:RGD.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0030182; P:neuron differentiation; IDA:RGD.::GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 412 | Q06187 | 659 | BTK_HUMAN Tyrosine-protein kinase BTK OS=Homo... | 176 | 0.002 | 43.1 | 26 | 43 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; TAS:HGNC.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:UniProtKB.::GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:UniProtKB. | | | | | | | | | | GO:0002250; P:adaptive immune response; TAS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042113; P:B cell activation; TAS:UniProtKB.::GO:0050853; P:B cell receptor signaling pathway; TAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; TAS:HGNC.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0045579; P:positive regulation of B cell differentiation; TAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0002902; P:regulation of B cell apoptotic process; TAS:UniProtKB.::GO:0002721; P:regulation of B cell cytokine production; TAS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 413 | P13863 | 303 | CDK1_CHICK Cyclin-dependent kinase 1 OS=Gallu... | 147 | 0.002 | 42.4 | 28 | 47 | GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; ISS:UniProtKB.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000724; P:double-strand break repair via homologous recombination; TAS:Reactome.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 414 | O13839 | 722 | FIN1_SCHPO G2-specific protein kinase fin1 OS... | 98 | 0.002 | 43.1 | 32 | 49 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0071958; C:new spindle pole body; IDA:PomBase.::GO:0005635; C:nuclear envelope; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase. | | | | | | | | | | GO:0071937; P:barrier septum assembly involved in cell cycle cytokinesis; IMP:PomBase.::GO:0034613; P:cellular protein localization; IGI:PomBase.::GO:0007076; P:mitotic chromosome condensation; IMP:PomBase.::GO:0031030; P:negative regulation of septation initiation signaling cascade; IMP:PomBase.::GO:0031028; P:septation initiation signaling cascade; IMP:PomBase.::GO:0090307; P:spindle assembly involved in mitosis; IMP:PomBase. | 415 | Q81WH6 | 657 | PRKC_BACAN Serine/threonine-protein kinase Pr... | 95 | 0.002 | 43.1 | 27 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0042834; F:peptidoglycan binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0071224; P:cellular response to peptidoglycan; IMP:UniProtKB.::GO:0007165; P:signal transduction; IMP:UniProtKB.::GO:0009847; P:spore germination; IMP:UniProtKB. | 416 | Q8QGV6 | 447 | NLK2_XENLA Serine/threonine-protein kinase NL... | 212 | 0.002 | 42.7 | 19 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0004707; F:MAP kinase activity; IEA:EC.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB. | | | | | | | | | | GO:0009952; P:anterior/posterior pattern specification; IMP:UniProtKB.::GO:0001707; P:mesoderm formation; IMP:UniProtKB.::GO:0007399; P:nervous system development; IGI:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0031398; P:positive regulation of protein ubiquitination; IPI:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0033136; P:serine phosphorylation of STAT3 protein; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 417 | Q63638 | 3259 | SPEG_RAT Striated muscle-specific serine/thre... | 104 | 0.004 | 42.4 | 27 | 46 | GO:0005634; C:nucleus; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0042692; P:muscle cell differentiation; IEP:RGD. | 418 | P38970 | 855 | HAL5_YEAST Serine/threonine-protein kinase HA... | 119 | 0.002 | 43.1 | 26 | 40 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030003; P:cellular cation homeostasis; IGI:SGD.::GO:0034613; P:cellular protein localization; IGI:SGD.::GO:0006470; P:protein dephosphorylation; IMP:SGD. | 419 | Q3TYD6 | 1471 | LMTK2_MOUSE Serine/threonine-protein kinase L... | 116 | 0.002 | 43.1 | 28 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 420 | Q9Y6R4 | 1608 | M3K4_HUMAN Mitogen-activated protein kinase k... | 153 | 0.002 | 43.1 | 24 | 44 | GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB. | 421 | P05625 | 647 | RAF1_CHICK RAF proto-oncogene serine/threonin... | 129 | 0.002 | 42.7 | 24 | 47 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
