rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q03426 | 396 | KIME_HUMAN Mevalonate kinase OS=Homo sapiens ... | 408 | 4e-54 | 197 | 37 | 52 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0004496; F:mevalonate kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0008299; P:isoprenoid biosynthetic process; IDA:UniProtKB. | 32 | Q5E9T8 | 396 | KIME_BOVIN Mevalonate kinase OS=Bos taurus (B... | 402 | 2e-53 | 196 | 39 | 55 | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 33 | Q09780 | 404 | KIME_SCHPO Putative mevalonate kinase OS=Schi... | 386 | 1e-51 | 191 | 35 | 53 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; ISS:PomBase.::GO:0042803; F:protein homodimerization activity; ISS:PomBase. | | | | | | | | | | GO:0006696; P:ergosterol biosynthetic process; ISS:PomBase.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 34 | P55217 | 563 | METB_ARATH Cystathionine gamma-synthase, chlo... | 345 | 8e-51 | 192 | 33 | 53 | GO:0009570; C:chloroplast stroma; IDA:TAIR. | | | | | | | | | | GO:0003962; F:cystathionine gamma-synthase activity; IDA:TAIR.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IMP:TAIR.::GO:0001887; P:selenium compound metabolic process; IDA:TAIR. | 35 | Q9R008 | 395 | KIME_MOUSE Mevalonate kinase OS=Mus musculus ... | 399 | 2e-50 | 187 | 36 | 52 | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IDA:MGI. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW. | 36 | P17256 | 395 | KIME_RAT Mevalonate kinase OS=Rattus norvegic... | 405 | 2e-49 | 184 | 35 | 52 | GO:0005829; C:cytosol; IDA:RGD.::GO:0005777; C:peroxisome; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004496; F:mevalonate kinase activity; IDA:RGD.::GO:0003729; F:mRNA binding; IDA:RGD. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; TAS:RGD.::GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; IDA:RGD.::GO:0017148; P:negative regulation of translation; IDA:RGD.::GO:0045540; P:regulation of cholesterol biosynthetic process; NAS:RGD. | 37 | P55218 | 403 | METZ_PSEAE O-succinylhomoserine sulfhydrylase... | 340 | 4e-49 | 184 | 33 | 53 | | | | | | | | | | | GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 38 | Q86AG7 | 390 | KIME_DICDI Mevalonate kinase OS=Dictyostelium... | 402 | 1e-46 | 176 | 34 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; ISS:dictyBase. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 39 | P46086 | 378 | KIME_ARATH Mevalonate kinase OS=Arabidopsis t... | 393 | 2e-46 | 175 | 33 | 51 | GO:0005829; C:cytosol; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IGI:TAIR. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 40 | P95199 | 406 | METZ_MYCTU O-succinylhomoserine sulfhydrylase... | 364 | 2e-45 | 173 | 31 | 52 | | | | | | | | | | | GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.::GO:0016740; F:transferase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071268; P:homocysteine biosynthetic process; IEA:InterPro.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 41 | O13326 | 429 | CYSD_SCHPO O-acetylhomoserine (thiol)-lyase O... | 408 | 1e-37 | 151 | 32 | 45 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004124; F:cysteine synthase activity; ISS:PomBase.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; TAS:PomBase.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | | 42 | Q59829 | 392 | CYSA_STRCO Putative cystathionine gamma-lyase... | 352 | 2e-37 | 149 | 33 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004123; F:cystathionine gamma-lyase activity; IEA:EC.::GO:0080146; F:L-cysteine desulfhydrase activity; IEA:EC.::GO:0044540; F:L-cystine L-cysteine-lyase (deaminating); IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW. | 43 | Q07703 | 396 | METC_BORAV Cystathionine beta-lyase OS=Bordet... | 340 | 7e-37 | 148 | 30 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 44 | O59291 | 335 | KIME_PYRHO Mevalonate kinase OS=NBRC 100139 /... | 343 | 2e-33 | 137 | 33 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 45 | Q52811 | 396 | METC_RHIL3 Putative cystathionine beta-lyase ... | 388 | 2e-33 | 138 | 29 | 46 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 46 | P06721 | 395 | METC_ECOLI Cystathionine beta-lyase metC OS=E... | 361 | 2e-33 | 137 | 29 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IDA:EcoCyc.::GO:0080146; F:L-cysteine desulfhydrase activity; IMP:EcoCyc.::GO:0030170; F:pyridoxal phosphate binding; IDA:EcoCyc. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 47 | P44527 | 396 | METC_HAEIN Cystathionine beta-lyase OS=Haemop... | 403 | 6e-32 | 133 | 29 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 48 | Q9V187 | 335 | KIME_PYRAB Mevalonate kinase OS=Pyrococcus ab... | 346 | 6e-32 | 132 | 33 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:HAMAP.::GO:0000287; F:magnesium ion binding; IEA:HAMAP.::GO:0004496; F:mevalonate kinase activity; IEA:HAMAP. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 49 | Q8U0F3 | 334 | KIME_PYRFU Mevalonate kinase OS=Pyrococcus fu... | 379 | 2e-31 | 130 | 32 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 50 | P18949 | 395 | METC_SALTY Cystathionine beta-lyase OS=Salmon... | 343 | 1e-30 | 129 | 29 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 51 | C6A3T5 | 333 | KIME_THESM Mevalonate kinase OS=Thermococcus ... | 342 | 6e-30 | 126 | 30 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 52 | P50125 | 437 | CYSD_EMENI O-acetylhomoserine (thiol)-lyase O... | 431 | 8e-30 | 127 | 29 | 42 | | | | | | | | | | | GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW. | 53 | P06106 | 444 | MET17_YEAST Protein MET17 OS=Saccharomyces ce... | 438 | 2e-29 | 126 | 28 | 43 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD. | | | | | | | | | | GO:0004124; F:cysteine synthase activity; IDA:SGD.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IDA:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | | 54 | Q92441 | 444 | MET17_KLULA Protein MET17 OS=1267 / NRRL Y-11... | 443 | 1e-28 | 124 | 26 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004124; F:cysteine synthase activity; IEA:EC.::GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:EC.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | | 55 | Q5JJC6 | 337 | KIME_PYRKO Mevalonate kinase OS=(Thermococcus... | 349 | 7e-28 | 120 | 32 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 56 | B6YST1 | 334 | KIME_THEON Mevalonate kinase OS=Thermococcus ... | 345 | 3e-26 | 115 | 32 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 57 | C5A7L8 | 334 | KIME_THEGJ Mevalonate kinase OS=Thermococcus ... | 346 | 6e-25 | 111 | 30 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 58 | P38716 | 378 | YHR2_YEAST Uncharacterized trans-sulfuration ... | 341 | 4e-22 | 103 | 27 | 45 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 59 | O42851 | 398 | YFHE_SCHPO Uncharacterized trans-sulfuration ... | 327 | 7e-22 | 102 | 29 | 45 | | | | | | | | | | | GO:0016829; F:lyase activity; IEA:UniProtKB-KW.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. | 60 | P43623 | 340 | METC_YEAST Putative cystathionine beta-lyase ... | 310 | 2e-21 | 100 | 25 | 48 | GO:0005737; C:cytoplasm; IEA:InterPro. | | | | | | | | | | GO:0004121; F:cystathionine beta-lyase activity; IEA:EC.::GO:0047804; F:cysteine-S-conjugate beta-lyase activity; IDA:SGD.::GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. | | | | | | | | | | GO:0019450; P:L-cysteine catabolic process to pyruvate; IMP:SGD.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW. | 61 | Q58487 | 312 | KIME_METJA Mevalonate kinase OS=JCM 10045 / N... | 344 | 8e-20 | 95.5 | 26 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004496; F:mevalonate kinase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. |