| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q8MLZ5 | 1207 | GAP2_CAEEL Ras GTPase-activating protein gap-... | 409 | 8e-28 | 124 | 25 | 44 | GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 2 | Q5VWQ8 | 1189 | DAB2P_HUMAN Disabled homolog 2-interacting pr... | 513 | 9e-28 | 124 | 25 | 40 | GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; IDA:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0051721; F:protein phosphatase 2A binding; IDA:BHF-UCL.::GO:0005099; F:Ras GTPase activator activity; ISS:BHF-UCL.::GO:0035591; F:signaling adaptor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.::GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; ISS:BHF-UCL.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; ISS:BHF-UCL.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0010633; P:negative regulation of epithelial cell migration; TAS:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0034261; P:negative regulation of Ras GTPase activity; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IC:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. | 3 | Q3UHC7 | 1189 | DAB2P_MOUSE Disabled homolog 2-interacting pr... | 513 | 1e-27 | 124 | 25 | 41 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL. | 4 | Q6P730 | 996 | DAB2P_RAT Disabled homolog 2-interacting prot... | 436 | 3e-26 | 119 | 26 | 42 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0047485; F:protein N-terminus binding; IPI:RGD.::GO:0005099; F:Ras GTPase activator activity; IDA:RGD. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:RGD.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD. | 5 | Q8T498 | 1580 | GAP2_DROME Probable Ras GTPase-activating pro... | 540 | 3e-26 | 119 | 23 | 39 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro. | 6 | P09851 | 1044 | RASA1_BOVIN Ras GTPase-activating protein 1 O... | 502 | 2e-24 | 113 | 24 | 41 | GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome. | | | | | | | | | | GO:0051020; F:GTPase binding; ISS:AgBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome.::GO:0005102; F:receptor binding; ISS:AgBase. | | | | | | | | | | GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:AgBase.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:AgBase.::GO:0030833; P:regulation of actin filament polymerization; ISS:AgBase.::GO:0007165; P:signal transduction; ISS:AgBase.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 7 | P20936 | 1047 | RASA1_HUMAN Ras GTPase-activating protein 1 O... | 502 | 2e-23 | 110 | 24 | 41 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0001948; F:glycoprotein binding; IPI:UniProtKB.::GO:0051020; F:GTPase binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019870; F:potassium channel inhibitor activity; NAS:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0005102; F:receptor binding; IPI:UniProtKB. | | | | | | | | | | GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; IDA:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; NAS:UniProtKB.::GO:0051252; P:regulation of RNA metabolic process; NAS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 8 | P50904 | 1038 | RASA1_RAT Ras GTPase-activating protein 1 OS=... | 502 | 3e-23 | 109 | 24 | 41 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0007155; P:cell adhesion; NAS:UniProtKB.::GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.::GO:0007165; P:signal transduction; ISS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 9 | Q9UJF2 | 1139 | NGAP_HUMAN Ras GTPase-activating protein nGAP... | 514 | 4e-23 | 109 | 24 | 39 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; TAS:ProtInc. | 10 | Q9QUH6 | 1308 | SYGP1_RAT Ras GTPase-activating protein SynGA... | 502 | 2e-22 | 107 | 25 | 40 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB. | 11 | F6SEU4 | 1340 | SYGP1_MOUSE Ras GTPase-activating protein Syn... | 500 | 2e-22 | 106 | 24 | 40 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005097; F:Rab GTPase activator activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016358; P:dendrite development; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0050771; P:negative regulation of axonogenesis; IDA:MGI.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007389; P:pattern specification process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IDA:MGI.::GO:0043113; P:receptor clustering; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0043408; P:regulation of MAPK cascade; IMP:MGI.::GO:0050803; P:regulation of synapse structure and activity; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI. | 12 | Q96PV0 | 1343 | SYGP1_HUMAN Ras GTPase-activating protein Syn... | 500 | 3e-22 | 106 | 24 | 40 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB. | 13 | A6QQ91 | 1012 | RASL3_BOVIN RAS protein activator like-3 OS=B... | 390 | 2e-20 | 100 | 26 | 42 | GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro. | 14 | Q8C2K5 | 1041 | RASL3_MOUSE RAS protein activator like-3 OS=M... | 393 | 3e-20 | 100 | 25 | 42 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro. | 15 | Q54Y08 | 877 | NGAP_DICDI Probable Ras GTPase-activating-lik... | 91 | 3.1 | 35 | 33 | 44 | GO:0005813; C:centrosome; TAS:dictyBase.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro. | 16 | Q86YV0 | 1011 | RASL3_HUMAN RAS protein activator like-3 OS=H... | 389 | 7e-17 | 89 | 25 | 41 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro. | 17 | P48423 | 1163 | GAP1_DROME GTPase-activating protein OS=Droso... | 201 | 0.00000000000001 | 82 | 30 | 47 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IMP:FlyBase. | | | | | | | | | | GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0007067; P:mitosis; IMP:FlyBase.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045678; P:positive regulation of R7 cell differentiation; IGI:FlyBase.::GO:0007265; P:Ras protein signal transduction; IMP:FlyBase.::GO:0007062; P:sister chromatid cohesion; IMP:FlyBase.::GO:0008293; P:torso signaling pathway; NAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase. | 18 | O43374 | 803 | RASL2_HUMAN Ras GTPase-activating protein 4 O... | 127 | 2 | 35.4 | 24 | 45 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 19 | P33314 | 1104 | BUD2_YEAST Inhibitory regulator protein BUD2/... | 219 | 0.0000000000002 | 77.8 | 25 | 45 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0030447; P:filamentous growth; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. | 20 | C9J798 | 803 | RAS4B_HUMAN Putative Ras GTPase-activating pr... | 127 | 2 | 35.4 | 24 | 45 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 21 | Q28013 | 834 | RASA3_BOVIN Ras GTPase-activating protein 3 O... | 145 | 0.024 | 42 | 23 | 47 | GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome. | 22 | Q6PFQ7 | 802 | RASL2_MOUSE Ras GTPase-activating protein 4 O... | 91 | 3.6 | 34.7 | 26 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 23 | Q14644 | 834 | RASA3_HUMAN Ras GTPase-activating protein 3 O... | 145 | 0.03 | 41.6 | 23 | 46 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IDA:BHF-UCL. | | | | | | | | | | GO:0015278; F:calcium-release channel activity; IDA:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 24 | O95294 | 804 | RASL1_HUMAN RasGAP-activating-like protein 1 ... | 90 | 2.9 | 35 | 30 | 46 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 25 | Q04690 | 2841 | NF1_MOUSE Neurofibromin OS=Mus musculus (Mous... | 176 | 0.000000000003 | 74.3 | 28 | 53 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0005099; F:Ras GTPase activator activity; IGI:MGI. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0030325; P:adrenal gland development; IMP:MGI.::GO:0048844; P:artery morphogenesis; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.::GO:0021987; P:cerebral cortex development; IMP:MGI.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0021897; P:forebrain astrocyte development; IMP:MGI.::GO:0048853; P:forebrain morphogenesis; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0001889; P:liver development; IMP:MGI.::GO:0000165; P:MAPK cascade; IMP:MGI.::GO:0001656; P:metanephros development; IMP:MGI.::GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.::GO:0016525; P:negative regulation of angiogenesis; IGI:MGI.::GO:0048712; P:negative regulation of astrocyte differentiation; IMP:MGI.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI.::GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:MGI.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.::GO:0035021; P:negative regulation of Rac protein signal transduction; IGI:MGI.::GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:MGI.::GO:0021915; P:neural tube development; IGI:MGI.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:MGI.::GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IMP:MGI.::GO:0045124; P:regulation of bone resorption; IMP:MGI.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.::GO:0048745; P:smooth muscle tissue development; IMP:MGI.::GO:0021510; P:spinal cord development; IMP:MGI.::GO:0048485; P:sympathetic nervous system development; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI. | 26 | Q9QYJ2 | 834 | RASA3_RAT Ras GTPase-activating protein 3 OS=... | 145 | 0.011 | 42.7 | 24 | 48 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 27 | P97526 | 2820 | NF1_RAT Neurofibromin OS=Rattus norvegicus (R... | 164 | 0.000000000007 | 73.2 | 29 | 54 | GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; IDA:HGNC.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD. | | | | | | | | | | GO:0008017; F:microtubule binding; IDA:MGI.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0045545; F:syndecan binding; IPI:RGD. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; ISS:HGNC.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0045765; P:regulation of angiogenesis; ISS:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0045664; P:regulation of neuron differentiation; IMP:RGD.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC. | 28 | Q9Z268 | 799 | RASL1_MOUSE RasGAP-activating-like protein 1 ... | 89 | 5.3 | 34.3 | 28 | 43 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 29 | P21359 | 2839 | NF1_HUMAN Neurofibromin OS=Homo sapiens (Huma... | 176 | 0.00000000001 | 72.8 | 28 | 53 | GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; ISS:HGNC.::GO:0030425; C:dendrite; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; ISS:HGNC. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0005099; F:Ras GTPase activator activity; IDA:HGNC. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0043535; P:regulation of blood vessel endothelial cell migration; IMP:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC. | 30 | Q60790 | 834 | RASA3_MOUSE Ras GTPase-activating protein 3 O... | 145 | 0.012 | 42.7 | 24 | 48 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 31 | P58069 | 848 | RASA2_MOUSE Ras GTPase-activating protein 2 O... | 102 | 0.39 | 37.7 | 25 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. |
