| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q05655 | 676 | KPCD_HUMAN Protein kinase C delta type OS=Hom... | 147 | 5e-20 | 100 | 37 | 52 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004699; F:calcium-independent protein kinase C activity; TAS:BHF-UCL.::GO:0008047; F:enzyme activator activity; IDA:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0090398; P:cellular senescence; IMP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0030837; P:negative regulation of actin filament polymerization; ISS:UniProtKB.::GO:0051490; P:negative regulation of filopodium assembly; ISS:UniProtKB.::GO:0034351; P:negative regulation of glial cell apoptotic process; IMP:UniProtKB.::GO:0050728; P:negative regulation of inflammatory response; IC:BHF-UCL.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:BHF-UCL.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; ISS:BHF-UCL.::GO:0090331; P:negative regulation of platelet aggregation; ISS:UniProtKB.::GO:0032091; P:negative regulation of protein binding; TAS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0042119; P:neutrophil activation; IDA:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:2000304; P:positive regulation of ceramide biosynthetic process; IMP:BHF-UCL.::GO:2000753; P:positive regulation of glucosylceramide catabolic process; IMP:BHF-UCL.::GO:1900163; P:positive regulation of phospholipid scramblase activity; IMP:UniProtKB.::GO:0035307; P:positive regulation of protein dephosphorylation; IMP:BHF-UCL.::GO:2001022; P:positive regulation of response to DNA damage stimulus; IMP:UniProtKB.::GO:2000755; P:positive regulation of sphingomyelin catabolic process; IMP:BHF-UCL.::GO:0032930; P:positive regulation of superoxide anion generation; IMP:UniProtKB.::GO:0050821; P:protein stabilization; NAS:UniProtKB.::GO:0010469; P:regulation of receptor activity; TAS:BHF-UCL.::GO:0023021; P:termination of signal transduction; IMP:BHF-UCL. | 62 | Q63644 | 1369 | ROCK1_RAT Rho-associated protein kinase 1 OS=... | 150 | 0.0000000000004 | 79.3 | 35 | 52 | GO:0032059; C:bleb; IEA:UniProtKB-SubCell.::GO:0005814; C:centriole; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017049; F:GTP-Rho binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; NAS:RGD. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0007010; P:cytoskeleton organization; IMP:RGD.::GO:0007266; P:Rho protein signal transduction; IMP:MGI. | 63 | P70335 | 1354 | ROCK1_MOUSE Rho-associated protein kinase 1 O... | 150 | 0.0000000000004 | 79 | 35 | 52 | GO:0032059; C:bleb; IEA:UniProtKB-SubCell.::GO:0005814; C:centriole; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0032060; P:bleb assembly; IMP:MGI.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI. | 64 | Q63531 | 735 | KS6A1_RAT Ribosomal protein S6 kinase alpha-1... | 217 | 0.00000005 | 62.4 | 26 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004711; F:ribosomal protein S6 kinase activity; TAS:RGD.::GO:0008134; F:transcription factor binding; IDA:RGD. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:RGD. | 65 | Q13464 | 1354 | ROCK1_HUMAN Rho-associated protein kinase 1 O... | 150 | 0.0000000000006 | 78.6 | 35 | 52 | GO:0032059; C:bleb; IEA:UniProtKB-SubCell.::GO:0005814; C:centriole; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; TAS:ProtInc.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0050901; P:leukocyte tethering or rolling; IDA:BHF-UCL.::GO:0022614; P:membrane to membrane docking; IDA:BHF-UCL.::GO:0016525; P:negative regulation of angiogenesis; IMP:UniProtKB.::GO:2000145; P:regulation of cell motility; TAS:UniProtKB.::GO:2000114; P:regulation of establishment of cell polarity; TAS:UniProtKB.::GO:0051893; P:regulation of focal adhesion assembly; TAS:UniProtKB.::GO:0045616; P:regulation of keratinocyte differentiation; IMP:UniProtKB.::GO:0051492; P:regulation of stress fiber assembly; TAS:UniProtKB.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.::GO:0006939; P:smooth muscle contraction; TAS:UniProtKB. | 66 | P54265 | 631 | DMPK_MOUSE Myotonin-protein kinase OS=Mus mus... | 186 | 0.0000000000002 | 79.7 | 32 | 45 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.::GO:0031965; C:nuclear membrane; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0033017; C:sarcoplasmic reticulum membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017020; F:myosin phosphatase regulator activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006874; P:cellular calcium ion homeostasis; IMP:UniProtKB.::GO:0010657; P:muscle cell apoptotic process; ISS:UniProtKB.::GO:0006998; P:nuclear envelope organization; IMP:UniProtKB.::GO:0014853; P:regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction; IMP:MGI.::GO:0008016; P:regulation of heart contraction; IDA:UniProtKB.::GO:0010830; P:regulation of myotube differentiation; IMP:UniProtKB.::GO:0014722; P:regulation of skeletal muscle contraction by calcium ion signaling; IMP:UniProtKB.::GO:0002028; P:regulation of sodium ion transport; IMP:MGI.::GO:0051823; P:regulation of synapse structural plasticity; IMP:UniProtKB. | 67 | O77819 | 1354 | ROCK1_RABIT Rho-associated protein kinase 1 O... | 150 | 0.0000000000006 | 78.6 | 35 | 52 | GO:0032059; C:bleb; IEA:UniProtKB-SubCell.::GO:0005814; C:centriole; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 68 | Q15418 | 735 | KS6A1_HUMAN Ribosomal protein S6 kinase alpha... | 215 | 0.00000007 | 61.6 | 25 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045597; P:positive regulation of cell differentiation; TAS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; TAS:UniProtKB.::GO:2000491; P:positive regulation of hepatic stellate cell activation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043620; P:regulation of DNA-dependent transcription in response to stress; TAS:UniProtKB.::GO:0043555; P:regulation of translation in response to stress; TAS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 69 | Q09013 | 629 | DMPK_HUMAN Myotonin-protein kinase OS=Homo sa... | 146 | 0.000000000000004 | 84.7 | 36 | 49 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.::GO:0005640; C:nuclear outer membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0033017; C:sarcoplasmic reticulum membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017020; F:myosin phosphatase regulator activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006874; P:cellular calcium ion homeostasis; ISS:UniProtKB.::GO:0010657; P:muscle cell apoptotic process; IDA:UniProtKB.::GO:0006998; P:nuclear envelope organization; IMP:UniProtKB.::GO:0008016; P:regulation of heart contraction; IDA:UniProtKB.::GO:0010830; P:regulation of myotube differentiation; ISS:UniProtKB. | 70 | A8XNJ6 | 464 | SGK1_CAEBR Serine/threonine-protein kinase sg... | 135 | 1e-16 | 88.6 | 33 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 71 | P40376 | 512 | KAPB_SCHPO cAMP-dependent protein kinase cata... | 146 | 1e-21 | 104 | 38 | 58 | GO:0005952; C:cAMP-dependent protein kinase complex; TAS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IGI:PomBase.::GO:0005515; F:protein binding; IPI:PomBase. | | | | | | | | | | GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0001315; P:age-dependent response to reactive oxygen species; IMP:PomBase.::GO:0019933; P:cAMP-mediated signaling; IC:PomBase.::GO:0001300; P:chronological cell aging; IGI:PomBase.::GO:0031142; P:induction of conjugation upon nitrogen starvation; IMP:PomBase.::GO:0031138; P:negative regulation of conjugation with cellular fusion; IMP:PomBase.::GO:0045014; P:negative regulation of transcription by glucose; IMP:PomBase.::GO:0006110; P:regulation of glycolysis; NAS:PomBase. | 72 | Q80UW5 | 1551 | MRCKG_MOUSE Serine/threonine-protein kinase M... | 150 | 5e-16 | 89 | 33 | 51 | GO:0031252; C:cell leading edge; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 73 | Q6DT37 | 1551 | MRCKG_HUMAN Serine/threonine-protein kinase M... | 150 | 0.000000000000001 | 87.8 | 33 | 51 | GO:0031252; C:cell leading edge; IDA:UniProtKB.::GO:0005813; C:centrosome; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 74 | Q5PU49 | 674 | KPCD_CANFA Protein kinase C delta type OS=Can... | 147 | 3e-19 | 98.6 | 37 | 53 | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030837; P:negative regulation of actin filament polymerization; ISS:UniProtKB.::GO:0051490; P:negative regulation of filopodium assembly; ISS:UniProtKB.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0090331; P:negative regulation of platelet aggregation; ISS:UniProtKB.::GO:0032930; P:positive regulation of superoxide anion generation; ISS:UniProtKB. | 75 | P13677 | 700 | KPC2_DROME Protein kinase C, eye isozyme OS=D... | 161 | 4e-17 | 91.7 | 32 | 51 | GO:0016027; C:inaD signaling complex; TAS:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; ISS:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016062; P:adaptation of rhodopsin mediated signaling; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0006928; P:cellular component movement; IMP:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IMP:FlyBase.::GO:0008585; P:female gonad development; IMP:FlyBase.::GO:0030845; P:inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway; IMP:FlyBase.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0045471; P:response to ethanol; IDA:FlyBase. | 76 | P10666 | 629 | KS6AB_XENLA Ribosomal protein S6 kinase 2 bet... | 57 | 0.0009 | 48.1 | 40 | 56 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 77 | O75116 | 1388 | ROCK2_HUMAN Rho-associated protein kinase 2 O... | 150 | 0.00000000000007 | 81.6 | 34 | 52 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005198; F:structural molecule activity; NAS:ProtInc. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0051298; P:centrosome duplication; IMP:UniProtKB.::GO:0000910; P:cytokinesis; NAS:ProtInc.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016525; P:negative regulation of angiogenesis; IMP:UniProtKB.::GO:2000145; P:regulation of cell motility; TAS:UniProtKB.::GO:2000114; P:regulation of establishment of cell polarity; TAS:UniProtKB.::GO:0051893; P:regulation of focal adhesion assembly; TAS:UniProtKB.::GO:0045616; P:regulation of keratinocyte differentiation; IMP:UniProtKB.::GO:0051492; P:regulation of stress fiber assembly; TAS:UniProtKB.::GO:0006939; P:smooth muscle contraction; TAS:UniProtKB. | 78 | Q04759 | 706 | KPCT_HUMAN Protein kinase C theta type OS=Hom... | 140 | 4e-18 | 95.1 | 37 | 51 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0006509; P:membrane protein ectodomain proteolysis; ISS:BHF-UCL.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0070233; P:negative regulation of T cell apoptotic process; IMP:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0032740; P:positive regulation of interleukin-17 production; ISS:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:2000318; P:positive regulation of T-helper 17 type immune response; ISS:UniProtKB.::GO:2000570; P:positive regulation of T-helper 2 cell activation; ISS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. | 79 | Q7TT50 | 1713 | MRCKB_MOUSE Serine/threonine-protein kinase M... | 170 | 2e-19 | 100 | 34 | 52 | GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 80 | Q7TT49 | 1713 | MRCKB_RAT Serine/threonine-protein kinase MRC... | 170 | 2e-19 | 100 | 34 | 52 | GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0017048; F:Rho GTPase binding; IDA:RGD.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 81 | Q9WTQ0 | 707 | KPCT_RAT Protein kinase C theta type OS=Rattu... | 140 | 5e-18 | 94.7 | 37 | 51 | GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0031594; C:neuromuscular junction; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0042383; C:sarcolemma; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IDA:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0070233; P:negative regulation of T cell apoptotic process; ISS:UniProtKB.::GO:0030182; P:neuron differentiation; IEP:RGD.::GO:0051491; P:positive regulation of filopodium assembly; IMP:RGD.::GO:0032740; P:positive regulation of interleukin-17 production; ISS:UniProtKB.::GO:0032753; P:positive regulation of interleukin-4 production; ISS:UniProtKB.::GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IMP:RGD.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0050714; P:positive regulation of protein secretion; IDA:RGD.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:RGD.::GO:2000318; P:positive regulation of T-helper 17 type immune response; ISS:UniProtKB.::GO:2000570; P:positive regulation of T-helper 2 cell activation; ISS:UniProtKB.::GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:RGD.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0019229; P:regulation of vasoconstriction; IEP:RGD.::GO:0045730; P:respiratory burst; IEP:RGD.::GO:0009749; P:response to glucose stimulus; IEP:RGD.::GO:0009408; P:response to heat; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0032868; P:response to insulin stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0042246; P:tissue regeneration; IEP:RGD. | 82 | Q28021 | 1388 | ROCK2_BOVIN Rho-associated protein kinase 2 O... | 145 | 0.00000000000002 | 84 | 35 | 53 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:AgBase.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 83 | Q2PJ68 | 463 | SGK1_CAEEL Serine/threonine-protein kinase sg... | 136 | 4e-17 | 90.5 | 35 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0043053; P:dauer entry; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 84 | P18652 | 752 | KS6AA_CHICK Ribosomal protein S6 kinase 2 alp... | 118 | 0.0000001 | 61.2 | 31 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. | 85 | P10665 | 733 | KS6AA_XENLA Ribosomal protein S6 kinase 2 alp... | 179 | 0.00002 | 53.5 | 25 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. | 86 | P28867 | 674 | KPCD_MOUSE Protein kinase C delta type OS=Mus... | 147 | 5e-21 | 103 | 38 | 54 | GO:0005911; C:cell-cell junction; IDA:MGI.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042100; P:B cell proliferation; IMP:MGI.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0032613; P:interleukin-10 production; IMP:MGI.::GO:0032615; P:interleukin-12 production; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030837; P:negative regulation of actin filament polymerization; IMP:UniProtKB.::GO:0051490; P:negative regulation of filopodium assembly; IMP:UniProtKB.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:BHF-UCL.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0090331; P:negative regulation of platelet aggregation; IMP:UniProtKB.::GO:0032930; P:positive regulation of superoxide anion generation; ISS:UniProtKB. | 87 | P70336 | 1388 | ROCK2_MOUSE Rho-associated protein kinase 2 O... | 150 | 0.00000000000005 | 82 | 34 | 51 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0031616; C:spindle pole centrosome; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0010825; P:positive regulation of centrosome duplication; IMP:MGI. | 88 | Q62868 | 1388 | ROCK2_RAT Rho-associated protein kinase 2 OS=... | 150 | 0.000000000005 | 75.5 | 33 | 51 | GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030261; P:chromosome condensation; TAS:RGD.::GO:0000910; P:cytokinesis; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IMP:MGI. | 89 | Q9W1B0 | 1637 | GEK_DROME Serine/threonine-protein kinase Gen... | 147 | 2e-18 | 96.3 | 37 | 54 | GO:0030424; C:axon; IDA:FlyBase.::GO:0030426; C:growth cone; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0008154; P:actin polymerization or depolymerization; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030833; P:regulation of actin filament polymerization; IMP:UniProtKB.::GO:0008039; P:synaptic target recognition; IMP:FlyBase. | 90 | Q02111 | 707 | KPCT_MOUSE Protein kinase C theta type OS=Mus... | 140 | 1e-17 | 93.2 | 36 | 51 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0001772; C:immunological synapse; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004697; F:protein kinase C activity; IDA:MGI. | | | | | | | | | | GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0006509; P:membrane protein ectodomain proteolysis; IDA:BHF-UCL.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0070233; P:negative regulation of T cell apoptotic process; ISS:UniProtKB.::GO:0032740; P:positive regulation of interleukin-17 production; IMP:UniProtKB.::GO:0045086; P:positive regulation of interleukin-2 biosynthetic process; IMP:MGI.::GO:0032753; P:positive regulation of interleukin-4 production; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0042102; P:positive regulation of T cell proliferation; IMP:MGI.::GO:2000318; P:positive regulation of T-helper 17 type immune response; IMP:UniProtKB.::GO:2000570; P:positive regulation of T-helper 2 cell activation; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; IMP:UniProtKB. | 91 | O42626 | 623 | NRC2_NEUCR Serine/threonine-protein kinase nr... | 138 | 9e-18 | 93.6 | 34 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0048315; P:conidium formation; IEA:UniProtKB-KW.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. |
