| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q570Y9 | 409 | DPTOR_MOUSE DEP domain-containing mTOR-intera... | 54 | 0.006 | 44.7 | 39 | 56 | | | | | | | | | | | | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 32 | Q8TB45 | 409 | DPTOR_HUMAN DEP domain-containing mTOR-intera... | 54 | 0.004 | 45.4 | 39 | 57 | GO:0005622; C:intracellular; IDA:LIFEdb. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045792; P:negative regulation of cell size; IMP:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB. | 33 | Q05AS8 | 732 | DVL2_XENTR Segment polarity protein dishevell... | 95 | 0.0005 | 48.5 | 29 | 47 | GO:0009986; C:cell surface; ISS:UniProtKB.::GO:0035253; C:ciliary rootlet; ISS:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0045545; F:syndecan binding; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0009948; P:anterior/posterior axis specification; ISS:UniProtKB.::GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0060027; P:convergent extension involved in gastrulation; ISS:UniProtKB.::GO:0009950; P:dorsal/ventral axis specification; ISS:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0001736; P:establishment of planar polarity; ISS:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; ISS:UniProtKB.::GO:0001843; P:neural tube closure; ISS:UniProtKB.::GO:0022008; P:neurogenesis; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.::GO:0050821; P:protein stabilization; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; ISS:UniProtKB. | 34 | Q3LAC4 | 1598 | PREX2_MOUSE Phosphatidylinositol 3,4,5-trisph... | 83 | 0.0005 | 48.9 | 33 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 35 | Q70Z35 | 1606 | PREX2_HUMAN Phosphatidylinositol 3,4,5-trisph... | 59 | 0.93 | 38.1 | 32 | 54 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 36 | O14640 | 695 | DVL1_HUMAN Segment polarity protein dishevell... | 98 | 0.0007 | 48.1 | 24 | 46 | GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; ISS:BHF-UCL.::GO:0019717; C:synaptosome; ISS:BHF-UCL. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032091; P:negative regulation of protein binding; IDA:BHF-UCL.::GO:0006469; P:negative regulation of protein kinase activity; IDA:BHF-UCL.::GO:0021915; P:neural tube development; IEP:BHF-UCL.::GO:0007269; P:neurotransmitter secretion; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0034504; P:protein localization to nucleus; IMP:BHF-UCL.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. | 37 | Q5IS48 | 670 | DVL1_PANTR Segment polarity protein dishevell... | 93 | 0.001 | 47 | 25 | 47 | GO:0030424; C:axon; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome. | 38 | Q9Z1C8 | 926 | RPGF3_RAT Rap guanine nucleotide exchange fac... | 76 | 0.002 | 46.6 | 33 | 49 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 39 | Q61062 | 716 | DVL3_MOUSE Segment polarity protein dishevell... | 81 | 0.003 | 46.2 | 27 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 40 | Q92997 | 716 | DVL3_HUMAN Segment polarity protein dishevell... | 81 | 0.003 | 46.2 | 27 | 48 | GO:0005938; C:cell cortex; IBA:RefGenome. | | | | | | | | | | GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.::GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0002020; F:protease binding; IPI:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IDA:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:BHF-UCL.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0060026; P:convergent extension; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0003148; P:outflow tract septum morphogenesis; IBA:RefGenome.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0043507; P:positive regulation of JUN kinase activity; IMP:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL. | 41 | P51141 | 695 | DVL1_MOUSE Segment polarity protein dishevell... | 98 | 0.004 | 45.8 | 23 | 46 | GO:0030424; C:axon; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IBA:RefGenome.::GO:0030426; C:growth cone; IBA:RefGenome.::GO:0005874; C:microtubule; IBA:RefGenome.::GO:0043025; C:neuronal cell body; IBA:RefGenome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; NAS:BHF-UCL.::GO:0045202; C:synapse; IDA:MGI.::GO:0019717; C:synaptosome; IDA:MGI. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0048365; F:Rac GTPase binding; IBA:RefGenome.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IDA:MGI.::GO:0007411; P:axon guidance; IDA:MGI.::GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0048668; P:collateral sprouting; IDA:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IGI:MGI.::GO:0031122; P:cytoplasmic microtubule organization; IDA:MGI.::GO:0048813; P:dendrite morphogenesis; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001933; P:negative regulation of protein phosphorylation; IGI:MGI.::GO:0007269; P:neurotransmitter secretion; IGI:MGI.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IGI:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; IMP:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0060134; P:prepulse inhibition; IMP:MGI.::GO:0035372; P:protein localization to microtubule; IGI:MGI.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IMP:MGI.::GO:0035176; P:social behavior; IMP:MGI. | 42 | Q9WVB9 | 695 | DVL1_RAT Segment polarity protein dishevelled... | 98 | 0.004 | 45.8 | 23 | 46 | GO:0030424; C:axon; IDA:RGD.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0030425; C:dendrite; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0015630; C:microtubule cytoskeleton; IDA:MGI.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0048365; F:Rac GTPase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IBA:RefGenome.::GO:0007411; P:axon guidance; IBA:RefGenome.::GO:0060070; P:canonical Wnt receptor signaling pathway; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0048668; P:collateral sprouting; IBA:RefGenome.::GO:0048813; P:dendrite morphogenesis; IBA:RefGenome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0071340; P:skeletal muscle acetylcholine-gated channel clustering; IBA:RefGenome. | 43 | P51142 | 736 | DVL2_XENLA Segment polarity protein dishevell... | 70 | 0.004 | 45.4 | 29 | 47 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0035253; C:ciliary rootlet; IDA:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0045545; F:syndecan binding; IPI:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; IMP:UniProtKB.::GO:0009948; P:anterior/posterior axis specification; IMP:UniProtKB.::GO:0060070; P:canonical Wnt receptor signaling pathway; IGI:BHF-UCL.::GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0060027; P:convergent extension involved in gastrulation; IMP:UniProtKB.::GO:0009950; P:dorsal/ventral axis specification; IMP:UniProtKB.::GO:0048013; P:ephrin receptor signaling pathway; IDA:UniProtKB.::GO:0001736; P:establishment of planar polarity; IMP:UniProtKB.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0001843; P:neural tube closure; IMP:UniProtKB.::GO:0022008; P:neurogenesis; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:BHF-UCL.::GO:0051260; P:protein homooligomerization; IPI:UniProtKB.::GO:0050821; P:protein stabilization; IMP:UniProtKB. | 44 | P51140 | 623 | DSH_DROME Segment polarity protein dishevelle... | 92 | 0.005 | 45.4 | 26 | 47 | GO:0005912; C:adherens junction; TAS:FlyBase.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005112; F:Notch binding; NAS:FlyBase.::GO:0070300; F:phosphatidic acid binding; IDA:FlyBase.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0048675; P:axon extension; IMP:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0007394; P:dorsal closure, elongation of leading edge cells; IMP:FlyBase.::GO:0048730; P:epidermis morphogenesis; IMP:FlyBase.::GO:0045198; P:establishment of epithelial cell apical/basal polarity; IMP:FlyBase.::GO:0090163; P:establishment of epithelial cell planar polarity; IMP:FlyBase.::GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.::GO:0048106; P:establishment of thoracic bristle planar orientation; TAS:FlyBase.::GO:0008585; P:female gonad development; IMP:FlyBase.::GO:0046847; P:filopodium assembly; IMP:FlyBase.::GO:0060914; P:heart formation; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030032; P:lamellipodium assembly; IMP:FlyBase.::GO:0003136; P:negative regulation of heart induction by canonical Wnt receptor signaling pathway; IMP:FlyBase.::GO:0016318; P:ommatidial rotation; NAS:FlyBase.::GO:0008104; P:protein localization; TAS:FlyBase.::GO:0007464; P:R3/R4 cell fate commitment; NAS:FlyBase.::GO:0032231; P:regulation of actin filament bundle assembly; IGI:FlyBase.::GO:0048076; P:regulation of compound eye pigmentation; IMP:FlyBase.::GO:0035159; P:regulation of tube length, open tracheal system; IMP:FlyBase.::GO:0031290; P:retinal ganglion cell axon guidance; IMP:FlyBase.::GO:0007435; P:salivary gland morphogenesis; IMP:FlyBase.::GO:0007367; P:segment polarity determination; IEA:UniProtKB-KW.::GO:0035019; P:somatic stem cell maintenance; IMP:FlyBase.::GO:0035309; P:wing and notum subfield formation; IMP:FlyBase.::GO:0060071; P:Wnt receptor signaling pathway, planar cell polarity pathway; IBA:RefGenome. | 45 | Q60838 | 736 | DVL2_MOUSE Segment polarity protein dishevell... | 84 | 0.005 | 45.4 | 26 | 50 | GO:0045177; C:apical part of cell; IDA:MGI.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IDA:MGI.::GO:0005856; C:cytoskeleton; NAS:BHF-UCL.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IMP:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; NAS:BHF-UCL. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0019904; F:protein domain specific binding; IPI:MGI.::GO:0043621; F:protein self-association; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0034613; P:cellular protein localization; IDA:MGI.::GO:0090103; P:cochlea morphogenesis; IGI:MGI.::GO:0022007; P:convergent extension involved in neural plate elongation; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IMP:MGI.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0061098; P:positive regulation of protein tyrosine kinase activity; IGI:MGI.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IBA:RefGenome.::GO:0007379; P:segment specification; IMP:MGI. | 46 | P54792 | 670 | DVL1L_HUMAN Putative Segment polarity protein... | 93 | 0.006 | 45.1 | 24 | 46 | GO:0005737; C:cytoplasm; NAS:UniProtKB. | | | | | | | | | | GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0007507; P:heart development; NAS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 47 | Q8VCC8 | 918 | RPGF3_MOUSE Rap guanine nucleotide exchange f... | 76 | 0.009 | 44.7 | 32 | 50 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:MGI. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 48 | O14641 | 736 | DVL2_HUMAN Segment polarity protein dishevell... | 81 | 0.01 | 44.3 | 27 | 49 | GO:0045177; C:apical part of cell; IBA:RefGenome.::GO:0005938; C:cell cortex; IBA:RefGenome.::GO:0030136; C:clathrin-coated vesicle; IBA:RefGenome.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005109; F:frizzled binding; IPI:UniProtKB.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0044340; P:canonical Wnt receptor signaling pathway involved in regulation of cell proliferation; IDA:BHF-UCL.::GO:0021535; P:cell migration in hindbrain; IBA:RefGenome.::GO:0090103; P:cochlea morphogenesis; IBA:RefGenome.::GO:0035329; P:hippo signaling cascade; TAS:Reactome.::GO:0001843; P:neural tube closure; ISS:BHF-UCL.::GO:0003151; P:outflow tract morphogenesis; ISS:BHF-UCL.::GO:0090179; P:planar cell polarity pathway involved in neural tube closure; IBA:RefGenome.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0007379; P:segment specification; ISS:BHF-UCL.::GO:0006366; P:transcription from RNA polymerase II promoter; IDA:UniProtKB. | 49 | Q9Z1T6 | 2097 | FYV1_MOUSE 1-phosphatidylinositol 3-phosphate... | 81 | 0.012 | 44.3 | 33 | 46 | GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB. | 50 | Q9Y2I7 | 2098 | FYV1_HUMAN 1-phosphatidylinositol 3-phosphate... | 81 | 0.012 | 44.3 | 33 | 46 | GO:0031901; C:early endosome membrane; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:HGNC. | | | | | | | | | | GO:0000285; F:1-phosphatidylinositol-3-phosphate 5-kinase activity; IEA:EC.::GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; TAS:HGNC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0044267; P:cellular protein metabolic process; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034504; P:protein localization to nucleus; IMP:UniProtKB.::GO:0042147; P:retrograde transport, endosome to Golgi; IMP:UniProtKB. | 51 | Q6DKE2 | 717 | DVL3_XENLA Segment polarity protein dishevell... | 80 | 0.023 | 43.1 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; IMP:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 52 | B1WAP7 | 713 | DVL3_XENTR Segment polarity protein dishevell... | 81 | 0.025 | 43.1 | 25 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008013; F:beta-catenin binding; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro. | | | | | | | | | | GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032053; P:microtubule basal body organization; ISS:UniProtKB.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 53 | Q7Z3F1 | 870 | GP155_HUMAN Integral membrane protein GPR155 ... | 69 | 0.029 | 43.1 | 30 | 54 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0055085; P:transmembrane transport; IEA:InterPro. | 54 | O95398 | 923 | RPGF3_HUMAN Rap guanine nucleotide exchange f... | 76 | 0.042 | 42.4 | 30 | 47 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 55 | Q5R9A7 | 872 | GP155_PONAB Integral membrane protein GPR155 ... | 69 | 0.043 | 42.4 | 30 | 52 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0055085; P:transmembrane transport; IEA:InterPro. | 56 | P52948 | 1817 | NUP98_HUMAN Nuclear pore complex protein Nup9... | 78 | 0.67 | 38.5 | 36 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:ProtInc.::GO:0031080; C:Nup107-160 complex; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0017056; F:structural constituent of nuclear pore; NAS:UniProtKB.::GO:0005215; F:transporter activity; TAS:ProtInc. | | | | | | | | | | GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0006260; P:DNA replication; IMP:UniProtKB.::GO:0015758; P:glucose transport; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.::GO:0006999; P:nuclear pore organization; NAS:UniProtKB.::GO:0000059; P:protein import into nucleus, docking; NAS:UniProtKB.::GO:0010827; P:regulation of glucose transport; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0055085; P:transmembrane transport; TAS:Reactome.::GO:0016032; P:viral reproduction; TAS:Reactome. | 57 | P46869 | 786 | FLA10_CHLRE Kinesin-like protein FLA10 OS=Chl... | 142 | 1.5 | 37.4 | 28 | 42 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0097014; C:microtubule-based flagellar cytoplasm; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003777; F:microtubule motor activity; IEA:InterPro. | | | | | | | | | | GO:0009296; P:flagellum assembly; IMP:BHF-UCL.::GO:0035720; P:intraflagellar anterograde transport; IMP:BHF-UCL. | 58 | Q00002 | 436 | PDI_ALTAL Protein disulfide-isomerase OS=Alte... | 46 | 2.1 | 36.6 | 39 | 61 | GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003756; F:protein disulfide isomerase activity; IEA:EC. | | | | | | | | | | GO:0045454; P:cell redox homeostasis; IEA:InterPro. | 59 | Q86G47 | 1298 | GEFQ_DICDI Ras guanine nucleotide exchange fa... | 56 | 5.8 | 35.4 | 25 | 63 | GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 60 | P34578 | 1038 | RPGF1_CAEEL Rap guanine nucleotide exchange f... | 74 | 6.2 | 35.4 | 28 | 46 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro. | | | | | | | | | | GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 61 | Q8C0Q9 | 814 | RPGF5_MOUSE Rap guanine nucleotide exchange f... | 107 | 7.2 | 35 | 25 | 41 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; ISS:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
