| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
511 | P36897 | 503 | TGFR1_HUMAN TGF-beta receptor type-1 OS=Homo ... | 276 | 0.000000000000005 | 79.3 | 28 | 46 | GO:0005923; C:tight junction; IDA:UniProtKB.::GO:0070022; C:transforming growth factor beta receptor homodimeric complex; IC:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:HGNC.::GO:0070411; F:I-SMAD binding; IPI:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0050431; F:transforming growth factor beta binding; IDA:BHF-UCL.::GO:0005025; F:transforming growth factor beta receptor activity, type I; IDA:BHF-UCL.::GO:0005114; F:type II transforming growth factor beta receptor binding; IDA:BHF-UCL. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.::GO:0009952; P:anterior/posterior pattern specification; ISS:BHF-UCL.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048844; P:artery morphogenesis; ISS:BHF-UCL.::GO:0007050; P:cell cycle arrest; TAS:UniProtKB.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.::GO:0030199; P:collagen fibril organization; ISS:BHF-UCL.::GO:0048701; P:embryonic cranial skeleton morphogenesis; ISS:BHF-UCL.::GO:0001837; P:epithelial to mesenchymal transition; IDA:UniProtKB.::GO:0008354; P:germ cell migration; ISS:BHF-UCL.::GO:0007507; P:heart development; ISS:BHF-UCL.::GO:0001822; P:kidney development; ISS:BHF-UCL.::GO:0032331; P:negative regulation of chondrocyte differentiation; ISS:BHF-UCL.::GO:0048663; P:neuron fate commitment; ISS:BHF-UCL.::GO:0060021; P:palate development; ISS:BHF-UCL.::GO:0060017; P:parathyroid gland development; ISS:BHF-UCL.::GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.::GO:0060037; P:pharyngeal system development; ISS:BHF-UCL.::GO:0030307; P:positive regulation of cell growth; IDA:BHF-UCL.::GO:0008284; P:positive regulation of cell proliferation; IMP:HGNC.::GO:0051272; P:positive regulation of cellular component movement; IMP:BHF-UCL.::GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:BHF-UCL.::GO:0060391; P:positive regulation of SMAD protein import into nucleus; IDA:BHF-UCL.::GO:0045885; P:positive regulation of survival gene product expression; IMP:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0031396; P:regulation of protein ubiquitination; IDA:UniProtKB.::GO:0070723; P:response to cholesterol; IDA:BHF-UCL.::GO:0048538; P:thymus development; ISS:BHF-UCL.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:BHF-UCL.::GO:0042060; P:wound healing; TAS:UniProtKB. | 512 | Q13188 | 491 | STK3_HUMAN Serine/threonine-protein kinase 3 ... | 264 | 0.000000000000005 | 79.3 | 27 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0046983; F:protein dimerization activity; ISS:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; IDA:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:UniProtKB.::GO:0035329; P:hippo signaling cascade; TAS:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB. | 513 | A4K2W5 | 487 | STK4_AOTNA Serine/threonine-protein kinase 4 ... | 268 | 0.000000000000005 | 79.3 | 25 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 514 | A4K2T0 | 487 | STK4_MACMU Serine/threonine-protein kinase 4 ... | 268 | 0.000000000000005 | 79.3 | 25 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB. | 515 | P80204 | 501 | TGFR1_RAT TGF-beta receptor type-1 OS=Rattus ... | 276 | 0.000000000000006 | 79.3 | 28 | 46 | GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0016323; C:basolateral plasma membrane; IDA:RGD.::GO:0005901; C:caveola; IDA:MGI.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.::GO:0070022; C:transforming growth factor beta receptor homodimeric complex; IC:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IMP:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IMP:RGD.::GO:0050431; F:transforming growth factor beta binding; IDA:RGD.::GO:0005025; F:transforming growth factor beta receptor activity, type I; IMP:RGD.::GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048565; P:digestive tract development; IEP:RGD.::GO:0007566; P:embryo implantation; IEP:RGD.::GO:0030324; P:lung development; IEP:RGD.::GO:0045602; P:negative regulation of endothelial cell differentiation; IMP:RGD.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0046777; P:protein autophosphorylation; IMP:RGD.::GO:0051602; P:response to electrical stimulus; IEP:RGD.::GO:0043627; P:response to estrogen stimulus; IDA:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0034695; P:response to prostaglandin E stimulus; IEP:RGD.::GO:0009636; P:response to toxin; IEP:RGD.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:RGD. | 516 | Q64729 | 503 | TGFR1_MOUSE TGF-beta receptor type-1 OS=Mus m... | 276 | 0.000000000000006 | 79.3 | 28 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0050431; F:transforming growth factor beta binding; IPI:MGI. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0048844; P:artery morphogenesis; IMP:MGI.::GO:0001824; P:blastocyst development; IDA:MGI.::GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:MGI.::GO:0043542; P:endothelial cell migration; IMP:MGI.::GO:0008354; P:germ cell migration; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0006917; P:induction of apoptosis; IMP:MGI.::GO:0001822; P:kidney development; IGI:MGI.::GO:0002088; P:lens development in camera-type eye; IMP:MGI.::GO:0032331; P:negative regulation of chondrocyte differentiation; IMP:BHF-UCL.::GO:0048663; P:neuron fate commitment; IMP:MGI.::GO:0060021; P:palate development; IMP:MGI.::GO:0060017; P:parathyroid gland development; IMP:MGI.::GO:0060037; P:pharyngeal system development; IMP:MGI.::GO:0051491; P:positive regulation of filopodium assembly; IMP:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0043393; P:regulation of protein binding; IMP:MGI.::GO:0070723; P:response to cholesterol; IDA:BHF-UCL.::GO:0048538; P:thymus development; IMP:MGI.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:MGI. | 517 | Q8BLF2 | 595 | CDKL3_MOUSE Cyclin-dependent kinase-like 3 OS... | 213 | 0.000000000000006 | 79.3 | 27 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 518 | Q60750 | 977 | EPHA1_MOUSE Ephrin type-A receptor 1 OS=Mus m... | 268 | 0.000000000000006 | 79.7 | 25 | 45 | GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005005; F:transmembrane-ephrin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0032862; P:activation of Rho GTPase activity; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0030336; P:negative regulation of cell migration; ISS:UniProtKB.::GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.::GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0001954; P:positive regulation of cell-matrix adhesion; ISS:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; ISS:UniProtKB. | 519 | P11528 | 986 | GCY_ARBPU Resact receptor OS=Arbacia punctula... | 272 | 0.000000000000006 | 79.7 | 26 | 42 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:InterPro.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0004383; F:guanylate cyclase activity; IEA:EC.::GO:0004672; F:protein kinase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 520 | P83104 | 393 | M3K7L_DROME Putative mitogen-activated protei... | 280 | 0.000000000000006 | 79 | 24 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 521 | Q8MY86 | 854 | FGFR1_DUGJA Fibroblast growth factor receptor... | 278 | 0.000000000000006 | 79.7 | 26 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 522 | Q9LYX1 | 711 | LRK82_ARATH L-type lectin-domain containing r... | 311 | 0.000000000000006 | 79.3 | 25 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 523 | Q62073 | 579 | M3K7_MOUSE Mitogen-activated protein kinase k... | 270 | 0.000000000000006 | 79.3 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004708; F:MAP kinase kinase activity; IDA:MGI.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0060546; P:negative regulation of necroptosis; IMP:UniProtKB.::GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:UniProtKB.::GO:0001841; P:neural tube formation; IMP:MGI.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI. | 524 | Q0WPH8 | 956 | NEK5_ARATH Serine/threonine-protein kinase Ne... | 203 | 0.000000000000007 | 79.3 | 27 | 48 | GO:0055028; C:cortical microtubule; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009913; P:epidermal cell differentiation; IMP:TAIR.::GO:0007017; P:microtubule-based process; IMP:TAIR. | 525 | Q13043 | 487 | STK4_HUMAN Serine/threonine-protein kinase 4 ... | 268 | 0.000000000000007 | 79 | 25 | 44 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:MGI.::GO:0043539; F:protein serine/threonine kinase activator activity; IDA:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0000902; P:cell morphogenesis; IDA:MGI.::GO:0035329; P:hippo signaling cascade; TAS:UniProtKB.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:MGI. | 526 | Q9S9M3 | 730 | WAKLC_ARATH Wall-associated receptor kinase-l... | 233 | 0.000000000000007 | 79.3 | 27 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 527 | P0C8E4 | 606 | M3K7_RAT Mitogen-activated protein kinase kin... | 270 | 0.000000000000008 | 79 | 24 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:RGD. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:RGD.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 528 | P54753 | 998 | EPHB3_HUMAN Ephrin type-B receptor 3 OS=Homo ... | 287 | 0.000000000000008 | 79.3 | 26 | 46 | GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005003; F:ephrin receptor activity; IDA:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0007413; P:axonal fasciculation; ISS:UniProtKB.::GO:0016477; P:cell migration; IDA:UniProtKB.::GO:0022038; P:corpus callosum development; ISS:UniProtKB.::GO:0060997; P:dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048546; P:digestive tract morphogenesis; ISS:UniProtKB.::GO:0060021; P:palate development; ISS:UniProtKB.::GO:0051965; P:positive regulation of synapse assembly; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0050770; P:regulation of axonogenesis; ISS:UniProtKB.::GO:0043088; P:regulation of Cdc42 GTPase activity; IDA:UniProtKB.::GO:0022407; P:regulation of cell-cell adhesion; IDA:UniProtKB.::GO:0032314; P:regulation of Rac GTPase activity; IDA:UniProtKB.::GO:0034446; P:substrate adhesion-dependent cell spreading; IDA:UniProtKB.::GO:0048538; P:thymus development; ISS:UniProtKB.::GO:0001655; P:urogenital system development; ISS:UniProtKB. | 529 | Q0IHQ8 | 951 | STK10_XENTR Serine/threonine-protein kinase 1... | 265 | 0.000000000000008 | 79.3 | 27 | 43 | GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB. | 530 | Q13163 | 448 | MP2K5_HUMAN Dual specificity mitogen-activate... | 247 | 0.000000000000008 | 79 | 26 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:BHF-UCL.::GO:0071363; P:cellular response to growth factor stimulus; ISS:BHF-UCL.::GO:0071499; P:cellular response to laminar fluid shear stress; TAS:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; ISS:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISS:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051247; P:positive regulation of protein metabolic process; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. | 531 | Q5RFL3 | 606 | M3K7_PONAB Mitogen-activated protein kinase k... | 270 | 0.000000000000008 | 79 | 24 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 532 | Q07292 | 813 | KRAF1_CAEEL Raf homolog serine/threonine-prot... | 216 | 0.000000000000008 | 79.3 | 28 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0001708; P:cell fate specification; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007265; P:Ras protein signal transduction; IGI:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0040025; P:vulval development; IMP:WormBase. | 533 | P20806 | 2594 | 7LESS_DROVI Protein sevenless OS=Drosophila v... | 273 | 0.000000000000008 | 79.3 | 26 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.::GO:0007601; P:visual perception; IEA:UniProtKB-KW. | 534 | P23647 | 805 | FUSED_DROME Serine/threonine-protein kinase f... | 201 | 0.000000000000008 | 79.3 | 29 | 46 | GO:0035301; C:Hedgehog signaling complex; IPI:FlyBase.::GO:0016020; C:membrane; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase. | | | | | | | | | | GO:0007293; P:germarium-derived egg chamber formation; IMP:FlyBase.::GO:0007228; P:positive regulation of hh target transcription factor activity; IMP:FlyBase.::GO:0042993; P:positive regulation of transcription factor import into nucleus; IMP:FlyBase.::GO:0031647; P:regulation of protein stability; IDA:FlyBase.::GO:0030162; P:regulation of proteolysis; NAS:FlyBase.::GO:0007367; P:segment polarity determination; IMP:FlyBase. | 535 | O43318 | 606 | M3K7_HUMAN Mitogen-activated protein kinase k... | 270 | 0.000000000000008 | 79 | 24 | 45 | GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.::GO:0007252; P:I-kappaB phosphorylation; IDA:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; IDA:UniProtKB.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; NAS:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 536 | O59790 | 355 | ARK1_SCHPO Serine/threonine-protein kinase ar... | 216 | 0.000000000000008 | 78.2 | 27 | 47 | GO:0032133; C:chromosome passenger complex; NAS:PomBase.::GO:0000778; C:condensed nuclear chromosome kinetochore; IDA:PomBase.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0051233; C:spindle midzone; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IDA:PomBase. | | | | | | | | | | GO:0051315; P:attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation; TAS:PomBase.::GO:0033205; P:cell cycle cytokinesis; IMP:PomBase.::GO:2000775; P:histone H3-S10 phosphorylation involved in chromosome condensation; IDA:PomBase.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IMP:PomBase.::GO:0034501; P:protein localization to kinetochore; IGI:PomBase.::GO:0034503; P:protein localization to nucleolar rDNA repeats; IGI:PomBase.::GO:0031134; P:sister chromatid biorientation; TAS:PomBase. | 537 | P80203 | 504 | ACVL1_RAT Serine/threonine-protein kinase rec... | 280 | 0.000000000000009 | 79 | 27 | 45 | GO:0030425; C:dendrite; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0043025; C:neuronal cell body; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IDA:RGD.::GO:0046332; F:SMAD binding; IDA:RGD.::GO:0050431; F:transforming growth factor beta binding; TAS:RGD.::GO:0005025; F:transforming growth factor beta receptor activity, type I; IDA:RGD. | | | | | | | | | | GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:RGD. | 538 | P22455 | 802 | FGFR4_HUMAN Fibroblast growth factor receptor... | 175 | 0.000000000000009 | 79 | 32 | 47 | GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.::GO:0008201; F:heparin binding; IDA:UniProtKB. | | | | | | | | | | GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0055062; P:phosphate ion homeostasis; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0048554; P:positive regulation of metalloenzyme activity; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:2000188; P:regulation of cholesterol homeostasis; ISS:UniProtKB.::GO:0010715; P:regulation of extracellular matrix disassembly; IMP:UniProtKB. | 539 | O54748 | 491 | STK3_RAT Serine/threonine-protein kinase 3 OS... | 264 | 0.000000000000009 | 79 | 25 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0035329; P:hippo signaling cascade; ISS:UniProtKB. | 540 | A2VDU3 | 579 | M3K7_BOVIN Mitogen-activated protein kinase k... | 270 | 0.000000000000009 | 79 | 24 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 541 | P0A5S4 | 626 | PKNB_MYCTU Serine/threonine-protein kinase pk... | 189 | 0.000000000000009 | 79 | 31 | 52 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030145; F:manganese ion binding; IDA:MTBBASE.::GO:0008658; F:penicillin binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MTBBASE.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MTBBASE. | | | | | | | | | | GO:0040007; P:growth; IMP:MTBBASE.::GO:0043086; P:negative regulation of catalytic activity; IDA:MTBBASE.::GO:0032091; P:negative regulation of protein binding; IDA:MTBBASE.::GO:0043085; P:positive regulation of catalytic activity; IDA:MTBBASE.::GO:0043388; P:positive regulation of DNA binding; IDA:MTBBASE.::GO:0046777; P:protein autophosphorylation; IDA:MTBBASE.::GO:0008360; P:regulation of cell shape; IMP:MTBBASE.::GO:0051338; P:regulation of transferase activity; IDA:MTBBASE.::GO:0052572; P:response to host immune response; IDA:MTBBASE. |
