| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
991 | Q54I36 | 1338 | PYK3_DICDI Dual specificity protein kinase py... | 167 | 0.000007 | 51.6 | 24 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase. | 992 | Q5RB23 | 1132 | JAK2_PONAB Tyrosine-protein kinase JAK2 OS=Po... | 292 | 0.000007 | 51.6 | 22 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 993 | O60674 | 1132 | JAK2_HUMAN Tyrosine-protein kinase JAK2 OS=Ho... | 292 | 0.000008 | 51.6 | 22 | 43 | GO:0005901; C:caveola; ISS:BHF-UCL.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0031904; C:endosome lumen; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); IDA:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0019901; F:protein kinase binding; IDA:BHF-UCL.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB. | | | | | | | | | | GO:0030041; P:actin filament polymerization; NAS:BHF-UCL.::GO:0008636; P:activation of caspase activity by protein phosphorylation; ISS:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0006928; P:cellular component movement; TAS:ProtInc.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0061180; P:mammary gland epithelium development; ISS:BHF-UCL.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; IDA:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; ISS:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0032496; P:response to lipopolysaccharide; ISS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; ISS:BHF-UCL.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:BHF-UCL. | 994 | Q21734 | 784 | KS6A1_CAEEL Putative ribosomal protein S6 kin... | 218 | 0.000008 | 51.2 | 25 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. | 995 | O12990 | 1153 | JAK1_DANRE Tyrosine-protein kinase JAK1 OS=Da... | 242 | 0.00003 | 49.7 | 24 | 43 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 996 | Q09178 | 1156 | JAK1_CYPCA Tyrosine-protein kinase JAK1 OS=Cy... | 168 | 0.00004 | 49.3 | 25 | 47 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. | 997 | Q75R65 | 1129 | JAK2_CHICK Tyrosine-protein kinase JAK2 OS=Ga... | 296 | 0.00007 | 48.5 | 23 | 42 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 998 | Q86HG9 | 1024 | Y9871_DICDI Probable serine/threonine-protein... | 129 | 0.00008 | 48.1 | 27 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 999 | Q75JK0 | 781 | ZAK1_DICDI Dual specificity protein kinase za... | 55 | 1.8 | 34.3 | 38 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IMP:UniProtKB.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IMP:UniProtKB.::GO:0001708; P:cell fate specification; IMP:UniProtKB.::GO:0033674; P:positive regulation of kinase activity; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0060176; P:regulation of aggregation involved in sorocarp development; IMP:dictyBase.::GO:0042659; P:regulation of cell fate specification; IMP:dictyBase.::GO:0061118; P:regulation of positive chemotaxis to cAMP; IMP:dictyBase.::GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase. | 1000 | Q24592 | 1177 | JAK_DROME Tyrosine-protein kinase hopscotch O... | 170 | 5.1 | 33.1 | 18 | 40 | GO:0005737; C:cytoplasm; TAS:FlyBase.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0003383; P:apical constriction; IMP:FlyBase.::GO:0007298; P:border follicle cell migration; IMP:FlyBase.::GO:0006968; P:cellular defense response; NAS:FlyBase.::GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.::GO:0000910; P:cytokinesis; TAS:FlyBase.::GO:0051607; P:defense response to virus; IMP:FlyBase.::GO:0035010; P:encapsulation of foreign target; NAS:FlyBase.::GO:0045317; P:equator specification; IMP:FlyBase.::GO:0007455; P:eye-antennal disc morphogenesis; IMP:FlyBase.::GO:0042078; P:germ-line stem cell division; TAS:FlyBase.::GO:0035172; P:hemocyte proliferation; TAS:FlyBase.::GO:0007442; P:hindgut morphogenesis; IMP:FlyBase.::GO:0006959; P:humoral immune response; TAS:FlyBase.::GO:0007480; P:imaginal disc-derived leg morphogenesis; NAS:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; NAS:FlyBase.::GO:0035171; P:lamellocyte differentiation; TAS:FlyBase.::GO:0007616; P:long-term memory; IMP:FlyBase.::GO:0060031; P:mediolateral intercalation; IMP:FlyBase.::GO:0016318; P:ommatidial rotation; IMP:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.::GO:0007365; P:periodic partitioning; IMP:FlyBase.::GO:0007538; P:primary sex determination; IMP:FlyBase.::GO:0016476; P:regulation of embryonic cell shape; IMP:FlyBase.::GO:0045610; P:regulation of hemocyte differentiation; IMP:FlyBase.::GO:0046425; P:regulation of JAK-STAT cascade; IMP:FlyBase.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0048103; P:somatic stem cell division; TAS:FlyBase.::GO:0007262; P:STAT protein import into nucleus; TAS:FlyBase.::GO:0019827; P:stem cell maintenance; IMP:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007260; P:tyrosine phosphorylation of STAT protein; TAS:FlyBase. |
