| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q54TK8 | 1502 | GEFP_DICDI Ras guanine nucleotide exchange fa... | 181 | 0.000000000004 | 74.3 | 28 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 2 | Q8SSQ3 | 929 | GEFM_DICDI Ras guanine nucleotide exchange fa... | 258 | 0.000000001 | 65.5 | 23 | 47 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 3 | Q8SSQ0 | 1721 | GEFR_DICDI Ras guanine nucleotide exchange fa... | 219 | 0.00000002 | 62.4 | 26 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005488; F:binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 4 | Q54PQ4 | 605 | GEFA_DICDI Ras guanine nucleotide exchange fa... | 108 | 0.0000003 | 57.8 | 31 | 59 | GO:0005829; C:cytosol; IDA:dictyBase. | | | | | | | | | | GO:0030250; F:guanylate cyclase activator activity; IMP:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0007190; P:activation of adenylate cyclase activity; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 5 | Q8ST25 | 1556 | GEFG_DICDI Ras guanine nucleotide exchange fa... | 157 | 0.00000003 | 61.6 | 27 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 6 | Q54FF3 | 1557 | GEFK_DICDI Ras guanine nucleotide exchange fa... | 204 | 0.00000008 | 60.1 | 25 | 49 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 7 | Q8TDF6 | 673 | GRP4_HUMAN RAS guanyl-releasing protein 4 OS=... | 98 | 0.0000002 | 58.2 | 28 | 52 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; TAS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019992; F:diacylglycerol binding; TAS:UniProtKB.::GO:0030742; F:GTP-dependent protein binding; NAS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:UniProtKB. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; NAS:UniProtKB.::GO:0016049; P:cell growth; IDA:UniProtKB.::GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0030099; P:myeloid cell differentiation; TAS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0009991; P:response to extracellular stimulus; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; NAS:UniProtKB. | 8 | Q9D300 | 466 | RGF1C_MOUSE Ras-GEF domain-containing family ... | 380 | 0.0000007 | 56.2 | 23 | 39 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 9 | Q8R5I4 | 678 | GRP4_RAT RAS guanyl-releasing protein 4 OS=Ra... | 98 | 0.0000007 | 56.6 | 27 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0009991; P:response to extracellular stimulus; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 10 | Q13905 | 1077 | RPGF1_HUMAN Rap guanine nucleotide exchange f... | 139 | 0.0000009 | 56.6 | 27 | 49 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 11 | Q1LZ97 | 673 | GRP4_BOVIN RAS guanyl-releasing protein 4 OS=... | 98 | 0.000002 | 55.5 | 27 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0009991; P:response to extracellular stimulus; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 12 | Q8IS14 | 812 | GEFJ_DICDI Ras guanine nucleotide exchange fa... | 109 | 0.007 | 43.9 | 29 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 13 | Q3MIN7 | 710 | RGL3_HUMAN Ral guanine nucleotide dissociatio... | 343 | 0.000006 | 53.5 | 24 | 40 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 14 | Q8IS15 | 824 | GEFI_DICDI Ras guanine nucleotide exchange fa... | 103 | 0.047 | 40.8 | 28 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 15 | Q8AVS6 | 248 | RSLBB_XENLA Ras-like protein family member 11... | 205 | 0.00005 | 49.3 | 24 | 43 | GO:0016020; C:membrane; IEA:InterPro. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0003924; F:GTPase activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 16 | Q8TEU7 | 1601 | RPGF6_HUMAN Rap guanine nucleotide exchange f... | 157 | 0.00007 | 50.4 | 24 | 48 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; IDA:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:UniProtKB. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0043087; P:regulation of GTPase activity; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 17 | Q9USU1 | 987 | EFC25_SCHPO Ras guanine nucleotide exchange f... | 216 | 0.0001 | 49.3 | 23 | 41 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IMP:PomBase. | | | | | | | | | | GO:0032488; P:Cdc42 protein signal transduction; TAS:PomBase.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0007163; P:establishment or maintenance of cell polarity; IGI:PomBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 18 | Q55FD8 | 1982 | GEFV_DICDI Ras guanine nucleotide exchange fa... | 145 | 0.0001 | 49.3 | 28 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase. | 19 | Q8IS18 | 1037 | GEFE_DICDI Ras guanine nucleotide exchange fa... | 148 | 0.0002 | 48.9 | 24 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0043052; P:thermotaxis; IMP:dictyBase. | 20 | Q9UHV5 | 662 | RPGFL_HUMAN Rap guanine nucleotide exchange f... | 155 | 0.0003 | 48.1 | 23 | 46 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0007399; P:nervous system development; TAS:ProtInc.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 21 | Q68EF8 | 662 | RPGFL_MOUSE Rap guanine nucleotide exchange f... | 155 | 0.0007 | 46.6 | 22 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 22 | Q5TJE5 | 780 | RGL2_CANFA Ral guanine nucleotide dissociatio... | 380 | 0.0007 | 47 | 23 | 36 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 23 | Q03386 | 895 | GNDS_RAT Ral guanine nucleotide dissociation ... | 374 | 0.0008 | 47 | 23 | 40 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; TAS:RGD. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:RGD. | 24 | Q8CHG7 | 1496 | RPGF2_MOUSE Rap guanine nucleotide exchange f... | 133 | 0.0008 | 47 | 26 | 48 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 25 | Q5R9B2 | 456 | RPGFL_PONPY Rap guanine nucleotide exchange f... | 155 | 0.0008 | 46.6 | 23 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 26 | Q8N431 | 466 | RGF1C_HUMAN Ras-GEF domain-containing family ... | 331 | 0.0008 | 46.6 | 22 | 38 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 27 | F1M386 | 1496 | RPGF2_RAT Rap guanine nucleotide exchange fac... | 133 | 0.0008 | 47 | 26 | 48 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0019901; F:protein kinase binding; IPI:UniProtKB. | | | | | | | | | | GO:0048167; P:regulation of synaptic plasticity; IDA:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 28 | Q95KH6 | 466 | RGF1C_MACFA Ras-GEF domain-containing family ... | 380 | 0.0008 | 46.2 | 22 | 37 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 29 | Q60695 | 768 | RGL1_MOUSE Ral guanine nucleotide dissociatio... | 102 | 0.49 | 37.7 | 27 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 30 | Q8C0Q9 | 814 | RPGF5_MOUSE Rap guanine nucleotide exchange f... | 154 | 0.001 | 46.2 | 25 | 47 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0030742; F:GTP-dependent protein binding; ISS:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 31 | Q9Y4G8 | 1499 | RPGF2_HUMAN Rap guanine nucleotide exchange f... | 133 | 0.001 | 46.2 | 26 | 48 | GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0005622; C:intracellular; TAS:GOC. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0017034; F:Rap guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB. | | | | | | | | | | GO:0019933; P:cAMP-mediated signaling; NAS:UniProtKB.::GO:0000165; P:MAPK cascade; NAS:UniProtKB.::GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:UniProtKB. |
