| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
961 | P53767 | 1336 | VGFR1_RAT Vascular endothelial growth factor ... | 195 | 0.000000000001 | 72.8 | 28 | 46 | GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0019838; F:growth factor binding; IPI:RGD.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; TAS:RGD.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IMP:RGD. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; IMP:RGD.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0048598; P:embryonic morphogenesis; ISS:UniProtKB.::GO:0030522; P:intracellular receptor mediated signaling pathway; IMP:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0006940; P:regulation of smooth muscle contraction; IDA:RGD.::GO:0001666; P:response to hypoxia; IDA:RGD. | 962 | Q2H332 | 360 | HOG1_CHAGB Mitogen-activated protein kinase H... | 231 | 0.000000000001 | 71.6 | 28 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 963 | P25323 | 295 | MYLKA_DICDI Myosin light chain kinase A OS=Di... | 210 | 0.000000000001 | 70.9 | 26 | 49 | GO:0005737; C:cytoplasm; IDA:dictyBase. | | | | | | | | | | GO:0030898; F:actin-dependent ATPase activity; IDA:dictyBase.::GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004687; F:myosin light chain kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; IDA:dictyBase.::GO:0019934; P:cGMP-mediated signaling; IDA:dictyBase.::GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase. | 964 | Q02846 | 1103 | GUC2D_HUMAN Retinal guanylyl cyclase 1 OS=Hom... | 229 | 0.000000000001 | 72.4 | 28 | 44 | GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005640; C:nuclear outer membrane; TAS:ProtInc. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0004383; F:guanylate cyclase activity; TAS:ProtInc.::GO:0004672; F:protein kinase activity; IEA:InterPro.::GO:0004872; F:receptor activity; TAS:ProtInc. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007168; P:receptor guanylyl cyclase signaling pathway; TAS:ProtInc.::GO:0007601; P:visual perception; TAS:ProtInc. | 965 | Q8SSV3 | 652 | MKCD_DICDI Probable serine/threonine-protein ... | 212 | 0.000000000001 | 72.4 | 26 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 966 | Q07176 | 387 | MMK1_MEDSA Mitogen-activated protein kinase h... | 188 | 0.000000000001 | 71.6 | 30 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000746; P:conjugation; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 967 | A8XJW8 | 494 | CST1_CAEBR Serine/threonine-protein kinase cs... | 169 | 0.000000000001 | 72 | 32 | 51 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0008340; P:determination of adult lifespan; ISS:UniProtKB.::GO:0048747; P:muscle fiber development; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 968 | Q06060 | 394 | MAPK_PEA Mitogen-activated protein kinase hom... | 188 | 0.000000000001 | 71.6 | 30 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW. | 969 | P14617 | 1300 | INSRR_CAVPO Insulin receptor-related protein ... | 295 | 0.000000000002 | 72.4 | 24 | 40 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0071469; P:cellular response to alkalinity; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. | 970 | Q1KTF2 | 357 | HOG1_MYCGM Mitogen-activated protein kinase H... | 210 | 0.000000000002 | 71.6 | 29 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 971 | P70218 | 827 | M4K1_MOUSE Mitogen-activated protein kinase k... | 212 | 0.000000000002 | 72.4 | 30 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:MGI.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0006950; P:response to stress; IDA:UniProtKB. | 972 | P14616 | 1297 | INSRR_HUMAN Insulin receptor-related protein ... | 266 | 0.000000000002 | 72.4 | 25 | 41 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043560; F:insulin receptor substrate binding; IEA:InterPro.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IEA:InterPro.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0071469; P:cellular response to alkalinity; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB. | 973 | P54739 | 543 | PKAA_STRCO Serine/threonine-protein kinase pk... | 264 | 0.000000000002 | 72 | 26 | 44 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 974 | Q5J4W4 | 394 | MPK2_ORYSJ Mitogen-activated protein kinase 2... | 193 | 0.000000000002 | 71.6 | 31 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 975 | C0LGG3 | 885 | Y5182_ARATH Probable LRR receptor-like serine... | 289 | 0.000000000002 | 72.4 | 25 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 976 | O81833 | 815 | SD11_ARATH G-type lectin S-receptor-like seri... | 218 | 0.000000000002 | 72.4 | 27 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0044459; C:plasma membrane part; ISS:UniProtKB.::GO:0009506; C:plasmodesma; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005516; F:calmodulin binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048544; P:recognition of pollen; IEA:InterPro. | 977 | Q9LMM5 | 369 | MPK11_ARATH Mitogen-activated protein kinase ... | 173 | 0.000000000002 | 71.6 | 32 | 48 | GO:0005829; C:cytosol; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0009737; P:response to abscisic acid stimulus; IEP:TAIR. | 978 | Q8BG48 | 372 | ST17B_MOUSE Serine/threonine-protein kinase 1... | 205 | 0.000000000002 | 71.6 | 28 | 50 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB. | 979 | Q91ZT1 | 1363 | VGFR3_RAT Vascular endothelial growth factor ... | 166 | 0.000000000002 | 72.4 | 27 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IEA:InterPro.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019838; F:growth factor binding; IMP:RGD.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IMP:RGD. | | | | | | | | | | GO:0001946; P:lymphangiogenesis; ISS:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IDA:RGD.::GO:0060312; P:regulation of blood vessel remodeling; ISS:UniProtKB.::GO:0002040; P:sprouting angiogenesis; ISS:UniProtKB.::GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:RGD. | 980 | O75460 | 977 | ERN1_HUMAN Serine/threonine-protein kinase/en... | 117 | 0.000000000002 | 72.4 | 38 | 61 | GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007050; P:cell cycle arrest; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0006397; P:mRNA processing; IEA:InterPro.::GO:1900103; P:positive regulation of endoplasmic reticulum unfolded protein response; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 981 | Q552C6 | 635 | ZAK2_DICDI Dual specificity protein kinase za... | 184 | 0.000000002 | 62.4 | 27 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0045860; P:positive regulation of protein kinase activity; IDA:dictyBase.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0042659; P:regulation of cell fate specification; IMP:dictyBase.::GO:0010468; P:regulation of gene expression; IDA:dictyBase.::GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase. | 982 | P52333 | 1124 | JAK3_HUMAN Tyrosine-protein kinase JAK3 OS=Ho... | 231 | 0.00000004 | 58.5 | 22 | 45 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0030183; P:B cell differentiation; ISS:BHF-UCL.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0035771; P:interleukin-4-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:UniProtKB.::GO:0002731; P:negative regulation of dendritic cell cytokine production; ISS:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; ISS:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; ISS:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; ISS:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:BHF-UCL.::GO:0070672; P:response to interleukin-15; TAS:BHF-UCL.::GO:0070669; P:response to interleukin-2; TAS:BHF-UCL.::GO:0071104; P:response to interleukin-9; TAS:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; TAS:UniProtKB.::GO:0043029; P:T cell homeostasis; TAS:UniProtKB. | 983 | P52332 | 1153 | JAK1_MOUSE Tyrosine-protein kinase JAK1 OS=Mu... | 245 | 0.0000002 | 56.6 | 24 | 45 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. | 984 | P23458 | 1154 | JAK1_HUMAN Tyrosine-protein kinase JAK1 OS=Ho... | 245 | 0.0000009 | 54.7 | 24 | 45 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0046677; P:response to antibiotic; IDA:MGI.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. | 985 | Q62120 | 1129 | JAK2_MOUSE Tyrosine-protein kinase JAK2 OS=Mu... | 294 | 0.0000009 | 54.3 | 22 | 43 | GO:0005901; C:caveola; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:BHF-UCL.::GO:0016363; C:nuclear matrix; ISS:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; ISS:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0005143; F:interleukin-12 receptor binding; IPI:MGI.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0019901; F:protein kinase binding; ISS:BHF-UCL. | | | | | | | | | | GO:0008636; P:activation of caspase activity by protein phosphorylation; IDA:BHF-UCL.::GO:0042977; P:activation of JAK2 kinase activity; IDA:UniProtKB.::GO:0000186; P:activation of MAPKK activity; ISS:BHF-UCL.::GO:0031103; P:axon regeneration; ISS:BHF-UCL.::GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; IMP:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:BHF-UCL.::GO:0009755; P:hormone-mediated signaling pathway; ISS:BHF-UCL.::GO:0008631; P:induction of apoptosis by oxidative stress; ISS:BHF-UCL.::GO:0060333; P:interferon-gamma-mediated signaling pathway; ISS:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; IMP:UniProtKB.::GO:0061180; P:mammary gland epithelium development; IMP:MGI.::GO:0031959; P:mineralocorticoid receptor signaling pathway; ISS:BHF-UCL.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0022408; P:negative regulation of cell-cell adhesion; ISS:BHF-UCL.::GO:0043392; P:negative regulation of DNA binding; IDA:MGI.::GO:0045822; P:negative regulation of heart contraction; ISS:BHF-UCL.::GO:0043526; P:neuroprotection; ISS:BHF-UCL.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0050867; P:positive regulation of cell activation; ISS:BHF-UCL.::GO:0045597; P:positive regulation of cell differentiation; ISS:BHF-UCL.::GO:0030335; P:positive regulation of cell migration; ISS:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; ISS:BHF-UCL.::GO:0010811; P:positive regulation of cell-substrate adhesion; ISS:BHF-UCL.::GO:0043388; P:positive regulation of DNA binding; ISS:BHF-UCL.::GO:0060399; P:positive regulation of growth hormone receptor signaling pathway; IMP:BHF-UCL.::GO:0050729; P:positive regulation of inflammatory response; ISS:BHF-UCL.::GO:0032024; P:positive regulation of insulin secretion; ISS:BHF-UCL.::GO:0032731; P:positive regulation of interleukin-1 beta production; ISS:BHF-UCL.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISS:BHF-UCL.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:BHF-UCL.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; ISS:BHF-UCL.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.::GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:BHF-UCL.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; IDA:UniProtKB.::GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0097012; P:response to granulocyte macrophage colony-stimulating factor stimulus; NAS:BHF-UCL.::GO:0033194; P:response to hydroperoxide; ISS:BHF-UCL.::GO:0032496; P:response to lipopolysaccharide; IDA:BHF-UCL.::GO:0007262; P:STAT protein import into nucleus; IDA:MGI.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; ISS:BHF-UCL.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; ISS:BHF-UCL.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; ISS:BHF-UCL. | 986 | Q62689 | 1132 | JAK2_RAT Tyrosine-protein kinase JAK2 OS=Ratt... | 294 | 0.0000009 | 54.3 | 22 | 43 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; IDA:RGD.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016363; C:nuclear matrix; IDA:RGD. | | | | | | | | | | GO:0033130; F:acetylcholine receptor binding; IPI:RGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005131; F:growth hormone receptor binding; IPI:BHF-UCL.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0051428; F:peptide hormone receptor binding; IPI:RGD.::GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0031702; F:type 1 angiotensin receptor binding; IPI:RGD. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0000186; P:activation of MAPKK activity; IMP:RGD.::GO:0031103; P:axon regeneration; IMP:RGD.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0009755; P:hormone-mediated signaling pathway; IDA:RGD.::GO:0008631; P:induction of apoptosis by oxidative stress; IMP:RGD.::GO:0060333; P:interferon-gamma-mediated signaling pathway; IDA:BHF-UCL.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0031959; P:mineralocorticoid receptor signaling pathway; IMP:RGD.::GO:0022408; P:negative regulation of cell-cell adhesion; IMP:RGD.::GO:0045822; P:negative regulation of heart contraction; IMP:RGD.::GO:0043526; P:neuroprotection; IMP:RGD.::GO:0048008; P:platelet-derived growth factor receptor signaling pathway; IMP:RGD.::GO:0050867; P:positive regulation of cell activation; IMP:RGD.::GO:0045597; P:positive regulation of cell differentiation; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0008284; P:positive regulation of cell proliferation; IMP:RGD.::GO:0043388; P:positive regulation of DNA binding; IMP:RGD.::GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.::GO:0032024; P:positive regulation of insulin secretion; IMP:RGD.::GO:0032731; P:positive regulation of interleukin-1 beta production; IMP:RGD.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.::GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IDA:BHF-UCL.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; IMP:RGD.::GO:0033160; P:positive regulation of protein import into nucleus, translocation; IMP:RGD.::GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IMP:RGD.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0033194; P:response to hydroperoxide; IMP:RGD.::GO:0042508; P:tyrosine phosphorylation of Stat1 protein; IMP:RGD.::GO:0042503; P:tyrosine phosphorylation of Stat3 protein; IMP:RGD.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IMP:RGD. | 987 | Q63272 | 1100 | JAK3_RAT Tyrosine-protein kinase JAK3 OS=Ratt... | 270 | 0.000003 | 52.8 | 21 | 42 | GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0008134; F:transcription factor binding; IC:RGD. | | | | | | | | | | GO:0030183; P:B cell differentiation; ISS:BHF-UCL.::GO:0019221; P:cytokine-mediated signaling pathway; IDA:RGD.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:RGD.::GO:0007167; P:enzyme linked receptor protein signaling pathway; ISS:BHF-UCL.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0002731; P:negative regulation of dendritic cell cytokine production; ISS:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; ISS:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; ISS:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; ISS:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; ISS:BHF-UCL.::GO:0042104; P:positive regulation of activated T cell proliferation; IMP:RGD.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:BHF-UCL.::GO:0051928; P:positive regulation of calcium ion transport; IMP:RGD.::GO:0050778; P:positive regulation of immune response; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IMP:RGD.::GO:0043029; P:T cell homeostasis; ISS:BHF-UCL.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; IMP:RGD. | 988 | O19064 | 1131 | JAK2_PIG Tyrosine-protein kinase JAK2 OS=Sus ... | 293 | 0.000005 | 52 | 22 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0035401; F:histone kinase activity (H3-Y41 specific); ISS:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0042977; P:activation of JAK2 kinase activity; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; ISS:UniProtKB.::GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 989 | Q62137 | 1100 | JAK3_MOUSE Tyrosine-protein kinase JAK3 OS=Mu... | 273 | 0.000005 | 52 | 21 | 43 | GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0030183; P:B cell differentiation; IMP:BHF-UCL.::GO:0019221; P:cytokine-mediated signaling pathway; IDA:MGI.::GO:0007204; P:elevation of cytosolic calcium ion concentration; ISS:BHF-UCL.::GO:0007167; P:enzyme linked receptor protein signaling pathway; IDA:MGI.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0048535; P:lymph node development; TAS:MGI.::GO:0002731; P:negative regulation of dendritic cell cytokine production; IMP:BHF-UCL.::GO:0045221; P:negative regulation of FasL biosynthetic process; IMP:BHF-UCL.::GO:0032693; P:negative regulation of interleukin-10 production; IMP:BHF-UCL.::GO:0032695; P:negative regulation of interleukin-12 production; IMP:BHF-UCL.::GO:0045626; P:negative regulation of T-helper 1 cell differentiation; IMP:BHF-UCL.::GO:0070244; P:negative regulation of thymocyte apoptotic process; IMP:BHF-UCL.::GO:0042104; P:positive regulation of activated T cell proliferation; ISS:BHF-UCL.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:BHF-UCL.::GO:0051928; P:positive regulation of calcium ion transport; ISS:BHF-UCL.::GO:0050778; P:positive regulation of immune response; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0046777; P:protein autophosphorylation; ISS:BHF-UCL.::GO:0070672; P:response to interleukin-15; TAS:BHF-UCL.::GO:0070669; P:response to interleukin-2; TAS:BHF-UCL.::GO:0070670; P:response to interleukin-4; ISS:BHF-UCL.::GO:0071104; P:response to interleukin-9; TAS:BHF-UCL.::GO:0043029; P:T cell homeostasis; IMP:BHF-UCL.::GO:0042506; P:tyrosine phosphorylation of Stat5 protein; ISS:BHF-UCL. | 990 | Q8C050 | 863 | KS6A5_MOUSE Ribosomal protein S6 kinase alpha... | 165 | 0.000006 | 52 | 27 | 48 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0043990; P:histone H2A-S1 phosphorylation; ISS:UniProtKB.::GO:0043987; P:histone H3-S10 phosphorylation; ISS:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; ISS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. | 991 | Q54I36 | 1338 | PYK3_DICDI Dual specificity protein kinase py... | 167 | 0.000007 | 51.6 | 24 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IC:dictyBase.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IDA:dictyBase. | | | | | | | | | | GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0031156; P:regulation of sorocarp development; IMP:dictyBase. |
