| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
91 | A8WUG4 | 597 | KPC3_CAEBR Protein kinase C-like 3 OS=Caenorh... | 59 | 0.27 | 39.7 | 36 | 44 | GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019904; F:protein domain specific binding; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007163; P:establishment or maintenance of cell polarity; ISS:UniProtKB.::GO:0007369; P:gastrulation; IEA:UniProtKB-KW.::GO:0007506; P:gonadal mesoderm development; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007338; P:single fertilization; IEA:UniProtKB-KW. | 92 | Q62074 | 595 | KPCI_MOUSE Protein kinase C iota type OS=Mus ... | 59 | 0.29 | 39.7 | 32 | 44 | GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043220; C:Schmidt-Lanterman incisure; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:MGI.::GO:0045216; P:cell-cell junction organization; ISS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IMP:BHF-UCL.::GO:0035089; P:establishment of apical/basal cell polarity; IMP:MGI.::GO:0042462; P:eye photoreceptor cell development; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:BHF-UCL.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB. | 93 | F1M7Y5 | 596 | KPCI_RAT Protein kinase C iota type OS=Rattus... | 59 | 0.29 | 39.7 | 32 | 44 | GO:0031252; C:cell leading edge; IDA:RGD.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD.::GO:0004697; F:protein kinase C activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016477; P:cell migration; IMP:RGD.::GO:0034613; P:cellular protein localization; IMP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IMP:RGD.::GO:0048194; P:Golgi vesicle budding; IDA:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:2000353; P:positive regulation of endothelial cell apoptotic process; ISS:UniProtKB.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0070555; P:response to interleukin-1; IMP:RGD. | 94 | P52824 | 942 | DGKQ_HUMAN Diacylglycerol kinase theta OS=Hom... | 60 | 0.32 | 39.7 | 35 | 48 | GO:0005856; C:cytoskeleton; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0016607; C:nuclear speck; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0033613; F:activating transcription factor binding; IPI:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004143; F:diacylglycerol kinase activity; IDA:UniProtKB.::GO:0019900; F:kinase binding; IPI:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0043274; F:phospholipase binding; IPI:UniProtKB. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0019933; P:cAMP-mediated signaling; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0070528; P:protein kinase C signaling cascade; IDA:UniProtKB.::GO:0034339; P:regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor; IDA:UniProtKB.::GO:0033198; P:response to ATP; IDA:UniProtKB.::GO:0070493; P:thrombin receptor signaling pathway; IDA:UniProtKB. | 95 | Q6ZMT1 | 411 | STAC2_HUMAN SH3 and cysteine-rich domain-cont... | 68 | 0.36 | 39.3 | 32 | 43 | | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 96 | P34125 | 887 | DGKA_DICDI Diacylglycerol kinase A OS=Dictyos... | 45 | 0.42 | 39.3 | 33 | 51 | GO:0005626; C:insoluble fraction; IDA:dictyBase.::GO:0005622; C:intracellular; IDA:GOC.::GO:0016020; C:membrane; IDA:UniProtKB.::GO:0005625; C:soluble fraction; IDA:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0019992; F:diacylglycerol binding; IDA:UniProtKB.::GO:0004143; F:diacylglycerol kinase activity; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.::GO:0009653; P:anatomical structure morphogenesis; IMP:dictyBase.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase.::GO:0050926; P:regulation of positive chemotaxis; IMP:dictyBase. | 97 | B9MP50 | 337 | BIOB_ANATD Biotin synthase OS=Anaerocellum th... | 79 | 0.52 | 38.5 | 32 | 47 | | | | | | | | | | | GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.::GO:0004076; F:biotin synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009102; P:biotin biosynthetic process; IEA:UniProtKB-KW. | 98 | Q90XF2 | 588 | KPCI_DANRE Protein kinase C iota type OS=Dani... | 87 | 0.57 | 38.5 | 25 | 39 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031226; C:intrinsic to plasma membrane; IDA:ZFIN.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005915; C:zonula adherens; IDA:ZFIN. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; ISS:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0034334; P:adherens junction maintenance; IMP:ZFIN.::GO:0045217; P:cell-cell junction maintenance; IMP:ZFIN.::GO:0007502; P:digestive tract mesoderm development; IMP:ZFIN.::GO:0048546; P:digestive tract morphogenesis; IMP:ZFIN.::GO:0021744; P:dorsal motor nucleus of vagus nerve development; IMP:ZFIN.::GO:0035050; P:embryonic heart tube development; IMP:ZFIN.::GO:0000132; P:establishment of mitotic spindle orientation; IMP:ZFIN.::GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; IMP:ZFIN.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IMP:ZFIN.::GO:0008078; P:mesodermal cell migration; IMP:ZFIN.::GO:0001738; P:morphogenesis of a polarized epithelium; IMP:ZFIN.::GO:0001841; P:neural tube formation; IGI:ZFIN.::GO:0007405; P:neuroblast proliferation; IMP:ZFIN.::GO:0007097; P:nuclear migration; IMP:ZFIN.::GO:0042476; P:odontogenesis; IMP:ZFIN.::GO:0060042; P:retina morphogenesis in camera-type eye; IMP:ZFIN. | 99 | O88673 | 730 | DGKA_MOUSE Diacylglycerol kinase alpha OS=Mus... | 93 | 0.8 | 38.1 | 32 | 47 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004143; F:diacylglycerol kinase activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IDA:MGI. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 100 | Q9Y5L0 | 923 | TNPO3_HUMAN Transportin-3 OS=Homo sapiens (Hu... | 308 | 0.8 | 38.1 | 22 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; TAS:ProtInc. | | | | | | | | | | GO:0035048; P:splicing factor protein import into nucleus; IDA:UniProtKB. | 101 | O95267 | 797 | GRP1_HUMAN RAS guanyl-releasing protein 1 OS=... | 42 | 0.81 | 38.1 | 33 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; TAS:ProtInc.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; TAS:ProtInc.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:Reactome.::GO:0008289; F:lipid binding; TAS:ProtInc. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 102 | P05625 | 647 | RAF1_CHICK RAF proto-oncogene serine/threonin... | 42 | 0.84 | 38.1 | 38 | 48 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 103 | P43057 | 1097 | KPC1_CANAX Protein kinase C-like 1 OS=Candida... | 138 | 0.85 | 38.1 | 25 | 33 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 104 | Q5R5M7 | 648 | RAF1_PONAB RAF proto-oncogene serine/threonin... | 42 | 0.88 | 38.1 | 38 | 48 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 105 | P04049 | 648 | RAF1_HUMAN RAF proto-oncogene serine/threonin... | 42 | 0.88 | 38.1 | 38 | 48 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005741; C:mitochondrial outer membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0000165; P:MAPK cascade; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:UniProtKB.::GO:0031333; P:negative regulation of protein complex assembly; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0045595; P:regulation of cell differentiation; TAS:UniProtKB.::GO:2000145; P:regulation of cell motility; TAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; TAS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 106 | P11345 | 648 | RAF1_RAT RAF proto-oncogene serine/threonine-... | 42 | 0.89 | 38.1 | 38 | 48 | GO:0005829; C:cytosol; TAS:RGD.::GO:0005626; C:insoluble fraction; IDA:RGD.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IMP:RGD.::GO:0046982; F:protein heterodimerization activity; IPI:RGD. | | | | | | | | | | GO:0007507; P:heart development; IEP:RGD.::GO:0001666; P:response to hypoxia; IDA:RGD. | 107 | Q99N57 | 648 | RAF1_MOUSE RAF proto-oncogene serine/threonin... | 42 | 0.89 | 38.1 | 38 | 48 | GO:0005829; C:cytosol; TAS:MGI.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0031143; C:pseudopodium; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0017016; F:Ras GTPase binding; IPI:MGI. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IMP:MGI.::GO:0048011; P:nerve growth factor receptor signaling pathway; IMP:MGI. | 108 | A7E3S4 | 648 | RAF1_BOVIN RAF proto-oncogene serine/threonin... | 42 | 0.89 | 38.1 | 38 | 48 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 109 | P97306 | 403 | STAC_MOUSE SH3 and cysteine-rich domain-conta... | 78 | 0.91 | 37.7 | 26 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0034605; P:cellular response to heat; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 110 | Q9Z1S3 | 795 | GRP1_MOUSE RAS guanyl-releasing protein 1 OS=... | 42 | 0.92 | 38.1 | 33 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 111 | Q9R1K8 | 795 | GRP1_RAT RAS guanyl-releasing protein 1 OS=Ra... | 42 | 0.94 | 38.1 | 33 | 43 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; TAS:RGD. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 112 | Q8R5I4 | 678 | GRP4_RAT RAS guanyl-releasing protein 4 OS=Ra... | 47 | 1.1 | 37.7 | 32 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0009991; P:response to extracellular stimulus; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 113 | A4IJ06 | 791 | GRP1_XENTR RAS guanyl-releasing protein 1 OS=... | 42 | 1.2 | 37.7 | 33 | 43 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 114 | P87253 | 1142 | KPC1_NEUCR Protein kinase C-like OS=1257 / FG... | 139 | 1.2 | 37.7 | 22 | 35 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 115 | Q6NTL4 | 791 | GRP1_XENLA RAS guanyl-releasing protein 1 OS=... | 42 | 1.3 | 37.7 | 33 | 43 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 116 | P05130 | 679 | KPC1_DROME Protein kinase C, brain isozyme OS... | 123 | 1.4 | 37.4 | 23 | 33 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 117 | Q6P2B1 | 923 | TNPO3_MOUSE Transportin-3 OS=Mus musculus (Mo... | 308 | 1.6 | 37.4 | 22 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro. | | | | | | | | | | GO:0035048; P:splicing factor protein import into nucleus; ISS:UniProtKB. | 118 | Q46CU8 | 269 | TRUA_METBF tRNA pseudouridine synthase A OS=M... | 140 | 2 | 36.2 | 26 | 46 | | | | | | | | | | | GO:0009982; F:pseudouridine synthase activity; IEA:EC.::GO:0003723; F:RNA binding; IEA:InterPro. | | | | | | | | | | GO:0001522; P:pseudouridine synthesis; IEA:InterPro.::GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. | 119 | Q9R0C8 | 847 | VAV3_MOUSE Guanine nucleotide exchange factor... | 44 | 2.5 | 36.6 | 34 | 45 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.::GO:0006906; P:vesicle fusion; IGI:MGI. | 120 | Q9UKW4 | 847 | VAV3_HUMAN Guanine nucleotide exchange factor... | 44 | 2.6 | 36.6 | 34 | 45 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; TAS:ProtInc.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0030890; P:positive regulation of B cell proliferation; IMP:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.::GO:0042493; P:response to drug; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 121 | Q12873 | 2000 | CHD3_HUMAN Chromodomain-helicase-DNA-binding ... | 126 | 3.2 | 36.6 | 26 | 39 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0016581; C:NuRD complex; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004003; F:ATP-dependent DNA helicase activity; TAS:ProtInc.::GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB. | | | | | | | | | | GO:0051297; P:centrosome organization; IDA:UniProtKB.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.::GO:0007051; P:spindle organization; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
