| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O13819 | 559 | YMR1_SCHPO Phosphoinositide 3-phosphatase OS=... | 685 | 5e-151 | 459 | 38 | 52 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:PomBase.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0048017; P:inositol lipid-mediated signaling; ISS:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0016192; P:vesicle-mediated transport; ISS:PomBase. | 2 | P47147 | 688 | YMR1_YEAST Phosphoinositide 3-phosphatase OS=... | 743 | 5e-118 | 378 | 35 | 48 | GO:0005737; C:cytoplasm; IDA:SGD. | | | | | | | | | | GO:0003729; F:mRNA binding; IDA:SGD.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IMP:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:UniProtKB. | 3 | Q9Z2C9 | 660 | MTMR7_MOUSE Myotubularin-related protein 7 OS... | 83 | 1e-17 | 90.9 | 48 | 65 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI. | 4 | Q9Y216 | 660 | MTMR7_HUMAN Myotubularin-related protein 7 OS... | 130 | 4e-19 | 95.5 | 39 | 58 | | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. | | | | | | | | | | | 5 | Q5R6F6 | 660 | MTMR7_PONAB Myotubularin-related protein 7 OS... | 127 | 3e-19 | 96.3 | 38 | 55 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 6 | Q8VE11 | 617 | MTMR6_MOUSE Myotubularin-related protein 6 OS... | 130 | 2e-17 | 90.5 | 36 | 58 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 7 | Q9Y217 | 621 | MTMR6_HUMAN Myotubularin-related protein 6 OS... | 83 | 2e-16 | 87.4 | 48 | 67 | GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0015269; F:calcium-activated potassium channel activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; NAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; NAS:UniProtKB. | | | | | | | | | | | 8 | Q5F452 | 629 | MTMR8_CHICK Myotubularin-related protein 8 OS... | 126 | 9e-19 | 94.4 | 39 | 54 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 9 | Q6TEL0 | 632 | MTMR8_DANRE Myotubularin-related protein 8 OS... | 226 | 2e-19 | 97.1 | 31 | 45 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 10 | Q96EF0 | 704 | MTMR8_HUMAN Myotubularin-related protein 8 OS... | 126 | 9e-20 | 97.8 | 39 | 55 | GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 11 | Q8K296 | 1196 | MTMR3_MOUSE Myotubularin-related protein 3 OS... | 106 | 3e-16 | 87 | 43 | 57 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB. | 12 | Q9NYA4 | 1195 | MTMR4_HUMAN Myotubularin-related protein 4 OS... | 92 | 0.000000000000007 | 82.8 | 47 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:ProtInc. | | | | | | | | | | | 13 | Q13614 | 643 | MTMR2_HUMAN Myotubularin-related protein 2 OS... | 80 | 2e-17 | 90.5 | 53 | 68 | GO:0030424; C:axon; ISS:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:BHF-UCL.::GO:0097060; C:synaptic membrane; ISS:BHF-UCL.::GO:0008021; C:synaptic vesicle; ISS:BHF-UCL. | | | | | | | | | | GO:0004437; F:inositol or phosphatidylinositol phosphatase activity; TAS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; NAS:UniProtKB. | | | | | | | | | | GO:0097062; P:dendritic spine maintenance; ISS:BHF-UCL.::GO:0090394; P:negative regulation of excitatory postsynaptic membrane potential; ISS:BHF-UCL.::GO:2000645; P:negative regulation of receptor catabolic process; ISS:BHF-UCL.::GO:0002091; P:negative regulation of receptor internalization; ISS:BHF-UCL.::GO:2000643; P:positive regulation of early endosome to late endosome transport; ISS:BHF-UCL. | 14 | Q5PQT2 | 1194 | MTMR3_RAT Myotubularin-related protein 3 OS=R... | 106 | 6e-16 | 86.3 | 43 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB. | 15 | Q5REB9 | 643 | MTMR2_PONAB Myotubularin-related protein 2 OS... | 80 | 2e-17 | 90.5 | 53 | 68 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 16 | Q9Z2D1 | 643 | MTMR2_MOUSE Myotubularin-related protein 2 OS... | 80 | 1e-17 | 91.3 | 54 | 68 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005774; C:vacuolar membrane; IDA:MGI. | | | | | | | | | | GO:0042803; F:protein homodimerization activity; IPI:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:MGI.::GO:0051262; P:protein tetramerization; IPI:MGI. | 17 | Q5ZIV1 | 571 | MTMR2_CHICK Myotubularin-related protein 2 OS... | 80 | 6e-18 | 91.7 | 53 | 69 | | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 18 | Q91XS1 | 1190 | MTMR4_MOUSE Myotubularin-related protein 4 OS... | 87 | 0.00000000000001 | 82 | 48 | 59 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | | 19 | A6QLT2 | 643 | MTMR2_BOVIN Myotubularin-related protein 2 OS... | 80 | 2e-17 | 90.1 | 53 | 66 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 20 | Q13615 | 1198 | MTMR3_HUMAN Myotubularin-related protein 3 OS... | 106 | 8e-16 | 85.9 | 43 | 55 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:UniProtKB. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB. | 21 | Q7ZXF1 | 1078 | MTMR4_XENLA Myotubularin-related protein 4 OS... | 84 | 0.0000000000001 | 78.6 | 46 | 57 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | | 22 | A0JMK5 | 620 | MTMR2_DANRE Myotubularin-related protein 2 OS... | 80 | 7e-17 | 88.6 | 48 | 69 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 23 | Q52KU6 | 602 | MTM1_XENLA Myotubularin OS=Xenopus laevis (Af... | 97 | 1e-17 | 90.9 | 44 | 63 | GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 24 | Q13613 | 665 | MTMR1_HUMAN Myotubularin-related protein 1 OS... | 80 | 4e-16 | 86.3 | 46 | 66 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 25 | Q9Z2C5 | 603 | MTM1_MOUSE Myotubularin OS=Mus musculus (Mous... | 97 | 7e-17 | 88.6 | 44 | 62 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.::GO:0046716; P:muscle cell homeostasis; IMP:MGI.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 26 | Q5R9S3 | 603 | MTM1_PONAB Myotubularin OS=Pongo abelii (Suma... | 97 | 3e-18 | 92.4 | 46 | 63 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. | 27 | Q13496 | 603 | MTM1_HUMAN Myotubularin OS=Homo sapiens (Huma... | 97 | 4e-18 | 92.4 | 46 | 63 | GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0005770; C:late endosome; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; IDA:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; IDA:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; IDA:UniProtKB.::GO:0045109; P:intermediate filament organization; IMP:UniProtKB.::GO:0048311; P:mitochondrion distribution; IMP:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; IDA:UniProtKB. | 28 | Q5EB32 | 602 | MTM1_XENTR Myotubularin OS=Xenopus tropicalis... | 97 | 4e-18 | 92.4 | 44 | 64 | GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0005770; C:late endosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IEA:EC.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 29 | Q22712 | 1006 | MTMR3_CAEEL Myotublarin-related protein 3 OS=... | 150 | 0.0000000003 | 67.8 | 31 | 47 | | | | | | | | | | | GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:WormBase.::GO:0008289; F:lipid binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:WormBase.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC. | | | | | | | | | | GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0040002; P:collagen and cuticulin-based cuticle development; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:WormBase.::GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0045807; P:positive regulation of endocytosis; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0040017; P:positive regulation of locomotion; IMP:WormBase.::GO:0046662; P:regulation of oviposition; IMP:WormBase. | 30 | Q9Z2C4 | 669 | MTMR1_MOUSE Myotubularin-related protein 1 OS... | 80 | 3e-16 | 86.7 | 46 | 66 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IDA:MGI.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | | 31 | Q6AXQ4 | 602 | MTM1_RAT Myotubularin OS=Rattus norvegicus (R... | 99 | 4e-17 | 89.4 | 43 | 61 | GO:0030175; C:filopodium; ISS:UniProtKB.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0019215; F:intermediate filament binding; ISS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0052629; F:phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; ISS:UniProtKB.::GO:0004438; F:phosphatidylinositol-3-phosphatase activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. | | | | | | | | | | GO:0008333; P:endosome to lysosome transport; ISS:UniProtKB.::GO:0045109; P:intermediate filament organization; ISS:UniProtKB.::GO:0048311; P:mitochondrion distribution; ISS:UniProtKB.::GO:0070584; P:mitochondrion morphogenesis; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0044088; P:regulation of vacuole organization; ISS:UniProtKB. |
