Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Candida albicans WO1
Locus:
CAWG_00024
Length:
1256
Number of sequences:
5931
Description:
conserved hypothetical protein
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12200    1170   NPC1_YEAST Niemann-Pick type C-related protei...12250     952     43     61GO:0000329; C:fungal-type vacuole membrane; IDA:SGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0046624; F:sphingolipid transporter activity; IMP:SGD.
GO:0006665; P:sphingolipid metabolic process; IMP:SGD.
2P56941    1277   NPC1_PIG Niemann-Pick C1 protein OS=Sus scrof...12940     582     31     51GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005635; C:nuclear envelope; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0008206; P:bile acid metabolic process; ISS:UniProtKB.::GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.::GO:0030301; P:cholesterol transport; IEA:InterPro.::GO:0007041; P:lysosomal transport; ISS:UniProtKB.
3O35604    1278   NPC1_MOUSE Niemann-Pick C1 protein OS=Mus mus...12962e-180     573     31     51GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005635; C:nuclear envelope; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0008206; P:bile acid metabolic process; ISS:UniProtKB.::GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.::GO:0030301; P:cholesterol transport; IEA:InterPro.::GO:0007041; P:lysosomal transport; ISS:UniProtKB.
4O15118    1278   NPC1_HUMAN Niemann-Pick C1 protein OS=Homo sa...12961e-174     558     31     49GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.::GO:0005635; C:nuclear envelope; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0015248; F:sterol transporter activity; TAS:ProtInc.
GO:0006914; P:autophagy; IGI:MGI.::GO:0008206; P:bile acid metabolic process; ISS:UniProtKB.::GO:0033344; P:cholesterol efflux; IDA:BHF-UCL.::GO:0042632; P:cholesterol homeostasis; IDA:UniProtKB.::GO:0007041; P:lysosomal transport; ISS:UniProtKB.
5Q6T3U3    1331   NPCL1_RAT Niemann-Pick C1-like protein 1 OS=R...13131e-150     495     28     47GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0031526; C:brush border membrane; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008144; F:drug binding; IDA:RGD.::GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0030301; P:cholesterol transport; IEA:InterPro.::GO:0042493; P:response to drug; IEP:RGD.
6Q9UHC9    1359   NPCL1_HUMAN Niemann-Pick C1-like protein 1 OS...13382e-144     479     28     47GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IDA:UniProtKB.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0031489; F:myosin V binding; IPI:UniProtKB.::GO:0017137; F:Rab GTPase binding; IPI:UniProtKB.
GO:0006695; P:cholesterol biosynthetic process; IMP:HGNC.::GO:0030299; P:intestinal cholesterol absorption; IMP:HGNC.::GO:0042157; P:lipoprotein metabolic process; IMP:HGNC.
7Q6T3U4    1333   NPCL1_MOUSE Niemann-Pick C1-like protein 1 OS...13242e-139     464     28     47GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0042632; P:cholesterol homeostasis; IMP:MGI.
8Q19127    1383   NPC1_CAEEL Niemann-Pick C1 protein homolog 1 ...13216e-96     341     24     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0042632; P:cholesterol homeostasis; IMP:WormBase.::GO:0030301; P:cholesterol transport; IMP:WormBase.::GO:0040024; P:dauer larval development; IGI:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0046662; P:regulation of oviposition; IMP:WormBase.
9P34389    1274   NPC2_CAEEL Niemann-Pick C1 protein homolog 2 ...12476e-82     297     24     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0042632; P:cholesterol homeostasis; IGI:WormBase.::GO:0030301; P:cholesterol transport; IGI:WormBase.::GO:0040024; P:dauer larval development; IGI:WormBase.::GO:0040025; P:vulval development; IGI:WormBase.
10Q0EEE2    906   PTHD3_MOUSE Patched domain-containing protein...8336e-30     132     20     40GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
11Q90693    1442   PTC1_CHICK Protein patched homolog 1 OS=Gallu...5030.000005     55.1     22     39GO:0005887; C:integral to plasma membrane; NAS:Roslin.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0007224; P:smoothened signaling pathway; NAS:Roslin.
12Q13635    1447   PTC1_HUMAN Protein patched homolog 1 OS=Homo ...900.011     43.9     30     52GO:0005901; C:caveola; IDA:BHF-UCL.::GO:0005887; C:integral to plasma membrane; ISS:BHF-UCL.::GO:0043231; C:intracellular membrane-bounded organelle; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0015485; F:cholesterol binding; IDA:BHF-UCL.::GO:0030332; F:cyclin binding; IPI:BHF-UCL.::GO:0097108; F:hedgehog family protein binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; IEA:InterPro.::GO:0005119; F:smoothened binding; IPI:BHF-UCL.
GO:0007420; P:brain development; ISS:BHF-UCL.::GO:0071397; P:cellular response to cholesterol; IMP:BHF-UCL.::GO:0030326; P:embryonic limb morphogenesis; ISS:UniProtKB.::GO:0040015; P:negative regulation of multicellular organism growth; ISS:UniProtKB.::GO:0045668; P:negative regulation of osteoblast differentiation; IMP:BHF-UCL.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:BHF-UCL.::GO:0045879; P:negative regulation of smoothened signaling pathway; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0021997; P:neural plate axis specification; ISS:BHF-UCL.::GO:0060037; P:pharyngeal system development; IMP:BHF-UCL.::GO:0010875; P:positive regulation of cholesterol efflux; IDA:BHF-UCL.::GO:0016485; P:protein processing; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; IDA:BHF-UCL.::GO:0007224; P:smoothened signaling pathway; IEP:UniProtKB.::GO:0061053; P:somite development; IMP:BHF-UCL.
13Q61115    1434   PTC1_MOUSE Protein patched homolog 1 OS=Mus m...5160.0000000008     67.4     23     39GO:0005576; C:extracellular region; TAS:Roslin.::GO:0005887; C:integral to plasma membrane; TAS:MGI.::GO:0030496; C:midbody; IDA:UniProtKB.
GO:0015485; F:cholesterol binding; TAS:Roslin.::GO:0030332; F:cyclin binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; TAS:MGI.::GO:0008201; F:heparin binding; IDA:Roslin.::GO:0005113; F:patched binding; IDA:Roslin.::GO:0032403; F:protein complex binding; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; NAS:Roslin.
GO:0007420; P:brain development; IMP:BHF-UCL.::GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.::GO:0061005; P:cell differentiation involved in kidney development; IGI:MGI.::GO:0072203; P:cell proliferation involved in metanephros development; IMP:MGI.::GO:0071397; P:cellular response to cholesterol; IEP:BHF-UCL.::GO:0021904; P:dorsal/ventral neural tube patterning; IMP:MGI.::GO:0030326; P:embryonic limb morphogenesis; IMP:MGI.::GO:0008544; P:epidermis development; IMP:MGI.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0003007; P:heart morphogenesis; IMP:MGI.::GO:0035137; P:hindlimb morphogenesis; IMP:MGI.::GO:0043616; P:keratinocyte proliferation; IMP:MGI.::GO:0060603; P:mammary gland duct morphogenesis; IMP:MGI.::GO:0060644; P:mammary gland epithelial cell differentiation; IMP:MGI.::GO:0051782; P:negative regulation of cell division; IMP:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:MGI.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:MGI.::GO:0045879; P:negative regulation of smoothened signaling pathway; IGI:BHF-UCL.::GO:0021997; P:neural plate axis specification; IMP:BHF-UCL.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0016485; P:protein processing; IMP:MGI.::GO:0007346; P:regulation of mitotic cell cycle; IMP:MGI.::GO:0032880; P:regulation of protein localization; IDA:BHF-UCL.::GO:0010157; P:response to chlorate; IDA:MGI.::GO:0007224; P:smoothened signaling pathway; IDA:MGI.::GO:0061053; P:somite development; IMP:BHF-UCL.
14Q9Y6C5    1203   PTC2_HUMAN Protein patched homolog 2 OS=Homo ...4040.0006     48.1     22     38GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0097108; F:hedgehog family protein binding; IPI:BHF-UCL.::GO:0008158; F:hedgehog receptor activity; TAS:BHF-UCL.::GO:0005119; F:smoothened binding; IPI:BHF-UCL.
GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL.
15O35595    1182   PTC2_MOUSE Protein patched homolog 2 OS=Mus m...1310.0006     48.1     27     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0042633; P:hair cycle; IMP:MGI.::GO:0043588; P:skin development; IMP:MGI.
16Q3KNS1    767   PTHD3_HUMAN Patched domain-containing protein...3643e-16     88.2     23     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0007286; P:spermatid development; NAS:UniProtKB.
17Q98864    1220   PTC1_DANRE Protein patched homolog 1 OS=Danio...4050.00002     52.8     21     38GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
18Q12770    1279   SCAP_HUMAN Sterol regulatory element-binding ...2260.0000000000001     80.1     25     51GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; NAS:UniProtKB.
GO:0051082; F:unfolded protein binding; NAS:UniProtKB.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0045541; P:negative regulation of cholesterol biosynthetic process; NAS:UniProtKB.::GO:0045716; P:positive regulation of low-density lipoprotein particle receptor biosynthetic process; NAS:UniProtKB.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; IMP:UniProtKB.
19Q5MNU5    1279   SCAP_PIG Sterol regulatory element-binding pr...2260.0000000000001     79.7     25     51GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
20A6QM06    1278   SCAP_BOVIN Sterol regulatory element-binding ...2250.0000000000001     79.7     24     51GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
21Q6GQT6    1276   SCAP_MOUSE Sterol regulatory element-binding ...2100.0000000000003     78.6     26     52GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0015485; F:cholesterol binding; TAS:MGI.::GO:0005515; F:protein binding; IPI:MGI.
GO:0008203; P:cholesterol metabolic process; IDA:MGI.::GO:0045540; P:regulation of cholesterol biosynthetic process; IMP:MGI.::GO:0042304; P:regulation of fatty acid biosynthetic process; IMP:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0032868; P:response to insulin stimulus; IMP:MGI.
22A0JPH4    1311   SCAP_XENLA Sterol regulatory element-binding ...4610.0000000000003     78.6     23     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
23A2RRU4    1276   SCAP_RAT Sterol regulatory element-binding pr...2100.0000000000009     77     26     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.
GO:0007568; P:aging; IEP:RGD.::GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
24P97260    1276   SCAP_CRIGR Sterol regulatory element-binding ...2090.000000000001     76.3     25     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.
GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.::GO:0006994; P:positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway; ISS:UniProtKB.::GO:0006993; P:sterol regulatory element binding protein import into nucleus involved in sterol depletion response; IMP:UniProtKB.
25Q09614    1408   PTC1_CAEEL Protein patched homolog 1 OS=Caeno...2050.00000003     62.4     26     46GO:0005887; C:integral to plasma membrane; IDA:WormBase.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.
26P18502    1286   PTC_DROME Protein patched OS=Drosophila melan...2020.0000000007     67.4     25     46GO:0030139; C:endocytic vesicle; IDA:FlyBase.::GO:0005887; C:integral to plasma membrane; TAS:FlyBase.::GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
GO:0008158; F:hedgehog receptor activity; IMP:FlyBase.::GO:0030228; F:lipoprotein particle receptor activity; IDA:FlyBase.::GO:0005515; F:protein binding; IPI:FlyBase.
GO:0048099; P:anterior/posterior lineage restriction, imaginal disc; TAS:FlyBase.::GO:0007411; P:axon guidance; IMP:FlyBase.::GO:0001746; P:Bolwig's organ morphogenesis; IMP:FlyBase.::GO:0016311; P:dephosphorylation; TAS:FlyBase.::GO:0035225; P:determination of genital disc primordium; IMP:FlyBase.::GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase.::GO:0042078; P:germ-line stem cell division; TAS:FlyBase.::GO:0008406; P:gonad development; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0055088; P:lipid homeostasis; IMP:FlyBase.::GO:0045879; P:negative regulation of smoothened signaling pathway; IGI:FlyBase.::GO:0030707; P:ovarian follicle cell development; TAS:FlyBase.::GO:0007422; P:peripheral nervous system development; TAS:FlyBase.::GO:0006508; P:proteolysis; TAS:FlyBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:FlyBase.::GO:0042306; P:regulation of protein import into nucleus; IMP:FlyBase.::GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.::GO:0007224; P:smoothened signaling pathway; IMP:FlyBase.::GO:0048103; P:somatic stem cell division; TAS:FlyBase.::GO:0048100; P:wing disc anterior/posterior pattern formation; TAS:FlyBase.
27B9EKX1    904   PTHD4_MOUSE Patched domain-containing protein...2230.0002     49.7     22     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
28Q6ZW05    846   PTHD4_HUMAN Patched domain-containing protein...2320.00007     50.8     23     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
29Q5RIV7    897   PTHD1_DANRE Patched domain-containing protein...7350.0000007     57.8     19     39GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008158; F:hedgehog receptor activity; IEA:InterPro.
30Q03602    844   PTR9_CAEEL Patched-related protein 9 OS=Caeno...2040.0003     48.9     24     42GO:0016021; C:integral to membrane; IEA:InterPro.
GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.
31Q12649    1176   HMDH_PHYBL 3-hydroxy-3-methylglutaryl-coenzym...2110.0006     48.1     23     46GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.
GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
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