| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q08227 | 384 | INP54_YEAST Phosphatidylinositol 4,5-bisphosp... | 361 | 1e-17 | 87.4 | 23 | 44 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD. | | | | | | | | | | GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 32 | Q6P4S2 | 1019 | SHIP1_XENLA Phosphatidylinositol 3,4,5-trisph... | 212 | 2e-17 | 88.6 | 33 | 49 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 33 | Q92835 | 1189 | SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisph... | 252 | 3e-17 | 87.8 | 31 | 47 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome. | 34 | Q9ES52 | 1191 | SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisph... | 364 | 3e-17 | 87.8 | 28 | 45 | GO:0005622; C:intracellular; IMP:GOC.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:MGI.::GO:0034594; F:phosphatidylinositol trisphosphate phosphatase activity; IDA:MGI.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0051425; F:PTB domain binding; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0008340; P:determination of adult lifespan; IMP:MGI.::GO:0016064; P:immunoglobulin mediated immune response; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0050869; P:negative regulation of B cell activation; IMP:MGI.::GO:0030889; P:negative regulation of B cell proliferation; IMP:MGI.::GO:0045779; P:negative regulation of bone resorption; IMP:MGI.::GO:0050777; P:negative regulation of immune response; IMP:MGI.::GO:0045409; P:negative regulation of interleukin-6 biosynthetic process; IMP:MGI.::GO:0045656; P:negative regulation of monocyte differentiation; IMP:MGI.::GO:0045659; P:negative regulation of neutrophil differentiation; IMP:MGI.::GO:0045671; P:negative regulation of osteoclast differentiation; IMP:MGI.::GO:0009968; P:negative regulation of signal transduction; IMP:MGI.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0043065; P:positive regulation of apoptotic process; IMP:MGI.::GO:0045579; P:positive regulation of B cell differentiation; IMP:MGI.::GO:0045648; P:positive regulation of erythrocyte differentiation; IMP:MGI. | 35 | Q2I6J0 | 1226 | SHP2B_DANRE Phosphatidylinositol 3,4,5-trisph... | 249 | 9e-17 | 86.7 | 31 | 43 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 36 | Q9NRR6 | 644 | INP5E_HUMAN 72 kDa inositol polyphosphate 5-p... | 215 | 2e-16 | 84.7 | 32 | 46 | GO:0035085; C:cilium axoneme; IDA:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; TAS:UniProtKB.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 37 | A0FI79 | 644 | INP5E_PANTR 72 kDa inositol polyphosphate 5-p... | 215 | 4e-16 | 84 | 32 | 46 | GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 38 | Q9LR47 | 617 | IP5P3_ARATH Type I inositol 1,4,5-trisphospha... | 226 | 5e-16 | 84 | 29 | 48 | | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0010588; P:cotyledon vascular tissue pattern formation; IMP:TAIR.::GO:0046855; P:inositol phosphate dephosphorylation; IMP:TAIR.::GO:0048016; P:inositol phosphate-mediated signaling; IC:TAIR.::GO:0032957; P:inositol trisphosphate metabolic process; IMP:TAIR.::GO:0010305; P:leaf vascular tissue pattern formation; IMP:TAIR.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0010067; P:procambium histogenesis; IMP:TAIR. | 39 | Q8C5L6 | 468 | INP5K_MOUSE Inositol polyphosphate 5-phosphat... | 333 | 0.000000000000002 | 81.3 | 26 | 44 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0043005; C:neuron projection; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; ISS:UniProtKB. | | | | | | | | | | GO:0016312; F:inositol bisphosphate phosphatase activity; IMP:UniProtKB.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005000; F:vasopressin receptor activity; IDA:UniProtKB. | | | | | | | | | | GO:0071320; P:cellular response to cAMP; IDA:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0043922; P:negative regulation by host of viral transcription; ISS:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; ISS:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; IMP:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; ISS:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; IMP:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IMP:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; ISS:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; ISS:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; IDA:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0035810; P:positive regulation of urine volume; IDA:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; IDA:UniProtKB.::GO:0097178; P:ruffle assembly; ISS:UniProtKB. | 40 | O14306 | 1191 | YE8A_SCHPO Probable inositol polyphosphate 5-... | 332 | 0.00000000000008 | 77.4 | 27 | 42 | GO:0030479; C:actin cortical patch; ISS:PomBase.::GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; ISS:PomBase. | | | | | | | | | | GO:0006897; P:endocytosis; ISS:PomBase.::GO:0031505; P:fungal-type cell wall organization; ISS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 41 | O43001 | 1076 | SYJ1_SCHPO Inositol-1,4,5-trisphosphate 5-pho... | 339 | 0.0000000000002 | 76.3 | 26 | 42 | GO:0032153; C:cell division site; IDA:PomBase.::GO:0051286; C:cell tip; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IDA:PomBase.::GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0006897; P:endocytosis; NAS:PomBase.::GO:0048017; P:inositol lipid-mediated signaling; IC:PomBase.::GO:0046856; P:phosphatidylinositol dephosphorylation; ISS:PomBase.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 42 | Q9BT40 | 448 | INP5K_HUMAN Inositol polyphosphate 5-phosphat... | 343 | 0.0000000000002 | 75.1 | 26 | 43 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0043005; C:neuron projection; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB. | | | | | | | | | | GO:0016312; F:inositol bisphosphate phosphatase activity; IDA:UniProtKB.::GO:0046030; F:inositol trisphosphate phosphatase activity; IDA:MGI.::GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC.::GO:0042577; F:lipid phosphatase activity; NAS:UniProtKB.::GO:0034485; F:phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005000; F:vasopressin receptor activity; ISS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0071320; P:cellular response to cAMP; ISS:UniProtKB.::GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:UniProtKB.::GO:0032869; P:cellular response to insulin stimulus; IDA:UniProtKB.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0046855; P:inositol phosphate dephosphorylation; IDA:MGI.::GO:0043922; P:negative regulation by host of viral transcription; IDA:UniProtKB.::GO:0051926; P:negative regulation of calcium ion transport; IDA:UniProtKB.::GO:0035305; P:negative regulation of dephosphorylation; ISS:UniProtKB.::GO:0010829; P:negative regulation of glucose transport; IDA:UniProtKB.::GO:2000466; P:negative regulation of glycogen (starch) synthase activity; ISS:UniProtKB.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:UniProtKB.::GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IDA:UniProtKB.::GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IDA:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IDA:UniProtKB.::GO:0090315; P:negative regulation of protein targeting to membrane; IDA:UniProtKB.::GO:0045869; P:negative regulation of retroviral genome replication; IDA:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:2001153; P:positive regulation of renal water transport; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0035810; P:positive regulation of urine volume; ISS:UniProtKB.::GO:0072661; P:protein targeting to plasma membrane; ISS:UniProtKB.::GO:0097178; P:ruffle assembly; IDA:UniProtKB. | 43 | P34370 | 398 | YLJ7_CAEEL Uncharacterized protein C50C3.7 OS... | 275 | 0.00000000007 | 67.4 | 26 | 41 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 44 | P40559 | 946 | INP51_YEAST Phosphatidylinositol 4,5-bisphosp... | 329 | 0.0000000003 | 66.2 | 23 | 43 | GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:SGD. | | | | | | | | | | GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046856; P:phosphatidylinositol dephosphorylation; IDA:SGD.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro.::GO:0015031; P:protein transport; IEA:UniProtKB-KW. | 45 | Q14642 | 412 | I5P1_HUMAN Type I inositol 1,4,5-trisphosphat... | 115 | 0.49 | 36.2 | 30 | 47 | GO:0016020; C:membrane; NAS:UniProtKB. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; NAS:UniProtKB.::GO:0042731; F:PH domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0007154; P:cell communication; NAS:UniProtKB.::GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. | 46 | Q9Q8N4 | 203 | VH23_MYXVL Probable host range protein 2-3 OS... | 115 | 0.63 | 35.4 | 27 | 43 | | | | | | | | | | | | | | | | | | | | | GO:0016032; P:viral reproduction; IEA:InterPro. | 47 | Q29467 | 412 | I5P1_CANFA Type I inositol 1,4,5-trisphosphat... | 50 | 4.9 | 33.1 | 36 | 48 | GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0052659; F:inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; IEA:EC.::GO:0052658; F:inositol-1,4,5-trisphosphate 5-phosphatase activity; IEA:EC.::GO:0004445; F:inositol-polyphosphate 5-phosphatase activity; IEA:EC. | | | | | | | | | | GO:0046854; P:phosphatidylinositol phosphorylation; IEA:InterPro. |
