| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P27421 | 186 | DYR_SHV24 Viral dihydrofolate reductase OS=sa... | 74 | 0.00000003 | 56.6 | 35 | 57 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 32 | P22573 | 213 | DYR_SHV2C Viral dihydrofolate reductase OS=Sa... | 74 | 0.00000005 | 56.2 | 35 | 57 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 33 | P0A546 | 159 | DYR_MYCTU Dihydrofolate reductase OS=Mycobact... | 70 | 0.00000008 | 55.1 | 41 | 57 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IDA:MTBBASE.::GO:0070401; F:NADP+ binding; IDA:MTBBASE. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IDA:MTBBASE.::GO:0046654; P:tetrahydrofolate biosynthetic process; IDA:MTBBASE. | 34 | P0A547 | 159 | DYR_MYCBO Dihydrofolate reductase OS=Mycobact... | 70 | 0.00000008 | 55.1 | 41 | 57 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 35 | Q5UQG3 | 563 | DRTS_MIMIV Bifunctional dihydrofolate reducta... | 75 | 0.0000002 | 56.6 | 36 | 59 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 36 | P46103 | 182 | DRTS_PLAVN Bifunctional dihydrofolate reducta... | 92 | 0.0000002 | 53.9 | 29 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 37 | Q86XF0 | 187 | DYRL1_HUMAN Dihydrofolate reductase, mitochon... | 73 | 0.0000002 | 53.9 | 38 | 59 | GO:0005743; C:mitochondrial inner membrane; IMP:UniProtKB.::GO:0005759; C:mitochondrial matrix; IMP:UniProtKB. | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IMP:UniProtKB.::GO:0003729; F:mRNA binding; IDA:UniProtKB.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:UniProtKB.::GO:0046105; P:thymidine biosynthetic process; IDA:UniProtKB. | 38 | P13922 | 608 | DRTS_PLAFK Bifunctional dihydrofolate reducta... | 91 | 0.0000003 | 55.8 | 31 | 48 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 39 | O02604 | 623 | DRTS_PLAVI Bifunctional dihydrofolate reducta... | 101 | 0.000001 | 53.9 | 28 | 45 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 40 | Q9CBW1 | 165 | DYR_MYCLE Dihydrofolate reductase OS=Mycobact... | 70 | 0.000002 | 51.2 | 40 | 56 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 41 | P20712 | 583 | DRTS_PLACH Bifunctional dihydrofolate reducta... | 101 | 0.000002 | 53.1 | 27 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 42 | Q9JSQ9 | 162 | DYR_NEIMA Dihydrofolate reductase OS=Neisseri... | 72 | 0.000004 | 50.1 | 42 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 43 | Q9K168 | 162 | DYR_NEIMB Dihydrofolate reductase OS=Neisseri... | 72 | 0.000005 | 49.7 | 42 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 44 | P04174 | 162 | DYR_NEIGO Dihydrofolate reductase OS=Neisseri... | 72 | 0.000005 | 49.7 | 42 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. | 45 | Q23695 | 515 | DRTS_CRIFA Bifunctional dihydrofolate reducta... | 82 | 0.000005 | 52 | 41 | 59 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 46 | Q27828 | 462 | DRTS_PARTE Bifunctional dihydrofolate reducta... | 81 | 0.000007 | 51.2 | 33 | 54 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0004799; F:thymidylate synthase activity; IEA:EC. | | | | | | | | | | GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 47 | P11045 | 168 | DYR_BACSU Dihydrofolate reductase OS=Bacillus... | 69 | 0.0002 | 45.1 | 36 | 55 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 48 | P0ABQ8 | 169 | DYR8_SHISO Dihydrofolate reductase type 8 OS=... | 70 | 0.0004 | 44.3 | 39 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 49 | P0ABQ7 | 169 | DYR8_ECOLX Dihydrofolate reductase type 8 OS=... | 70 | 0.0004 | 44.3 | 39 | 50 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 50 | P47470 | 160 | DYR_MYCGE Dihydrofolate reductase OS=Mycoplas... | 75 | 0.001 | 42.7 | 33 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 51 | P31073 | 159 | DYR_CITFR Dihydrofolate reductase OS=Citrobac... | 69 | 0.003 | 41.6 | 35 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 52 | P43791 | 160 | DYR_HAEIN Dihydrofolate reductase OS=Haemophi... | 70 | 0.003 | 41.2 | 37 | 53 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW. | 53 | Q59487 | 168 | DYR_LACLA Dihydrofolate reductase OS=lactis).... | 83 | 0.003 | 41.6 | 31 | 48 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 54 | Q89AV2 | 164 | DYR_BUCBP Dihydrofolate reductase OS=Buchnera... | 80 | 0.004 | 41.2 | 30 | 54 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 55 | P0ABQ6 | 159 | DYR_SHIFL Dihydrofolate reductase OS=Shigella... | 69 | 0.005 | 40.8 | 35 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 56 | P0ABQ4 | 159 | DYR_ECOLI Dihydrofolate reductase OS=Escheric... | 69 | 0.005 | 40.8 | 35 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:EcoliWiki.::GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0042493; P:response to drug; IDA:EcoliWiki.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 57 | P0ABQ5 | 159 | DYR_ECOL6 Dihydrofolate reductase OS=Escheric... | 69 | 0.005 | 40.8 | 35 | 52 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 58 | P12833 | 162 | DYR3_SALTM Dihydrofolate reductase type 3 OS=... | 71 | 0.005 | 40.8 | 37 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 59 | P31074 | 159 | DYR_ENTAE Dihydrofolate reductase OS=Enteroba... | 69 | 0.006 | 40.4 | 35 | 51 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 60 | Q59397 | 177 | DYR9_ECOLX Dihydrofolate reductase type 9 OS=... | 71 | 0.014 | 39.7 | 35 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.::GO:0031427; P:response to methotrexate; IEA:UniProtKB-KW. | 61 | P0C0P1 | 161 | DYR_STAES Dihydrofolate reductase OS=Staphylo... | 79 | 0.04 | 38.1 | 32 | 49 | | | | | | | | | | | GO:0004146; F:dihydrofolate reductase activity; IEA:EC.::GO:0050661; F:NADP binding; IEA:InterPro. | | | | | | | | | | GO:0006545; P:glycine biosynthetic process; IEA:InterPro.::GO:0009165; P:nucleotide biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |
