| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q9VUC6 | 1183 | Y2138_DROME Formin-like protein CG32138 OS=Dr... | 47 | 0.21 | 35 | 40 | 47 | | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. | 2 | O75962 | 3097 | TRIO_HUMAN Triple functional domain protein O... | 136 | 0.37 | 34.7 | 27 | 41 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc. | 3 | P19158 | 3079 | IRA2_YEAST Inhibitory regulator protein IRA2 ... | 127 | 0.4 | 34.3 | 25 | 43 | GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IDA:SGD. | | | | | | | | | | GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0006950; P:response to stress; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 4 | P35991 | 659 | BTK_MOUSE Tyrosine-protein kinase BTK OS=Mus ... | 42 | 0.74 | 33.5 | 43 | 52 | GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048469; P:cell maturation; IMP:MGI.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IMP:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 5 | Q12514 | 560 | NOT5_YEAST General negative regulator of tran... | 80 | 0.75 | 33.5 | 33 | 45 | GO:0030015; C:CCR4-NOT core complex; IPI:SGD.::GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0031087; P:deadenylation-independent decapping of nuclear-transcribed mRNA; IMP:SGD.::GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IDA:SGD.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IDA:SGD.::GO:0016567; P:protein ubiquitination; IMP:SGD.::GO:0006368; P:transcription elongation from RNA polymerase II promoter; IMP:SGD. | 6 | P14248 | 2452 | RPB1_PLAFD DNA-directed RNA polymerase II sub... | 103 | 1.1 | 33.1 | 28 | 42 | GO:0005665; C:DNA-directed RNA polymerase II, core complex; IEA:InterPro. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006366; P:transcription from RNA polymerase II promoter; IEA:InterPro. | 7 | Q14524 | 2016 | SCN5A_HUMAN Sodium channel protein type 5 sub... | 65 | 2.2 | 32 | 35 | 40 | GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0042383; C:sarcolemma; IDA:BHF-UCL.::GO:0001518; C:voltage-gated sodium channel complex; IC:BHF-UCL. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005248; F:voltage-gated sodium channel activity; IDA:UniProtKB. | | | | | | | | | | GO:0008015; P:blood circulation; NAS:ProtInc.::GO:0061337; P:cardiac conduction; IMP:BHF-UCL.::GO:0071277; P:cellular response to calcium ion; IDA:UniProtKB.::GO:0045760; P:positive regulation of action potential; IDA:BHF-UCL.::GO:0060452; P:positive regulation of cardiac muscle contraction; IMP:BHF-UCL.::GO:0060371; P:regulation of atrial cardiomyocyte membrane depolarization; TAS:BHF-UCL.::GO:0060372; P:regulation of atrial cardiomyocyte membrane repolarization; TAS:BHF-UCL.::GO:0002027; P:regulation of heart rate; IMP:BHF-UCL.::GO:0060373; P:regulation of ventricular cardiomyocyte membrane depolarization; TAS:BHF-UCL.::GO:0060307; P:regulation of ventricular cardiomyocyte membrane repolarization; TAS:BHF-UCL. | 8 | A2AAJ9 | 8891 | OBSCN_MOUSE Obscurin OS=Mus musculus (Mouse).... | 90 | 3.8 | 31.6 | 28 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 9 | O42130 | 1553 | TOP2A_CHICK DNA topoisomerase 2-alpha OS=Gall... | 115 | 3.9 | 31.2 | 25 | 40 | GO:0009330; C:DNA topoisomerase complex (ATP-hydrolyzing); ISS:AgBase.::GO:0005654; C:nucleoplasm; ISS:AgBase.::GO:0000795; C:synaptonemal complex; IBA:RefGenome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003682; F:chromatin binding; IBA:RefGenome.::GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; ISS:AgBase.::GO:0008144; F:drug binding; ISS:AgBase.::GO:0042826; F:histone deacetylase binding; IBA:RefGenome.::GO:0005080; F:protein kinase C binding; IBA:RefGenome. | | | | | | | | | | GO:0030263; P:apoptotic chromosome condensation; ISS:AgBase.::GO:0006266; P:DNA ligation; ISS:AgBase.::GO:0006265; P:DNA topological change; IBA:RefGenome.::GO:0006261; P:DNA-dependent DNA replication; IBA:RefGenome.::GO:0070683; P:mitotic cell cycle G2/M transition decatenation checkpoint; IBA:RefGenome.::GO:0006312; P:mitotic recombination; IBA:RefGenome.::GO:0043065; P:positive regulation of apoptotic process; ISS:AgBase.::GO:0000712; P:resolution of meiotic recombination intermediates; IBA:RefGenome.::GO:0006974; P:response to DNA damage stimulus; ISS:AgBase.::GO:0000819; P:sister chromatid segregation; IBA:RefGenome. | 10 | Q5RAB8 | 1045 | FARP1_PONAB FERM, RhoGEF and pleckstrin domai... | 44 | 4.6 | 31.2 | 34 | 48 | GO:0005737; C:cytoplasm; IEA:InterPro.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0019898; C:extrinsic to membrane; IEA:InterPro. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0010923; P:negative regulation of phosphatase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 11 | P48994 | 1124 | TRPL_DROME Transient-receptor-potential-like ... | 129 | 5.2 | 30.8 | 24 | 42 | GO:0016027; C:inaD signaling complex; IPI:UniProtKB.::GO:0016021; C:integral to membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; IDA:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IPI:UniProtKB.::GO:0015279; F:store-operated calcium channel activity; NAS:FlyBase. | | | | | | | | | | GO:0007589; P:body fluid secretion; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; IMP:FlyBase.::GO:0071454; P:cellular response to anoxia; IGI:FlyBase.::GO:0050908; P:detection of light stimulus involved in visual perception; ISS:UniProtKB. | 12 | O88508 | 908 | DNM3A_MOUSE DNA (cytosine-5)-methyltransferas... | 53 | 5.8 | 30.8 | 34 | 45 | GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0000791; C:euchromatin; ISS:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:MGI.::GO:0016363; C:nuclear matrix; ISS:UniProtKB. | | | | | | | | | | GO:0003682; F:chromatin binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.::GO:0043045; P:DNA methylation involved in embryo development; IMP:UniProtKB.::GO:0043046; P:DNA methylation involved in gamete generation; IMP:UniProtKB.::GO:0044027; P:hypermethylation of CpG island; IDA:BHF-UCL.::GO:0010216; P:maintenance of DNA methylation; TAS:BHF-UCL.::GO:0006346; P:methylation-dependent chromatin silencing; IDA:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0006349; P:regulation of gene expression by genetic imprinting; IMP:MGI.::GO:0007283; P:spermatogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 13 | Q9P219 | 2028 | DAPLE_HUMAN Protein Daple OS=Homo sapiens (Hu... | 137 | 7 | 30.8 | 28 | 42 | GO:0005737; C:cytoplasm; IEA:InterPro.::GO:0005626; C:insoluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0008017; F:microtubule binding; IEA:InterPro.::GO:0030165; F:PDZ domain binding; ISS:UniProtKB.::GO:0043621; F:protein self-association; ISS:UniProtKB. | | | | | | | | | | GO:0000226; P:microtubule cytoskeleton organization; IEA:InterPro.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 14 | P37088 | 669 | SCNNA_HUMAN Amiloride-sensitive sodium channe... | 62 | 9.9 | 30 | 31 | 45 | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.::GO:0050699; F:WW domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0007588; P:excretion; TAS:ProtInc.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0050909; P:sensory perception of taste; IEA:UniProtKB-KW. |
