| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | B3LTF3 | 1252 | SDC25_YEAS1 Guanine nucleotide exchange facto... | 159 | 0.015 | 42.7 | 22 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 62 | B5VMS9 | 1265 | SDC25_YEAS6 Guanine nucleotide exchange facto... | 159 | 0.015 | 42.7 | 22 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 63 | Q03385 | 852 | GNDS_MOUSE Ral guanine nucleotide dissociatio... | 107 | 0.52 | 37.7 | 26 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 64 | Q9EQZ6 | 1011 | RPGF4_MOUSE Rap guanine nucleotide exchange f... | 144 | 0.017 | 42.4 | 22 | 47 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005829; C:cytosol; IDA:MGI. | | | | | | | | | | GO:0030552; F:cAMP binding; IDA:UniProtKB.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0017016; F:Ras GTPase binding; IPI:UniProtKB.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0017156; P:calcium ion-dependent exocytosis; IDA:MGI.::GO:0019933; P:cAMP-mediated signaling; IDA:MGI.::GO:0030073; P:insulin secretion; IDA:MGI.::GO:0017157; P:regulation of exocytosis; IDA:MGI.::GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 65 | P28818 | 1244 | RGRF1_RAT Ras-specific guanine nucleotide-rel... | 159 | 0.018 | 42.4 | 25 | 46 | GO:0005829; C:cytosol; ISS:HGNC.::GO:0030426; C:growth cone; ISS:HGNC. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; TAS:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; ISS:HGNC.::GO:0031175; P:neuron projection development; ISS:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0035020; P:regulation of Rac protein signal transduction; ISS:HGNC.::GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 66 | P26674 | 911 | STE6_SCHPO Protein ste6 OS=Schizosaccharomyce... | 153 | 0.019 | 42.4 | 23 | 50 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000747; P:conjugation with cellular fusion; IMP:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 67 | Q8IS11 | 944 | GEFO_DICDI Ras guanine nucleotide exchange fa... | 147 | 0.021 | 42.4 | 24 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 68 | C8ZCV7 | 1252 | SDC25_YEAS8 Guanine nucleotide exchange facto... | 158 | 0.022 | 42.4 | 22 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 69 | P27671 | 1262 | RGRF1_MOUSE Ras-specific guanine nucleotide-r... | 259 | 0.024 | 42 | 22 | 42 | GO:0005829; C:cytosol; IDA:HGNC.::GO:0030426; C:growth cone; IDA:HGNC. | | | | | | | | | | GO:0035254; F:glutamate receptor binding; IPI:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0032863; P:activation of Rac GTPase activity; IDA:HGNC.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0031175; P:neuron projection development; IDA:HGNC.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:MGI.::GO:0035020; P:regulation of Rac protein signal transduction; IDA:HGNC.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 70 | A2CEA7 | 1244 | RGRF2_DANRE Ras-specific guanine nucleotide-r... | 107 | 0.028 | 42 | 30 | 50 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 71 | Q12967 | 914 | GNDS_HUMAN Ral guanine nucleotide dissociatio... | 106 | 0.029 | 41.6 | 27 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IDA:UniProtKB. | | | | | | | | | | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 72 | Q6IMA7 | 247 | RSLBB_RAT Ras-like protein family member 11B ... | 176 | 0.03 | 40.8 | 24 | 43 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 73 | Q55EC7 | 960 | GEFX_DICDI RasGEF domain-containing serine/th... | 129 | 1.3 | 36.2 | 23 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 74 | Q5FVY2 | 247 | RSLBB_XENTR Ras-like protein family member 11... | 205 | 0.032 | 40.4 | 23 | 41 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 75 | Q9Z1C7 | 436 | RPGF4_RAT Rap guanine nucleotide exchange fac... | 144 | 0.037 | 40.8 | 22 | 47 | GO:0016324; C:apical plasma membrane; IDA:RGD.::GO:0030424; C:axon; IDA:RGD.::GO:0016323; C:basolateral plasma membrane; IDA:RGD.::GO:0043197; C:dendritic spine; IDA:RGD.::GO:0060076; C:excitatory synapse; IDA:RGD.::GO:0001917; C:photoreceptor inner segment; IDA:RGD.::GO:0001750; C:photoreceptor outer segment; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD. | | | | | | | | | | GO:0030552; F:cAMP binding; ISS:UniProtKB.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0017016; F:Ras GTPase binding; ISS:UniProtKB.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007507; P:heart development; IEP:RGD.::GO:0050805; P:negative regulation of synaptic transmission; IDA:RGD.::GO:0014911; P:positive regulation of smooth muscle cell migration; IDA:RGD.::GO:0050773; P:regulation of dendrite development; IMP:RGD.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 76 | P34147 | 598 | RACA_DICDI Rho-related protein racA OS=Dictyo... | 163 | 0.041 | 41.2 | 26 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:dictyBase. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 77 | P0CF32 | 1253 | SDC25_YEASX Guanine nucleotide exchange facto... | 158 | 0.041 | 41.2 | 21 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 78 | Q9BPW5 | 248 | RSLBB_HUMAN Ras-like protein family member 11... | 176 | 0.042 | 40 | 24 | 43 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 79 | Q02342 | 1095 | CDC25_LACKL Cell division control protein 25 ... | 159 | 0.048 | 41.2 | 23 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 80 | Q12526 | 212 | RAS_EMENI Ras-like protein OS=194 / M139) (As... | 174 | 0.052 | 39.7 | 24 | 43 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 81 | P70426 | 219 | RIT1_MOUSE GTP-binding protein Rit1 OS=Mus mu... | 158 | 0.057 | 39.7 | 23 | 45 | GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005525; F:GTP binding; IDA:MGI.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 82 | Q55CC0 | 216 | RASW_DICDI Ras-like protein rasW OS=Dictyoste... | 180 | 0.063 | 39.7 | 24 | 44 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; ISS:dictyBase. | 83 | A2AR50 | 585 | RGPS1_MOUSE Ras-specific guanine nucleotide-r... | 125 | 0.088 | 40 | 25 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 84 | P0CF34 | 1048 | YL017_YEAST Putative guanine nucleotide excha... | 158 | 0.089 | 40 | 21 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 85 | Q6P112 | 804 | RGL1_DANRE Ral guanine nucleotide dissociatio... | 171 | 0.7 | 37.4 | 22 | 41 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 86 | Q5JS13 | 557 | RGPS1_HUMAN Ras-specific guanine nucleotide-r... | 115 | 0.093 | 40 | 25 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 87 | Q5E9J3 | 248 | RSLBB_BOVIN Ras-like protein family member 11... | 176 | 0.093 | 39.3 | 24 | 42 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 88 | Q55CB7 | 216 | RASY_DICDI Ras-like protein rasY OS=Dictyoste... | 177 | 0.099 | 38.9 | 24 | 44 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; ISS:dictyBase. | 89 | P26675 | 1596 | SOS_DROME Protein son of sevenless OS=Drosoph... | 40 | 0.11 | 40 | 43 | 73 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0045500; P:sevenless signaling pathway; TAS:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0008293; P:torso signaling pathway; TAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase. | 90 | O00212 | 210 | RHOD_HUMAN Rho-related GTP-binding protein Rh... | 131 | 0.12 | 38.5 | 25 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; TAS:ProtInc. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc. | 91 | P34144 | 194 | RAC1A_DICDI Rho-related protein rac1A OS=Dict... | 185 | 0.13 | 38.1 | 24 | 40 | GO:0045335; C:phagocytic vesicle; IDA:dictyBase.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:dictyBase. | | | | | | | | | | GO:0030838; P:positive regulation of actin filament polymerization; IDA:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
