| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
571 | Q8VCT9 | 570 | TESK2_MOUSE Dual specificity testis-specific ... | 157 | 0.0000000000004 | 72 | 32 | 53 | GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; ISS:UniProtKB.::GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; ISS:UniProtKB. | 572 | P26619 | 1087 | PGFRA_XENLA Platelet-derived growth factor re... | 151 | 0.0000000000004 | 72.4 | 30 | 51 | GO:0005887; C:integral to plasma membrane; IEA:InterPro. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro. | 573 | Q9STK6 | 516 | WNK3_ARATH Probable serine/threonine-protein ... | 208 | 0.0000000000004 | 71.6 | 28 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 574 | Q64261 | 326 | CDK6_MOUSE Cyclin-dependent kinase 6 OS=Mus m... | 190 | 0.0000000000004 | 70.9 | 31 | 53 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0002244; P:hemopoietic progenitor cell differentiation; IMP:MGI.::GO:0060218; P:hemopoietic stem cell differentiation; IMP:MGI.::GO:0007219; P:Notch signaling pathway; IDA:MGI.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0033077; P:T cell differentiation in thymus; IMP:MGI. | 575 | P24719 | 497 | MEK1_YEAST Meiosis-specific serine/threonine-... | 208 | 0.0000000000004 | 71.6 | 29 | 43 | GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD. | | | | | | | | | | GO:0051598; P:meiotic recombination checkpoint; IMP:SGD. | 576 | P43405 | 635 | KSYK_HUMAN Tyrosine-protein kinase SYK OS=Hom... | 187 | 0.0000000000004 | 72 | 31 | 45 | GO:0005829; C:cytosol; IC:UniProtKB.::GO:0032009; C:early phagosome; ISS:UniProtKB.::GO:0042101; C:T cell receptor complex; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005178; F:integrin binding; IPI:UniProtKB.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0071226; P:cellular response to molecule of fungal origin; ISS:UniProtKB.::GO:0042742; P:defense response to bacterium; ISS:UniProtKB.::GO:0045087; P:innate immune response; ISS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; ISS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007159; P:leukocyte cell-cell adhesion; IDA:UniProtKB.::GO:0001945; P:lymph vessel development; ISS:UniProtKB.::GO:0002281; P:macrophage activation involved in immune response; ISS:UniProtKB.::GO:0002283; P:neutrophil activation involved in immune response; ISS:UniProtKB.::GO:0030593; P:neutrophil chemotaxis; IDA:UniProtKB.::GO:0009887; P:organ morphogenesis; TAS:ProtInc.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0045780; P:positive regulation of bone resorption; ISS:UniProtKB.::GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.::GO:0090237; P:regulation of arachidonic acid secretion; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0043313; P:regulation of neutrophil degranulation; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0032928; P:regulation of superoxide anion generation; ISS:UniProtKB.::GO:0002554; P:serotonin secretion by platelet; ISS:UniProtKB. | 577 | Q6DE08 | 361 | AUKBA_XENLA Aurora kinase B-A OS=Xenopus laev... | 183 | 0.0000000000004 | 71.2 | 29 | 47 | | | | | | | | | | | | | | | | | | | | | | 578 | Q6C842 | 706 | BUR1_YARLI Serine/threonine-protein kinase BU... | 199 | 0.0000000000004 | 72 | 29 | 50 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC.::GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity; IEA:EC. | | | | | | | | | | | 579 | Q5S007 | 2527 | LRRK2_HUMAN Leucine-rich repeat serine/threon... | 251 | 0.0000000000004 | 72.4 | 26 | 45 | GO:0032473; C:external side of mitochondrial outer membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0043005; C:neuron projection; IDA:BHF-UCL.::GO:0043025; C:neuronal cell body; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005525; F:GTP binding; IDA:UniProtKB.::GO:0034211; F:GTP-dependent protein kinase activity; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IDA:UniProtKB.::GO:0003924; F:GTPase activity; IDA:BHF-UCL.::GO:0004708; F:MAP kinase kinase activity; IDA:BHF-UCL.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:BHF-UCL.::GO:0015631; F:tubulin binding; IDA:BHF-UCL. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; IDA:BHF-UCL.::GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.::GO:0035640; P:exploration behavior; IMP:BHF-UCL.::GO:0048312; P:intracellular distribution of mitochondria; IMP:BHF-UCL.::GO:2000173; P:negative regulation of branching morphogenesis of a nerve; IMP:BHF-UCL.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; IMP:BHF-UCL.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:BHF-UCL.::GO:0014043; P:negative regulation of neuron maturation; IMP:BHF-UCL.::GO:0007528; P:neuromuscular junction development; IMP:BHF-UCL.::GO:0070997; P:neuron death; IMP:BHF-UCL.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:BHF-UCL.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:BHF-UCL.::GO:0010508; P:positive regulation of autophagy; ISS:BHF-UCL.::GO:0060161; P:positive regulation of dopamine receptor signaling pathway; IMP:BHF-UCL.::GO:0043068; P:positive regulation of programmed cell death; IDA:UniProtKB.::GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:BHF-UCL.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:BHF-UCL.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0035564; P:regulation of kidney size; ISS:BHF-UCL.::GO:0040012; P:regulation of locomotion; IMP:BHF-UCL.::GO:0042391; P:regulation of membrane potential; IMP:BHF-UCL.::GO:0006979; P:response to oxidative stress; IMP:BHF-UCL.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0022028; P:tangential migration from the subventricular zone to the olfactory bulb; IMP:BHF-UCL. | 580 | B3NE99 | 766 | PLK4_DROER Serine/threonine-protein kinase PL... | 177 | 0.0000000000004 | 72 | 26 | 50 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 581 | B4PDM5 | 766 | PLK4_DROYA Serine/threonine-protein kinase PL... | 177 | 0.0000000000004 | 72 | 26 | 50 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 582 | P05622 | 1098 | PGFRB_MOUSE Platelet-derived growth factor re... | 146 | 0.0000000000004 | 72 | 34 | 55 | GO:0016324; C:apical plasma membrane; ISS:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IEA:InterPro.::GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005019; F:platelet-derived growth factor beta-receptor activity; ISS:UniProtKB.::GO:0048407; F:platelet-derived growth factor binding; TAS:DFLAT.::GO:0005102; F:receptor binding; IPI:UniProtKB.::GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro. | | | | | | | | | | GO:0030325; P:adrenal gland development; IGI:MGI.::GO:0035909; P:aorta morphogenesis; IGI:BHF-UCL.::GO:0055003; P:cardiac myofibril assembly; IGI:UniProtKB.::GO:0060947; P:cardiac vascular smooth muscle cell differentiation; TAS:DFLAT.::GO:0060981; P:cell migration involved in coronary angiogenesis; IMP:UniProtKB.::GO:0035441; P:cell migration involved in vasculogenesis; IMP:UniProtKB.::GO:0048568; P:embryonic organ development; IEP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0072277; P:metanephric glomerular capillary formation; IGI:UniProtKB.::GO:0072262; P:metanephric glomerular mesangial cell proliferation involved in metanephros development; IMP:UniProtKB.::GO:0006807; P:nitrogen compound metabolic process; IMP:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0090280; P:positive regulation of calcium ion import; IMP:UniProtKB.::GO:0038091; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0050921; P:positive regulation of chemotaxis; IDA:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.::GO:0043406; P:positive regulation of MAP kinase activity; IDA:UniProtKB.::GO:0035793; P:positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway; IMP:UniProtKB.::GO:0045840; P:positive regulation of mitosis; IDA:UniProtKB.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; ISS:UniProtKB.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IDA:UniProtKB.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:UniProtKB.::GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:UniProtKB.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; IGI:BHF-UCL.::GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.::GO:0061298; P:retina vasculature development in camera-type eye; IMP:UniProtKB.::GO:0048705; P:skeletal system morphogenesis; IMP:MGI.::GO:0071670; P:smooth muscle cell chemotaxis; IGI:BHF-UCL.::GO:0048745; P:smooth muscle tissue development; IMP:MGI.::GO:0001894; P:tissue homeostasis; IMP:MGI.::GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro. | 583 | Q03146 | 911 | DDR1_MOUSE Epithelial discoidin domain-contai... | 260 | 0.0000000000004 | 72 | 28 | 42 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005518; F:collagen binding; IMP:UniProtKB.::GO:0038062; F:protein tyrosine kinase collagen receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0043583; P:ear development; IMP:MGI.::GO:0007566; P:embryo implantation; IMP:MGI.::GO:0007595; P:lactation; IEA:UniProtKB-KW.::GO:0060749; P:mammary gland alveolus development; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0038083; P:peptidyl-tyrosine autophosphorylation; ISS:UniProtKB.::GO:0001558; P:regulation of cell growth; IMP:MGI.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.::GO:0010715; P:regulation of extracellular matrix disassembly; IMP:UniProtKB.::GO:0014909; P:smooth muscle cell migration; IMP:UniProtKB.::GO:0061302; P:smooth muscle cell-matrix adhesion; IMP:UniProtKB.::GO:0044319; P:wound healing, spreading of cells; IMP:UniProtKB. | 584 | Q9M3D8 | 664 | LRK13_ARATH L-type lectin-domain containing r... | 184 | 0.0000000000004 | 72 | 27 | 49 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IDA:TAIR. | | | | | | | | | | GO:0071369; P:cellular response to ethylene stimulus; IEP:UniProtKB.::GO:0071472; P:cellular response to salt stress; IEP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB. | 585 | Q78DX7 | 2340 | ROS1_MOUSE Proto-oncogene tyrosine-protein ki... | 242 | 0.0000000000004 | 72.4 | 30 | 41 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0016049; P:cell growth; ISS:UniProtKB.::GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0002066; P:columnar/cuboidal epithelial cell development; IMP:UniProtKB.::GO:0010629; P:negative regulation of gene expression; IMP:MGI.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.::GO:0010966; P:regulation of phosphate transport; IMP:MGI.::GO:0032006; P:regulation of TOR signaling cascade; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IMP:UniProtKB. | 586 | Q62862 | 448 | MP2K5_RAT Dual specificity mitogen-activated ... | 230 | 0.0000000000004 | 71.2 | 26 | 43 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; IC:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL.::GO:0070375; P:ERK5 cascade; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; IMP:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IMP:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; IMP:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0030307; P:positive regulation of cell growth; IMP:RGD.::GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:RGD.::GO:0051247; P:positive regulation of protein metabolic process; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. | 587 | Q8SRU0 | 319 | CSK2A_ENCCU Probable casein kinase II subunit... | 186 | 0.0000000000004 | 70.5 | 25 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 588 | Q54M77 | 1867 | ROCO8_DICDI Probable serine/threonine-protein... | 226 | 0.0000000000004 | 72.4 | 27 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 589 | P18106 | 1325 | FPS_DROME Tyrosine-protein kinase Fps85D OS=D... | 238 | 0.0000000000004 | 72 | 28 | 44 | GO:0005912; C:adherens junction; IDA:FlyBase.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | GO:0051017; P:actin filament bundle assembly; IMP:FlyBase.::GO:0007411; P:axon guidance; IMP:FlyBase.::GO:0046664; P:dorsal closure, amnioserosa morphology change; IMP:FlyBase.::GO:0007394; P:dorsal closure, elongation of leading edge cells; IMP:FlyBase. | 590 | B0WAU8 | 761 | PLK4_CULQU Serine/threonine-protein kinase PL... | 248 | 0.0000000000004 | 72 | 22 | 44 | GO:0005814; C:centriole; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | | 591 | P48025 | 629 | KSYK_MOUSE Tyrosine-protein kinase SYK OS=Mus... | 185 | 0.0000000000004 | 71.6 | 31 | 45 | GO:0019815; C:B cell receptor complex; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0032009; C:early phagosome; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:MGI.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:MGI.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; IDA:MGI. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; IMP:MGI.::GO:0002250; P:adaptive immune response; ISS:UniProtKB.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0050853; P:B cell receptor signaling pathway; IDA:MGI.::GO:0043366; P:beta selection; IGI:MGI.::GO:0071226; P:cellular response to molecule of fungal origin; IMP:UniProtKB.::GO:0042742; P:defense response to bacterium; IMP:UniProtKB.::GO:0007167; P:enzyme linked receptor protein signaling pathway; IDA:MGI.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:MGI.::GO:0045087; P:innate immune response; IMP:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; IMP:UniProtKB.::GO:0007159; P:leukocyte cell-cell adhesion; ISS:UniProtKB.::GO:0019370; P:leukotriene biosynthetic process; IMP:MGI.::GO:0001945; P:lymph vessel development; IMP:UniProtKB.::GO:0002281; P:macrophage activation involved in immune response; IMP:UniProtKB.::GO:0002283; P:neutrophil activation involved in immune response; IMP:UniProtKB.::GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:UniProtKB.::GO:0046638; P:positive regulation of alpha-beta T cell differentiation; IGI:MGI.::GO:0046641; P:positive regulation of alpha-beta T cell proliferation; IGI:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045780; P:positive regulation of bone resorption; IMP:UniProtKB.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:MGI.::GO:0033630; P:positive regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0050715; P:positive regulation of cytokine secretion; IGI:MGI.::GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IMP:MGI.::GO:0045425; P:positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; IMP:MGI.::GO:0045401; P:positive regulation of interleukin-3 biosynthetic process; IMP:MGI.::GO:0043306; P:positive regulation of mast cell degranulation; IMP:MGI.::GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.::GO:0046777; P:protein autophosphorylation; IDA:MGI.::GO:0090237; P:regulation of arachidonic acid secretion; IMP:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0043313; P:regulation of neutrophil degranulation; IMP:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; IMP:UniProtKB.::GO:0032928; P:regulation of superoxide anion generation; IMP:UniProtKB.::GO:0002554; P:serotonin secretion by platelet; IMP:UniProtKB. | 592 | P05986 | 398 | KAPC_YEAST cAMP-dependent protein kinase type... | 200 | 0.0000000000004 | 71.2 | 29 | 47 | GO:0005952; C:cAMP-dependent protein kinase complex; IGI:SGD.::GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0007005; P:mitochondrion organization; IMP:SGD.::GO:0007265; P:Ras protein signal transduction; ISS:SGD. | 593 | Q7TYY6 | 399 | PKNL_MYCBO Probable serine/threonine-protein ... | 142 | 0.0000000000004 | 71.2 | 32 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 594 | O53510 | 399 | PKNL_MYCTU Probable serine/threonine-protein ... | 142 | 0.0000000000005 | 71.2 | 32 | 51 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:MTBBASE. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MTBBASE. | | | | | | | | | | GO:0018107; P:peptidyl-threonine phosphorylation; IDA:MTBBASE.::GO:0046777; P:protein autophosphorylation; IDA:MTBBASE. | 595 | P21802 | 821 | FGFR2_HUMAN Fibroblast growth factor receptor... | 258 | 0.0000000000005 | 72 | 26 | 45 | GO:0005938; C:cell cortex; IDA:UniProtKB.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0060076; C:excitatory synapse; ISS:UniProtKB.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; IDA:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IDA:UniProtKB.::GO:0008201; F:heparin binding; IEA:UniProtKB-KW.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007409; P:axonogenesis; ISS:UniProtKB.::GO:0030282; P:bone mineralization; ISS:UniProtKB.::GO:0060349; P:bone morphogenesis; ISS:UniProtKB.::GO:0060667; P:branch elongation involved in salivary gland morphogenesis; ISS:UniProtKB.::GO:0060670; P:branching involved in embryonic placenta morphogenesis; ISS:UniProtKB.::GO:0048755; P:branching morphogenesis of a nerve; ISS:UniProtKB.::GO:0060449; P:bud elongation involved in lung branching; ISS:UniProtKB.::GO:0045165; P:cell fate commitment; ISS:UniProtKB.::GO:0007267; P:cell-cell signaling; ISS:UniProtKB.::GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.::GO:0009880; P:embryonic pattern specification; ISS:UniProtKB.::GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis; ISS:UniProtKB.::GO:0035603; P:fibroblast growth factor receptor signaling pathway involved in hemopoiesis; ISS:UniProtKB.::GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification; ISS:UniProtKB.::GO:0035602; P:fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow; ISS:UniProtKB.::GO:0035607; P:fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development; ISS:UniProtKB.::GO:0035604; P:fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow; ISS:UniProtKB.::GO:0031069; P:hair follicle morphogenesis; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0032808; P:lacrimal gland development; ISS:UniProtKB.::GO:0060601; P:lateral sprouting from an epithelium; ISS:UniProtKB.::GO:0060174; P:limb bud formation; ISS:UniProtKB.::GO:0048286; P:lung alveolus development; ISS:UniProtKB.::GO:0060463; P:lung lobe morphogenesis; ISS:UniProtKB.::GO:0060484; P:lung-associated mesenchyme development; ISS:UniProtKB.::GO:0060615; P:mammary gland bud formation; ISS:UniProtKB.::GO:0003149; P:membranous septum morphogenesis; ISS:UniProtKB.::GO:0060915; P:mesenchymal cell differentiation involved in lung development; ISS:UniProtKB.::GO:0060916; P:mesenchymal cell proliferation involved in lung development; ISS:UniProtKB.::GO:0030901; P:midbrain development; ISS:UniProtKB.::GO:0035264; P:multicellular organism growth; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0042476; P:odontogenesis; ISS:UniProtKB.::GO:0035265; P:organ growth; ISS:UniProtKB.::GO:0030916; P:otic vesicle formation; ISS:UniProtKB.::GO:0003148; P:outflow tract septum morphogenesis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0060045; P:positive regulation of cardiac muscle cell proliferation; ISS:UniProtKB.::GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.::GO:0051781; P:positive regulation of cell division; ISS:UniProtKB.::GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0002053; P:positive regulation of mesenchymal cell proliferation; ISS:UniProtKB.::GO:0010518; P:positive regulation of phospholipase activity; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0009791; P:post-embryonic development; ISS:UniProtKB.::GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis; ISS:UniProtKB.::GO:0060523; P:prostate epithelial cord elongation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0021860; P:pyramidal neuron development; ISS:UniProtKB.::GO:0060687; P:regulation of branching involved in prostate gland morphogenesis; ISS:UniProtKB.::GO:0010453; P:regulation of cell fate commitment; ISS:UniProtKB.::GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway; ISS:UniProtKB.::GO:0040014; P:regulation of multicellular organism growth; ISS:UniProtKB.::GO:0045667; P:regulation of osteoblast differentiation; TAS:UniProtKB.::GO:0033688; P:regulation of osteoblast proliferation; TAS:UniProtKB.::GO:0051150; P:regulation of smooth muscle cell differentiation; ISS:UniProtKB.::GO:0008589; P:regulation of smoothened signaling pathway; ISS:UniProtKB.::GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development; ISS:UniProtKB.::GO:0001657; P:ureteric bud development; ISS:UniProtKB.::GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:UniProtKB.::GO:0021847; P:ventricular zone neuroblast division; ISS:UniProtKB. | 596 | Q91009 | 778 | NTRK1_CHICK High affinity nerve growth factor... | 250 | 0.0000000000005 | 72 | 28 | 44 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0048406; F:nerve growth factor binding; ISS:UniProtKB.::GO:0010465; F:nerve growth factor receptor activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0060385; P:axonogenesis involved in innervation; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0032320; P:positive regulation of Ras GTPase activity; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB. | 597 | Q80XP9 | 1789 | WNK3_MOUSE Serine/threonine-protein kinase WN... | 207 | 0.0000000000005 | 72 | 29 | 47 | GO:0005912; C:adherens junction; IDA:BHF-UCL.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0035827; F:rubidium ion transmembrane transporter activity; ISS:UniProtKB.::GO:0015081; F:sodium ion transmembrane transporter activity; ISS:UniProtKB. | | | | | | | | | | GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.::GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.::GO:2000688; P:positive regulation of rubidium ion transmembrane transporter activity; ISS:UniProtKB.::GO:2000682; P:positive regulation of rubidium ion transport; ISS:UniProtKB.::GO:2000651; P:positive regulation of sodium ion transmembrane transporter activity; ISS:UniProtKB.::GO:0010765; P:positive regulation of sodium ion transport; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB. | 598 | Q498D6 | 800 | FGFR4_RAT Fibroblast growth factor receptor 4... | 260 | 0.0000000000005 | 71.6 | 27 | 45 | GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017134; F:fibroblast growth factor binding; ISS:UniProtKB.::GO:0005007; F:fibroblast growth factor-activated receptor activity; IPI:MGI.::GO:0008201; F:heparin binding; ISS:UniProtKB. | | | | | | | | | | GO:0016477; P:cell migration; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0055062; P:phosphate ion homeostasis; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000573; P:positive regulation of DNA biosynthetic process; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0048554; P:positive regulation of metalloenzyme activity; ISS:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.::GO:2000188; P:regulation of cholesterol homeostasis; ISS:UniProtKB.::GO:0010715; P:regulation of extracellular matrix disassembly; ISS:UniProtKB. | 599 | Q55GC2 | 1142 | DST2_DICDI Serine/threonine-protein kinase ds... | 229 | 0.0000000000005 | 72 | 24 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006950; P:response to stress; ISS:dictyBase. | 600 | Q3UFB7 | 799 | NTRK1_MOUSE High affinity nerve growth factor... | 253 | 0.0000000000005 | 71.6 | 29 | 45 | GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0048406; F:nerve growth factor binding; ISS:UniProtKB.::GO:0010465; F:nerve growth factor receptor activity; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; ISS:UniProtKB. | | | | | | | | | | GO:0060385; P:axonogenesis involved in innervation; IMP:UniProtKB.::GO:0030183; P:B cell differentiation; IMP:MGI.::GO:0010623; P:developmental programmed cell death; ISS:UniProtKB.::GO:0042490; P:mechanoreceptor differentiation; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0043068; P:positive regulation of programmed cell death; ISS:UniProtKB.::GO:0032320; P:positive regulation of Ras GTPase activity; ISS:UniProtKB.::GO:0046579; P:positive regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0048485; P:sympathetic nervous system development; IMP:UniProtKB. | 601 | O97143 | 769 | PLK4_DROME Serine/threonine-protein kinase PL... | 177 | 0.0000000000006 | 71.6 | 26 | 50 | GO:0005814; C:centriole; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro. | | | | | | | | | | GO:0007099; P:centriole replication; IMP:FlyBase.::GO:0007052; P:mitotic spindle organization; IMP:FlyBase.::GO:0046599; P:regulation of centriole replication; IDA:FlyBase.::GO:0007288; P:sperm axoneme assembly; IMP:FlyBase. |
