rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q757T0 | 839 | HUL4_ASHGO Probable E3 ubiquitin-protein liga... | 447 | 3e-34 | 145 | 26 | 45 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 2 | Q05086 | 875 | UBE3A_HUMAN Ubiquitin-protein ligase E3A OS=H... | 185 | 2e-27 | 124 | 39 | 61 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007420; P:brain development; TAS:ProtInc.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 3 | O08759 | 885 | UBE3A_MOUSE Ubiquitin-protein ligase E3A OS=M... | 182 | 3e-26 | 120 | 40 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000502; C:proteasome complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB. | 4 | Q15034 | 1050 | HERC3_HUMAN Probable E3 ubiquitin-protein lig... | 299 | 1e-22 | 108 | 31 | 50 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 5 | Q5U5R9 | 776 | HECD2_HUMAN Probable E3 ubiquitin-protein lig... | 190 | 5e-24 | 113 | 35 | 56 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 6 | Q5RD78 | 776 | HECD2_PONAB Probable E3 ubiquitin-protein lig... | 190 | 3e-24 | 113 | 35 | 56 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro. | | | | | | | | | | GO:0006464; P:protein modification process; IEA:InterPro. | 7 | Q8CDU6 | 774 | HECD2_MOUSE Probable E3 ubiquitin-protein lig... | 190 | 1e-24 | 115 | 35 | 56 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 8 | Q5GLZ8 | 1057 | HERC4_HUMAN Probable E3 ubiquitin-protein lig... | 301 | 6e-21 | 103 | 28 | 51 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB. | 9 | Q6PAV2 | 1057 | HERC4_MOUSE Probable E3 ubiquitin-protein lig... | 238 | 3e-26 | 120 | 31 | 53 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IMP:UniProtKB. | 10 | Q5PQN1 | 1057 | HERC4_RAT Probable E3 ubiquitin-protein ligas... | 238 | 1e-26 | 122 | 31 | 53 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB. | 11 | Q76N89 | 1606 | HECW1_HUMAN E3 ubiquitin-protein ligase HECW1... | 187 | 0.00000002 | 62.8 | 29 | 44 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 12 | Q6I6G8 | 1578 | HECW2_MOUSE E3 ubiquitin-protein ligase HECW2... | 192 | 0.0000000005 | 68.2 | 30 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 13 | Q9P2P5 | 1572 | HECW2_HUMAN E3 ubiquitin-protein ligase HECW2... | 190 | 0.0000000004 | 68.6 | 29 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 14 | Q9UII4 | 1024 | HERC5_HUMAN E3 ISG15--protein ligase HERC5 OS... | 166 | 4e-16 | 88.2 | 36 | 52 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042296; F:ISG15 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0032020; P:ISG15-protein conjugation; IDA:UniProtKB.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0000079; P:regulation of cyclin-dependent protein kinase activity; TAS:ProtInc.::GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB.::GO:0009615; P:response to virus; IEA:UniProtKB-KW. | 15 | Q8K4P8 | 1604 | HECW1_MOUSE E3 ubiquitin-protein ligase HECW1... | 186 | 0.00000002 | 62.8 | 28 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 16 | Q9VVI3 | 1007 | NEDD4_DROME E3 ubiquitin-protein ligase Nedd-... | 135 | 0.0000002 | 59.3 | 30 | 52 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005112; F:Notch binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IDA:FlyBase.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB. | | | | | | | | | | GO:0016199; P:axon midline choice point recognition; IMP:UniProtKB.::GO:0045746; P:negative regulation of Notch signaling pathway; IMP:UniProtKB.::GO:0007528; P:neuromuscular junction development; IMP:FlyBase.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0002092; P:positive regulation of receptor internalization; IMP:FlyBase.::GO:0051965; P:positive regulation of synapse assembly; IMP:FlyBase.::GO:0031623; P:receptor internalization; IMP:UniProtKB. | 17 | Q62940 | 887 | NEDD4_RAT E3 ubiquitin-protein ligase NEDD4 O... | 134 | 0.0000003 | 58.9 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005902; C:microvillus; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008022; F:protein C-terminus binding; IDA:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006955; P:immune response; IEP:RGD.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IDA:UniProtKB. | 18 | P46935 | 887 | NEDD4_MOUSE E3 ubiquitin-protein ligase NEDD4... | 133 | 0.0000001 | 60.5 | 29 | 53 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IPI:MGI. | | | | | | | | | | GO:0050815; F:phosphoserine binding; IDA:BHF-UCL.::GO:0050816; F:phosphothreonine binding; IDA:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI. | | | | | | | | | | GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; IDA:UniProtKB.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0048814; P:regulation of dendrite morphogenesis; IMP:UniProtKB. | 19 | Q5BDP1 | 821 | RSP5_EMENI E3 ubiquitin-protein ligase RSP5 O... | 181 | 0.0000002 | 59.7 | 26 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. | 20 | Q2UBP1 | 816 | RSP5_ASPOR Probable E3 ubiquitin-protein liga... | 189 | 0.00000005 | 61.6 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. | | | | | | | | | | | 21 | B8N7E5 | 812 | RSP5_ASPFN Probable E3 ubiquitin-protein liga... | 188 | 0.000000002 | 65.9 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. | | | | | | | | | | | 22 | Q8IVU3 | 1022 | HERC6_HUMAN Probable E3 ubiquitin-protein lig... | 146 | 0.00000000001 | 73.6 | 35 | 51 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 23 | P46934 | 1319 | NEDD4_HUMAN E3 ubiquitin-protein ligase NEDD4... | 124 | 0.000001 | 57 | 29 | 52 | GO:0016327; C:apicolateral plasma membrane; TAS:BHF-UCL.::GO:0005938; C:cell cortex; IDA:BHF-UCL.::GO:0000785; C:chromatin; IDA:BHF-UCL.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0000151; C:ubiquitin ligase complex; ISS:BHF-UCL. | | | | | | | | | | GO:0031698; F:beta-2 adrenergic receptor binding; IDA:UniProtKB.::GO:0050815; F:phosphoserine binding; ISS:BHF-UCL.::GO:0050816; F:phosphothreonine binding; ISS:BHF-UCL.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0070063; F:RNA polymerase binding; IPI:BHF-UCL.::GO:0019871; F:sodium channel inhibitor activity; IDA:BHF-UCL.::GO:0043130; F:ubiquitin binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0044111; P:development involved in symbiotic interaction; IMP:UniProtKB.::GO:0042921; P:glucocorticoid receptor signaling pathway; IDA:BHF-UCL.::GO:0010766; P:negative regulation of sodium ion transport; IDA:UniProtKB.::GO:0010768; P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage; IMP:BHF-UCL.::GO:0030948; P:negative regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0031175; P:neuron projection development; IEP:BHF-UCL.::GO:0046824; P:positive regulation of nucleocytoplasmic transport; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0045732; P:positive regulation of protein catabolic process; IDA:MGI.::GO:0050847; P:progesterone receptor signaling pathway; IDA:BHF-UCL.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0006622; P:protein targeting to lysosome; IDA:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0032801; P:receptor catabolic process; IDA:UniProtKB.::GO:0031623; P:receptor internalization; IDA:UniProtKB.::GO:0048814; P:regulation of dendrite morphogenesis; ISS:UniProtKB.::GO:0051592; P:response to calcium ion; TAS:BHF-UCL.::GO:0019089; P:transmission of virus; IMP:BHF-UCL.::GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IMP:BHF-UCL. | 24 | Q5RBF2 | 959 | NED4L_PONAB E3 ubiquitin-protein ligase NEDD4... | 180 | 0.000001 | 57 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro. | | | | | | | | | | | 25 | Q8CFI0 | 1004 | NED4L_MOUSE E3 ubiquitin-protein ligase NEDD4... | 180 | 0.000003 | 55.8 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0019871; F:sodium channel inhibitor activity; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0010766; P:negative regulation of sodium ion transport; IDA:MGI.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 26 | Q96PU5 | 975 | NED4L_HUMAN E3 ubiquitin-protein ligase NEDD4... | 180 | 0.000003 | 55.5 | 26 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; NAS:UniProtKB. | | | | | | | | | | GO:0006883; P:cellular sodium ion homeostasis; NAS:UniProtKB.::GO:0007588; P:excretion; NAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0045807; P:positive regulation of endocytosis; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0042176; P:regulation of protein catabolic process; NAS:UniProtKB.::GO:0010038; P:response to metal ion; IDA:UniProtKB.::GO:0006814; P:sodium ion transport; NAS:UniProtKB.::GO:0030104; P:water homeostasis; NAS:UniProtKB. | 27 | Q0CCL1 | 808 | RSP5_ASPTN Probable E3 ubiquitin-protein liga... | 188 | 0.000000002 | 65.9 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:UniProtKB. | 28 | A2QQ28 | 821 | RSP5_ASPNC Probable E3 ubiquitin-protein liga... | 188 | 0.000000004 | 65.1 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:UniProtKB. | 29 | Q4WTF3 | 813 | RSP5_ASPFU Probable E3 ubiquitin-protein liga... | 188 | 0.000000002 | 65.9 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:UniProtKB. | 30 | B0XQ72 | 813 | RSP5_ASPFC Probable E3 ubiquitin-protein liga... | 188 | 0.000000002 | 65.9 | 28 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB. | | | | | | | | | | GO:0043328; P:protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; ISS:UniProtKB. | 31 | Q1K9C4 | 1029 | YFK7_SCHPO Probable E3 ubiquitin protein liga... | 180 | 0.00000002 | 62.8 | 27 | 45 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005635; C:nuclear envelope; IDA:PomBase. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase. | | | | | | | | | | GO:0033554; P:cellular response to stress; IEP:PomBase.::GO:0030433; P:ER-associated protein catabolic process; ISS:PomBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:RefGenome. |