| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P22817 | 990 | IDE_DROME Insulin-degrading enzyme OS=Drosoph... | 245 | 0.00006 | 51.2 | 25 | 43 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 32 | Q10040 | 856 | YQA4_CAEEL Putative zinc protease C28F5.4 OS=... | 243 | 0.0001 | 50.1 | 28 | 42 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 33 | Q8BHG1 | 1161 | NRDC_MOUSE Nardilysin OS=Mus musculus (Mouse)... | 234 | 0.0001 | 50.1 | 26 | 40 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 34 | P47245 | 1161 | NRDC_RAT Nardilysin OS=Rattus norvegicus (Rat... | 234 | 0.0001 | 50.1 | 26 | 40 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 35 | P0A5S9 | 438 | Y2805_MYCBO Uncharacterized zinc protease Mb2... | 311 | 0.0001 | 49.3 | 23 | 37 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 36 | P0A5S8 | 438 | Y2782_MYCTU Uncharacterized zinc protease Rv2... | 311 | 0.0001 | 49.3 | 23 | 37 | GO:0005886; C:plasma membrane; IDA:MTBBASE. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 37 | O43847 | 1150 | NRDC_HUMAN Nardilysin OS=Homo sapiens (Human)... | 230 | 0.0002 | 49.7 | 26 | 42 | GO:0009986; C:cell surface; TAS:UniProtKB.::GO:0005829; C:cytosol; TAS:UniProtKB. | | | | | | | | | | GO:0048408; F:epidermal growth factor binding; TAS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016477; P:cell migration; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0007528; P:neuromuscular junction development; TAS:ProtInc.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IDA:BHF-UCL.::GO:0006508; P:proteolysis; NAS:UniProtKB.::GO:0052548; P:regulation of endopeptidase activity; IDA:BHF-UCL. | 38 | Q5R4H6 | 1152 | NRDC_PONAB Nardilysin OS=Pongo abelii (Sumatr... | 234 | 0.0003 | 48.9 | 26 | 40 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 39 | O14077 | 969 | MU138_SCHPO Putative zinc protease mug138 OS=... | 228 | 0.0003 | 48.5 | 22 | 39 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0071432; P:peptide mating pheromone maturation involved in conjugation with cellular fusion; ISS:PomBase.::GO:0006508; P:proteolysis; ISS:PomBase. | 40 | Q06010 | 1027 | STE23_YEAST A-factor-processing enzyme OS=Sac... | 276 | 0.001 | 47 | 22 | 38 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:SGD. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007323; P:peptide pheromone maturation; IGI:SGD.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW.::GO:0019236; P:response to pheromone; IEA:UniProtKB-KW. | 41 | Q5UPX9 | 440 | YL233_MIMIV Putative zinc protease L233 OS=Ac... | 223 | 0.015 | 42.7 | 21 | 44 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 42 | Q54JQ2 | 962 | IDE_DICDI Insulin-degrading enzyme homolog OS... | 170 | 0.019 | 42.7 | 25 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 43 | O22941 | 970 | PXM16_ARATH Zinc-metallopeptidase, peroxisoma... | 191 | 0.02 | 42.7 | 26 | 43 | GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 44 | P35559 | 1019 | IDE_RAT Insulin-degrading enzyme OS=Rattus no... | 167 | 0.029 | 42.4 | 22 | 40 | GO:0009986; C:cell surface; IDA:RGD.::GO:0031597; C:cytosolic proteasome complex; IDA:RGD.::GO:0005615; C:extracellular space; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.::GO:0005782; C:peroxisomal matrix; IDA:RGD.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0016887; F:ATPase activity; IDA:RGD.::GO:0001540; F:beta-amyloid binding; IPI:RGD.::GO:0031626; F:beta-endorphin binding; IMP:RGD.::GO:0043559; F:insulin binding; IMP:RGD.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0042447; P:hormone catabolic process; IDA:RGD.::GO:0045861; P:negative regulation of proteolysis; IDA:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0051289; P:protein homotetramerization; IDA:RGD.::GO:0051603; P:proteolysis involved in cellular protein catabolic process; IMP:RGD. | 45 | Q24K02 | 1019 | IDE_BOVIN Insulin-degrading enzyme OS=Bos tau... | 168 | 0.07 | 40.8 | 21 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 46 | Q9JHR7 | 1019 | IDE_MOUSE Insulin-degrading enzyme OS=Mus mus... | 179 | 0.082 | 40.8 | 23 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; ISS:UniProtKB.::GO:0010815; P:bradykinin catabolic process; ISS:UniProtKB.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 47 | Q4W6B5 | 469 | MPPB_DICDI Mitochondrial-processing peptidase... | 186 | 0.1 | 40 | 24 | 45 | GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.::GO:0017087; C:mitochondrial processing peptidase complex; ISS:dictyBase.::GO:0031982; C:vesicle; IDA:dictyBase. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; ISS:dictyBase.::GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0031930; P:mitochondria-nucleus signaling pathway; IMP:dictyBase.::GO:0006627; P:protein processing involved in protein targeting to mitochondrion; ISS:dictyBase.::GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 48 | O32965 | 445 | Y855_MYCLE Uncharacterized zinc protease ML08... | 315 | 0.11 | 40 | 23 | 37 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 49 | Q8ZMB5 | 962 | PTRA_SALTY Protease 3 OS=Salmonella typhimuri... | 177 | 0.12 | 40 | 25 | 40 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 50 | Q8Z418 | 962 | PTRA_SALTI Protease 3 OS=Salmonella typhi. GN... | 177 | 0.13 | 40 | 25 | 40 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 51 | O86835 | 459 | Y5738_STRCO Uncharacterized zinc protease SCO... | 338 | 0.15 | 39.7 | 22 | 39 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 52 | P05458 | 962 | PTRA_ECOLI Protease 3 OS=Escherichia coli (st... | 174 | 0.21 | 39.3 | 26 | 41 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IDA:EcoCyc. | 53 | Q83QC3 | 962 | PTRA_SHIFL Protease 3 OS=Shigella flexneri. G... | 174 | 0.23 | 39.3 | 26 | 41 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 54 | Q8X6M8 | 962 | PTRA_ECO57 Protease 3 OS=Escherichia coli O15... | 174 | 0.24 | 39.3 | 26 | 41 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 55 | Q8CVS2 | 962 | PTRA_ECOL6 Protease 3 OS=Escherichia coli O6:... | 174 | 0.26 | 38.9 | 26 | 41 | GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 56 | P14735 | 1019 | IDE_HUMAN Insulin-degrading enzyme OS=Homo sa... | 168 | 0.3 | 38.9 | 21 | 39 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004222; F:metalloendopeptidase activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0050435; P:beta-amyloid metabolic process; IDA:UniProtKB.::GO:0010815; P:bradykinin catabolic process; IDA:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW. | 57 | Q8RIH1 | 177 | RL6_FUSNN 50S ribosomal protein L6 OS=101130 ... | 34 | 0.34 | 37.4 | 47 | 65 | GO:0005840; C:ribosome; IEA:UniProtKB-KW. | | | | | | | | | | GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.::GO:0003735; F:structural constituent of ribosome; IEA:InterPro. | | | | | | | | | | GO:0006412; P:translation; IEA:InterPro. | 58 | A3QCM3 | 363 | FLGI_SHELP Flagellar P-ring protein OS=Shewan... | 117 | 0.53 | 37.7 | 28 | 44 | GO:0009428; C:bacterial-type flagellum basal body, distal rod, P ring; IEA:InterPro.::GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro. | | | | | | | | | | GO:0005198; F:structural molecule activity; IEA:InterPro. | | | | | | | | | | GO:0001539; P:ciliary or flagellar motility; IEA:InterPro. | 59 | P42789 | 596 | SDP_EIMBO Sporozoite developmental protein OS... | 50 | 0.78 | 37.4 | 40 | 56 | | | | | | | | | | | GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006508; P:proteolysis; IEA:UniProtKB-KW. | 60 | B1KLG5 | 363 | FLGI_SHEWM Flagellar P-ring protein OS=Shewan... | 126 | 0.79 | 37 | 25 | 43 | GO:0009428; C:bacterial-type flagellum basal body, distal rod, P ring; IEA:InterPro.::GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro. | | | | | | | | | | GO:0005198; F:structural molecule activity; IEA:InterPro. | | | | | | | | | | GO:0001539; P:ciliary or flagellar motility; IEA:InterPro. | 61 | P15392 | 494 | CP2A4_MOUSE Cytochrome P450 2A4 OS=Mus muscul... | 212 | 0.91 | 37 | 23 | 41 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0035634; P:response to stilbenoid; IEP:UniProtKB. |
