| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
61 | Q9HCS2 | 524 | CP4FC_HUMAN Cytochrome P450 4F12 OS=Homo sapi... | 208 | 0.00000001 | 60.8 | 26 | 42 | GO:0016324; C:apical plasma membrane; ISS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; ISS:UniProtKB. | | | | | | | | | | GO:0018685; F:alkane 1-monooxygenase activity; ISS:UniProtKB.::GO:0008392; F:arachidonic acid epoxygenase activity; ISS:UniProtKB.::GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050051; F:leukotriene-B4 20-monooxygenase activity; ISS:UniProtKB.::GO:0047057; F:vitamin-K-epoxide reductase (warfarin-sensitive) activity; ISS:UniProtKB. | | | | | | | | | | GO:0017144; P:drug metabolic process; ISS:UniProtKB.::GO:0019373; P:epoxygenase P450 pathway; ISS:UniProtKB.::GO:0030195; P:negative regulation of blood coagulation; ISS:UniProtKB.::GO:0003095; P:pressure natriuresis; ISS:UniProtKB.::GO:0003091; P:renal water homeostasis; ISS:UniProtKB.::GO:0055078; P:sodium ion homeostasis; ISS:UniProtKB.::GO:0042360; P:vitamin E metabolic process; ISS:UniProtKB.::GO:0042371; P:vitamin K biosynthetic process; ISS:UniProtKB.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 62 | Q09128 | 514 | CP24A_RAT 1,25-dihydroxyvitamin D(3) 24-hydro... | 224 | 0.00000001 | 60.8 | 23 | 47 | GO:0005739; C:mitochondrion; TAS:RGD. | | | | | | | | | | GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; TAS:BHF-UCL.::GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IDA:RGD.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0042369; P:vitamin D catabolic process; TAS:RGD. | 63 | Q07973 | 514 | CP24A_HUMAN 1,25-dihydroxyvitamin D(3) 24-hyd... | 218 | 0.00000001 | 60.8 | 22 | 48 | GO:0005743; C:mitochondrial inner membrane; TAS:Reactome. | | | | | | | | | | GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IDA:UniProtKB.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; TAS:UniProtKB. | | | | | | | | | | GO:0001649; P:osteoblast differentiation; IEP:BHF-UCL.::GO:0042369; P:vitamin D catabolic process; NAS:BHF-UCL.::GO:0070561; P:vitamin D receptor signaling pathway; IEP:BHF-UCL.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 64 | Q05421 | 493 | CP2E1_MOUSE Cytochrome P450 2E1 OS=Mus muscul... | 285 | 0.00000001 | 60.8 | 24 | 44 | GO:0005792; C:microsome; IDA:MGI. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB.::GO:0016709; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen; IEA:EC. | | | | | | | | | | | 65 | Q9VE00 | 536 | C12A4_DROME Probable cytochrome P450 12a4, mi... | 221 | 0.00000001 | 60.8 | 26 | 48 | GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | GO:0017085; P:response to insecticide; IMP:FlyBase. | 66 | P20678 | 491 | CP2H2_CHICK Cytochrome P450 2H2 OS=Gallus gal... | 275 | 0.00000002 | 60.5 | 24 | 39 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 67 | Q9STL1 | 490 | C71AM_ARATH Cytochrome P450 71A22 OS=Arabidop... | 249 | 0.00000002 | 60.5 | 23 | 45 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 68 | Q64462 | 511 | CP4B1_MOUSE Cytochrome P450 4B1 OS=Mus muscul... | 191 | 0.00000002 | 60.1 | 25 | 42 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 69 | Q9STL0 | 483 | C71AN_ARATH Cytochrome P450 71A23 OS=Arabidop... | 173 | 0.00000002 | 60.1 | 26 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.::GO:0005515; F:protein binding; IPI:TAIR. | | | | | | | | | | | 70 | Q64464 | 503 | CP3AD_MOUSE Cytochrome P450 3A13 OS=Mus muscu... | 176 | 0.00000002 | 60.1 | 27 | 46 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0010628; P:positive regulation of gene expression; IMP:MGI. | 71 | Q9VFP1 | 508 | CP6D5_DROME Probable cytochrome P450 6d5 OS=D... | 207 | 0.00000003 | 60.1 | 28 | 47 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 72 | Q42716 | 502 | C71A8_MENPI Cytochrome P450 71A8 OS=Mentha pi... | 182 | 0.00000003 | 59.7 | 24 | 47 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 73 | P33272 | 492 | CP2BC_RAT Cytochrome P450 2B12 OS=Rattus norv... | 272 | 0.00000003 | 59.7 | 24 | 41 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 74 | Q64417 | 503 | CP3AE_CAVPO Cytochrome P450 3A14 OS=Cavia por... | 188 | 0.00000003 | 59.7 | 26 | 47 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 75 | Q9VVN6 | 510 | CP312_DROME Probable cytochrome P450 312a1 OS... | 247 | 0.00000003 | 59.7 | 25 | 44 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 76 | P20815 | 502 | CP3A5_HUMAN Cytochrome P450 3A5 OS=Homo sapie... | 195 | 0.00000003 | 59.7 | 25 | 47 | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005792; C:microsome; TAS:ProtInc. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0019825; F:oxygen binding; TAS:ProtInc. | | | | | | | | | | GO:0009822; P:alkaloid catabolic process; IDA:BHF-UCL.::GO:0042737; P:drug catabolic process; IDA:BHF-UCL.::GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0008202; P:steroid metabolic process; TAS:ProtInc.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 77 | P14263 | 528 | CP51_CANTR Lanosterol 14-alpha demethylase OS... | 218 | 0.00000003 | 59.7 | 26 | 45 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008398; F:sterol 14-demethylase activity; IEA:EC. | | | | | | | | | | GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 78 | Q27606 | 526 | CP4E2_DROME Cytochrome P450 4e2 OS=Drosophila... | 189 | 0.00000003 | 59.7 | 25 | 47 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 79 | P11511 | 503 | CP19A_HUMAN Cytochrome P450 19A1 OS=Homo sapi... | 344 | 0.00000003 | 59.7 | 24 | 43 | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0005624; C:membrane fraction; TAS:ProtInc. | | | | | | | | | | GO:0070330; F:aromatase activity; IDA:UniProtKB.::GO:0009055; F:electron carrier activity; TAS:UniProtKB.::GO:0020037; F:heme binding; IDA:UniProtKB.::GO:0019825; F:oxygen binding; TAS:ProtInc. | | | | | | | | | | GO:0006703; P:estrogen biosynthetic process; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 80 | Q64148 | 503 | CP3AA_MESAU Lithocholate 6-beta-hydroxylase O... | 197 | 0.00000004 | 59.3 | 23 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0033777; F:lithocholate 6beta-hydroxylase activity; IEA:EC.::GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro. | | | | | | | | | | | 81 | Q9W011 | 510 | C4D20_DROME Probable cytochrome P450 4d20 OS=... | 187 | 0.00000004 | 59.3 | 27 | 46 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 82 | P50859 | 533 | CP51_CANGA Lanosterol 14-alpha demethylase OS... | 232 | 0.00000004 | 59.3 | 23 | 42 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008398; F:sterol 14-demethylase activity; IEA:EC. | | | | | | | | | | GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 83 | P24456 | 504 | CP2DA_MOUSE Cytochrome P450 2D10 OS=Mus muscu... | 300 | 0.00000006 | 58.9 | 25 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 84 | P98187 | 520 | CP4F8_HUMAN Cytochrome P450 4F8 OS=Homo sapie... | 247 | 0.00000007 | 58.5 | 24 | 43 | GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0018685; F:alkane 1-monooxygenase activity; TAS:ProtInc.::GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0006693; P:prostaglandin metabolic process; TAS:ProtInc.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 85 | O46512 | 503 | CP19A_HORSE Cytochrome P450 19A1 OS=Equus cab... | 246 | 0.00000008 | 58.5 | 26 | 45 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; ISS:UniProtKB.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; ISS:UniProtKB. | | | | | | | | | | | 86 | P48416 | 545 | CP10_LYMST Cytochrome P450 10 OS=Lymnaea stag... | 221 | 0.00000008 | 58.5 | 24 | 47 | | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | | 87 | O55071 | 492 | CP2BJ_MOUSE Cytochrome P450 2B19 OS=Mus muscu... | 287 | 0.00000009 | 58.2 | 25 | 43 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005792; C:microsome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | | 88 | P04800 | 504 | CP3A1_RAT Cytochrome P450 3A1 OS=Rattus norve... | 186 | 0.00000009 | 58.2 | 23 | 47 | GO:0005789; C:endoplasmic reticulum membrane; IDA:RGD.::GO:0005792; C:microsome; IDA:RGD. | | | | | | | | | | GO:0070330; F:aromatase activity; IEA:EC.::GO:0032451; F:demethylase activity; IDA:RGD.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0050649; F:testosterone 6-beta-hydroxylase activity; IDA:RGD. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0017144; P:drug metabolic process; IDA:RGD.::GO:0070989; P:oxidative demethylation; IDA:RGD.::GO:0046686; P:response to cadmium ion; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD. | 89 | Q64441 | 514 | CP24A_MOUSE 1,25-dihydroxyvitamin D(3) 24-hyd... | 192 | 0.0000001 | 58.2 | 23 | 49 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IMP:MGI.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro. | | | | | | | | | | GO:0042359; P:vitamin D metabolic process; IMP:MGI. | 90 | P10613 | 528 | CP51_CANAL Lanosterol 14-alpha demethylase OS... | 234 | 0.0000001 | 58.2 | 24 | 42 | GO:0016021; C:integral to membrane; IDA:CGD.::GO:0005624; C:membrane fraction; IDA:CGD.::GO:0005886; C:plasma membrane; IDA:CGD. | | | | | | | | | | GO:0008144; F:drug binding; IDA:CGD.::GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0008398; F:sterol 14-demethylase activity; IDA:CGD. | | | | | | | | | | GO:0035690; P:cellular response to drug; IMP:CGD.::GO:0006696; P:ergosterol biosynthetic process; IGI:CGD.::GO:0001766; P:membrane raft polarization; IMP:CGD. | 91 | O23976 | 490 | C76B1_HELTU 7-ethoxycoumarin O-deethylase OS=... | 239 | 0.0000001 | 57.8 | 26 | 44 | | | | | | | | | | | GO:0009055; F:electron carrier activity; IEA:InterPro.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.::GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro. | | | | | | | | | | |
