| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P16184 | 206 | DYR_PNECA Dihydrofolate reductase OS=Pneumocy... | 37 | 5.3 | 32.3 | 38 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 2 | P22906 | 192 | DYR_CANAX Dihydrofolate reductase OS=Candida ... | 77 | 0.00000000000005 | 73.9 | 43 | 65 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 3 | Q9U8B8 | 185 | DYR_HELVI Dihydrofolate reductase OS=Heliothi... | 73 | 0.0000000000002 | 72 | 45 | 68 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 4 | Q2QRX6 | 494 | DRTS_ORYSJ Putative bifunctional dihydrofolat... | 75 | 0.0000000000005 | 73.9 | 48 | 65 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 5 | O62583 | 205 | DYR_ENCCU Dihydrofolate reductase OS=Encephal... | 78 | 0.000000000001 | 69.7 | 47 | 67 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 6 | P07807 | 211 | DYR_YEAST Dihydrofolate reductase OS=Saccharo... | 72 | 0.000000000003 | 68.9 | 44 | 67 | GO:0005829; C:cytosol; TAS:SGD. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IMP:SGD.::GO:0003729; F:mRNA binding; IDA:SGD.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006760; P:folic acid-containing compound metabolic process; IMP:SGD.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 7 | P09503 | 187 | DYR_SHV21 Viral dihydrofolate reductase OS=Sa... | 75 | 0.000000000003 | 68.6 | 41 | 61 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 8 | Q27783 | 527 | DRTS_TRYBB Bifunctional dihydrofolate reducta... | 187 | 0.000000000003 | 71.2 | 33 | 41 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 9 | Q05762 | 519 | DRTS1_ARATH Bifunctional dihydrofolate reduct... | 74 | 0.000000000003 | 71.2 | 46 | 68 | GO:0005829; C:cytosol; IDA:TAIR. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 10 | P36591 | 461 | DYR_SCHPO Dihydrofolate reductase OS=Schizosa... | 125 | 0.000000000003 | 71.2 | 34 | 49 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004146; F:dihydrofolate reductase activity; IGI:PomBase.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006760; P:folic acid-containing compound metabolic process; ISS:PomBase.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 11 | P45350 | 528 | DRTS_DAUCA Bifunctional dihydrofolate reducta... | 77 | 0.000000000003 | 71.2 | 49 | 62 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 12 | P51820 | 530 | DRTS_SOYBN Bifunctional dihydrofolate reducta... | 94 | 0.00000000001 | 69.7 | 41 | 56 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 13 | Q93341 | 189 | DYR_CAEEL Putative dihydrofolate reductase OS... | 71 | 0.00000000001 | 66.6 | 46 | 62 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0000003; P:reproduction; IMP:WormBase. | 14 | O81395 | 521 | DRTS_MAIZE Bifunctional dihydrofolate reducta... | 97 | 0.00000000002 | 69.3 | 41 | 56 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 15 | Q27793 | 521 | DRTS_TRYCR Bifunctional dihydrofolate reducta... | 187 | 0.00000000004 | 67.8 | 30 | 43 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 16 | Q05763 | 565 | DRTS2_ARATH Bifunctional dihydrofolate reduct... | 86 | 0.00000000004 | 67.8 | 41 | 64 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 17 | P28019 | 186 | DYR_AEDAL Dihydrofolate reductase OS=Aedes al... | 75 | 0.00000000006 | 64.7 | 43 | 61 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 18 | P17719 | 182 | DYR_DROME Dihydrofolate reductase OS=Drosophi... | 71 | 0.00000000008 | 64.3 | 46 | 62 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IDA:FlyBase.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 19 | Q920D2 | 187 | DYR_RAT Dihydrofolate reductase OS=Rattus nor... | 75 | 0.0000000002 | 63.5 | 39 | 60 | GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0051871; F:dihydrofolic acid binding; IDA:RGD.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IDA:RGD. | | | | | | | | | | GO:0046452; P:dihydrofolate metabolic process; IDA:RGD.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0035094; P:response to nicotine; IEP:RGD.::GO:0046654; P:tetrahydrofolate biosynthetic process; IDA:RGD. | 20 | P00374 | 187 | DYR_HUMAN Dihydrofolate reductase OS=Homo sap... | 75 | 0.0000000004 | 62.4 | 39 | 61 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IDA:UniProtKB.::GO:0008144; F:drug binding; IDA:UniProtKB.::GO:0003729; F:mRNA binding; IDA:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0006545; P:glycine biosynthetic process; NAS:UniProtKB.::GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.::GO:0009165; P:nucleotide biosynthetic process; NAS:UniProtKB.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.::GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; TAS:Reactome.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:UniProtKB. | 21 | Q07801 | 229 | DYR_CRYNJ Dihydrofolate reductase OS=ATCC MYA... | 71 | 0.0000000004 | 62.8 | 49 | 66 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 22 | P04753 | 187 | DYR_MESAU Dihydrofolate reductase OS=Mesocric... | 75 | 0.0000000004 | 62 | 37 | 59 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB. | 23 | P00375 | 187 | DYR_MOUSE Dihydrofolate reductase OS=Mus musc... | 73 | 0.0000000005 | 62 | 40 | 60 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 24 | P00377 | 186 | DYR_PIG Dihydrofolate reductase OS=Sus scrofa... | 75 | 0.0000000006 | 61.6 | 39 | 60 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB. | 25 | P16126 | 520 | DRTS_LEIAM Bifunctional dihydrofolate reducta... | 70 | 0.000000001 | 63.5 | 47 | 64 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 26 | Q07422 | 610 | DRTS_TOXGO Bifunctional dihydrofolate reducta... | 236 | 0.000000001 | 63.5 | 26 | 38 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 27 | P00376 | 187 | DYR_BOVIN Dihydrofolate reductase OS=Bos taur... | 75 | 0.000000002 | 60.5 | 37 | 59 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB. | 28 | P00378 | 189 | DYR_CHICK Dihydrofolate reductase OS=Gallus g... | 75 | 0.000000002 | 60.1 | 37 | 60 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; ISS:UniProtKB.::GO:0008144; F:drug binding; ISS:UniProtKB.::GO:0003729; F:mRNA binding; ISS:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; ISS:UniProtKB. | 29 | P07382 | 520 | DRTS_LEIMA Bifunctional dihydrofolate reducta... | 70 | 0.000000004 | 61.6 | 44 | 63 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 30 | Q27713 | 587 | DRTS_PLABA Bifunctional dihydrofolate reducta... | 96 | 0.00000002 | 59.7 | 31 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 31 | P27421 | 186 | DYR_SHV24 Viral dihydrofolate reductase OS=sa... | 74 | 0.00000003 | 56.6 | 35 | 57 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |
