| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
631 | Q6QNF3 | 1103 | PGFRB_CANFA Platelet-derived growth factor re... | 209 | 0.0000000000007 | 71.2 | 27 | 46 | GO:0016324; C:apical plasma membrane; ISS:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IEA:InterPro.::GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005019; F:platelet-derived growth factor beta-receptor activity; ISS:UniProtKB.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0060981; P:cell migration involved in coronary angiogenesis; ISS:UniProtKB.::GO:0035441; P:cell migration involved in vasculogenesis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:UniProtKB.::GO:0048015; P:phosphatidylinositol-mediated signaling; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.::GO:0010863; P:positive regulation of phospholipase C activity; ISS:UniProtKB.::GO:0032516; P:positive regulation of phosphoprotein phosphatase activity; ISS:UniProtKB.::GO:0014911; P:positive regulation of smooth muscle cell migration; ISS:UniProtKB.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0061298; P:retina vasculature development in camera-type eye; ISS:UniProtKB.::GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro. | 632 | P51954 | 1203 | NEK1_MOUSE Serine/threonine-protein kinase Ne... | 237 | 0.0000000000007 | 71.2 | 24 | 48 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006974; P:response to DNA damage stimulus; IMP:MGI.::GO:0010212; P:response to ionizing radiation; IMP:MGI. | 633 | Q9PUF6 | 1087 | PGFRA_CHICK Platelet-derived growth factor re... | 151 | 0.0000000000008 | 71.2 | 30 | 51 | GO:0005887; C:integral to plasma membrane; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0048704; P:embryonic skeletal system morphogenesis; IMP:UniProtKB.::GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro. | 634 | Q8NG66 | 645 | NEK11_HUMAN Serine/threonine-protein kinase N... | 153 | 0.0000000000008 | 70.9 | 31 | 52 | GO:0005730; C:nucleolus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0031572; P:G2/M transition DNA damage checkpoint; IMP:UniProtKB.::GO:0031573; P:intra-S DNA damage checkpoint; IDA:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB. | 635 | Q96GD4 | 344 | AURKB_HUMAN Aurora kinase B OS=Homo sapiens (... | 183 | 0.0000000000008 | 70.1 | 28 | 47 | GO:0032133; C:chromosome passenger complex; IPI:UniProtKB.::GO:0000780; C:condensed nuclear chromosome, centromeric region; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030496; C:midbody; TAS:UniProtKB.::GO:0005819; C:spindle; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:UniProtKB. | | | | | | | | | | GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0008608; P:attachment of spindle microtubules to kinetochore; TAS:UniProtKB.::GO:0034644; P:cellular response to UV; IDA:UniProtKB.::GO:0016570; P:histone modification; TAS:UniProtKB.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0002903; P:negative regulation of B cell apoptotic process; IDA:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0071777; P:positive regulation of cell cycle cytokinesis; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; TAS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; IMP:UniProtKB.::GO:0051983; P:regulation of chromosome segregation; TAS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; IMP:UniProtKB. | 636 | Q96TL5 | 358 | HOG1_NEUCR Mitogen-activated protein kinase h... | 210 | 0.0000000000008 | 70.1 | 26 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 637 | A4IGM9 | 360 | AURKB_XENTR Aurora kinase B OS=Xenopus tropic... | 183 | 0.0000000000008 | 70.1 | 29 | 47 | GO:0000785; C:chromatin; ISS:UniProtKB.::GO:0032133; C:chromosome passenger complex; ISS:UniProtKB.::GO:0000775; C:chromosome, centromeric region; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035175; F:histone kinase activity (H3-S10 specific); ISS:UniProtKB.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.::GO:0071777; P:positive regulation of cell cycle cytokinesis; ISS:UniProtKB.::GO:0034501; P:protein localization to kinetochore; ISS:UniProtKB.::GO:0051256; P:spindle midzone assembly involved in mitosis; ISS:UniProtKB. | 638 | Q9LSS0 | 668 | LRK17_ARATH L-type lectin-domain containing r... | 181 | 0.0000000000008 | 70.9 | 30 | 46 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 639 | P0C8E4 | 606 | M3K7_RAT Mitogen-activated protein kinase kin... | 248 | 0.0000000000008 | 70.9 | 25 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:RGD. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:RGD.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 640 | A2VDU3 | 579 | M3K7_BOVIN Mitogen-activated protein kinase k... | 248 | 0.0000000000008 | 70.9 | 25 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 641 | Q8QFP8 | 662 | LIMK1_CHICK LIM domain kinase 1 OS=Gallus gal... | 168 | 0.0000000000008 | 70.9 | 27 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 642 | Q8SSV3 | 652 | MKCD_DICDI Probable serine/threonine-protein ... | 158 | 0.0000000000008 | 70.9 | 30 | 49 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 643 | P20594 | 1047 | ANPRB_HUMAN Atrial natriuretic peptide recept... | 222 | 0.0000000000008 | 71.2 | 30 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; TAS:ProtInc. | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW.::GO:0004383; F:guanylate cyclase activity; IDA:UniProtKB.::GO:0016941; F:natriuretic peptide receptor activity; IDA:UniProtKB.::GO:0004672; F:protein kinase activity; IEA:InterPro.::GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc. | | | | | | | | | | GO:0097011; P:cellular response to granulocyte macrophage colony-stimulating factor stimulus; IEP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001503; P:ossification; IEA:UniProtKB-KW.::GO:0007168; P:receptor guanylyl cyclase signaling pathway; IDA:UniProtKB.::GO:0008217; P:regulation of blood pressure; TAS:ProtInc. | 644 | Q96KB5 | 322 | TOPK_HUMAN Lymphokine-activated killer T-cell... | 256 | 0.0000000000008 | 69.7 | 27 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; TAS:UniProtKB. | | | | | | | | | | GO:0007067; P:mitosis; NAS:UniProtKB. | 645 | P53668 | 647 | LIMK1_MOUSE LIM domain kinase 1 OS=Mus muscul... | 168 | 0.0000000000008 | 70.9 | 28 | 49 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0043005; C:neuron projection; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IPI:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0045773; P:positive regulation of axon extension; IGI:MGI. | 646 | Q55GV3 | 477 | PAKC_DICDI Serine/threonine-protein kinase pa... | 244 | 0.0000000000008 | 70.5 | 24 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0048365; F:Rac GTPase binding; IPI:dictyBase. | | | | | | | | | | GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0031273; P:negative regulation of pseudopodium assembly; IMP:dictyBase. | 647 | Q91287 | 796 | FGFR3_PLEWA Fibroblast growth factor receptor... | 249 | 0.0000000000009 | 70.9 | 26 | 48 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008284; P:positive regulation of cell proliferation; IEA:InterPro. | 648 | Q00655 | 628 | KSYK_PIG Tyrosine-protein kinase SYK OS=Sus s... | 188 | 0.0000000000009 | 70.9 | 31 | 44 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0032009; C:early phagosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0071226; P:cellular response to molecule of fungal origin; ISS:UniProtKB.::GO:0042742; P:defense response to bacterium; ISS:UniProtKB.::GO:0045087; P:innate immune response; ISS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007159; P:leukocyte cell-cell adhesion; ISS:UniProtKB.::GO:0001945; P:lymph vessel development; ISS:UniProtKB.::GO:0002281; P:macrophage activation involved in immune response; ISS:UniProtKB.::GO:0002283; P:neutrophil activation involved in immune response; ISS:UniProtKB.::GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.::GO:0045780; P:positive regulation of bone resorption; ISS:UniProtKB.::GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IEA:InterPro.::GO:0090237; P:regulation of arachidonic acid secretion; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043313; P:regulation of neutrophil degranulation; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0032928; P:regulation of superoxide anion generation; ISS:UniProtKB.::GO:0002554; P:serotonin secretion by platelet; ISS:UniProtKB. | 649 | Q9UM73 | 1620 | ALK_HUMAN ALK tyrosine kinase receptor OS=Hom... | 241 | 0.0000000000009 | 71.2 | 27 | 44 | GO:0005887; C:integral to plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004704; F:NF-kappaB-inducing kinase activity; TAS:UniProtKB.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; TAS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:UniProtKB.::GO:0048666; P:neuron development; TAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; TAS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro. | 650 | F1NBT0 | 969 | STK10_CHICK Serine/threonine-protein kinase 1... | 252 | 0.0000000000009 | 71.2 | 25 | 47 | GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0071593; P:lymphocyte aggregation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:2000401; P:regulation of lymphocyte migration; ISS:UniProtKB. | 651 | Q2H332 | 360 | HOG1_CHAGB Mitogen-activated protein kinase H... | 210 | 0.0000000000009 | 70.1 | 26 | 46 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004707; F:MAP kinase activity; IEA:EC. | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 652 | O43318 | 606 | M3K7_HUMAN Mitogen-activated protein kinase k... | 248 | 0.0000000000009 | 70.9 | 25 | 45 | GO:0005671; C:Ada2/Gcn5/Ada3 transcription activator complex; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0043966; P:histone H3 acetylation; IDA:BHF-UCL.::GO:0007252; P:I-kappaB phosphorylation; IDA:UniProtKB.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; IDA:UniProtKB.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:Reactome.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; NAS:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:ProtInc.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 653 | Q9QUK0 | 568 | CDKL2_MOUSE Cyclin-dependent kinase-like 2 OS... | 264 | 0.0000000000009 | 70.9 | 25 | 44 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | | 654 | Q9BYP7 | 1800 | WNK3_HUMAN Serine/threonine-protein kinase WN... | 207 | 0.0000000000009 | 71.2 | 29 | 47 | GO:0005912; C:adherens junction; ISS:BHF-UCL.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005923; C:tight junction; ISS:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0035827; F:rubidium ion transmembrane transporter activity; IDA:UniProtKB.::GO:0015081; F:sodium ion transmembrane transporter activity; IDA:UniProtKB. | | | | | | | | | | GO:0006916; P:anti-apoptosis; IMP:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; ISS:UniProtKB.::GO:0051928; P:positive regulation of calcium ion transport; IMP:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IDA:BHF-UCL.::GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:2000688; P:positive regulation of rubidium ion transmembrane transporter activity; IDA:UniProtKB.::GO:2000682; P:positive regulation of rubidium ion transport; IDA:UniProtKB.::GO:2000651; P:positive regulation of sodium ion transmembrane transporter activity; IDA:UniProtKB.::GO:0010765; P:positive regulation of sodium ion transport; IDA:BHF-UCL.::GO:0046777; P:protein autophosphorylation; IDA:BHF-UCL.::GO:2000021; P:regulation of ion homeostasis; IMP:UniProtKB. | 655 | Q8SRL5 | 272 | IPL1_ENCCU Probable spindle assembly checkpoi... | 161 | 0.0000000000009 | 68.9 | 28 | 47 | GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW. | 656 | Q00534 | 326 | CDK6_HUMAN Cyclin-dependent kinase 6 OS=Homo ... | 190 | 0.0000000000009 | 69.7 | 31 | 53 | GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IDA:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:BHF-UCL.::GO:0001726; C:ruffle; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0030332; F:cyclin binding; IPI:BHF-UCL.::GO:0004693; F:cyclin-dependent protein kinase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0014002; P:astrocyte development; ISS:UniProtKB.::GO:0007050; P:cell cycle arrest; TAS:UniProtKB.::GO:0043697; P:cell dedifferentiation; IMP:BHF-UCL.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0021542; P:dentate gyrus development; ISS:UniProtKB.::GO:0000080; P:G1 phase of mitotic cell cycle; IEP:BHF-UCL.::GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:UniProtKB.::GO:0048699; P:generation of neurons; ISS:UniProtKB.::GO:0021670; P:lateral ventricle development; ISS:UniProtKB.::GO:2000773; P:negative regulation of cellular senescence; IDA:UniProtKB.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0045638; P:negative regulation of myeloid cell differentiation; IDA:UniProtKB.::GO:0045668; P:negative regulation of osteoblast differentiation; IDA:BHF-UCL.::GO:0001954; P:positive regulation of cell-matrix adhesion; IDA:BHF-UCL.::GO:0048146; P:positive regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:2000145; P:regulation of cell motility; ISS:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; IMP:BHF-UCL.::GO:0009615; P:response to virus; IEP:UniProtKB.::GO:0003323; P:type B pancreatic cell development; IDA:UniProtKB. | 657 | Q62073 | 579 | M3K7_MOUSE Mitogen-activated protein kinase k... | 248 | 0.0000000000009 | 70.9 | 25 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004708; F:MAP kinase kinase activity; IDA:MGI.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0001525; P:angiogenesis; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0060546; P:negative regulation of necroptosis; IMP:UniProtKB.::GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:UniProtKB.::GO:0001841; P:neural tube formation; IMP:MGI.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI. | 658 | B4HBU3 | 777 | PLK4_DROPE Serine/threonine-protein kinase PL... | 232 | 0.0000000000009 | 70.9 | 23 | 45 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 659 | Q5RFL3 | 606 | M3K7_PONAB Mitogen-activated protein kinase k... | 248 | 0.0000000000009 | 70.9 | 25 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004709; F:MAP kinase kinase kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007252; P:I-kappaB phosphorylation; ISS:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 660 | Q13163 | 448 | MP2K5_HUMAN Dual specificity mitogen-activate... | 230 | 0.0000000000009 | 70.5 | 26 | 43 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:BHF-UCL.::GO:0071363; P:cellular response to growth factor stimulus; ISS:BHF-UCL.::GO:0071499; P:cellular response to laminar fluid shear stress; TAS:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; ISS:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISS:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051247; P:positive regulation of protein metabolic process; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. | 661 | Q2LYK3 | 777 | PLK4_DROPS Serine/threonine-protein kinase PL... | 232 | 0.0000000000009 | 70.9 | 23 | 45 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | |
