| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 133 | 0.001 | 46.2 | 26 | 48 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. | 32 | B0M0P8 | 2356 | GEFL_DICDI Ras guanine nucleotide exchange fa... | 151 | 0.001 | 46.6 | 25 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 33 | Q552M5 | 1508 | GEFY_DICDI Ras guanine nucleotide exchange fa... | 104 | 0.001 | 46.2 | 27 | 54 | GO:0005813; C:centrosome; IDA:dictyBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 34 | Q54C94 | 1127 | GEFF_DICDI Ras guanine nucleotide exchange fa... | 157 | 0.001 | 45.8 | 26 | 45 | GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 35 | Q55CB0 | 213 | RASU_DICDI Ras-like protein rasU OS=Dictyoste... | 192 | 0.002 | 44.3 | 25 | 46 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; ISS:dictyBase. | 36 | O15211 | 777 | RGL2_HUMAN Ral guanine nucleotide dissociatio... | 97 | 0.007 | 43.5 | 31 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 37 | Q8IS19 | 668 | GEFD_DICDI Ras guanine nucleotide exchange fa... | 105 | 0.002 | 45.4 | 28 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 38 | Q5ZJK0 | 584 | RGPS1_CHICK Ras-specific guanine nucleotide-r... | 116 | 0.002 | 45.1 | 31 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 39 | Q8SSW7 | 1043 | GEFS_DICDI Ras guanine nucleotide exchange fa... | 99 | 0.002 | 45.4 | 26 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 40 | Q61193 | 778 | RGL2_MOUSE Ral guanine nucleotide dissociatio... | 113 | 3.6 | 34.7 | 27 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 41 | P83900 | 580 | RPGF5_RAT Rap guanine nucleotide exchange fac... | 154 | 0.003 | 45.1 | 25 | 47 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 42 | Q3UYI5 | 709 | RGL3_MOUSE Ral guanine nucleotide dissociatio... | 113 | 0.003 | 45.1 | 25 | 52 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IDA:MGI.::GO:0017016; F:Ras GTPase binding; IDA:MGI. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. | 43 | Q9NZL6 | 768 | RGL1_HUMAN Ral guanine nucleotide dissociatio... | 102 | 1.4 | 36.2 | 28 | 48 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 44 | Q99578 | 217 | RIT2_HUMAN GTP-binding protein Rit2 OS=Homo s... | 71 | 0.003 | 43.5 | 34 | 51 | GO:0005886; C:plasma membrane; TAS:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005525; F:GTP binding; TAS:ProtInc.::GO:0003924; F:GTPase activity; NAS:UniProtKB. | | | | | | | | | | GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0007268; P:synaptic transmission; TAS:ProtInc. | 45 | Q9ERD6 | 590 | RGPS2_MOUSE Ras-specific guanine nucleotide-r... | 120 | 0.003 | 44.7 | 31 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 46 | Q4R7W3 | 557 | RGPS2_MACFA Ras-specific guanine nucleotide-r... | 120 | 0.003 | 44.7 | 31 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 47 | Q55CB8 | 213 | RASX_DICDI Ras-like protein rasX OS=Dictyoste... | 180 | 0.004 | 43.1 | 25 | 44 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; ISS:dictyBase.::GO:0003924; F:GTPase activity; ISS:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; ISS:dictyBase. | 48 | Q86X27 | 583 | RGPS2_HUMAN Ras-specific guanine nucleotide-r... | 120 | 0.004 | 44.3 | 31 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 49 | Q8IS21 | 1529 | GEFB_DICDI Ras guanine nucleotide exchange fa... | 92 | 0.51 | 37.7 | 25 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:dictyBase. | | | | | | | | | | GO:0007015; P:actin filament organization; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0030866; P:cortical actin cytoskeleton organization; IMP:dictyBase.::GO:0051271; P:negative regulation of cellular component movement; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050766; P:positive regulation of phagocytosis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0019953; P:sexual reproduction; IEP:dictyBase. | 50 | Q6P0U3 | 244 | RSLBB_DANRE Ras-like protein family member 11... | 153 | 0.004 | 43.1 | 29 | 43 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 51 | Q92565 | 580 | RPGF5_HUMAN Rap guanine nucleotide exchange f... | 154 | 0.005 | 44.3 | 25 | 47 | GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; IPI:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0007399; P:nervous system development; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB. | 52 | P34443 | 207 | RHEB1_CAEEL GTP-binding protein Rheb homolog ... | 93 | 0.005 | 42.7 | 28 | 48 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0040011; P:locomotion; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 53 | Q55CA9 | 214 | RASZ_DICDI Ras-like protein rasZ OS=Dictyoste... | 180 | 0.007 | 42.4 | 26 | 44 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; ISS:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0019953; P:sexual reproduction; IEP:dictyBase. | 54 | Q5BJQ5 | 217 | RIT2_RAT GTP-binding protein Rit2 OS=Rattus n... | 107 | 0.008 | 42.4 | 25 | 45 | GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 55 | Q8IS16 | 604 | GEFH_DICDI Ras guanine nucleotide exchange fa... | 172 | 0.009 | 43.1 | 22 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 56 | P13856 | 272 | RSR1_YEAST Ras-related protein RSR1 OS=Saccha... | 126 | 0.009 | 42.4 | 27 | 47 | GO:0005935; C:cellular bud neck; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IDA:SGD.::GO:0004871; F:signal transducer activity; TAS:SGD. | | | | | | | | | | GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD. | 57 | P70425 | 217 | RIT2_MOUSE GTP-binding protein Rit2 OS=Mus mu... | 104 | 0.01 | 42 | 26 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 58 | Q8WZA2 | 1011 | RPGF4_HUMAN Rap guanine nucleotide exchange f... | 146 | 0.011 | 43.1 | 23 | 47 | GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0030552; F:cAMP binding; ISS:UniProtKB.::GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0017016; F:Ras GTPase binding; ISS:UniProtKB.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 59 | A7A0P0 | 1252 | SDC25_YEAS7 Guanine nucleotide exchange facto... | 159 | 0.014 | 42.7 | 22 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 60 | A1DZY4 | 253 | RSLBL_DANRE Ras-like protein family member 11... | 134 | 0.015 | 41.6 | 27 | 46 | GO:0016020; C:membrane; IEA:InterPro.::GO:0005730; C:nucleolus; ISS:UniProtKB. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0045943; P:positive regulation of transcription from RNA polymerase I promoter; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 61 | B3LTF3 | 1252 | SDC25_YEAS1 Guanine nucleotide exchange facto... | 159 | 0.015 | 42.7 | 22 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
