rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P54839 | 491 | HMCS_YEAST Hydroxymethylglutaryl-CoA synthase... | 473 | 0 | 570 | 59 | 74 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:SGD. | | | | | | | | | | GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 2 | P54874 | 447 | HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase... | 475 | 0 | 551 | 57 | 71 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005783; C:endoplasmic reticulum; IC:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:PomBase. | | | | | | | | | | GO:0006084; P:acetyl-CoA metabolic process; IMP:PomBase.::GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IMP:PomBase.::GO:0070317; P:negative regulation of G0 to G1 transition; IMP:PomBase. | 3 | Q5R7Z9 | 520 | HMCS1_PONAB Hydroxymethylglutaryl-CoA synthas... | 477 | 1e-164 | 483 | 52 | 69 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 4 | Q8JZK9 | 520 | HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthas... | 477 | 1e-164 | 483 | 52 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 5 | P54872 | 482 | HMCSA_DICDI Hydroxymethylglutaryl-CoA synthas... | 470 | 1e-164 | 481 | 50 | 68 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 6 | Q01581 | 520 | HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthas... | 477 | 2e-164 | 481 | 52 | 68 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; TAS:ProtInc. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 7 | P17425 | 520 | HMCS1_RAT Hydroxymethylglutaryl-CoA synthase,... | 477 | 5e-164 | 481 | 52 | 68 | GO:0005829; C:cytosol; IDA:RGD. | | | | | | | | | | GO:0008144; F:drug binding; IDA:RGD.::GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD.::GO:0016853; F:isomerase activity; IDA:RGD.::GO:0043177; F:organic acid binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD. | | | | | | | | | | GO:0007420; P:brain development; IEP:RGD.::GO:0071397; P:cellular response to cholesterol; IEP:RGD.::GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0001889; P:liver development; IEP:RGD.::GO:0008584; P:male gonad development; IEP:RGD.::GO:0001101; P:response to acid; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0055094; P:response to lipoprotein stimulus; IEP:RGD.::GO:0009645; P:response to low light intensity stimulus; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IDA:RGD.::GO:0014074; P:response to purine-containing compound; IEP:RGD.::GO:0046690; P:response to tellurium ion; IEP:RGD.::GO:0033197; P:response to vitamin E; IEP:RGD. | 8 | P23228 | 522 | HMCS1_CHICK Hydroxymethylglutaryl-CoA synthas... | 482 | 7e-164 | 480 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 9 | P13704 | 520 | HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthas... | 477 | 3e-163 | 479 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 10 | P54961 | 453 | HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthas... | 477 | 4e-160 | 468 | 50 | 67 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 11 | Q86HL5 | 468 | HMCSB_DICDI Hydroxymethylglutaryl-CoA synthas... | 496 | 2e-155 | 457 | 48 | 65 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 12 | Q2KIE6 | 508 | HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthas... | 477 | 5e-154 | 455 | 48 | 68 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 13 | P54869 | 508 | HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthas... | 477 | 7e-153 | 452 | 48 | 67 | GO:0005743; C:mitochondrial inner membrane; IDA:MGI. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 14 | P22791 | 508 | HMCS2_RAT Hydroxymethylglutaryl-CoA synthase,... | 477 | 4e-151 | 447 | 47 | 67 | GO:0005759; C:mitochondrial matrix; IDA:RGD. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD. | | | | | | | | | | GO:0060612; P:adipose tissue development; IEP:RGD.::GO:0007420; P:brain development; IEP:RGD.::GO:0071230; P:cellular response to amino acid stimulus; IEP:RGD.::GO:0071398; P:cellular response to fatty acid; IEP:RGD.::GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; IEP:RGD.::GO:0001822; P:kidney development; IEP:RGD.::GO:0001889; P:liver development; IEP:RGD.::GO:0030324; P:lung development; IEP:RGD.::GO:0007494; P:midgut development; IEP:RGD.::GO:0033555; P:multicellular organismal response to stress; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0033762; P:response to glucagon stimulus; IEP:RGD.::GO:0060416; P:response to growth hormone stimulus; IEP:RGD.::GO:0070543; P:response to linoleic acid; IEP:RGD.::GO:0010038; P:response to metal ion; IEP:RGD.::GO:0034284; P:response to monosaccharide stimulus; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.::GO:0034696; P:response to prostaglandin F stimulus; IEP:RGD.::GO:0042594; P:response to starvation; IEP:RGD.::GO:0009266; P:response to temperature stimulus; IEP:RGD.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0034014; P:response to triglyceride; IEP:RGD. | 15 | O02734 | 508 | HMCS2_PIG Hydroxymethylglutaryl-CoA synthase,... | 477 | 1e-150 | 446 | 47 | 67 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 16 | P54868 | 508 | HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthas... | 477 | 4e-149 | 442 | 46 | 67 | GO:0005759; C:mitochondrial matrix; TAS:Reactome. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; TAS:Reactome. | 17 | P54870 | 455 | HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthas... | 481 | 8e-149 | 439 | 48 | 65 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 18 | P54873 | 461 | HMCS_ARATH Hydroxymethylglutaryl-CoA synthase... | 481 | 1e-144 | 429 | 47 | 62 | GO:0005829; C:cytosol; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IGI:TAIR. | | | | | | | | | | GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; TAS:TAIR.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 19 | P54871 | 462 | HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase... | 474 | 7e-90 | 288 | 37 | 54 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 20 | P40830 | 420 | PKSG_BACSU Polyketide biosynthesis 3-hydroxy-... | 436 | 0.000000000001 | 73.2 | 23 | 39 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro. | | | | | | | | | | GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 21 | A1RSQ5 | 350 | Y811_PYRIL UPF0219 protein Pisl_0811 OS=Pyrob... | 153 | 0.00007 | 48.5 | 29 | 48 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 22 | O26883 | 346 | Y792_METTH UPF0219 protein MTH_792 OS=thermoa... | 429 | 0.0006 | 45.4 | 22 | 33 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 23 | Q4J933 | 348 | Y1362_SULAC UPF0219 protein Saci_1362 OS=NBRC... | 195 | 0.0007 | 45.4 | 27 | 45 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 24 | O58410 | 350 | Y677_PYRHO UPF0219 protein PH0677 OS=NBRC 100... | 433 | 0.004 | 42.7 | 22 | 36 | | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.] | 25 | Q8ZVP4 | 350 | Y2185_PYRAE UPF0219 protein PAE2185 OS=/ NBRC... | 83 | 0.005 | 42.7 | 33 | 51 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 26 | A3MV40 | 350 | Y1082_PYRCJ UPF0219 protein Pcal_1082 OS=Pyro... | 84 | 0.005 | 42.7 | 30 | 51 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 27 | C5A401 | 350 | Y461_THEGJ UPF0219 protein TGAM_0461 OS=Therm... | 196 | 0.006 | 42.4 | 25 | 43 | | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.] | 28 | Q46F10 | 349 | Y551_METBF UPF0219 protein Mbar_A0551 OS=Meth... | 168 | 0.006 | 42.4 | 26 | 40 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 29 | Q2NHU7 | 346 | Y117_METST UPF0219 protein Msp_0117 OS=Methan... | 205 | 0.009 | 42 | 25 | 41 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 30 | Q6GIA4 | 313 | FABH_STAAR 3-oxoacyl-[acyl-carrier-protein] s... | 195 | 0.02 | 40.8 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.::GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.] | 31 | P99159 | 313 | FABH_STAAN 3-oxoacyl-[acyl-carrier-protein] s... | 195 | 0.02 | 40.8 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro.::GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.] |