| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O13819 | 559 | YMR1_SCHPO Phosphoinositide 3-phosphatase OS=... | 719 | 2e-116 | 369 | 35 | 48 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:PomBase.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0048017; P:inositol lipid-mediated signaling; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; ISS:PomBase. | 2 | P47147 | 688 | YMR1_YEAST Phosphoinositide 3-phosphatase OS=... | 749 | 6e-112 | 361 | 34 | 53 | GO:0005737; C:cytoplasm; IDA:SGD. | | | | | | | | | | GO:0003729; F:mRNA binding; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IMP:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:UniProtKB. | 3 | Q96EF0 | 704 | MTMR8_HUMAN Myotubularin-related protein 8 OS... | 122 | 4e-16 | 85.9 | 38 | 55 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 4 | Q5F452 | 629 | MTMR8_CHICK Myotubularin-related protein 8 OS... | 134 | 0.00000000000001 | 81.3 | 34 | 53 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 5 | Q6TEL0 | 632 | MTMR8_DANRE Myotubularin-related protein 8 OS... | 130 | 0.00000000002 | 71.2 | 30 | 52 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 6 | Q9Z2D1 | 643 | MTMR2_MOUSE Myotubularin-related protein 2 OS... | 86 | 5e-16 | 85.9 | 45 | 66 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005774; C:vacuolar membrane; IDA:MGI. | | | | | | | | | | GO:0042803; F:protein homodimerization activity; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.::GO:0051262; P:protein tetramerization; IPI:MGI. | 7 | Q13614 | 643 | MTMR2_HUMAN Myotubularin-related protein 2 OS... | 86 | 4e-16 | 85.9 | 45 | 66 | GO:0030424; C:axon; ISS:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL.::GO:0097060; C:synaptic membrane; ISS:BHF-UCL.::GO:0008021; C:synaptic vesicle; ISS:BHF-UCL. | | | | | | | | | | GO:0004437; F:inositol or phosphatidylinositol phosphatase activity; TAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; NAS:UniProtKB. | | | | | | | | | | GO:0097062; P:dendritic spine maintenance; ISS:BHF-UCL.::GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:2000645; P:negative regulation of receptor catabolic process; ISS:BHF-UCL.::GO:0002091; P:negative regulation of receptor internalization; ISS:BHF-UCL.::GO:2000643; P:positive regulation of early endosome to late endosome transport; ISS:BHF-UCL. | 8 | Q5REB9 | 643 | MTMR2_PONAB Myotubularin-related protein 2 OS... | 86 | 4e-16 | 85.9 | 45 | 66 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 9 | Q9Y217 | 621 | MTMR6_HUMAN Myotubularin-related protein 6 OS... | 122 | 0.0000000000003 | 76.6 | 34 | 59 | GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; NAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB. | | | | | | | | | | | 10 | A6QLT2 | 643 | MTMR2_BOVIN Myotubularin-related protein 2 OS... | 84 | 4e-16 | 86.3 | 46 | 68 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 11 | Q5ZIV1 | 571 | MTMR2_CHICK Myotubularin-related protein 2 OS... | 88 | 3e-16 | 86.3 | 44 | 65 | | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 12 | Q9Z2C5 | 603 | MTM1_MOUSE Myotubularin OS=Mus musculus (Mous... | 91 | 0.000000000000003 | 82.8 | 45 | 63 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.::GO:0046716; P:muscle cell homeostasis; IMP:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 13 | Q13496 | 603 | MTM1_HUMAN Myotubularin OS=Homo sapiens (Huma... | 89 | 0.000000000000003 | 83.2 | 46 | 65 | GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; IDA:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.::GO:0045109; P:intermediate filament organization; IMP:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; IDA:UniProtKB. | 14 | Q5R9S3 | 603 | MTM1_PONAB Myotubularin OS=Pongo abelii (Suma... | 89 | 0.000000000000003 | 83.2 | 46 | 65 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 15 | Q5R6F6 | 660 | MTMR7_PONAB Myotubularin-related protein 7 OS... | 120 | 5e-17 | 89 | 39 | 59 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 16 | Q9Z2C9 | 660 | MTMR7_MOUSE Myotubularin-related protein 7 OS... | 120 | 7e-16 | 85.1 | 38 | 58 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI. | 17 | Q9Y216 | 660 | MTMR7_HUMAN Myotubularin-related protein 7 OS... | 121 | 1e-16 | 87.8 | 39 | 59 | | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. | | | | | | | | | | | 18 | Q8VE11 | 617 | MTMR6_MOUSE Myotubularin-related protein 6 OS... | 122 | 0.0000000000003 | 77 | 34 | 58 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 19 | A0JMK5 | 620 | MTMR2_DANRE Myotubularin-related protein 2 OS... | 118 | 9e-17 | 88.2 | 39 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 20 | Q6AXQ4 | 602 | MTM1_RAT Myotubularin OS=Rattus norvegicus (R... | 105 | 0.000000000000003 | 83.2 | 42 | 58 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 21 | Q9Z2C4 | 669 | MTMR1_MOUSE Myotubularin-related protein 1 OS... | 119 | 2e-16 | 86.7 | 38 | 59 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 22 | Q8K296 | 1196 | MTMR3_MOUSE Myotubularin-related protein 3 OS... | 111 | 0.00000000000002 | 80.9 | 38 | 57 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB. | 23 | Q5PQT2 | 1194 | MTMR3_RAT Myotubularin-related protein 3 OS=R... | 111 | 0.00000000000002 | 80.9 | 38 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB. | 24 | Q13613 | 665 | MTMR1_HUMAN Myotubularin-related protein 1 OS... | 119 | 8e-17 | 88.2 | 38 | 59 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 25 | A6QLT4 | 603 | MTM1_BOVIN Myotubularin OS=Bos taurus (Bovine... | 91 | 6e-16 | 85.1 | 46 | 64 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 26 | Q13615 | 1198 | MTMR3_HUMAN Myotubularin-related protein 3 OS... | 111 | 0.00000000000002 | 81.3 | 38 | 57 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB. | 27 | Q52KU6 | 602 | MTM1_XENLA Myotubularin OS=Xenopus laevis (Af... | 104 | 0.00000000000006 | 79 | 39 | 61 | GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 28 | Q5EB32 | 602 | MTM1_XENTR Myotubularin OS=Xenopus tropicalis... | 104 | 0.00000000000008 | 78.6 | 39 | 61 | GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 29 | Q9NYA4 | 1195 | MTMR4_HUMAN Myotubularin-related protein 4 OS... | 86 | 0.0000000001 | 68.6 | 43 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. | | | | | | | | | | | 30 | Q91XS1 | 1190 | MTMR4_MOUSE Myotubularin-related protein 4 OS... | 86 | 0.0000000001 | 68.6 | 43 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | | 31 | Q7ZXF1 | 1078 | MTMR4_XENLA Myotubularin-related protein 4 OS... | 85 | 0.00000000002 | 71.2 | 42 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | |
