rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q14191 | 1432 | WRN_HUMAN Werner syndrome ATP-dependent helic... | 157 | 3e-17 | 87 | 37 | 51 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; IDA:MGI. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IEA:InterPro.::GO:0000405; F:bubble DNA binding; IDA:UniProtKB.::GO:0009378; F:four-way junction helicase activity; IDA:UniProtKB.::GO:0051880; F:G-quadruplex DNA binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0030145; F:manganese ion binding; IDA:UniProtKB.::GO:0032403; F:protein complex binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0000403; F:Y-form DNA binding; IDA:UniProtKB. | | | | | | | | | | GO:0006284; P:base-excision repair; IDA:UniProtKB.::GO:0009267; P:cellular response to starvation; IDA:MGI.::GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0000731; P:DNA synthesis involved in DNA repair; IDA:UniProtKB.::GO:0010259; P:multicellular organismal aging; IMP:UniProtKB.::GO:0032066; P:nucleolus to nucleoplasm transport; IDA:MGI.::GO:0051345; P:positive regulation of hydrolase activity; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IGI:MGI.::GO:0031297; P:replication fork processing; IDA:UniProtKB.::GO:0006979; P:response to oxidative stress; IDA:UniProtKB.::GO:0010225; P:response to UV-C; IDA:UniProtKB.::GO:0000723; P:telomere maintenance; IMP:UniProtKB. | 2 | O09053 | 1401 | WRN_MOUSE Werner syndrome ATP-dependent helic... | 163 | 7e-17 | 85.9 | 36 | 52 | GO:0005654; C:nucleoplasm; IDA:MGI. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0030145; F:manganese ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0010259; P:multicellular organismal aging; IGI:MGI.::GO:0040009; P:regulation of growth rate; IMP:MGI.::GO:0001302; P:replicative cell aging; IMP:MGI.::GO:0000723; P:telomere maintenance; IMP:MGI. | 3 | O93530 | 1436 | WRN_XENLA Werner syndrome ATP-dependent helic... | 163 | 8e-17 | 85.9 | 36 | 51 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0043140; F:ATP-dependent 3'-5' DNA helicase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0030145; F:manganese ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0006310; P:DNA recombination; IEA:InterPro.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006260; P:DNA replication; IEA:InterPro. | 4 | Q84LH3 | 288 | WEX_ARATH Werner Syndrome-like exonuclease OS... | 176 | 0.0000000000002 | 73.2 | 31 | 52 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IDA:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | | 5 | B4N9D3 | 356 | WRNXO_DROWI Werner Syndrome-like exonuclease ... | 190 | 0.0000002 | 55.8 | 29 | 45 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 6 | Q9VE86 | 353 | WRNXO_DROME Werner Syndrome-like exonuclease ... | 159 | 0.0000003 | 55.5 | 29 | 46 | GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IMP:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0000738; P:DNA catabolic process, exonucleolytic; IC:FlyBase.::GO:0045950; P:negative regulation of mitotic recombination; IMP:FlyBase. | 7 | B4I298 | 354 | WRNXO_DROSE Werner Syndrome-like exonuclease ... | 159 | 0.0000003 | 55.5 | 29 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 8 | B4PLB3 | 354 | WRNXO_DROYA Werner Syndrome-like exonuclease ... | 159 | 0.0000003 | 55.5 | 29 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 9 | B4QUF6 | 354 | WRNXO_DROSI Werner Syndrome-like exonuclease ... | 159 | 0.0000003 | 55.5 | 29 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 10 | Q299L3 | 356 | WRNXO_DROPS Werner Syndrome-like exonuclease ... | 159 | 0.0000006 | 54.3 | 28 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 11 | B4G5C9 | 355 | WRNXO_DROPE Werner Syndrome-like exonuclease ... | 159 | 0.0000007 | 54.3 | 28 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 12 | Q8N9H8 | 876 | MUT7_HUMAN Probable exonuclease mut-7 homolog... | 200 | 0.0000008 | 54.7 | 28 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | | 13 | Q5UQM4 | 399 | YR431_MIMIV Putative 3'-5' exonuclease R431 O... | 179 | 0.000001 | 53.9 | 30 | 46 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | | 14 | B3LWP6 | 355 | WRNXO_DROAN Werner Syndrome-like exonuclease ... | 159 | 0.000002 | 53.1 | 28 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 15 | B4K934 | 329 | WRNXO_DROMO Werner Syndrome-like exonuclease ... | 159 | 0.000002 | 52.8 | 28 | 46 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 16 | B4JF25 | 331 | WRNXO_DROGR Werner Syndrome-like exonuclease ... | 159 | 0.000003 | 52 | 28 | 44 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 17 | B3NZ68 | 354 | WRNXO_DROER Werner Syndrome-like exonuclease ... | 159 | 0.000005 | 51.6 | 28 | 47 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 18 | B4M401 | 330 | WRNXO_DROVI Werner Syndrome-like exonuclease ... | 187 | 0.00001 | 50.4 | 28 | 44 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | GO:0045950; P:negative regulation of mitotic recombination; ISS:UniProtKB. | 19 | Q9NVH0 | 496 | EXD2_HUMAN Exonuclease 3'-5' domain-containin... | 122 | 0.0002 | 47.4 | 30 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | | 20 | Q8VEG4 | 496 | EXD2_MOUSE Exonuclease 3'-5' domain-containin... | 118 | 0.0005 | 45.8 | 32 | 42 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.::GO:0003676; F:nucleic acid binding; IEA:InterPro. | | | | | | | | | | | 21 | Q16WU7 | 317 | WSCD_AEDAE WSCD family member AAEL009094 OS=A... | 120 | 0.69 | 35.4 | 26 | 44 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008146; F:sulfotransferase activity; IEA:InterPro. | | | | | | | | | | | 22 | A6UX24 | 349 | Y1470_META3 Uncharacterized solute-binding pr... | 87 | 2.8 | 33.5 | 28 | 46 | | | | | | | | | | | | | | | | | | | | | |